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All Journal Medical Journal of Indonesia Majalah Kedokteran The Indonesian Biomedical Journal Paediatrica Indonesiana Jurnal Entomologi Indonesia ASEAN Journal of Community Engagement eJournal Kedokteran Indonesia Archives of Pediatric Gastroenterology, Hepatology, and Nutrition The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Saleha Sungkar
Department Of Parasitology Faculty Of Medicine Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Entomofobia yang Mengarah ke Delusi Parasitosis Rawina Winita; Agus Aulung; Saleha Sungkar
Majalah Kedokteran UKI Vol. 27 No. 2 (2010): APRIL - JUNI
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Entomofobia dan delusi parasitosis adalah dua kondisi yang berhubungan dengan rasa takut yang berlebihan terhadap arthropoda seperti serangga dan parasit lain yang menyebabkan gangguan psikologis. Kasus entomofobia di Indonesia jarang dilaporkan. Tulisan ini melaporkan seorang perempuan yang semula didiagnosis sebagai penderita miasis kutan karena larva serangga. Secara fisik pasien sembuh setelah pengobatan tetapi ia tidak dapat menerima keadaan tersebut. Pasien tetap merasakan ketakutan yang berlebihan. Selanjutnya diagnosis ditetapkan yaitu entomofobia yang mengarah ke delusi parasitosis Kata kunci: entomofobia, delusi parasitosis, miasis kutan Abstract Entomophobia and delusional parasitosis are two different conditions associated with excessive fear of arthropods such as insects and other parasites, which causes psychological disorders. So far entomophobia cases are rarely reported in Indonesia. This paper reports of a woman who previously diagnosed as cutaneous myasis caused by insect’s larvae. Physically she was recovered after treatment, but she remains having excessive fear of insect. Further more, she was diagnosed as delusional parasitosis. Keyword: entomophobia, delusional parasitosis, cutaneus myasis
Hyaluronic Acid Accelerates VEGF and PDGF Release from Advance Platelet Rich Fibrin in Diabetic Foot Ulcer Ronald Winardi Kartika; Idrus Alwi; Franciscus Dhyanagiri Suyatna; Ferry Sandra; Em Yunir; Sarwono Waspadji; Suzzana Immanuel; Todung Silalahi; Saleha Sungkar; Jusuf Rachmat; Saptawati Bardosono; Mirta Hediyati Reksodiputro
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1523

Abstract

BACKGROUND: Hyaluronic acid (HA) is an essential component of extracellular matrix and mediates signaling in wound healing. HA could induce growth factor release from Advanced Platelet Rich Fibrin (A-PRF), including Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF). However, concentrations of the released-VEGF and PDGF have not been clearly disclosed. Therefore, current study was conducted to measure the release of these growth factors in HA + A-PRF gel of diabetic foot ulcer (DFU) subjects.METHODS: Twenty DFU subjects were included in the study and treated with A-PRF or HA+A-PRF. A-PRF was derived from autologous peripheral blood and processed with low-speed centrifugation. HA was added with a ratio of 1:0.6. A-PRF or HA + A-PRF was applied topically on DFU. Upper tips of A-PRF or HA + A-PRF gels were collected on day 0, 3 and 7 for measurements of VEGF and PDGF concentrations with Enzyme-linked Immune-sorbent Assay (ELISA) methods.RESULTS: On day-3, both VEGF and PDGF concentrations of HA + A-PRF group were significantly higher than the VEGF (p=0.000) and PDGF (p=0.019) concentrations of A-PRF group. The VEGF and PDGF concentrations were continuously and significantly increased on day-7 of HA + A-PRF group, compared to the VEGF (p=0.000) and PDGF (p=0.004) concentrations of A-PRF group.CONCLUSION: Combination HA+A-PRF induces VEGF and PDGF release from A-PRF. A mixture of A-PRF and HA could be more effective than A-PRF alone for treatment of DFU.KEYWORDS: hyaluronic acid, advanced platelet rich fibrin, PRF, growth factor, VEGF, PDGF, diabetic foot ulcer
Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients Ronald Winardi Kartika; Idrus Alwi; Franciscus Dhyanagiri Suyatna; Em Yunir; Sarwono Waspadji; Suzanna Immanuel; Todung Silalahi; Saleha Sungkar; Jusuf Rachmat; Saptawati Bardosono; Mirta Hediyati Reksodiputro
The Indonesian Biomedical Journal Vol 13, No 2 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i2.1501

Abstract

BACKGROUND: Diabetic foot ulcer (DFU) is the most common and threatening complication of Diabetes Mellitus (DM). Ideal wound dressing for DFU management should relieve symptoms, provide wound protection, and encourage healing. Advanced-Platelet Rich Fibrin (A-PRF) and Hyaluronic Acid (HA) have been proven to improve wound healing process. This study was aimed to demonstrate the ability of combination of A-PRF and HA in reducing inflammation and improving DFU tissue healing.METHODS: Twenty DFU subjects were involved in this study, and divided into two groups based on the topical fibrin gel treatment: A-PRF + HA group and A-PRF only group. A-PRF was obtained by peripheral blood centrifugation. A-PRF + HA was prepared by homogening A-PRF and AH with a ratio of 1:0.6. Interleukin-6 (IL-6) level, granulation index (GI), numeric pain score (NPS), and inflammation clinical symptoms (ICS) were assessed on day-0, 3, 7 and 14.RESULTS: Wound swabs’ IL-6 level on day-7 was found to be significantly lower in A-PRF + HA compared to A-PRF alone (p=0.041). The IL-6 level reduction also found to be significant higher either in wound swabs (day 0-7, p=0.015) or fibrin gel (day 0-3, p=0.049; day 0-7, p=0.034). A-PRF + HA treatment significantly increased the GI even since day-3 (p=0.043), with lower NPS (p<0.001), and ICS score.CONCLUSION: The combination of A-PRF and HA increases the GI in DFU healing by reducing the inflammation state which will induce the angiogenesis process, as well as reducing pain in DFU subjects better than A-PRF alone.KEYWORDS: inflammation, interleukin-6, wound healing, angiogenesis, proliferation 
Ultraviolet-related ocular problems in children living on the coast of Southwest Sumba, Indonesia Ratna Sitompul; Rita Sitorus; Julie Barliana; Rossalyn Andrisa; Budiman Prakoso; Hisar Daniel; Gladys Kusumowidagdo; Saleha Sungkar
Paediatrica Indonesiana Vol 58 No 3 (2018): May 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.339 KB) | DOI: 10.14238/pi58.3.2018.128-32

Abstract

Background A previous study has shown a high proportion of visual impairment and blindness in the adults of Southwest Sumba, Indonesia due to ultraviolet-radiation (UVR)- related ocular problems, such as cataract and pterygium. Currently, there is no data regarding the effect of ultraviolet (UV) exposure on children and its future implications. Objective To seek the predisposing factors of UVR ocular problems in the children of Southwest Sumba. Methods A population-based cross-sectional study was conducted in Perokonda Village, Southwest Sumba in May 2017. A total of 337 children <16 years old were examined for ocular problems by ophthalmologists. Subjects with ocular problems were then treated accordingly. Results Visual acuity was normal in 98.2% of subjects. Visual impairment and blindness were found in 1.2% and 0.3% of subjects, respectively. Ocular problems were found in 38%, consisting of conjunctival pigment deposits (60.2%), pinguecula (15.6%), and pterygium (13.3%). The UVR ocular problems constituted 33.8% of all ocular problems, comprising conjunctival pigment deposits (22.8%), pinguecula (6%), and pterygium (5%). Conclusion The proportion of UVR ocular problems in the children of Perokonda village is 34.5%, the most common of which being conjunctival pigment deposits. Such deposits may be early signs of UVR ocular problems. This study serves as a platform to highlight the possible relationship between pigment deposits and future UVR ocular problems, which warrants further study.
Prevalensi Infeksi Cacing Usus di Kawasan Pedesaan dan Perkotaan: Studi Berbasis Sekolah Sri Wahdini; Diadikma Bellarosa; Saleha Sungkar
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.079 KB) | DOI: 10.23886/ejki.9.59.187-91

Abstract

Di Indonesia infeksi cacing usus masih menjadi masalah kesehatan yang penting. Hal ini dikaitkan dengan higienitas dan sanitasi yang buruk, kekurangan air bersih, kekurangan nutrisi, serta kontak dengan tanah yang berisi telur cacing. Penelitian ini bertujuan untuk mengetahui perbandingan prevalensi infeksi cacing dan dihubungkan dengan kawasan pedesaan dan perkotaan. Penelitian menggunakan desain cross-sectional berbasis sekolah yang dilakukan pada tahun 2018. Sebanyak minimal 7 siswa dipilih secara acak dari 30 sekolah setingkat taman kanak-kanak atau Sekolah Dasar di Kabupaten Bogor (sebagai kawasan pedesaan) dan Kota Administrasi Jakarta Barat (sebagai kawasan perkotaan). Total sample feses yang terkumpul sebanyak 610 dan diperiksa di Laboratorium Parasitologi Klinik, Fakultas Kedokteran Universitas Indonesia. Sampel feses dibuat sediaan dan diwarnai dengan lugol kemudian diperiksa secara langsung dengan mikroskop. Data diolah dengan SPSS versi 20.00 Prevalensi infeksi cacing usus di kawasan rural 3,2% sedangkan di kawasan urban 1% (chi square, p = 0,09; OR = 4,33; IK 95% = 0,93 – 11,99). Infeksi cacing usus didominasi spesies Ascaris lumbricoides.  Infeksi cacing memiliki prevalensi relatif rendah. Pada penelitian ini tidak terdapat perbedaan prevalensi infeksi cacing usus pada anak di kawasan pedesaan dan perkotaan.
Acupuncture in the Management of Functional Dyspepsia Anastasia Yoveline; Murdani Abdullah; Guntur Darmawan; Hasan Mihardja; Saleha Sungkar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.501 KB) | DOI: 10.24871/131201249-55

Abstract

Dyspepsia is an uncomfortable sensation or pain in the upper abdomen which is persisting or recurring. Dyspepsia can be classified into functional and organic dyspepsia. Functional dyspepsia is more commonly found compared to the organic type, approximately 60%. Pharmacologic therapy in the management of functional dyspepsia has not shown optimal results, with the multifactorial etiology of functional dyspepsia as the main challenge. Therefore, the management of functional dyspepsia is widened and involves variety treatment modalities, acupuncture being one of them. Acupuncture is a way of treatment by puncturing needles to particular area on the skin to eliminate pain and treat particular diseases. Acupuncture affects stomach motility and gastric acid secretion in functional dyspepsia patients. Two acupuncture points commonly used in functional dyspepsia are ST 36 and PC 6. Acupuncture can restore gastric motility in patients with functional dyspepsia, who have gastric emptying disturbance. Besides, functional dyspepsia complaints, such as epigastric pain, nausea, vomiting, anorexia, burning sensation, and bloating were found to improve after acupuncture therapy. Side effects of acupuncture are not life threatening with low incidence rate. The effectiveness of acupuncture therapy compared to standard medication shows varies results. Further studies are needed to determine the characteristics of functional dyspepsia patients which could have optimal results through acupuncture therapy. Keywords: epigastric pain, gastric motility, ST 36, PC 6
Level of Evidence Diagnosis Skabies Berdasarkan Oxford Centre for Evidence-Based Medicine Keiko Gunardi; Prof Saleha Sungkar; Sandra Widaty; Yudo Irawan
eJournal Kedokteran Indonesia Vol 10, No. 3 - Desember 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.224.276-83

Abstract

Abstrak Skabies merupakan masalah kesehatan komunitas di seluruh dunia dan penyakit ini menjadi infeksi tropis yang sering terabaikan di Indonesia. Manifestasi kulit pada skabies yang tidak khas, namun tetap digunakan sebagai dasar dalam mendiagnosis skabies dengan tambahan pemeriksaan mikroskopik langsung. Tinjauan pustaka ini membahas penegakan diagnostik skabies berdasarkan level of evidence dari berbagai pemeriksaan penunjang. Pemeriksaan penunjang yang dibahas adalah pemeriksaan langsung mikroskopik, pemeriksaan dermoskopi, dan pemeriksaan imunologi antara lain Polymerase Chain Reaction (PCR) dan Enzyme-linked immunosorbent assay (ELISA) yang mempunyai LoE 1B. Pemahaman yang tepat mengenai metode diagnosis skabies akan memberikan tata laksana serta mendukung eradikasi penyakit ini. Abstract Scabies become a public health burden worldwide and the most common neglected tropical skin diseases in Indonesia. However, atypical skin manifestations are frequent and the widely used diagnostic test based on microscopic examinations has limited sensitivity. This literature review discuss about diagnostic method in patient with scabies according to level of evidence. We compared the classical manifestation, the new diagnostic consensus criteria, microscopic examination, dermoscopy examination and immunological assay such as polymerase chain reaction (PCR) and Enzyme-linked immunosorbent assay (ELISA) categorized in LoE 1B. The knowledge about the diagnostic method will give an effective treatment for scabies patient and will eradicate this disease.
Superior mesenteric artery blood flow in infants of very preterm and very low birthweight and its related factors Evita Karianni Bermanshah Ifran; Wresti Indriatmi; Tetty Yuniarti; Nadjib Advani; Saleha Sungkar; Dewi Irawati Soeria Santoso; Rinawati Rohsiswatmo; Yvan Vandenplas; Badriul Hegar
Paediatrica Indonesiana Vol 63 No 2 (2023): March 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.2.2023.80-7

Abstract

Abstract Background Significant hemodynamic changes in preterm infants during early life could have consequences, especially on the intestinal blood flow. Alteration of superior mesenteric artery (SMA) blood flow may lead to impairment in gut function and feeding intolerance. Objectives To assess SMA blood flow velocity in very preterm and/or very low birth weight (VLBW) infants in early life and to elucidate the factors influencing them. Methods This is a cross-sectional study conducted in NICU at Cipto Mangunkusumo Hospital, Jakarta. Superior mesenteric artery (SMA) blood flow was evaluated by peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) measurement using Color Doppler US at < 48 hours after birth. Maternal and neonatal data that could be potentially associated with SMA blood flow were obtained. Bivariate analyses were conducted with a P value of < 0.05 considered significant. Results We examined 156 infants eligible for the study. PSV, EDV, and RI of SMA blood flow were not related to both gestational age and birth weight. Infant with small for gestational age (SGA) showed significantly lower EDV median [15.5 (range 0.0-32.8) vs 19.4 (range 0.0-113.0)] and higher RI [0.80 (range 0.58-1.00) vs 0.78 (range 0.50-1.00)] compared to appropriate for gestational age (AGA). Infants born from mother with preeclampsia showed lower PSV median [(78.2 (range 32.0-163.0) vs 89.7 (range 29.2-357.0)]) and EDV [16.2 (range 0.0-48.5) vs 19.4 (range 0.0-113.0)] compared to without PE, while absent/reverse end-diastolic velocity (AREDV) revealed a lower EDV median [16.9 (range 0.0 – 32.4) vs 19.4 (range 0.0 – 113.0)] compared to no AREDV. Furthermore, infants with hs-PDA showed lower EDV median [16.2 (range 0.0-113.0) vs 19.4 (range 0.0-71.1)] but higher RI median [0.80 (range 0.50-1.00) vs 0.78 (range 0.55-1.00)] compared to non hs-PDA. No difference in SMA blood flow across other factors was observed.
The Prevalence of Myopia and its Associated Factors Among School-Aged Children in Pamijahan Village, Bogor District Julie Dewi Barliana; Yeni Dwi Lestari; Ghina Fedora; Laura Agnestasia Djunaedi; Anthea Casey; Tri Rahayu; Ratna Sitompul; Andi Arus Victor; Saleha Sungkar
eJournal Kedokteran Indonesia Vol 11, No. 1 - April 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.210.3

Abstract

Globaly, the prevalence of refractive errors, especially myopia in children, has increased significantly. The cause of myopia is multifactorial. Near-work activities and family history are some suggested factors associated with myopia. However, there has not been enough data on these factors and their association with myopia in Indonesia. This study aims to determine the prevalence and factors associated with myopia in primary and middle schoolaged children in Pamijahan Village, Bogor District, West Java, Indonesia. Data were taken in a cross-sectional design based on the visual acuity, anterior and posterior eye examination. A 14-item questionnaire regarding myopia-associated factors including family history, playing outdoors, and near-work activities, was distributed to the subjects. The data were taken from June to September 2018. Analysis was conducted using SPSS version 20. The prevalence of myopia in Pamijahan Village is 4,9% out of 474 subjects. Family history, including parental (p=0.001, OR 4.49) and sibling history (p=0.001, OR 5.58), was shown to be associated with the increasing risk of myopia in children while near-work activities and playing outdoors were not associated with myopia in children of Pamijahan Village.
Aspek parasitologi Sarcoptes scabiei var. hominis: Parasitological aspects of Sarcoptes scabiei var. hominis Wahdini, Sri; Sungkar, Saleha
Jurnal Entomologi Indonesia Vol 20 No 3 (2023): November
Publisher : Perhimpunan Entomologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5994/jei.20.3.275

Abstract

Sarcoptes scabiei (Dee Geer) is the mite that causes scabies or mange. The mites live in the skin layers of humans and mammals. Nowadays, S. scabiei is classified according to their hospes and S. scabiei that lives in human is called Sarcoptes scabiei var. hominis. Controlling and eradicating human scabies, especially at the community level, requires understanding scabies as a pathogen and its interaction with humans. This paper discusses the biology of S. scabiei var. hominis and the interactions between mites and humans as hosts.
Co-Authors Agnes Kurniawan Agus Aulung Ahmad Fuady Ahmad P. Natanegara Aji W. Wardhana Amajida Fadia Ratnasari Anastasia Yoveline Anastasia Yoveline Andi Arus Victor Anthea Casey Aria Kekalih Ayudianingrum, Asti Badriul Hegar Budiman Prakoso Cara Tasya Handita Dani M. Trianto Danny Surya Dewita Kamaruddin Diadikma Bellarosa Em Yunir, Em Evita Karianni Bermanshah Fanny P. Irmawati Ferry Sandra Franciscus D. Suyatna Ghina Fedora Gladys - Gladys Kusumowidagdo Gozali, Meutia N. Guntur Darmawan Hansen Angkasa Hasan Mihardja Hasan Mihardja Herqutanto - Hilman Zulkifli Amin Hirzi Zulkarnain Hisar Daniel I Gusti N.A.A. Oktafandi Idrus Alwi Idrus Alwi Indra  Sianturi Irma Annisa Isfiyanto, Isfiyanto Julie Barliana Julie Dewi Barliana Jusuf Rachmat Jusuf Rachmat Kartika Hajarani Keiko Gunardi Kusumowidagdo, Gladys Laura Agnestasia Djunaedi Luddwi A. Rizky Matiur, Eiko B. Mohamad A. Sahala Monica E.T. Rosandi Muhamad S. Advani Muhammad P. Wiratama Murdani Abdullah Murdani Abdullah Nadjib Advani Pratiwi Sudarmono R. Sapto Hendri Boedi Soesatyo Ratna Sitompul Ratna Sitompul Ratna Sitompul Rawina Winita Rawina Winita Reksodiputro, Mirta Hediyati Reza Damayanti Rikeish R. Muralitharan Rilanda, Risa Rinawati Rohsiswatmo Rita Sitorus Ronald Winardi Kartika Rose A. Haswinzky Rossalyn Andrisa Sandra Widaty Santoso, Dewi Irawati Soeria Saptawati Bardosono Saptawati Bardosono Sari, Della P. Sarwono Waspadji Sarwono Waspadji Soefiannagoya Soedarman Soleman, Imam Rahadian Sri L. Menaldi Sri Wahdini Sri Wahdini Sri Wahdini Sukartini, Ninik Suzanna Immanuel Suzzana Immanuel Tambunan, Fitry B.J. Tanjungsari, Dian Wahyu Tetty Yuniarti Todung Silalahi Todung Silalahi Tri Rahayu Triana Agustin Victor Santawi Wirastuti, Aulia Wresti Indriatmi Yasmine A. Dwinastiti Yeni D. Lestari, Yeni D. Yeni Dwi Lestari Yudo Irawan Yusuf Ananda Yvan Vandenplas Zahrotul Habibah