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All Journal GHIDZA: Jurnal Gizi dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Media Bina Ilmiah Jurnal Katalisator Medical Sains : Jurnal Ilmiah Kefarmasian
Ratna Djamil
Universitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Studi Farmakognosi, Penapisan Fitokimia, dan Uji Hayati secara BSLT dari Buah Merah (Pandanus conoideus Lam.) Ratna Djamil; Dian Karina; Wiwi Winarti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (601.061 KB)

Abstract

Nowadays Buah Merah (Pandanus conoideus Lam.), the Indonesian herb is famous for medicinal treatment. The chemical constituens of the fruit have been examined, and brine shrimp lethality test (BSLT) have been carried out. On phytochemical screening, the fruit showed the existence of: volatile oil, sterol, triterpene, carrotene, higher fatty acid, flavon aglycon, emodols, coumarine, tannin, steroid glycoside, reducing compound, flavonoside, antosianoside and saponine. Brine Shrimp Lethality Test showed that the LCs of the n-hexane fraction of the fruit was 24.17 ppm, the ethyl acetate fraction was 29.24 ppm, while the methanol fraction was 94.01 ppm. It could be concluded that the n-hexane fraction has the highest biological activity.
Penapisan Fitokimia, Uji BSLT, dan Uji Antioksidan Ekstrak Metanol beberapa Spesies Papilionaceae RATNA DJAMIL; TRIA ANELIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 2 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

According to literatures, many plants of Papilionaceae family such as red bean (Phaseolus vulgaris L_), green bean (Phaseolus aureus Roxb.) and soybean (Glycine soja Sieb. & Zucc.) contain flavonoid, isoflavonoid and vitamin E. They all have antioxidant activity and are potential to reduce free radical. This research was aimed to identify secondary metabolites of crude powders and extracts of red bean, green bean and soybean. The bioactivity of each extracts was evaluated with Brine Shrimp Lethality Test (B SLT) method for preliminary assesment of toxicity. It was also evaluated for antioxidant activity using 1,1 difenil-2-pikrilhidrazil (DPPH) method. The results showed that red bean, green bean and soybean contain saponin, flavonoid, steroid/triterpenoid, coumarin, and tannin. The result of BSLT showed that LC50 (Lethality Concentration 50) of red bean was 213.21 ppm; green bean 390.71 ppm; and soybean 252.75 ppm. The result of DPPH tests showed that IC50 (Inhibition Concentration 50) of red bean was 47.54 ppm; green bean 95.08 ppm; and soybean 90.43 ppm.
PENGARUH EKSTRAK KOMBINASI DAN MIKROEMULSIFIKASI TERHADAP AKTIVITAS HAMBATAN TIROSINASE DAN ANTIOKSIDAN DARI KULIT BATANG NANGKA (Artocarpus heterophyllus L.) DAN KULIT BUAH DELIMA (Punica granatum L.) Stella Giovanny; Ratna Djamil; Deni Rahmat
Media Bina Ilmiah Vol. 17 No. 8: Maret 2023
Publisher : LPSDI Bina Patria

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33578/mbi.v17i8.340

Abstract

Penelitian ini bertujuan untuk mengevaluasi aktivitas penghambatan tirosinase dan antioksidan (AO) dari ekstrak kombinasi mikroemulsi (MCE) kulit batang nangka (Artocarpus heteropyllus L.) dan kulit buah delima (Punica granatum L.) memiliki efek mencerahkan kulit secara alami untuk meningkatkan depigmentasi dan menentukan mikroemulsi. Kombinasi ekstrak (MCE) dalam penghambatan tirosinase dan aktivitas antioksidan.
Analisis Senyawa Fitokimia, Organoleptik, Uji Aktivitas Inhibisi Enzim Tirosinase Minyak Biji Argan (Argan spinosa L.) dan Ekstrak Akar Murbei (Morus Alba L.) Sebagai Whitening Agent Pada Kulit Rina Hijayanti; Deni Rahmat; Ratna Djamil
Ghidza: Jurnal Gizi dan Kesehatan Vol 7 No 1 (2023): June
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v7i1.617

Abstract

Tujuan penelitian ini adalah untuk mengembangkan formulasi sediaan nanoemulgel yang mengandung nanoemulsi kombinasi minyak biji argan dan ekstrak akar murbei yang memiliki aktivitas penghambat enzim tirosinase, serta memberikan manfaat gizi dan meningkatkan kesehatan kulit. Jenis penelitian ini merupakan penelitian eksperimen. Bahan aktif yang digunakan adalah akar murbei (morus alba L) yang diperoleh dari perkebunan bogor dan minyak biji argan (Argania Spinosa L) yang diperoleh dari PT. Nardevchem. Bahan uji yaitu enzim tirosinase yang diperoleh dari Laboratorium Pusat Studi Biofarmaka. Hasil penetapan penapisan fitokimia dari ekstrak minyak biji argan dan akar murbei menunjukan bahwa minyak biji argan dan akar murbei mengandung alkaloid, saponin, tannin, fenolik, flavonoid, glikosida, triterpenoid. Hasil uji aktivitas inhibisi enzim tirosinase menunjukkan bahwa formula nanoemulgel memiliki potensi yang signifikan dalam menghambat aktivitas enzim tirosinase. Penambahan nanoemulsi minyak biji argan dan ekstrak akar murbei dalam formula nanoemulgel memberikan kontribusi positif terhadap efek inhibisi enzim tyrosinase. Formula terbaik yaitu formula II karena mempunyai zeta potensial dan TEM yang paling kecil.
SOLID EYELINER FORMULATION CONTAIN CLITORIA TERNATE L. EXTRACT IN PH ACID AND ALKALI AND IN VIVO IRRITATION TEST Linawaty Lee; Ratna Djamil; Deni Rahmat
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.828

Abstract

Clitoria ternatea flowers contain blue anthocyanin that has potential as natural coloring. The purpose of this study was to obtain an eyeliner product containing natural coloring that is safe, stable, and can replace hazardous chemicals. Clitoria ternatea flowers were extracted by kinetic maceration with 70% ethanol. The obtained extract was subjected to standard quality tests, phytochemical screening, and determination of total anthocyanin content and antioxidant activity (DPPH assay). Eyeliner-containing extracts were prepared in three pH variations (acidic, neutral, and alkaline). These three types of eyeliner preparations were subjected to an irritation test on shaved male albino white rabbit skin. stability test using the cycle test method, hardness, break point, and melting point were also performed. The results showed that Clitoria ternatea extract contains 0.2187% anthocyanin, has an antioxidant activity IC50 of104.7 µg/mL, and is free of heavy metals. The eyeliner contained Clitoria ternatea extract was dark blue when applied to the skin. Eyeliner preparations were stable in three stability cycle tests. The irritation test on the male albino rabbit skin showed no irritation. Clitorial ternatea extract can be used as natural coloring in eyeliner preparation. Keywords: Butterfly pea, Clitoria ternatea L., Anthocyanin, Antioxidant, Eyeliner.
SOLID EYELINER FORMULATION CONTAIN CLITORIA TERNATE L. EXTRACT IN PH ACID AND ALKALI AND IN VIVO IRRITATION TEST Linawaty Lee; Ratna Djamil; Deni Rahmat
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.828

Abstract

Clitoria ternatea flowers contain blue anthocyanin that has potential as natural coloring. The purpose of this study was to obtain an eyeliner product containing natural coloring that is safe, stable, and can replace hazardous chemicals. Clitoria ternatea flowers were extracted by kinetic maceration with 70% ethanol. The obtained extract was subjected to standard quality tests, phytochemical screening, and determination of total anthocyanin content and antioxidant activity (DPPH assay). Eyeliner-containing extracts were prepared in three pH variations (acidic, neutral, and alkaline). These three types of eyeliner preparations were subjected to an irritation test on shaved male albino white rabbit skin. stability test using the cycle test method, hardness, break point, and melting point were also performed. The results showed that Clitoria ternatea extract contains 0.2187% anthocyanin, has an antioxidant activity IC50 of104.7 µg/mL, and is free of heavy metals. The eyeliner contained Clitoria ternatea extract was dark blue when applied to the skin. Eyeliner preparations were stable in three stability cycle tests. The irritation test on the male albino rabbit skin showed no irritation. Clitorial ternatea extract can be used as natural coloring in eyeliner preparation. Keywords: Butterfly pea, Clitoria ternatea L., Anthocyanin, Antioxidant, Eyeliner.
PREPARASI DAN STANDARISASI EKSTRAK HASIL FERMENTASI KULIT BUAH DELIMA (Punica granatum L) Rosmawati; Faizatun; Ratna Djamil; Nur Miftahurrohmah
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/fq97ff66

Abstract

ABSTRAK Kulit buah delima kaya akan tanin yang dapat terhidrolisis terutama punicalagin yang merupakan prekursor senyawa aktif asam elagat yang banyak digunakan sebagai senyawa aktif untuk perawatan kulit. Proses fermentasi merupakan metode yang dapat meningkatkan kandungan asam elagat yang ramah lingkungan. Penelitian ini dilakukan untuk melakukan standarisasi ekstrak hasil fermentasi kulit buah delima (Punica granatum L) yang dikembangkan sebagai bahan baku pada sediaan kosmetik dengan menentukan parameter spesifik dan nonspesifik. Hasil yang diperoleh menunjukan pada penentuan parameter spesifik yang diuji meliputi identitas ekstrak, uji organoleptik, skrining fitokimia ekstrak positif terdapat senyawa alkaloid, antraquinon, glikosida, flavonoid, terpenoid, tanin, dan saponin. Pengujian parameter nonspesifik yang telah dilakukan antara lain nilai kadar air 0,19%, kadar abu total sebanyak 1,4%, kadar abu larut asam sebanyak 0,0034%, cemaran bakteri mikroba ALT dan AKK diperoleh 0 cfu/ml. Hasil penelitian memenuhi standarisasi mutu ekstrak. Data yang diperoleh diharapkan dapat menjadi informasi tambahan mengenai ekstrak hasil fermentasi kulit buah delima yang memenuhi standar mutu dalam pengembangan sebagai bahan baku sediaan kosmetika. Kata kunci : Kulit buah delima, standarisasi ekstrak, parameter spesifik ekstrak, parameter nonspesifik ekstrak ABSTRACT Pomegranate peel is rich punicalagin compounds a group of hydrolyzable tannins which is a precursor of the active compound ellagic acid, which is widely used as an active compound for skin care. The fermentation process is a method that can increase the content of ellagic acid that is environmentally friendly. This study was conducted to standardize the fermented extract of pomegranate peel (Punica granatum L) used as a raw material in cosmetic preparations by determining specific and nonspecific parameters. The specific parameter tests conducted were extract identity, organoleptic test, and phytochemical screening. Phytochemical screening showed that the extract contained positive alkaloids, anthraquinones, glycosides, terpenoids, flavonoids, saponins, and tannins. Non-specific parameter tests conducted included water content of 0.19%, total ash content of 1.4%, acid-soluble ash content of 0.0034%, microbial contamination of ALT and AKK obtained 0 cfu/ml. The results of the study met the extract quality standards. The data obtained are expected to be additional information regarding the fermented extract of pomegranate peel that meets quality standards in development as a raw material for cosmetic preparations. Keywords: Pomegranate peel, specific parametric extract, nonspessific parametric extract
Co-Authors CATHARINA YENNI Deni Rahmat Dian Karina Faizatun, Faizatun Farhana Hanida Al Qisthi FATIMAH BAKRIYYAH Indah Yuniasari Linawaty Lee Miftahurrohmah, Nur Nadya Vresya Saputri Nancy Dewi Yuliana Nani Khomeni Partomuan Simanjuntak Rina Hijayanti Rosmawati SITI Nuraini Stella Giovanny Suci Eka Lestari Supriyono, Supri Syamsudin Abdillah Syamsul Arifin Titi Parwati TRIA ANELIA Wiwi Winarti Zaidan, Sarah Zuhelmi Aziz