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Ali Sulaiman
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta.
Medicine & Pharmacology

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The role of splanchnic vasoconstrictor in decreasing peripheral vasodilatation to reduce ascites formation of liver cirrhosis Akbar, Nurul; Soemarno, Soemarno; Sumarsono, Sumedi; Lesmana, Laurentius; Husodo, Unggul B.; Sulaiman, Ali; Sjaifoellah Noer, H. M.
Medical Journal of Indonesia Vol 6, No 4 (1997): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.239 KB) | DOI: 10.13181/mji.v6i4.833

Abstract

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Genotyping of hepatitis B virus from dried and stored serum on filter paper Gani, Rino A.; Handayu, A. D.; Mulatsih, Reny; Lesmana, L. A.; Sulaiman, Ali; Akbar, Nurul
Medical Journal of Indonesia Vol 14, No 4 (2005): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.253 KB) | DOI: 10.13181/mji.v14i4.198

Abstract

HBV genotype has aclose association with prognosis and therapy as well as for epidemiology study. However, this examination can be done only in large cities that are not practical to send serum sample due to geographical burden and facilities. The aim of this study is to know whether HBV genotype can be determined from dried and stored serum on filter paper and compare the result with sera drawn directly from chronic hepatitis B (CHB) and hepatoma patients. Twenty-three serum samples were obtained from CHB patients. HBV DNA were quantitatively determined with Cobas Amplicor HBM (Roche Diagnostics GmBH, Germany) and dropped on to 3 x 1 cm filter papers. After allowed to dry in a plastic clip, it were put in a closed envelope then stored for 1 week in room condition (27 – 33 oC). DNA extraction were done from the filter papers after a short incubation period and HBV genotypes were determined with PCR and specific primers. For comparison, 20 CHB-Hbe(+) samples and 29 hepatoma samples were drawn directly and not dried. HBV genotype were detected in 18/23 (78.2%) from dried serum samples on filter paper while in sera that were not stored, from CHB-HBe(+) samples, 20/20 (100%) could be determined while from hepatoma patients, 24/29 (82.7%) samples. The proportion of genotype were in line with other reported HBV genotype examination for Indonesia. It is concluded that detection of HBV genotype can be done from dried serum in filter paper and stored for 1 week. (Med J Indones 2005; 14: 215-9)Keywords: Hepatitis B virus, genotype, filter paper
Combination of interferon alfa-2b and ribavirin in relapsed or nonresponding chronic hepatitis C patients following interferon therapy Lesmana, Laurentius A.; Budihusodo, Unggul; Akbar, Nurul; Sulaiman, Ali; Noer, Sjaifoellah; Kristanti, Inge A.; Setiabudy, Rianto
Medical Journal of Indonesia Vol 10, No 4 (2001): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502.199 KB) | DOI: 10.13181/mji.v10i4.37

Abstract

Twenty six patients (pts) with chronic hepatitis C (CHC) who reLapsed or non-responded following.interferon (IFN) therapy were given lFN alfa-2b 3   MIU three times a week for 48 weeks in combination with Ribavirin 800-1000 mg daily 2I (80,8%) of the 26.pts completed the study consisted of 12 relapsers and 9 non-responders. Five pts dropped out due to drug adverse events in three pts and non-drug related reason in the other two. In the relapsed group complete response, relapse and sustained response rates were obtained in 9/12(75%), 2/2 (16,5%) and 7/12(58,3%) pts respectively. In the non- responding group, these figures were 3/9 (33,3%), 1/9(I1,1%), and 2/9(22,2%) pts, respectively. The most frequent adverse event was flu-like syndrome, which was found in 18 pts (85,7%). Combination therapy of IFN alfa-2b and ribavirin may induce sustained virological response in relapsed and non-responding CHC patients. This combination therapy is more effective for relapsers compared to for non-responders. (Med J Indones 2001; 10: 214-8)Keywords: Chronic hepatitis C, combination therapy, interferon, ribavirin
Co-Authors A H Reksodiputro A. D. Handayu Agus Sudiro Waspodo Agus Sulaeman Andri Sanityoso Arman A Abdullah FX Pridady Gatot Susilo Lawrence H. M. Sjaifoellah Noer Helyanna Helyanna, Helyanna Indah Gianawati Inge A. Kristanti Irsan Hasan Kukuh B. Rachmat L A Lesmana L. A. Lesmana Laurentius A Lesmana, Laurentius A Laurentius A. Lesmana Laurentius Lesmana Nafrialdi Nafrialdi Nurul Akbar Prasna Pramita Reny Mulatsih Rianto Setiabudy Rino A Gani Rino A. Gani Rino Alvani Gani Sjaifoellah Noer Soemarno Soemarno Sumedi Sumarsono Syarifuddin Wahid Toar JM Lalisang Unggul B. Husodo Unggul Budihusodo Wirasmi Marwoto