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Journal : Sinergi

The influence of Silane Coupling Agent and porogen ratio on 3D scaffold PCL/HA Faqih, Mu'adz Abdullah; Purniawan, Agung; Rasyida, Amaliya; Susanti, Diah
SINERGI Vol 29, No 3 (2025)
Publisher : Universitas Mercu Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22441/sinergi.2025.3.016

Abstract

The design of scaffold based on polycaprolactone (PCL) and hydroxyapatite (HA) has attracted attention as a solution for bone tissue regeneration. However, the main challenge in its development is the difficulty in achieving an optimal balance between porosity and mechanical strength. Suboptimal porosity limits the scaffold ability to support cell proliferation, and weak mechanical properties result in the scaffold being less than optimal as a load-bearing implant material during the bone cell regeneration process. This study aims to address these issues by evaluating the effects of the silane coupling agent 3-aminopropyltriethoxysilane (APTES) and the porogen ratio (NaCl) on the mechanical properties, morphology, and biodegradation of PCL-HA-based 3D scaffold. The scaffold were synthesized using the solvent casting/particulate leaching (SCPL) method with varying APTES concentrations (1%, 3%, and 5%) and porogen ratios. (4:1, 6:1, and 8:1). The results of characterization show that the addition of 1% APTES increases compressive strength by 283% and tensile strength by 138% compared to scaffold without APTES. A higher porogen ratio (8:1) results in the highest porosity of 78.16%, but reduces mechanical strength by 84%. The optimal combination was found in scaffold with 1% APTES and a porogen ratio of 4:1, which have optimal mechanical strength, porosity of 69.65%, and a biodegradation time of up to 380 days. This research offers a comprehensive solution to enhance the properties of PCL-HA based 3D scaffold, making a significant contribution to the development of materials for bone tissue engineering applications. 
Co-Authors Abdu Arsu, Kuntum Achmad Azmy Adhytiawan Adinda Fitria Hidayati Adyansyah, Farhan Afif, Moh. Azmi Afira Ainur Rosidah Agung Purniawan, Agung Agung Seras Perdana Akbar Nur Prasetya Alfanda, Benedicta Dian Amaliya Rasyida Andini, Evi Fuji Anni Rahmat Ardhia Berlianto Ardhyananta, Hosta Ardiansyah Aan, Roni Arisela Distyawan Ariwibowo, Surya Augus Tino Tri Widyantoro Ayu Furoidah Azizah, Salma Nur Azwar Manaf Azzah Dyah Pramata Azzah Dyah Pramata, Azzah Dyah Bahfie, Fathan Burniadi Moballa Candra Maulana, Candra Dah Shyang Tsai Dayanti, Sinda Diah Ayu Safitri Dwi Jingga Dharma Kusuma Elok Amaylia Swasthika Candra Endah Lutfiana Erik Prasetyo Errahmah, Syifa' Ervianto, Yohan Fajar Nurjaman Fajarin, Rindang Fakhreza Abdul Faqih, Mu'adz Abdullah Farahdibah, Athirah Fischa Indaya Bathari Fredy Kurniawan Frizka Vietanti Haniffudin Nurdiansah Haniffudin Nurdiansyah Haniffudin Nurdiansyah Haniffudin Nurdiansyah Harahap, Rizki Anwar Hariyati Purwaningsih Hidayat, Mas Irfan Purbawanto Hosta Ardhyananta Indera Cahya Pradana Jayatin Jayatin, Jayatin Joddy Arya Laksmono Kamilah, Imada Millatul Kusuma, George Endri Lita Nur Azizah Luhur Prandika Lukman Noerochiem Lukman Noerochim Malik Anjelh Baqiya Mas Irfan P. Hidayat Maula Nafi Mavindra Ramadhani Mayasari Mayasari, Mayasari Meril Lia Priday Riskiana Mu'adz Abdullah Faqih Muhammad Junaidi Muhammad Rizki Ilhami Muhammad Yunus Nabila, Siti Ni Komang Alit Juliani Noerochiem, Lukman Noor Rohmannudin, Tubagus Nurdiansyah, Haniffudin Nurdiansyah, Haniffudin Pratama, Tata Bayu Pratiwi, Vania Mitha Putri, Elisa Beliana Putri, Imeilia Rahma, Elfrida Venia Rahman Faiz Suwandana Rahmawati, Yenni Rakhmawati, Yeny Widya Ramadhani, Ahmad Ilham Ramadhani, Mavindra Rasyida, Amaliya Retno Asih Riska Fitri Amalia Rochman Rochiem Rohmannudin, Tubagus Noor Ruknan Sahat M. R. Nadaek Sari, Eli Novita Sigit Tri Wicaksono, Sigit Tri Sipahutar, Wahyu Solafide Siti Nur Aini, Siti Nur Sugiharto, Rochman Sulistijono Sulistijono Sungging Pintowantoro Titik Nuryastuti Tri Mardji Atmono Tsai, Dah Shyang Tubagus Noor Rohmanuddin Vania Mitha Pratiwi Vicko Gestantyo Anugrah Vietanti, Frizka Wahyu Tirta Nugraha Wardhana Restu Dipakusuma Widi Astuti Widyani, Devi Widyastuti Widyastuti Wijaya, Ade Mundari Yeny Widya Rakhmawati Yoga Fredi Arisko Yogi Nuriana Yuli Setiyorini Yurian Ariandi Andrameda