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All Journal Sari Pediatri Paediatrica Indonesiana IJRETINA - International Journal of Retina Ophthalmologica Indonesiana
Rita S. Sitorus
Pediatric Opthalmology Division, Department Of Ophthalmology, Faculty Of Medicine Universitas Indonesia, Kirana Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Ultraviolet-related ocular problems in children living on the coast of Southwest Sumba, Indonesia Ratna Sitompul; Rita Sitorus; Julie Barliana; Rossalyn Andrisa; Budiman Prakoso; Hisar Daniel; Gladys Kusumowidagdo; Saleha Sungkar
Paediatrica Indonesiana Vol 58 No 3 (2018): May 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.339 KB) | DOI: 10.14238/pi58.3.2018.128-32

Abstract

Background A previous study has shown a high proportion of visual impairment and blindness in the adults of Southwest Sumba, Indonesia due to ultraviolet-radiation (UVR)- related ocular problems, such as cataract and pterygium. Currently, there is no data regarding the effect of ultraviolet (UV) exposure on children and its future implications. Objective To seek the predisposing factors of UVR ocular problems in the children of Southwest Sumba. Methods A population-based cross-sectional study was conducted in Perokonda Village, Southwest Sumba in May 2017. A total of 337 children <16 years old were examined for ocular problems by ophthalmologists. Subjects with ocular problems were then treated accordingly. Results Visual acuity was normal in 98.2% of subjects. Visual impairment and blindness were found in 1.2% and 0.3% of subjects, respectively. Ocular problems were found in 38%, consisting of conjunctival pigment deposits (60.2%), pinguecula (15.6%), and pterygium (13.3%). The UVR ocular problems constituted 33.8% of all ocular problems, comprising conjunctival pigment deposits (22.8%), pinguecula (6%), and pterygium (5%). Conclusion The proportion of UVR ocular problems in the children of Perokonda village is 34.5%, the most common of which being conjunctival pigment deposits. Such deposits may be early signs of UVR ocular problems. This study serves as a platform to highlight the possible relationship between pigment deposits and future UVR ocular problems, which warrants further study.
Ocular complications in pediatric nephrotic syndrome treated with corticosteroids L. Toruan, Yulia Margareta; Trihono, Partini Pudjihastuti; Sitorus, Rita Sita; Dwipoerwantoro, Pramita Gayatri
Paediatrica Indonesiana Vol. 64 No. 1 (2024): January 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.1.2024.1-9

Abstract

Background Posterior subcapsular cataracts (PSC) and raised intraocular pressure (IOP) are the most common ocular complications of oral steroid administration, particularly following long-term use or treatment with high doses. Objective To evaluate the association between cumulative steroid dose and duration of treatment with the occurrence of PSC and raised IOP, as well as its associated factors in children with idiopatic nephrotic syndrome (INS). Methods This cross-sectional study included children aged 4–18 years with INS who received oral steroid therapy for at least six consecutive months. Patients underwent complete eye examinations by an ophthalmologist to evaluate their visual acuity as well as the occurrence of PSC and/or raised IOP. Results Of 92 subjects, 19.6% had PSC, 12% had raised IOP, and one had a best corrected visual acuity (BCVA) of <6/20. The median cumulative steroid dose was 12,161 (range 1,795–81,398) mg and median treatment duration was 23 (range 6–84) months. There were significant positive associations between cumulative steroid dose as well as treatment duration and the occurrence of PSC, with cut-off points of 11,475 mg and 24 months, respectively, as determined by receiver operator characteristic (ROC) curves. Females were four times more likely to have PSC compared to males (PR 4; 95%CI 1.57 to 13.38; P=0.001). Cumulative steroid dose and duration of treatment were not associated with raised IOP. Conclusion Cumulative steroid dose of 11,475 mg or higher and/or duration of steroid therapy of 24 months of more were significantly associated with the occurrence of PSC, but not with raised IOP.
Pengaruh Stimulasi Bermain Ibu terhadap Kadar Brain Derived Neurotrophic Factor dan Perkembangan Psikososial pada Anak Usia 12-18 Bulan Soedjatmiko, Soedjatmiko; Gatot, Djajadiman; Rusmil, Kusnandi; Bardosono, Saptawati; Padmonodewo, Suminarti; Gutama, Gutama; Sitorus, Rita; Dwirestuti, Ratna
Sari Pediatri Vol 27, No 2 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.2.2025.118-25

Abstract

Latar belakang. Penelitian pada tikus dan orang dewasa menunjukkan bahwa stimulasi lingkungan dapat meningkatkan kadar BDNF di hipokampus, korteks, dan amigdala, yang berperan penting dalam proses pembelajaran dan memori. Namun, belum ada publikasi mengenai pengaruh stimulasi pada anak-anak.Tujuan. Penelitian ini bertujuan untuk membuktikan pengaruh stimulasi bermain yang berupa rangsangan visual, auditori, dan emosional oleh ibu terhadap kadar BDNF darah tepi, serta perkembangan kognitif, bahasa, emosi-sosial, dan memori anak.Metode. Sebanyak 80 anak berusia 12–18 bulan yang sehat (divalidasi melalui pemeriksaan fisik, laboratorium, dan psikologis) terlibat dalam penelitian ini. Subjek dibagi secara acak menjadi dua kelompok: kelompok stimulasi (n=40) dan kelompok kontrol (n=40). Stimulasi dilakukan oleh ibu setelah dilatih selama 2 jam oleh tim peneliti, dengan menunjukkan dan membacakan 5 kata, diakhiri dengan pujian dan pelukan; dilakukan tiga kali sehari, empat hari dalam seminggu, selama 8 minggu. Kata-kata diganti bertahap setiap harinya hingga mencapai total 60 kata. Kelompok kontrol tidak menerima stimulasi.Hasil. Terdapat perbedaan bermakna dalam kadar BDNF 24,6% lebih tinggi pada kelompok stimulasi, p<0,01), serta dalam perkembangan bahasa reseptif, emosi-sosial, dan memori anak (p<0,05). Namun, tidak terdapat perbedaan signifikan pada skala kognitif dan bahasa ekspresif (p>0,05).Kesimpulan. Metode stimulasi yang dilakukan tiga kali sehari selama 8 minggu terbukti bermanfaat untuk meningkatkan kadar BDNF serta perkembangan bahasa reseptif, emosi-sosial, dan memori anak usia 12–18 bulan.
Single Arterial Oxygen Tension Elevation Increases the Risk of Stage of Acute Disease Retinopathy of Prematurity Pratiwi, Karina Satyani; Yulia, Dian Estu; Barliana, Julie Dewi; Sitorus, Rita Sita
International Journal of Retina Vol 6 No 2 (2023): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2023.vol006.iss002.242

Abstract

Introduction: Numerous studies have shown inconclusive results regarding ideal parameter for oxygen supplementation to balance the risk of mortality and retinopathy of prematurity (ROP) development. The purpose of this study is to compare mean partial oxygen tension (PaO2) level in ROP. Methods: This retrospective study was performed on premature infants undergoing ROP screening at our neonatal intensive care unit during 2021. All infants born at our hospital at ≤ 30 weeks, birth weight (BW) ≤ 1500 grams, or high-risk infants with prolonged ventilation were included. ROP screening was performed at chronological age four to six weeks, were followed and managed according to the severity. ROP severity was categorized by International Classification of ROP 3rd edition (ICROP3). We reviewed the characteristics of each group and compared mean PaO2 level in day 1, day 5, and day 10 between incomplete vascularization (IV) group, stage of acute disease (SAD) group, and Aggressive ROP (A-ROP) group. Result: We investigated 124 eyes from 62 eligible PI. The incidence of IV, stage 1, stage 2, stage 3, and A-ROP were 58.9%, 2.4%, 7.3%, 23.4%, and 8.1%, respectively. Mean PaO2 level in day 5 was higher in SAD group compared to IV group (p=0.002). For each level increase in PaO2, there was 1.042 times higher odds of developing SAD (p=0.004). Multivariate logistic regression analysis showed consistent results, simultaneously, each week increase in GA was associated with lower risk of SAD development (p=0.018) and each level increase in PaO2 was associated with higher risk for SAD development (p=0.005). Conclusion: A single elevation in PaO2 during early life of PI increases the risk of developing stage of acute disease ROP, particularly in younger infants. Careful monitoring for PaO2 is mandatory to prevent development of ROP.
FACTORS THAT INFLUENCE SURVIVAL RATE IN EXTRAOCULAR RETINOBLASTOMA PATIENTS AT CIPTO MANGUNKUSUMO HOSPITAL : 2018 Aprina, Dwie; Barliana, Julie Dewi; Yulia, Dian Estu; Sitorus, Rita Sita
Majalah Oftalmologi Indonesia Vol 50 No 1 (2024): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fvstnp93

Abstract

Introduction: Optimal therapeutic approach for extraocular retinoblastoma has not been determined. The prognosis of extraocular retinoblastoma compared with intraocular retinoblastoma remains relatively poor. The aim of our study is to describe the factors that influence the survival rate of extraocular retinoblastoma. Methods: A retrospective study. Patients diagnosed with extraocular retinoblastoma in Cipto Mangunkusumo Hospital, within 1 January to 31 December 2018 were reviewed for patient and tumor characteristic, ocular management, and patient survival. Result: During the study period, a total of  80 patients were diagnosed with retinoblastoma in our center, 41.2% had an extra-ocular extension The mean age at diagnosis was 25.57 months, with 56.7% being males. Leukocoria is the initial sign most often noticed by parents. The median lag period was 12 months. Neoadjuvant chemotherapy was performed in 96.7% of cases, that carried out an average of 3-4 cycles before enucleation/exenteration. At the end of September 2019, there were 17 deaths in our study. Overall survival was 19.82 months with a mean age of 27.6 months, whereas extraocular death time ranged from 4 months to 55 months.  Conclusion: Death was more common in patients with age at first symptom less than 24 months, bilateral retinoblastoma, lag period more than 12 months, advanced stage (IVB) and delayed therapy after proptosis more than 3 months.
OVERVIEW OF PATIENTS SCREENED FOR AND DIAGNOSED WITH ROP IN PEDIATRIC OPHTHALMOLOGY OUTPATIENT CLINIC BEFORE, DURING, AND AFTER THE COVID-19 PANDEMIC: Poster Presentation - Observational Study - Ophthalmologist BARLIANA, JULIE DEWI; Sitorus, Rita Rita; Yulia, Dian Estu; Casey, Anthea; Zahra, Raihanny Andrea
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/hwpgv162

Abstract

Introduction & Objectives : The COVID-19 pandemic has profoundly impacted healthcare systems worldwide, leading to significant changes in the delivery of medical services. Non-urgent ophthalmology visits were canceled. However, premature infants at risk of retinopathy of prematurity (ROP) require timely and in-person care to prevent vision loss. This study aims to report on the high-risk babies screened and diagnosed with ROP before, during, and after the COVID-19 pandemic Methods : This is a descriptive study conducted on premature infants who visited the pediatric ophthalmology outpatient clinic at Cipto Mangunkusumo Hospital Jakarta between January 2019 and December 2022. Data was collected using medical records and presented using tables and charts Results : A total of 368 babies were screened for ROP in 2019, and 75% were diagnosed with ROP. During the lockdown in 2020, the number of babies screened for ROP decreased to 286, and the incidence of ROP was 38.5%. In 2021 and 2022, ROP screening increased to 458 and 515 babies per year, respectively. After the COVID-19 pandemic subsided, ROP screenings increased significantly from 2020 to 2021. The number of babies screened in 2021 and 2022 was similar, but the incidence of ROP decreased from 45.4% in 2021 to 20.3% in 2022 Conclusion : This study highlights the impact of the COVID-19 pandemic on ROP screening and diagnosis in a pediatric ophthalmology outpatient clinic. After the COVID-19 pandemic, the number of babies screened for ROP increased due to the end of the lockdown
Co-Authors Aprina, Dwie Budiman Prakoso Casey, Anthea Dewi Asih Djajadiman Gatot Djayadiman Gatot Dwirestuti, Ratna Estu Yulia, Dian Gladys Kusumowidagdo Gutama, Gutama Hisar Daniel Julie Dewi Barliana Kusnandi Rusmil L. Toruan, Yulia Margareta Padmonodewo, Suminarti Pramita Gayatri, Pramita Pratiwi, Karina Satyani Ratna Sitompul Rossalyn Andrisa Saleha Sungkar Saptawati Bardosono Soedjatmiko Soedjatmiko Trihono, Partini Pudjihastuti Zahra, Raihanny Andrea