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All Journal Dentika Dental Journal Jurnal Ilmu Kesehatan Masyarakat Jurnal Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Odonto dental journal Dental Agromedis
Desi Sandra Sari
Faculty Of Dentistry, Jember University, Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Dentika Dental Journal

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OUTER MEMBRANE PROTEIN OF PORPHYROMONAS GINGIVALIS AS BASIC OF DIAGNOSTIC TOOL IN AGGRESSIVE PERIODONTITIS: PROTEIN MEMBRAN BAGIAN LUAR PORPHYROMONAS GINGIVALIS SEBAGAI ALAT DIAGNOSTIK PERIODONTITIS AGRESIF Desi Sandra Sari; Candra Bumi; Yuliana Mahdiyah DA
Dentika: Dental Journal Vol. 16 No. 2 (2011): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.896 KB) | DOI: 10.32734/dentika.v16i2.1831

Abstract

Porphyromonas gingivalis is a gram-negative anaerobic bacteria and has been shown previously to be one of the major pathogens in aggressive periodontitis. Outer membrane protein is the major virulence factor of P. gingivalis and plays role in the host immune response impair againts P. gingivalis, which in turns, causing tissue destruction and bone resorption. This study was aimed to investigate the isolation and characteristic outer membrane protein of P. gingivalis. Protein of OMP P. gingivalis ATCC 33277 was isolated using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and than continued by hemaglutination test. The result showed that protein profil in SDSPAGE of OMP protein was 40 kDa molecular weight dan hemaglutination test was positive in titer of hemaglutination 1/8.In conclusion, outer membrane protein molecular mass of 40kDa produced by P. gingivalis is a key virulence factor involved in the co-aggregation activity of P. gingivalis
PROSPEK PROBIOTIK DALAM PENCEGAHAN AGRESIVITAS RESORBSI OSTEOKLASTIK TULANG ALVEOLAR YANG DIINDUKSI LIPOPOLISAKARIDA PADA PENYAKIT PERIODONTAL: PROBIOTIC PROSPECT IN THE PREVENTION OF AGGRESSIVENESS OSTEOCLASTIC ALVEOLAR BONE RESORPTION INDUCED BY LIPOPOLYSACCHARIDE ON PERIODONTAL DISEASE Muhammad Nurul Amin; Zahara Meilawaty; Desi Sandrasari
Dentika: Dental Journal Vol. 15 No. 2 (2010): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2174.271 KB) | DOI: 10.32734/dentika.v15i2.1927

Abstract

This study was an experimental laboratory. The purpose of this study was to determine the role of probiotics in inhibitingthe activity of pathogenic bacterial oral cavity. The result of study is expected to be used for prevention and treatment ofperiodontal disease which is still complex and derived products with high quality probiotics. The main product is thedevelopment potential of probiotics in maintaining oral health, especially periodontal disease is effectively and efficiently.This study used rats and divided into 4 groups: Group I, control without treatment; group II, induction of LPS E. coli for 5days, Group III, LPS induction of E. coli + Probiotic Bacterial Lactobacillus casei injection for 5 days together, and groupIV, induction of LPS E. coli for 5 days + 5 days injection of Lactobacillus casei. Immunohistochemical examination wasdone to evaluate the activity of osteoclasts in alveolar bone resorption to detect TRAP (tartarate-resistant acidphosphatase) and Carboxyterminal Telopeptide of Type 1 Collagen (1CTP) and subsequently analyzed the data collectedstatistically. The results of this study showed that induction of LPS could trigger the occurrence of alveolar boneresorption mediated by osteoclast and Lactobacillus casei administration both at the same time with the LPS induction orafter LPS induction can inhibit osteoclastic alveolar bone resorption. In conclusion, clinically it can be interpreted that theadministration of probiotic can be given at the beginning of periodontal disease occurs before or at the time of periodontaldisease is underway.
Co-Authors Adisty, Anggi Salwa Banun Kusumawardani Budi Yuwono Candra Bumi Depi Praharani Dessy Rachmawati Dhani Wijaya Dhani Wijaya, Dhani Ernie Maduratna Evi Umayah Ulfa Evi Umayah Ulfa Fany, Manta Farahdila, Nihla Adinda Fedik Abdul Rantam Ferdiansyah Mahyudin Happy Harmono Leersia Yusi M Melok M Melok, M M. Nurul Amin Melok Aris Wahyukundari Melok Aris Wahyukundari Melok Aris Wahyukundari, Melok Aris Muhammad Nurul Amin Neira Najatus Sakinah Nulend, Jenneke Klein Peni Pujiastuti Perdana, Mohammad Daffa Duta Prasetya, Rendra C. Prastifa, Febi Zulaikha Pudjiastuti, Peni Putri, Puspita Nabila Rahmawati, Iis Rina Nanda Prasasti Rina Sutjiati S.Pd. M Kes I Ketut Sudiana . Siti Aisyah Suryono Suryono Tantin Ermawati Utha, Maria Fransisca Wanodyo, Ari Tri Yuliana Mahdiyah DA Yuliana Mahdiyah DA Yuliana Mahdiyah Daat Arina Yuliana Mahdiyah Da’at Arina Zahara Meilawaty Zainina, Iris Amelinda