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All Journal International Journal of Public Health Science (IJPHS) Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Majalah Kedokteran Universa Medicina Paediatrica Indonesiana Majalah Kedokteran Andalas Nusantara Science and Technology Proceedings Makara Journal of Science Jurnal Kedokteran Meditek
Taniawati Supali
Departement Of Parasitology, Faculty Of Medicine, University Of Indonesia, Jakarta 10430, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Determinant Factors of Taking Anti-Filarial Medication Behavior in the First Round of the Mass Drug Administration Program with Ivermectin, Diethylcarbamazine Citrate, Albendazole: A Cross Sectional Study Ikrimah Nafilata; Tri Yunis Miko Wahyono; Taniawati Supali
Nusantara Science and Technology Proceedings 1st International Conference on Health and Medicine
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2023.3506

Abstract

Filariasis is still endemic in Indonesia with the criteria for a microfilaria rate of >1%, therefore WHO extended the Mass Drug Administration (MDA) program with Ivermectin, Diethylcarbamazine Citrate, Albendazole (IDA). Pekalongan City is one of the filariasis endemic areas in Central Java, Indonesia, which will receive an extension of the MDA program in 2021 and 2022, with a survey coverage of <65% of the population. The study aimed to prove the determinant factors associated with IDA drug-taking behavior to increase treatment coverage. Community-Based Survey conducted in 10 villages in 3 sub-districts in Pekalongan City with a Cross Sectional design using a structured questionnaire interview method, and a sample size of 546 respondents using Probability Proportional to Size and was taken by simple random sampling. Data analysis used the Chi Square statistical test and Logistic Regression. The age distribution of respondents > 42 years dominated by 54,0%, Female Gender dominated by 71,8%. Determinants of IDA Drug Distribution (p-value = 0,000, PR value = 2,498, 95% CI: 1,400-4,459), Willingness to Take Second IDA Drugs (p value = 0,000, PR value = 5,325, 95% CI:1,520-18,656), Assistance for Health Workers (p-value = 0,000, PR value = 2,690, 95% CI: 1,681-4,306), Agree to IDA drug distribution (p value = 0,008, PR value = 1,593, 95% CI: 0,778-3,259) has a significant relationship with IDA drug-taking behavior, and the logistic regression results of assisting health workers (OR = 76,002, 95% CI: 24,901-231,975) are the determinants most related to drug taking behavior IDA. It is necessary to assist health workers in the practice of taking IDA drugs in the next period. Health workers or health cadres must ensure that people take IDA drugs to increase treatment coverage, to accelerate the elimination of filariasis in Pekalongan City.
Soil-transmitted helminth infection, intestinal permeability, and intestinal inflammation in preschool-age children Aulia, Gina; Djuardi, Yenny; Supali, Taniawati
Paediatrica Indonesiana Vol. 65 No. 3 (2025): May 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.3.2025.232-8

Abstract

Background Soil-transmitted helminth (STH) infection is a major health problem in low-and middle-income countries (LMIC). The presence and activity of STH can cause changes in the intestinal mucosa, including cell damage that can affect intestinal permeability and stimulate immune responses such as inflammation. Objective To assess the inflammatory and permeability status of the intestinal mucosa in various STH infections in preschool-age children residing in Nangapanda District, Ende Regency, East Nusa Tenggara. Methods In this cross-sectional study, stool samples were obtained from children aged 12-59 months and examined for worm eggs using the Kato Katz method. Concentrations of biomarkers for intestinal permeability and inflammation were measured by enzyme-linked immunosorbent assay (ELISA). We measured fecal alpha-1-antitrypsin (AAT) as an intestinal permeability biomarker and fecal calprotectin (FC) as an intestinal inflammation biomarker and evaluated the association between these biomarkers with STH infection. Results The prevalence of STH infection in 111 evaluated preschool-age children was 17.1%. Ascaris lumbricoides was the predominant species, followed by Trichuris trichiura. Most subjects (64.7%) had AAT levels >0.27 mg/g, while only 35.1% had FC >50 mg/kg. STH infection status was not significantly associated with AAT concentration status, even when analyzed by STH species. A significant association was found only between T. trichiura infection and FC concentration. In this study, which included infected and uninfected groups, children infected with T. trichiura had higher concentrations of FC than those uninfected. Conclusion STH infection was not significantly correlated with fecal biomarkers except between T. trichiura infection status and increased gut inflammatory biomarker. AAT levels were generally elevated in the evaluated preschool-aged population regardless of STH infection, indicating that other factors may have contributed to increased gut permeability.
Co-Authors A.A. Ketut Agung Cahyawan W Abinawanto Abinawanto Abinawanto Agnes Kurniawan Bintari Rukmono Dante S. Harbuwono Endang S. Wardhani Felix Partono Freggy S Joprang Gina Aulia Helena Ullyartha Pangaribuan Heri Wibowo Hikmah, Kholisotul I Ketut Suada Ikrimah Nafilata Jane Florida Kalumpiu, Jane Florida Laurentius A. Pramono Lisawati Susanto Lisawati Susanto Maylasari, Roospita Monica Puspa Sari Nafilata, Ikrimah Nora Harminarti Pradana Soewondo Prihartono, Nurhayati Adnan Purnomo Purnomo Ria Buana, Ria Rita Ekarina Roospita Maylasari Sari, Monica Puspa Sarwono Waspadji Sendy Wulandhary Srisasi Gandahusada Srisasi Gandahusada Suharko Suharko Suriyani Tan Tjahaya Haerani Tri Yunis Miko Wahyono Wulandhary, Sendy Yenny Djuardi Yolazenia Yolazenia Yuli Puspita Devi Yuliana Yuliana