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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Seminar Nasional Teknik Kimia Kejuangan INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry International Journal of Community Service Learning JFIOnline Jurnal Jamu Indonesia Patria : Jurnal Pengabdian Kepada Masyarakat Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Jamu
Agustina Setiawati
Faculty Of Pharmacy, Universitas Sanata Dharma, Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Cytotoxic of Ganoderma lucidum in Colon Cancer through Cyclooxygenase 2 (COX-2) as Its Molecular Target Setiawati, Agustina
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.14

Abstract

Many studies were designed explore chemopreventive activity of natural products on colon cancer especially addressing COX-2 as molecular target. Another promising source of natural product that potentially exhibit anticancer activity on colon cancer is Ganoderma lucidum. This study assessed selectivity of cytotoxic effect of G. lucidum extract on WiDr to Vero cells and investigated molecular mechanism on COX-2. G. lucidum ex-tract was prepared by reflux extraction method; in vitro anticancer was assayed by MTT method on WiDr and Vero cell line. This study applied apoptosis induction assay to observe cell death mechanism using double staining method; further COX-2 expression was stained by immunocytochemistry method. G. lucidum extract has cytotoxic effect on WiDr cells with IC50 135 µg/mL. However, the cytotoxic effect had low selectivity to-wards Vero cells with Selectivity Index (SI) 3.66. The extract induced apoptosis and suppressed COX-2 ex-pression in WiDr cells. G. lucidum extract was potential to be developed as anticancer agent towards colon cancer.
Co-Authors Adam Hermawan Aditya Fitriasari Agnes Mutiara Kurniawan David Chandra Putra Dina Christin Ayuning Putri Edy Meiyanto Enade Perdana Istyastono Enade Perdana Istyastono Erna Tri Wulandari Evy Fenny Veronica Flavia Domitilla Erika Setyajati Florentinus Dika Octa Riswanto Hanindita, Fizkha Hartinni, Yustina Sri Husin, Amelia S Ivana, Cheryn Kencana, Nyoman Bayu Wisnu Lutfi Chabib Maria Andriani Gelu Michael Raharja Gani Olga Sancaya Dyah Permatasari Ratna Asmah Susidarti reza eka putra Rini Dwiastuti Sabatti, P. Henrietta Puji Dwi Astuti Dian Sendy Junedi Sri Hartati Yuliani Valentina Putri Embun Kinanti Widiyanto, Yohanes Baptista Cahya Yohanes Dwiatmaka Yunita Linawati Yustina Sri Hartini