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The difference of inhibitory zone between Katuk (Sauropus androgynous L. Merr.) leaf infusion and Roselle (Hibiscus sabdariffa L.) petals towards oral Candida albicans Kusumanegara, Kadek Seruni; Rachmawati, Emma; Setiawan, Ame Suciati
Padjadjaran Journal of Dentistry Vol 29, No 2 (2017): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Introduction: Katuk (Sauropus androgynus L. Merr.) leaf and roselle (Hibiscus sabdariffa L.) are part of plants that have antifungal activity against Candida albicans. The purpose of this study was to examine the inhibitory zone of katuk leafâs infusion compared to roselle petals towards the growth of oral Candida albicans. Methods: The research methods was experimental laboratory. Each of katuk leaf and roselleâs infusion were respectively made in four concentration, i.e 5, 10, 20, and 40%. The positive control was 2% ketoconazole, while negative control was sterile aquadest. Results: The result of the study showed that the mean of inhibitory zones of katuk leaf 5%, was 17.90Â±0.8 mm, katuk leaf of 10% was 19.67Â±1.78 mm, katuk leaf of 20% was 19.67Â±1.78 mm, and katuk leaf consentration of 40% was 22.93Â±1.00 mm, meanwhile the mean of inhibitions zones of roselle petals infusion of 5% shows its mean of 18.53Â±0.67 mm, roselle petals of 10% was 22.40Â±1.28 mm, roselle petals of 20% was 26.20Â±0.87 mm, and roselle petals of 40%was 29.47Â±2.87 mm. Conclusion: It can be concluded that the mean of inhibitions zones of katuk leafâs infusion was smaller than roselle petals toward the growth of oral Candida albicans.

Exposure time of virgin coconut oil against oral Candida albicans Tjin, Lui Dwen; Setiawan, Ame Suciati; Rachmawati, Emma
Padjadjaran Journal of Dentistry Vol 28, No 2 (2016): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Introduction: Virgin Coconut Oil (VCO) is an oil which is purely made as a product of the coconut palmand has been used for centuries in the culinary industry and the medical field. Currently, VCO is used widely in medical field due to its effectiveness as antibacterial, antiviral and antifungal properties. Objective of this experimental study was to prove the effectiveness of virgin coconut oil by determining its exposure time at concentration of 25% to inhibit growth of oral Candida albicans. Methode: The research was done by quasi experiment design using the serial dilution method. The exposure time test was performed using a spread plate technique with virgin coconut oil at concentration of 25 % against oral Candida albicans isolated from saliva. Intervals of day 0, 1, 2 and 3 were used. Result: shows that virgin coconut oil inhibited the growth of oral C. albicans cells at day 2. Conclusion: virgin coconut oil with concentration of 25% can inhibit the growth of oral C. albicans with the exposure time of 2 days, which is similar with other antifungals.

Efek Antidiabetes Kombinasi Ekstrak Bawang Putih (Allium sativum Linn.) dan Rimpang Kunyit (Curcumma domestica Val.) dengan Pembanding Glibenklamid pada Penderita Diabetes Melitus Tipe 2 Setiawan, Ame Suciati; Yulinah, Elin; Adnyana, I Ketut; Permana, Hikmat; Sudjana, Primal
Majalah Kedokteran Bandung Vol 43, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Kombinasi ekstrak bulbus bawang putih (Allium sativum Linn.) dan rimpang kunyit (Curcumma domestica Val.)Â dapat digunakan sebagai obat antidiabetes oral pada penderita diabetes melitus (DM) tipe 2, dan secara klinis telahÂ terbukti dapat menurunkan kadar glukosa darah dengan dosis 2,4 g/hari. Penelitian klinis dilakukan untuk melihat efek antidiabetes kombinasi ekstrak dibandingkan dengan antidiabetik oral, glibenklamid. Subjek adalah usia >35Â tahun dengan DM tipe 2 yang berobat ke poliklinik Penyakit Dalam dan Endokrin Rumah Sakit Hasan SadikinÂ Bandung periode November 2007â€“Agustus 2008 dan telah mendapat terapi gizi medis selama 2 minggu. Penelitian dilakukan secara paralel, acak, dan tersamar ganda. Penggunaan kombinasi ekstrak menunjukkan penurunan kadarÂ glukosa darah puasa rata-rata 9,25 mg/dL, glukosa darah 2 jam postprandial (PP) 22,25 mg/dL, HbA1c 1,30%,Â serta insulin 12,57 mg/dL bila dibandingkan dengan baseline glibenklamid rata-rata kadar glukosa darah puasa 72,37 mg/dL, glukosa darah 2 jam PP 114,25 mg/dL, dan HbA1c 4,12%, tetapi meningkatkan insulin 3,34 mg/Â dL. Kombinasi ekstrak tidak mempengaruhi fungsi hati, ginjal, dan profil hematologi. Kesimpulannya kombinasiÂ ekstrak memiliki efek antidiabetes tetapi efek yang ditimbulkan tidak sebaik glibenklamid.Â [MKB. 2011;43(1):26â€“34].Kata kunci: Bawang putih, kunyit, diabetes melitus tipe 2, glibenklamid, glukosa darahÂ Antidiabetic Effect of Garlic Extract (Allium sativum Linn.) and Curcumin Extract (Curcumma domestica Val.) Combination Compared to Glibenclamide in Type 2 Diabetes MellitusThe combination of garlic (Allium sativum Linn.) and curcumin extract (Curcumma domestica Val.) can be used as an oral antidiabetic in type 2 diabetes mellitus (DM) patients. The clinical trial has shown that the extract can decrease blood glucose at a dose of 2.4 g/day. This clinical trialÂ was conducted to explore the antidiabetic effect of garlic and curcumin extract combination compared to oral antidiabetics, glibenclamide. The subjects were >35 years old patients with type 2 DM who visited the internal and endocrine clinic of Dr. Hasan Sadikin Hospital Bandung and has been treated with medical nutrition therapy for 2 weeks during the period of November 2007â€“December 2008. This study was a parallel, randomized and double blind study. The garlic and curcumin extract combination decreased the mean value of fasting blood glucose 9.25 mg/dL, 2h PP blood glucose 22.25 mg/dL, HbA1c 1,30% and insulin 12.57 mg/dLÂ compared to baseline whereas glibenclamide decreased the mean value of fasting blood glucose to 72.37 mg/dL, 2h PP 114,25 mg/dL, HbA1c 4.12% and increased the insulin to 3.34 mg/dL. In conclusion, the extract combination has antidiabetic effect even though it is lower than the glibenclamide. [MKB. 2011;43(1):26â€“34].Key words: Blood glucose, curcumin, garlic, glibenclamide, type 2 diabetes mellitusÂ DOI:Â http://dx.doi.org/10.15395/mkb.v43n1.41

Exposure time of virgin coconut oil against oral Candida albicans Tjin, Lui Dwen; Setiawan, Ame Suciati; Rachmawati, Emma
Padjadjaran Journal of Dentistry Vol 28, No 2 (2016): July 2016
Publisher : Universitas Padjadjaran

Introduction: Virgin Coconut Oil (VCO) is an oil which is purely made as a product of the coconut palmand has been used for centuries in the culinary industry and the medical field. Currently, VCO is used widely in medical field due to its effectiveness as antibacterial, antiviral and antifungal properties. Objective of this experimental study was to prove the effectiveness of virgin coconut oil by determining its exposure time at concentration of 25% to inhibit growth of oral Candida albicans. Methode: The research was done by quasi experiment design using the serial dilution method. The exposure time test was performed using a spread plate technique with virgin coconut oil at concentration of 25 % against oral Candida albicans isolated from saliva. Intervals of day 0, 1, 2 and 3 were used. Result: shows that virgin coconut oil inhibited the growth of oral C. albicans cells at day 2. Conclusion: virgin coconut oil with concentration of 25% can inhibit the growth of oral C. albicans with the exposure time of 2 days, which is similar with other antifungals.

The difference of inhibitory zone between Katuk (Sauropus androgynous L. Merr.) leaf infusion and Roselle (Hibiscus sabdariffa L.) petals towards oral Candida albicans Kusumanegara, Kadek Seruni; Rachmawati, Emma; Setiawan, Ame Suciati
Padjadjaran Journal of Dentistry Vol 29, No 2 (2017): July 2017
Publisher : Universitas Padjadjaran

Introduction: Katuk (Sauropus androgynus L. Merr.) leaf and roselle (Hibiscus sabdariffa L.) are part of plants that have antifungal activity against Candida albicans. The purpose of this study was to examine the inhibitory zone of katuk leaf’s infusion compared to roselle petals towards the growth of oral Candida albicans. Methods: The research methods was experimental laboratory. Each of katuk leaf and roselle’s infusion were respectively made in four concentration, i.e 5, 10, 20, and 40%. The positive control was 2% ketoconazole, while negative control was sterile aquadest. Results: The result of the study showed that the mean of inhibitory zones of katuk leaf 5%, was 17.90±0.8 mm, katuk leaf of 10% was 19.67±1.78 mm, katuk leaf of 20% was 19.67±1.78 mm, and katuk leaf consentration of 40% was 22.93±1.00 mm, meanwhile the mean of inhibitions zones of roselle petals infusion of 5% shows its mean of 18.53±0.67 mm, roselle petals of 10% was 22.40±1.28 mm, roselle petals of 20% was 26.20±0.87 mm, and roselle petals of 40%was 29.47±2.87 mm. Conclusion: It can be concluded that the mean of inhibitions zones of katuk leaf’s infusion was smaller than roselle petals toward the growth of oral Candida albicans.

The inhibitory effectiveness of ethanol extract of selasih leaves towards Streptococcus sanguis growth Susilo, Ivhatry Rizky Octavia Putri; Satari, Mieke Hemiawati; Setiawan, Ame Suciati
Padjadjaran Journal of Dentistry Vol 27, No 1 (2015): March 2015
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol27no1.26694

Introduction: Selasih is one of tropical and subtropical plant used as traditional medicine. It has antibacterial activity especially toward Gram-positive bacteria because it contains volatile oils, tannin, flavonoid and tertepenoid. Method: The study was performed as an experimental laboratory study used Kirby Bauer agar diffusion applied to eight samples of Streptococcus sanguis which was done by twice repetition for each sample. The concentrations of ethanol extract were 16%, 8%, 4%, 2% and 1%.The result was analysed using ANOVA method for single factor of experimental design. The result of the study showed that there was evidence of the antibacterial effect contained in the ethanol extract of selasih leaves inhibiting the growth of Streptococcus sanguis . The average of inhibitory zone for each concentration in every sample, were: 5,25 mm for 16%, 3,22 mm for 8%, 1,84 mm for 4%, 1,53 mm for 2% and 0,19 mm for 1%. The conclusion of the study indicates that there is an antibacterial effects in ethanol extract of selasih leaves (Ocimum basilicum Linn) which inhibits the growth of Streptococcus sanguis. This antibacterial strength is caused by the active content of selasih leaves extract.Conclusion: The extract of basilicum ethanol (Ocimum basilicum L) effectively inhibits the growth of Streptococcus sanguis.

Correlation of premature loss and molar relationship of mixed dentition children with a very high def-t index Widyawati, Hanna; Zenab, Yuliawati; Setiawan, Ame Suciati
Padjadjaran Journal of Dentistry Vol 33, No 2 (2021): July 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no2.23621

Introduction: Premature loss mainly occurs in mixed dentition periods in their maxillary deciduous and/or mandibular canine, first molar, and/or second molar. The mixed dentition stage occurs in elementary school-aged children, mark with malocclusions and tooth decays, which can be observed from a very high def-t index. This condition will also lead to an abnormal molar relationship. This study was aimed to analyse the correlation of premature loss and molar relationship of mixed dentition children with a very high def-t index. Methods: An analytical observational study with a cross-sectional approach was conducted towards 43 elementary children of Ciawi, Cikeruh 1, and Cikeruh 2 Public Elementary School (SDN), Jatinangor Regency, West Java, Indonesia, aged 7-9 years. The sample was chosen using the purposive sampling method, based on the sample criteria and their willingness to be research subjects. The premature loss of deciduous teeth and primary first molar relationship were observed through extraoral and intraoral examination. The correlation of the premature loss and molar relationship was analysed using Spearman’s rank correlation test. Results: Premature loss significantly affected the permanent first molars relationship in children with no succedaneous teeth (p=0.02, p<0.05), however, it was showed no significant effect in children with succedaneous teeth (p=0.07, p>0.05). The Spearman’s rank correlation test results showed a positive correlation between premature loss and molar relationship of mixed dentition children with a very high def-t index. Conclusion: Premature loss significantly affected the permanent first molars relationship in children with no succedaneous teeth. However, it was showed no significant effect in children with succedaneous teeth. A positive correlation is found between premature loss and molar relationship of mixed dentition children with a very high def-t index. The higher the premature loss, the more abnormal molar relationship will be found in mixed dentition children with a very high def-t index.

Antibacterial effect of cinnamon essential oil (Cinnamon cassia) in different concentration towards Streptococcus sanguis Hajanajumudin, Hanizul; Satari, Mieke Hemiawati; Setiawan, Ame Suciati
Padjadjaran Journal of Dentistry Vol 22, No 2 (2010): July 2010
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol22no2.26845

Introduction: Streptococcus sanguis is a type of normal bacteria found in the oral cavity, particularly in plaque on tooth surfaces and can also be found in saliva, buccal mucosa, tongue and gingival sulcus. At present, the usage of herbal remedy for reducing plaque in oral cavity has been implemented widely and one of the herbal remedy used is cinnamon essential oil. The purpose of this study is to prove that there are differences in the antibacterial activity of cinnamon essential oil with different concentrations against Streptococcus sanguis. Methods: The study was performed using laboratory experiments, in which the sensitivity of the Streptococcus sanguis bacteria from the saliva of 10 KPBI batch 2006 dental students were tested in vitro against cinnamon essential oil by using Kirby-Bauer method. Results: The study shows that the cinnamon essential oil has different antibacterial abilities in inhibiting the growth of Streptococcus sanguis in different concentrations. This is due to the element cinnamaldehyde and eugenol that they posses as their main constituent. There is a significant difference between the antibacterial effects of Cinnamon cassia essential oil in different concentrations towards Streptococcus sanguis. Conclusion: Cinnamaldehyde and eugenol has been proved to have antibacterial effect towards wide variety of bacteria including Streptococcus sanguis.

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