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All Journal IPTEK The Journal for Technology and Science JURNAL FISIKA Prosiding SNFA (Seminar Nasional Fisika dan Aplikasinya) Journal of Physics and Its Applications Progress in Social Development
Suharyana Suharyana
Physics Department, Faculty of Mathematics and Natural Sciences, Sebelas Maret University Surakarta 57126, Indonesia
Humanities Astronomy Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Materials Science & Nanotechnology Physics Social Sciences

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Journal : Journal of Physics and Its Applications

 1 
Optimization of Energy for Proton Therapy with Pencil Beam Collimator Model in Craniopharyngioma Tumor Using MCNP6 Code Putri, Weni Antari; Riyatun, Riyatun; Darmanto, Darmanto; Suharyana, Suharyana; Arianto, Fajar
Journal of Physics and Its Applications Vol 6, No 1 (2023): November 2023
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v6i1.18100

Abstract

Computational simulations of proton therapy with a pencil beam collimator for craniopharyngioma have been done using MCNP6. A pencil beam was radiated towards cube shaped tumor cells in size 1.2 cm, located at a 5.4 cm depth from the surface of the scalp. A 0.1 cm pencil beam was radiated from the left 19.6 cm from the scalp. The cube of tumor cell is divided into the front layer, middle layer, and back layer. Each layer of the tumor cell is divided into 9 cubicles, thus there are 27 cubicles. Using various energy from 108 MeV to 115 MeV and various intensity of energy for each irradiation, it produces the dose for each cubicle in unit MeV/gram per proton. The best isodoses occurred in 5 variations of energy which is 108.2; 111.2; 113.4; 114.7 and 115 MeV. The healthy organ that received the largest dose of the proton is the brain, it is (7.38±0.01)×10-2 MeV/gram per proton, or only 0.412% compared to the tumor cell dose.
Analysis of Total Proton Therapy Dose Distribution with Pencil Beam Collimator Model and Varied Beam Directions in Craniopharyngioma Tumor using MCNP6 Software Hayati, Widia; Utari, Utari; Anwar, Fuad; Suharyana, Suharyana; Arianto, Fajar; Khakim, Azizul
Journal of Physics and Its Applications Vol 7, No 1 (2024): November 2024
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v7i1.23977

Abstract

Proton therapy modeling for treating craniopharyngioma tumors was conducted using a pencil beam collimator, and variations in beam directions were performed using MCNP6 software. The simulation was carried out on a head and neck phantom with the tumor cells modeled within a cubic irradiation area geometry with a 1.2 cm side length, divided into 27 small cubic voxels with a small voxel side length of 0.4 cm. The radiation source from the irradiation area's right, left, and top directions, with a diameter of 0.4 cm, was directed at each cubic voxel. Variation in radiation source directions indicated that irradiation from the right direction of the irradiation area is the most recommended approach, with a dose uniformity level of 83.47%. Healthy organs surrounding the irradiation area received lower doses than those obtained by tumor cells, and the majority remained below the Organ At Risk (OAR) threshold. Healthy organs received the highest dose, particularly in the brain region, at a relative 0.46% compared to the total dose received by tumor cells.
Analysis of Dose Distribution Alpha and Secondary Particles in Therapy Alpha for Glioblastoma Cancer Using MCNP6 Software Agustina, Sheila; Suharyana, Suharyana; Kusumandari, Kusumandari; Arianto, Fajar
Journal of Physics and Its Applications Vol 7, No 4 (2025): November 2025
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v7i4.25893

Abstract

The alpha therapy modeling was performed for the treatment of glioblastoma brain cancer using MCNP6 software. The simulation used a head and neck phantom geometry, with a spherical shape of the radiation direction of the cancer cells with a radius of one cm divided into 27 targets. One radiation source is directed to each target center of the cancer cells with five energy variations, namely (430, 425, 415, 410, and 400) MeV. The simulation results are in the form of a distribution of absorbed doses in all targets and healthy cells around them. The simulation results show an average dose distribution of (1.2902 ± 0.0024) 10-11 Gy/alpha with an isodose level of 69.75%. The healthy organ that receives the largest dose and secondary particle distribution after cancer cells is the brain, with an accumulative dose of (1.7446 ± 0.0033) 10-15 Gy/alpha. The dose distribution on cancer cells shows that the irradiation time to kill glioblastoma cancer cells is (1456±0.14) seconds with an alpha current of 1 nA.
Co-Authors Agustina, Sheila Ajeng Dewi Sekar Taji Kusumo Wardani, Raden Arrozaqi, M I M Artono Dwijo Sutomo Azizul Khakim, Azizul Budi Purnama Choiriyah, S Dadtun, Yusana Sasanti Darmanto Darmanto Darmarastri, Hayu Adi Fajar Arianto Fuad Anwar, Fuad Hayati, Widia Kusumandari, Kusumandari Muhtarom Putri, Ajeng Sarinda Yunia Putri, Weni Antari Riyatun, Riyatun Riyatun, Riyatun Sabrina, N Sudarno Sudarno Supariadi, Supariadi Susanto Susanto Sutirto, Tundjung Wahdi Utari Utari