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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Vini Vidi Vici Journal of Educational, Health and Community Psychology Journal of Biomedicine and Translational Research WMJ (Warmadewa Medical Journal) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Kesehatan Tumou Tou Jurnal Perempuan dan Anak Indonesia Epidemia: Jurnal Kesehatan Masyarakat UNIMA Cermin Dunia Kedokteran KAMPRET Journal JIKMA
Alva Sahiri Alexander Supit
Manado State University
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Subgenual cingulate cortex activity in predicting risk factor and treatment response in depression Alva S. A. Supit; Ireine Roosdy
WMJ (Warmadewa Medical Journal) Vol 3 No 2 (2018): November 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.2.743.53-60

Abstract

Major depressive disorder (MDD) contributes significantly to morbidity, disability, and decreased quality of life, despite the expansion of treatment options. This, in part, is caused by a lack of valid, applicable, and reliable biomarkers to predict the risk, treatment response, and prognosis of depression. In recent years, the anterior cingulate cortex, in particular pars subgenual (sgACC), has received much attention due to its potential utilization as a neural endophenotype for depression. This essay will discuss the functional activity of sgACC, mostly by functional magnetic resonance imaging, in relation to predicting risk for developing depression, predicting patient response-to-treatment, and eventually, to create a platform for personalized psychiatric approach to each patient. The caveats and conditions need to be met will also be discussed, in order to firmly establish sgACC activity as a valid biomarker for depression.
THE DEVELOPMENT of a SAFE and OPTIMIZED GENE THERAPY for HUMAN DISEASES Alva Supit; Linda Tompodung
JBIO: jurnal biosains (the journal of biosciences) Vol 5, No 3 (2019): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v5i3.12472

Abstract

Gene therapy is the therapeutic delivery of a gene or nucleic acid into a patient’s cells to cure or alleviate the symptoms of a disease that was caused by genetic malfunction, either gain- of loss-of function. Throughout the years, gene therapy has been faced with fluctuations of development before reaching its current stage. In the early stage, gene therapy was concerned to possess several problems such as toxicity, mutagenesis, and adverse immune responses which would harm the patients, instead of benefiting them. Fortunately, gene therapy has currently reached the phase where its administration can be performed in a safe, controllable manner with a good tolerability and excellent therapeutic effect. This review will recite the development of gene therapy research, highlight the vector-related safety issues, and discuss the latest updates in recent clinical trials with promising results in correcting gene defects in the cell, reducing the symptoms of the disease, as well as improving the patient’s quality of life.
HUBUNGAN ANTARA TINGKAT PENGETAHUAN DENGAN SIKAP DALAM MENCEGAH HIPERTENSI PADA SISWA KELAS XI DAN XII SMK KRISTEN KAWANGKOAN Morgen Pangaila; Ahmad Paturusi; Alva Supit
Epidemia : Jurnal Kesehatan Masyarakat Unima Volume 1. No 1. FEBRUARI 2020
Publisher : Program Studi Ilmu Kesehatan Masyarakat Fakultas Ilmu Keolahragaan Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ejkmu.v1i1.572

Abstract

AbstrakHipertensi menjadi ancaman bagi sebagian besar penduduk dunia termasuk di Indonesia. Penyakit ini sering disebut sebagai the silent killer karena dapat menyebabkan kematian tanpa gejala klinik yang jelas. Prevalensi hipertensi pada remaja di Indonesia sebesar 8,4%. Pada remaja, hipertensi juga merupakan suatu masalah, karena remaja yang mengalami hipertensi dapat terus berlanjut pada usia dewasa dan memiliki risiko morbiditas dan mortalitas yang lebih tinggi. Untuk itu diperlukan upaya pencegahan sejak dini, yang dapat diawali dengan memiliki pengetahuan dan sikap untuk mencegah penyakit tersebut. Tujuan penelitian ini ialah untuk mengetahui hubungan tingkat pengetahuan dengan sikap dalam mencegah hipertensi pada siswa. Metode penelitian yang digunakan yaitu metode cross sectional dengan populasi seluruh siswa kelas XI dan XII SMK Kristen Kawangkoan, dengan jumlah sampel 129 siswa menggunakan cluster sampling. Hasil penelitian menunjukkan nilai p = 0,00 (< 0,05). Dengan demikian dapat disimpulkan adanya hubungan antara tingkat pengetahuan dengan sikap dalam mencegah hipertensi pada siswa kelas XI dan XII SMK Kristen Kawangkoan.Kata kunci: Pengetahuan, Sikap, Hipertensi AbstractHypertension is a threat to most of the world's population, including in Indonesia. This disease is often referred to as the silent killer because it can cause death without clear clinical symptoms. The prevalence of hypertension in adolescents in Indonesia is 8.4%. In adolescents, hypertension is also a problem, because adolescents who have hypertension can continue into adulthood and have a higher risk of morbidity and mortality. For this reason, prevention efforts are needed from an early age, which can be started by having the knowledge and attitude to prevent the disease. The purpose of this study was to determine the relationship between the level of knowledge and attitudes in preventing hypertension in students. The research method used is a cross sectional method with a population of all class XI and XII students of SMK Kristen Kawangkoan, with a sample size of 129 students using cluster sampling. The results showed the value of p = 0.00 (<0.05). Thus it can be concluded that there is a relationship between the level of knowledge and attitudes in preventing hypertension in class XI and XII students of SMK Kristen Kawangkoan. Keywords: Knowledge, Attitude, Hypertension
An original meaning of Si Tou Timou Tumou Tou in post-independence war Indonesia: A first-hand experience of Sam Ratulangi’s oldest daughter Alva Supit; Emilia A. Pangalila-Ratulangie
Tumou Tou Vol. 9 No. 1 (2022): Januari 2022
Publisher : Institut Agama Kristen Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.41 KB) | DOI: 10.51667/tt.v9i1.625

Abstract

Sitou timou tumou tou (ST4) has been a well-recognized philosophy adopted by the Minahasan people. During its development, it has become even more popular within the scope of education. ST4 was said to be first mentioned by the Minahasan national hero, Sam Ratulangi. The interpretations of ST4 have been abundant, mostly reciting the educational aspect: “a man lives to make other men humans.” However, a direct historical record on when and in what situation ST4 was first mentioned by Sam Ratulangi is not well known by the academia and general public. In fact, there has not been any written authoritative source about this manner. In this auto-narrative historical research, the authors took advantage of the direct experiential account of the oldest daughter of Sam Ratulangi (the second author) when ST4 was first said by Sam Ratulangi himself. This has revealed a novel, but rather the original intention of Sam Ratulangi when he first mentioned ST4 in the context of post-war Indonesia: “a man lives to live as a real man.”
Ketergantungan Nikotin: Aspek Molekuler dan Implikasi Terapi Berbasis Bukti Alva S. A. Supit
Cermin Dunia Kedokteran Vol 43, No 4 (2016): Adiksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v43i4.45

Abstract

Ketergantungan nikotin merupakan masalah kesehatan masyarakat yang perlu ditangani dengan serius karena tingginya angka morbiditas dan mortalitas. Di tingkat molekuler, nikotin akan berikatan dengan reseptor asetilkolin nikotinik di membran neuron area tegmental ventral, memicu serangkaian depolarisasi dan pelepasan dopamin terutama di nukleus akumbens dan korteks prefrontal, yang akan diinterpretasi sebagai kenikmatan oleh seorang individu. Pada pemakaian nikotin kronis, akan terjadi serangkaian desensitisasi reseptor di tingkat sirkuit ataupun di tingkat transkripsi genetik pada neuron yang terlibat, sehingga kadar dopamin yang dilepaskan akan makin tinggi dan makin euforia. Aspek genetik dan epigenetik juga berpengaruh dalam patogenesis ketergantungan nikotin. Penanganan farmakologik yang telah terbukti berupa terapi penggantian nikotin, bupropion, dan vareniklin, sedangkan yang masih dalam tahap riset berupa vaksin nikotin, dianiklin, NCT00741884, NCT01234142, dan rimonabant.
Motivasi, tantangan, dan mekanisme koping pekerja migran perempuan asal Sulawesi Utara di Hong Kong: Tulang rusuk yang menjadi tulang punggung Alva Supit; Marco Chan
JPAI: Jurnal Perempuan dan Anak Indonesia Vol. 3 No. 2 (2022): JPAI: Jurnal Perempuan dan Anak Indonesia
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/jpai.3.2.2021.37771

Abstract

Pekerja migran perempuan Indonesia (PMPI) memiliki peranan amat penting dalam meningkatkan devisa negara Indonesia. Saat ini terdapat sekitar puluhan ribu PMPI di Hong Kong, 2.191 di antaranya berasal dari Sulawesi Utara. Sampai saat ini belum ada laporan khusus yang meneliti tentang keadaan PMPI asal Sulawesi Utara secara spesifik, terutama dari sudut pandang psikologis. Penelitian  ini bertujuan untuk mengetahui motivasi, tantangan, dan mekanisme koping para PMPI asal Sulawesi Utara dengan menggunakan metode penelitian kualitatif berupa wawancara, sintesis, dan triangulasi. Secara umum, mayoritas PMPI Sulawesi Utara di Hong Kong merasa puas dengan keberadaan mereka di Hong Kong, terutama dari segi penggajian dan perlakuan majikan. Tantangan yang dialami justru kebanyakan berasal dari keluarga di Indonesia. Terlepas dari berbagai tantangan yang dihadapi, mereka tetap bertahan di Hong Kong karena mereka adalah sumber nafkah utama bagi keluarga inti dan keluarga luas mereka. Mekanisme koping yang diambil untuk bertahan kebanyakan berupa sugesti diri dan berdoa, dan melakukan kegiatan keagamaan bersama teman-teman PMPI lainnya.  
Mikroplastik sebagai Kontaminan Anyar dan Efek Toksiknya terhadap Kesehatan Supit, Alva; Tompodung, Linda; Kumaat, Sicilia
Jurnal Kesehatan Vol 13 No 1 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i1.2511

Abstract

Microplastics are synthetic polymers that are unable to be completely degraded and will stay as an environmental contaminant for a long period of time. Due to their microscopic size, microplastics are able to enter the human body, either directly or indirectly via the food chain, where both processes will induce pathological changes in-vivo. So far, clinically, there has been no direct evidence yet about any microplastic-related disease in humans. However, since Indonesia is a maritime country and has been producing microplastics on a large scale, it is critical for our healthcare personnel to have the knowledge about microplastic toxicokinetics and the possible pathological responses elicited by humans when exposed to microplastics. This review article aims to discuss the definition, genesis, accumulation process, toxicokinetics, and pathological responses due to microplastic exposure, emphasizing the biomolecular aspects and implying the possible effects on public health. An internet search in Google Scholar and Pubmed was performed using keywords "microplastics" and "health", as well as their Indonesian language counterparts. Full-text English or Indonesian text from the year 2018 to 2020 were gathered and used as the primary references for this literature review. Microplastics are a novel emerging contaminant that is currently accumulating in the earth's biomass with the potency to induce pathological changes in the human body. Health practitioners are expected to have knowledge about the harm of microplastic to humans. Eventually, follow-up acts should be taken to prevent and manage the microplastic-related pathologies as discussed further in this review.
Complex interaction between allopurinol-induced uric acid reduction and glycemic control: a clinical and molecular study Pongoh, Lucyana; Manoppo, Jonesius Eden; Supit, Gerry; Supit, Alva
Journal of Biomedicine and Translational Research Vol 10, No 3 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i3.22185

Abstract

Background: Diabetes mellitus type 2 (DMT2) and hyperuricemia are two prevalent metabolic diseases worldwide, including in Indonesia. In fact, in the Minahasa tribe, the prevalence of these diseases is among the highest in Indonesia. The interaction between hyperuricemia and DMT2 level is inconclusive, as previous studies about whether allopurinol and its related uric acid reduction correlate with insulin resistance have shown conflicting results.Objective: To examine whether allopurinol-induced uric acid reduction can modify insulin resistance in nondiabetic Minahasan male subjects and study the putative molecular mechanisms of this interaction.Methods: The clinical part of this research was a pseudo-experiment with a pre-test/post-test design. Twenty nondiabetic Minahasan male subjects were subjected to the daily dose of 300 mg allopurinol for three months. Plasma glucose, uric acid, and insulin levels were measured pre- and post-treatment. Homeostatic model assessment of insulin resistance (HOMA-ir) values were calculated by the Oxford HOMA calculator. For the wet lab experiment, the human embryonic kidney cell line was treated with tolerable allopurinol. The expression of glucose transporter 4 (Glut4) mRNA, an insulin-inducible glucose transporter was analyzed by quantitative real-time polymerase chain reaction (qPCR).Results: In nondiabetic Minahasan male subjects, allopurinol administration decreased uric acid serum level, but did not affect plasma glucose and insulin levels. In fact, there is a trend of increasing HOMA-ir among the subjects following allopurinol administration. In vitro, allopurinol treatment also did not increase Glut4 expression, suggesting that allopurinol's effect on diabetes control has other, complex mediative pathways.Conclusion: Allopurinol administration and its related uric acid plasma reduction does not significantly affect insulin resistance; a trend however exists that allopurinol and uric acid reduction increased HOMA-ir. At the molecular level, Glut4 expression is not affected by allopurinol.
Craving foods from social media: Which one to blame? For-you-page, followed culinary accounts, or friends who posted food content Supit, Alva; Mamosey, Carmenita; Telew, Agusteivie
Kampret Journal Vol. 4 No. 3 (2025): May: CALL FOR PAPER: Sosial, Budaya, Politik, Masyarakat dan Komunikasi
Publisher : IHSA Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In social media, food references may come from multiple sources, including algorithm-induced content (for-you-page, FYP), culinary accounts, and friends' posts. It is not known, however, which source exerted more effect on the food purchase decision. This study investigates the influence of social media on food purchasing behaviour among young adults, focusing on the impact of content exposure from these sources. A total of 73 respondents from the final year student population participated, predominantly female (mean age = 21.79 years). Results indicated that 76.7% of participants spent more than three hours daily on social media, with 94.5% exposed to culinary content from for-you pages (FYPs). Interestingly, while exposure to FYP content was massive, it did not significantly correlate with food purchases (p=0.138). Instead, content from followed culinary accounts and friends showed significant positive correlations (OR: 3.17 and 4.35, respectively; p<0.05) with purchasing decisions. After further analysis using binomial regression, only friends' posts persisted as a predictor for food purchases. The findings suggest that peer influence plays a crucial role in shaping food choices, highlighting the need for public health initiatives to promote healthier eating behaviours among young adults.
ANALISIS EPIDEMIOLOGI PENYAKIT TUBERCULOSIS PARU DI PUSKESMAS KOYA TAHUN 2021-2023 Lele, Gabriella Charoline; Telew, Agusteivie; Supit, Alva
JURNAL ILMIAH KESEHATAN MANADO Vol. 3 No. 2 (2024): JURNAL ILMIAH KESEHATAN MANADO
Publisher : Yayasan Syalom Cipta Sumikolah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64418/jikma.v3i2.125

Abstract

Tuberculosis is a disease caused by Mycobacterium tuberculosis which most often attacks the lungs. The source of infection, TBBTA patients were positive through splashes of phlegm they expelled. Epidemiologically, tuberculosis more often attacks the productive age group, but in all age groups there are many people affected by tuberculosis. The aim of this research is to analyze the epidemiology of tuberculosis, as well as analyze the factors of age, gender and occupation of tuberculosis sufferers at the Koya Health Center, South Tondano District. Using quantitative descriptive methods and the analysis used is univariate analysis. Respondents totaled 107 tuberculosis patients. Based on the results of data analysis, it is known that based on the patient's age category, namely 15>50 years, the number is 58.9% with a frequency of 63, and at ages>50 years it is 41.1% with a frequency of 44. Furthermore, for the first gender category, male there were 63 people with a percentage of 59.9%, and 44 women with a percentage of 41.1%. Next, in the non-employed worker category there were 15 people with a percentage of 14%, then there were 45 people in the private sector with a percentage of 42.1%, and finally there were 47 civil servants with a percentage of 43.9%. This statement provides an initial description of the prevalence of pulmonary TB in the population studied. In conclusion, the majority of sample respondents are under 50 years old, while only a small portion are over 50 years old. The majority of survey respondents were men with a proportion of around 58.9% of the total surveyed population. Meanwhile, the number of women who took part in this survey was smaller, namely around 41.1% of the total respondents. The majority of the 107 individuals surveyed were workers, which is around 85.9% of the total sample. Of those who work, the majority are divided between private sector (42.1%) and civil servants (43.9%). Despite this, about 14% of the total sample is unemployed. This information provides an overview of the prevalence of pulmonary TB in the studied population, which can be used to analyze risk factors and the effectiveness of preventive and treatment measures.
Co-Authors Agusteivie A. J. Telew Agusteivie Albert Jefta Telew Ahmad Paturusi Carmenita Jennifer, Mamosey Emilia A. Pangalila-Ratulangie Fandy E. Rampengan Firman P. Lasanudin Hence Rompas Ireine Roosdy J. Bokau Jansen B Kawengian Jonesius Eden Manopo Kristina Pesak Kumaat, Sicilia Lele, Gabriella Charoline Linda Tompodung Lucyana Leonita Pongoh Mamosey, Carmenita Marco Chan Meity Martina Pungus Mesak A.S.F Rambitan Morgen Pangaila Nancy Sylvia Bawiling Puji Amartiwi Roosdy, Ireine Sartono Syahrain Supit, Gerry Tompodung, Linda