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All Journal Majalah Kedokteran Bandung Althea Medical Journal Damianus Journal of Medicine Indonesian Journal of Tropical and Infectious Disease SRIWIJAYA JOURNAL OF MEDICINE MEDICINUS Journal of Urban Health Research
Kurniawan, Sandy Vitria
Departement Of Pharmacology And Pharmacy School Of Medicine And Health Sciences Atma Jaya Catholic University Of Indonesia
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Perbandingan Efektivitas Antibakteri Moringa oleifera dan Ziziphus mauritiana dengan Ekstrak Etanol 96% terhadap Escherichia Coli Sania, Eli; Kurniawan, Sandy Vitria; Angelina, Yohanna
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Escherichia coli is a normal bacterium in the lower part of human digestion, but if the amount is above normal, E. coli will cause various diseases. Inappropriate use of antibiotics can cause resistance, so alternative treatments such as herbal medicines are needed. Herbal plants that have been explored as antibacterial compounds are Moringa oleifera leaves and Bidara leaves (Ziziphus mauritiana). This research was conducted to see the comparison of the antibacterial effectiveness of Moringa oleifera and Ziziphus mauritiana with 96% ethanol solvent against E.coli. The design of this study used an experimental study conducted in vitro. Moringa oleifera and Ziziphus mauritiana were extracted at 10 different concentrations. The test method used was disk diffusion on Mueller-Hinton agar. The treatment group is E. coli ATCC 25922, Ciproflxacin were used as positive controls and discs immersed in 96% ethanol were used as negative controls.The average zone of inhibition of Moringa oleifera leaf extract was 10 mm, while Ziziphus mauritiana leaf extract gave an average of inhibition zone of 14 mm. The average zone of inhibition from positive control is 33 mm. Negative control has no zone of inhibition. Moringa oleifera leaf extract can inhibit the growth of E. coli bacteria at a concentration of 30% with a zone of inhibition of 7 mm, and leaf extract of Ziziphus mauritiana can inhibit the growth of E. coli bacteria at a concentration of 20% with a 12 mm inhibition zone. This proves that Ziziphus mauritiana has more effective antibacterial ability than Moringa oleifera.
Preservation in Paraffin Oil: Alternative for Fungi Preservation in Simple Laboratory Concept Sem Samuel Surja; Gabi Vania Sally; Favian Sergius Ruby Hartoyo; Sandy Vitria Kurniawan; Yanto Budiman
Althea Medical Journal Vol 7, No 3 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n3.1975

Abstract

Background: A good collection of fungi culture can be maintained with good preservation methods. With appropriate methods, preservation can be performed in low-budget laboratories, such as with periodic subculture and preservation in either sterile water or in paraffin oil. The aim of this study was to assess the viability, morphology, contamination, and antifungal susceptibility profile of fungi preserved in sterile water or paraffin oil compared to a periodic subculture.Methods: This study was an experimental study using Aspergillus sp., Trichophyton mentagrophytes and Candida albicans. The fungi were preserved by a periodic subculture or in sterile water or in paraffin oil for six months. A comparison of viability, morphology, contamination, and antifungal susceptibility profile between methods were made before and after six months of study.Results: The viability of all the fungi was maintained in both periodic subculture and preservation with paraffin oil. However, the T. mentagrophytes was not viable in preservation using sterile water. All methods could maintain the morphology without contamination. There were reductions in the inhibition zone against antifungal drug in preservation with sterile water and paraffin oil.Conclusion: Preservation in paraffin oil is superior to preservation in sterile water in terms of maintaining fungal viability. This method is suitable for the use in a simple laboratory, albeit considerations should be given to the reduction of inhibition zone.
ANALISIS METODE PRESERVASI SUBKULTUR BERKALA DAN DENGAN AIR STERIL UNTUK JAMUR Aspergillus sp. DAN Candida albicans Gabi Vania Sally; Sandy Vitria Kurniawan; Sem Samuel Surja
Bahasa Indonesia Vol 19 No 2 (2020): Damianus : Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v19i2.1193

Abstract

Introduction: A good and proper preservation can maintain all collection of culture. Periodic subculture preservation is an old technique that is less able to guarantee the genetic characteristic for a long time. Sterile water is an alternative method in various studies to ensure the genetic characteristic for a long time and can be done in a simple laboratory concept. This study aimed to examine the method of periodic subculture and with sterile water Methods: This research was a descriptive study with an experimental laboratory design on Aspergillus sp. and Candida albicans. This study examined at periodic subculture methods and with sterile water in maintaining viability, level of contamination, morphology, and antifungal resistance after six months Results: The fungus had lived after being preserved with periodic subcultures without contamination, morphological changes, and resistance. Aspergillus sp. and Candida albicans also lived after being preserved with sterile water for six months with the same morphology and without contamination. The zone of inhibition of Aspergillus sp. had decreased but in Candida albicans remains the same. Conclusion: Preservation with periodic subculture and with sterile water can be applied to Aspergillus sp. and Candida albicans.
UJI SINERGITAS ANTIFUNGAL FLUCONAZOLE DENGAN MINYAK ATSIRI CYMBOPOGON CITRATUS TERHADAP JAMUR CANDIDA ALBICANS Sharon Claudia Ethelyn Sihole; Sandy Vitria Kurniawan
Bahasa Indonesia Vol 20 No 2 (2021): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v20i2.2513

Abstract

Introduction: Candida albicans is a common human flora. However, if the amount is above average, it can cause a disease called candidiasis. Fluconazole is an antifungal medication that can cure candidiasis but its number of resistance is increasing. Therefore alternative treatments are needed like using herbs. Cymbopogon citratus essential oil is proven to have an antifungal effect. The purpose of this study is to see the synergistic antifungal effect of fluconazole combined with lemongrass against C. albicans. Methods: Experimental study design was used in this research and conducted in vitro. C. citratus was extracted with hydrodistillation method. Disc diffusion method was performed using MHA agar with Glucose 2% and methylene blue. Lemongrass essential oil concentration that are used are 2,5%, 5%, 10%, and 20% using tween as a solvent. Results: Minimum concentration of lemongrass essential oil that could inhibit C. albicans growth is 10% with average diameter of inhibition zone 10 mm. Minimum concentration of fluconazole combined with lemongrass essential oil that could inhibit C. albicans growth is 2,5% with average diameter 21,3333 mm. Average diameter of inhibition zone by fluconazole combined with lemongrass essential oil is greater than fluconazole’s inhibition zone added with lemongrass essential oil inhibition zone alone, therefore fluconazole combined with C. citratus essential oil work synergistically. Conclusion: There is a synergistic antifungal effect of fluconazole combined with C. citratus essential oil against C. albicans. Key Words: Candida albicans, Cymbopogon citratus, fluconazole, synergistic
Comparison of Antibacterial Efficacy between 96% Ethanolic Extracts from Abrus precatorius L. and Piper betle L. Leaves against Escherichia coli Felicia Saraswati; Yohanna Angelina; Sandy Vitria Kurniawan
Majalah Kedokteran Bandung Vol 52, No 2 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.01 KB) | DOI: 10.15395/mkb.v51n2.1970

Abstract

Escherichia coli (E.coli) is a frequently found infectious pathogen commonly transmitted through water. In Indonesia, the level of this pathogen exceeds the accepted standard. Several studies have shown the presence of antibiotic-resistant E.coli, making studies on alternative treatments for E.coli necessary. Abrus precatorius L. and Piper betle L. leaves are among herbs that have herbal antibacterial properties. This study observed and compared the antibacterial effects of Abrus precatorius L. and Piper betle L. leaves against E.coli. This was an in vitro experimental study performed at the Laboratory of the Department of Microbiology, Faculty of Medicine and Health Science, Atma Jaya Catholic University, from August to November 2019. Abrus precatorius L. and Piper betle L. leaves were extracted by maceration in 96% Ethanol, and further processed into concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%. Disc-diffusion on Mueller-Hinton Agar was used to identify the inhibition zones of the extracts against E.coli ATCC 25922. Ciprofloxacin disc and 96% ethanol impregnated-discs were used as positive and negative controls, respectively. Independent t-test results showed a significant difference between Abrus precatorius L. and Piper betle L. leaves effects against E.coli with p=0.044 and p=0.045 (p<0.05), respectively. In conclusion, Abrus precatorius L. and Piper betle L. leaves have antibacterial effects against E.coli ATCC 25922, albeit less sensitivity than Ciprofloxacin, with Piper betle L. presents a greater effect than Abrus precatorius L.Perbandingan Efektivitas Antibakteri Ekstrak Etanol 96% Daun Abrus precatorius L. dan Daun Piper betle L. Terhadap Escherichia coliEscherichia coli (E.coli) adalah patogen infeksius yang sering ditemukan dan ditularkan melalui air. Di Indonesia, tingkat patogen ini melebihi standar yang diterima. Beberapa penelitian telah menunjukkan ada E.coli yang kebal antibiotik, membuat penelitian tentang pengobatan alternatif untuk E.coli diperlukan. Daun Abrus precatorius L. dan Piper betle L. berpotensi sebagai pengobatan herbal antibakteri. Penelitian ini bertujuan melihat dan membandingkan efek antimikroba kedua daun tersebut terhadap E.coli. Penelitian eksperimental in vitro ini dilakukan di Laboratorium Mikrobiologi Fakultas Kedokteran dan Ilmu Kesehatan Atma Jaya mulai dari Agustus sampai November 2019. Daun  Abrus precatorius L. dan Piper betle L.  dimaserasi menggunakan etanol 96%, lalu dibentuk konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, dan 100%. Difusi cakram pada agar Mueller-Hinton dilakukan untuk menguji zona hambat kedua ekstrak terhadap bakteri E.coli ATCC 25922. Cakram ciprofloksasin merupakan kontrol positif, dan kontrol negatif adalah cakram yang direndam etanol 96%. Hasil uji independent t-test didapatkan perbedaan bermakna antara efektivitas ekstrak kedua daun terhadap E.coli, yaitu daun Abrus precatorius L. p=0.044 dan daun Piper betle L. p=0.045 (p<0.05). Simpulan, daun  Abrus precatorius L. dan Piper betle L. memiliki efek antibakteri terhadap E.coli ATCC 25922 walaupun tidak lebih sensitif dari Ciprofloksasin dengan Piper betle L. memiliki efek yang lebih besar dibanding dengan Abrus precatorius L.
Perbandingan Efektivitas Antibakteri Moringa oleifera dan Ziziphus mauritiana dengan Ekstrak Etanol 96% terhadap Escherichia Coli Eli Sania; Sandy Vitria Kurniawan; Yohanna Angelina
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Vol 3, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i1.63

Abstract

Escherichia coli adalah bakteri normal pada pencernaan bagian bawah manusia, namun jika dalam jumlah di atas normal, E. coli akan menimbulkan berbagai penyakit. Penggunaan antibiotik yang tidak tepat dapat menyebabkan resistensi sehingga diperlukan pengobatan alternatif seperti obat-obatan herbal. Tanaman obat yang sudah banyak dieksplorasi sebagai senyawa antibakterial adalah daun kelor (Moringa oleifera) dan daun bidara (Ziziphus mauritiana). Penelitian ini dilakukan untuk melihat perbandingan efektivitas antibakteri Moringa oleifera dan Ziziphus mauritiana dengan pelarut etanol 96% terhadap E.coli. Desain penelitian ini menggunakan studi eksperimental in vitro. Moringa oleifera dan Ziziphus mauritiana diekstrak pada 10 konsentrasi yang berbeda. Metode uji yang digunakan adalah difusi cakram pada agar Mueller-Hinton. Kelompok perlakuan yaitu E. coli ATCC 25922, Ciprofloksasin digunakan sebagai kontrol positif dan cakram yang direndam dalam etanol 96% digunakan sebagai kontrol negatif. Rata–rata zona inhibisi ekstrak daun Moringa oleifera adalah 10 mm,sedangkan ekstrak daun Ziziphus mauritiana menimbulkan rata–rata zona inhibisi sebesar 14 mm. Rata–rata zona inhibisi dari kontrol positif adalah 33 mm. Kontrol negatif tidak memiliki zona inhibisi. Ekstrak daun Moringa oleifera dapat menginhibisi pertumbuhan bakteri E. coli pada konsentrasi 30% dengan zona inhibisi sebesar 7 mm, dan ekstrak daun Ziziphus mauritiana dapat menginhibisi pertumbuhan bakteri E. coli pada konsentrasi 20% dengan zona inhibisi 12 mm. Hal ini membuktikan bahwa Ziziphus mauritiana memiliki kemampuan antibakteri yang lebih efektif daripada Moringa oleifera.
Germ Tube Induction Test Comparing Total of Six Liquid and Three Solid Media in Candida albicans Ruby, Rivaldi; Arifin, Erlangga Saputra; Kurniawan, Sandy Vitria; Surja, Sem Samuel
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.34097

Abstract

Invasive candidiasis (IC) has a high mortality rate of 70%, thus diagnosis should be established without delay. Given its fast result, serological test such as β-d-glucan (BDG) test is one alternative diagnosis modalities. However, it lacks specificity. Candida albicans germ tube antibody (CAGTA) test is an alternative serological test which has a high sensitivity of 76.2% and specificity of 80.3%.  Manufacturing CAGTA serological test requires provision of specific germ tube antigen. In this study, various culture media were tested to find the best media for germ tube induction. This study was an experimental in vitro study. The number and length of the germ tube were recorded in two- and three-hour incubation periods. A total of six samples containing one C. albicans ATCC 90028, four C. albicans wild type strains, and one C. krusei wild type strain were used. Nine media were tested to induce germ   tube formation: human and sheep serum, fetal bovine serum, mueller hinton agar and broth, tryptic soy agar and broth, brain heart infusion agar and broth. At both incubation periods, the medium with the highest number of germ tube was human serum (p=0.001 and p=0). The longest germ tube was found in sheep serum at two-hour incubation period (p=0.005). Mueller hinton broth (MHB) showed comparable results with human and sheep serum (p>0.05). Human serum is a superior inducer of morphogenesis. However, the use of MHB is recommended in this study, since provision of fresh human and sheep serum on a regular basis is impractical.
Assessing the Correlation between Spicy Food Consumption and Dyspepsia Symptoms in Medical and Health Students at Atma Jaya Catholic University of Indonesia Lonah; Divara Ariesta Sekar Suryadi, Made; Arieselia, Zita; Vitria Kurniawan, Sandy; Hananta, Linawati; Setiawan, Jonny; Surjono, Edward; Santosa, Mariani; Ulina Margareta Situmorang, Evi; Fan, Tan Fei; Yuliana; Budiyanti, Ecie
Journal of Urban Health Research Vol. 2 No. 3 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v2i3.5463

Abstract

Introduction: The capsaicin (8-methyl-N-vanillyl-6-nonenamide) content in spicy foods can trigger irritation and increase gastric acid production, which potentially damages the stomach mucous layer by increasing chloric acid levels (HCl). It is known that dyspepsia has a variety of causes and one of them can be triggered by the consumption of irritating foods, such as spicy foods. Therefore, the research was conducted to determine whether there was a significant relationship between the consumption of spicy foods and the incidence of dyspepsia in students of the Faculty of Medicine and Health Sciences at the Atma Jaya Catholic University of Indonesia. Methods: This research method is an analytical observational study using cross-sectional methods. The main variables in this study were dyspepsia, measured using the Rome III questionnaire, and the frequency of spicy food consumption measured using the Food Frequency Questionnaire (FFQ). The sample consisted of 107 people randomly selected. The data was analyzed statistically using the Fischer Exact test. Results: This study showed that 56.1% of respondents frequently eat spicy foods, while the majority, as much as 95.3%, also have dyspepsia. There was a significant correlation between spicy eating habits and dyspepsia, with a p-value of 0.014 (p<0.05). Conclusion: The results showed a statistically significant relationship between spicy eating habits and dyspepsia, so it is recommended for students to reduce spicy food consumption as it can affect the onset of dyspepsia. Keywords: dyspepsia - spicy foods - stomach - Rome III questionnaire - food frequency questionnaire
Antioxidant, Antimicrobial, Anti-Inflammatory, and Gut Microbiota Modulation Effects of Kombucha: a Literature Review Hananta, Linawati; Kurniawan, Sandy Vitria; Lonah; Arieselia, Zita; Surjono, Edward; Setiawan, Jonny; Lieputra, Andrew Adhytia; Puspa Bunardi, Dewi; Prayoga Tjendratama, Jason; Vallerie Satyadi, Richelle; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6445

Abstract

Introduction: The interest in probiotics has increased significantly in recent years. While most probiotic-containing foods are dairy-based, an increasing number of non-dairy probiotic products have emerged, including kombucha. Kombucha is a fermented tea beverage originating from China, known for its high polyphenol content and potential health benefits. Methods: This literature review aims to provide a comprehensive understanding of the health benefits of kombucha. A systematic search of published studies was conducted using the keywords "kombucha," "antioxidant," "anti-inflammatory," "antimicrobial," and "gut microbiota modulation." Only English-language articles were included, and there was no restriction on publication date to capture the full spectrum of research on kombucha. Results: Kombucha exhibits significant antioxidant capacity, with green tea kombucha demonstrating the highest Ferric Ion Reducing Antioxidant Power (FRAP) due to its high polyphenol content. Additionally, kombucha possesses antimicrobial properties attributed to organic acids, lactones, aldehydes, fatty acids, and alkaloids, which act synergistically. It also exhibits anti-inflammatory effects by inhibiting nitric oxide production and downregulating pro-inflammatory cytokines such as IL-1β and TNF-α. Furthermore, kombucha modulates gut microbiota composition by inhibiting the growth of Gram-negative bacteria, leading to reduced systemic inflammation and oxidative stress. Conclusion: Kombucha, a traditional fermented tea, has notable health benefits, including antioxidant, antimicrobial, anti-inflammatory, and gut microbiota-modulating properties. These findings highlight its potential as a functional beverage for health promotion. Keywords: kombucha – antioxidant - anti-inflammatory – antimicrobial - gut microbiota modulation
Analisis In Silico Interaksi antara Interferon Beta dengan Senyawa Turunan Flavonoid dan Terpenoid dari Bunga Carthamus tinctorius Lismayana Hansur; Nurmasita; Paisal; Sandy Vitria Kurniawan
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/nej0dw97

Abstract

Background: Kasumba turatea (Carthamus tinctorius) has long been empirically used by the people of South Sulawesi as a traditional medicine for diseases caused by viral infections. This plant is known to contain compounds such as thymol, carvacrol, carthamon, chalcone, and linalool, which have potential immunomodulatory activity, including relevance to multiple sclerosis. One of the immune mechanisms which play a role is interferon beta (IFN-β), whose function is influenced by β-glucan, which can enhance IFN-β expression. Objective: This study aims to explore the interaction between thymol, carvacrol, carthamon, chalcone, and linalool — compounds with immunomodulatory— and IFN-β through acomputational (in silico) approach. Methods: The method used in this study is molecular docking using AutoDock Tools, AutoDock Vina, and Discovery Studio applications. The 3D structure of interferon beta was obtained from the Protein Data Bank (PDB) with PDB ID 1AU1. Beta-D-glucan (BDG) was used as the control compound. The ligands examined included carthamon, carvacrol, chalcone, linalool, and thymol. Results: Docking results showed that carthamon exhibitedthe highest binding affinity among the ligands. Key residues involved in ligand interaction at the active site of IFN-β were glutamic acid 42, arginine 28, serine 13, asparagine 90, and leucine 9, which interacted via hydrogen bonds. Conclusion:This study provides preliminary evidence that active compounds from kasumba turatea, particularly carthamon, have the potential to interact wit IFN-β. These findings can serve as a foundation for further research to examine the interaction of carthamon with IFN-β, which could enhance immunomodulatory capabilities.
Co-Authors Andrew Liputra Angelina, Yohanna Arifin, Erlangga Saputra Budiyanti, Ecie Divara Ariesta Sekar Suryadi, Made Edward Surjono Edward Surjono, Edward Eli Sania Evi Ulina Margaretha Situmorang Fan, Tan Fei Favian Sergius Ruby Hartoyo Felicia Saraswati Freggy Spicano Joprang Gabi Vania Sally Gabi Vania Sally Jennifer Jonny Setiawan Jonny Setiawan Lieputra, Andrew Adhytia Linawati Hananta Linawati Hananta, Linawati Lismayana hansur Lonah, Lonah Mariani Santosa, Mariani Nurmasita Paisal Prayoga Tjendratama, Jason Puspa Bunardi, Dewi Rita Dewi Ruby, Rivaldi Sania, Eli Sem Samuel Surja Sharon Claudia Ethelyn Sihole Vallerie Satyadi, Richelle Yanto Budiman Yohanna Angelina Yohanna Angelina Yuliana Yuliana Zita Arieselia