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All Journal Jurnal Ilmu Kefarmasian Indonesia
SARAH ZAIDAN
UNIVERSITAS PANCASILA
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Karakterisasi Sediaan Granul Biji Sirsak (Annona muricata L.) dan Uji Efektivitas terhadap Larva Aedes aegypti L. sebagai Kandidat Biolarvasida SARAH ZAIDAN; RATNA DJAMIL; SUPRIYONO SUPRIYONO; SITI Nuraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A. aegypti mosquito is a vector of virus caused dengue fever. The effort to control A. aegypti vector has been done so many times, including chemical, physical and biological method. A biological control against this vector can be performed by utilizing soursop seeds which are known to have larvicidal effect against the larva. Previously, it has been proven that the extract of soursop seed demonstrated larvicidal activity against A. aegypti. In this research, the extraction of soursop seed has been carried out by kinetic maceration with the solvent 70% of ethanol. Furthermore, the wet granulation of the obtained extract was used for the preparation of granules which were then tested its larvicidal activity against A. aegypti. Based on the activity test against the larva of Aedes aegypti, the granules showed LC50 values of 295.434 ppm smaller than temephos as a positive control that has larvicidal activity of 1 ppm cause 100% mortality A. aegypti.
Aktivitas Ekstrak dan Tablet Nanopartikel Buah Okra (Abelmoschus esculentus (L) Moench.) Sebagai Anti- Dislipidemia Pada Tikus Yang Diberi High Fat Diet Sarah Zaidan; Deni Rahmat; Ratna Djamil; Nadya Vresya Saputri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1097

Abstract

Dyslipidemia is a condition caused by disruption of lipid metabolism due to the interaction of genetic factors and environmental factors. There is strong evidence of an association between LDL cholesterol and cardiovascular events based on clinical outcome studies, so LDL cholesterol is the main target in the management of dyslipidemia. In addition to using synthetic drugs, dyslipidemia can be treated by consuming natural ingredients, one of which is okra (Abelmoschus esculentus (L) Moench). The form of nanoparticles and nanoparticle tablets of okra fruit extract is an effort to increase antidyslipidemic activity and to make it easier to use. This study aims to obtain nanoparticle extracts and nanoparticle tablets of okra fruit extract which have antidyslipidemic activity in vivo against mice given the High Fat Diet (HFD). The research used 24 rats divided into 6 treatment groups, namely group I as normal control, group II as positive control using simvastatin as the control control, group III as a negative control, group IV as a control treatment of ethanol extract 70% okra fruit, group V as a control treatment of okra fruit extract nanoparticles, and group VI as a treatment of okra fruit extract nanoparticles tablets. All test substances are given for 14 days. Blood sampling was carried out on days 0, 14, and 28, with the parameters measured were lipid profiles including total cholesterol (KT), LDL, Triglycerides (TG) and HDL. 70% ethanol extract, extract nanoparticles, and okra fruit extract nanoparticle tablets can decrease KT levels by 33.14%, 46.31%, 45.42%, decrease TG levels by 39.46%, 43.56%, 41, 62%, decrease LDL levels by 45.22%, 68.76%, 59.94%, and can increase HDL levels by 103.80%, 119.20%, 114.39%. Based on the lipid profile of mice given HFD, 70% ethanol extract, nanoparticles, and okra fruit extract nanoparticle tablets had antidyslipidemic activity.
Isolasi Senyawa Flavonoid dari Ekstrak Metanol Daun Katuk (Sauropus androgynus (L.) Merr), Euphorbiaceae RATNA DJAMIL; SARAH ZAIDAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Katuk (Sauropus androgyrus (L.) Merr) is one of the plants used for medicinal purposes. It has been carried out the research to isolate and to identify flavonoid compounds in the methanol extract of katuk leaves using paper chromatography and spectrophotometry ultraviolet-visible. The results demonstrated that light spectrum of uv-visible in the presence of a reagent gave an isolate NB-3 which was a compound suspected of flavonol with OH group in positions 5,7,4 ‘and o-di OH groups in the position of the A-ring (6,7 or 7,8) whrereas NB-4 isolate was suspected as flavonoids with OH groups at 5.7 and the prenil groups in position 6, methylation or glycosylation at OH group in a position 3 and o-di OH groupsin position of the a-ring (6,7 or 7,8).
Pemodelan Statistik Pemberian Air Susu Ibu (ASI) Eksklusif Berdasarkan Faktor Demograli SARAH ZAIDAN; SWASONO R. TAMAT; NURITA ANDAYANI; ANNY VICTOR PURBA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Exclusive breastfeeding is defined as giving breast milk to a baby without any additional drink, food or beverages during the first 6 months after birth. Today there is a decline in exclusive breastfeeding, and among others, one reason is the increase in the participation of mothers in the workforce, especially in urban areas. Many factors that affect the regularity of exclusive breastfeeding by working mothers, one of which, is the demographic factor. This study aims to obtain profile data of exclusive breastfeeding by working mothers and statistical modelling of exclusive breastfeeding by working mothers based on demographic factor, by conducting a survey on 384 respondents. This research uses descriptive analysis and logistic regression analysis with SPSS software version 15.0. Descriptive analysis showed that most mothers working in Jakarta (61.2%) did not give exclusive breastfeeding. Logistic regression statistical analysis showed that age, occupation, distance to work, and travel time to the workplace of working mothers are dominant factors that influence exclusive breastfeedings, with the p-value is smaller than the p value (Sig) = 0.05.
Co-Authors Anny Victor Purba Deni Rahmat Nadya Vresya Saputri Nurita Andayani Ratna Djamil SITI Nuraini Supriyono, Supri Swasono R. Tamat