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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Pharmacon Pharmed: Journal of Pharmaceutical Science and Medical Research JPSCR : Journal of Pharmaceutical Science and Clinical Research JFM (Jurnal Farmasi Malahayati) Jurnal Farmasi dan Sains Indonesia (JFSI) INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Archives Pharmacia Media Farmasi Indonesia Sciences of Pharmacy Indonesian Journal of Community Empowerment (IJCE)
Willi Wahyu Timur
Program Studi Farmasi Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Effectiveness Test of Epigallocatechin Gallate Cream Formula in Acne Vulgaris Therapy Widyaningrum, Naniek; Dhea, Alda Rasni; Rofi, Alina Nur; Arief, Thendi Abdul; Timur, Willi Wahyu
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502542

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that affects more than 80% of adolescents and young adults. Conventional therapies such as antibiotics and topical retinoids have limitations in the form of resistance and irritation. Epigallocatechin gallate (EGCG) from green tea leaves (Camellia sinensis L.) has antibacterial, anti-inflammatory, and antioxidant activities that make it a safe natural anti-acne candidate. The aim of this study was to assess the clinical efficacy and safety of topical EGCG cream on the improvement of inflammatory and non-inflammatory acne lesions. A pre-post clinical trial was conducted on ten participants aged 17–50 years with active acne. Respondents applied 6% EGCG cream twice daily for six months. The number of lesions (papules, pustules, and blackheads) was evaluated monthly and analyzed using a paired t-test (p<0.05). There was a significant decrease in the number of papules (9.4 ± 5.97 to 3.0 ± 3.13), pustules (1.7 ± 1.57 to 0), and comedones (21.5 ± 10.76 to 4.2 ± 3.05) in five months (p<0.05), with the onset of improvement since the first month without side effects. Topical EGCG cream is effective and safe in reducing acne lesions quickly and sustainably. With its multi-target mechanism, EGCG has the potential to be developed as a phytocosmetic active ingredient for acne vulgaris therapy.
Perbedaan Efektivitas Penggunaan Metformin-Insulin versus Metformin-Vildagliptin Terhadap Profil Glikemik Pasien DMT2 di Instalasi Rawat Jalan RSISA Periode 2022 Timur, Willi Wahyu; Pradesti, Asmahan Nabila
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.71945

Abstract

Diabetes Mellitus (DM) merupakan penyakit tidak menular yang ditandai dengan gangguan kondisi metabolisme dengan gejala umum yaitu peningkatan kadar glukosa darah (hiperglikemia). Jumlah kasus DM semakin meningkat dari tahun ke tahun.Tata laksana terapi  pasien DM tipe 2 dapat dilakukan melalui 4 pilar, yaitu edukasi, pola makan, aktivitas fisik, dan terapi farmakologi. Terapi farmakologi obat antidiabetik terbagi atas injeksi insulin dan oral. Tujuan penelitian ini adalah untuk mengetahui perbandingan efektivititas penggunaan obat metformin-insulin versus metformin-vildagliptin pada pasien DM tipe 2 di RS Islam Sultan Agung Semarang. Penelitian ini termasuk jenis penelitian observasional. Pengambilan data secara retrospektif.Data dilakukan analisis menggunakan SPSS dengan uji parametrik yaitu uji independent t-test  dan uji non parametrik menggunakan Mann-Whitney test untuk mengetahui perbandingan efektivitas 2 kelompok obat.Hasil penelitian analisis perbandingan efektivitas penggunaan Metformin-insulin versus metformin-vildagliptin terhadap profil glikemik diperoleh nilai signifikansi profil glikemik HbA1c 0,494 p(>0,05) dan GDS 0,638 p(>0,05).Kesimpulan yang dapat diambil dari penelitian ini menunjukkan bahwa tidak terdapat perbedaan yang signifikan terhadap profil glikemik pada kelompok metformin-insulin maupun metformin-vidagliptin. 
Co-Authors Abdur Rosyid Amajida, Neva Linsya Arief, Thendi Abdul Chilmia Nurul Fatiha Dewi, Peggy Anastia Dewi, Rissa Maharani Dhea, Alda Rasni Dwi Monika Ningrum Fita Rahmawati Kurniawati , Indah Lukman Hakim Mardiyanti, Devi Mufadillah, Isna Naili nafirin, Athikan Naniek Widyaningrum Nastiti, Nindita Sari Pradesti, Asmahan Nabila Riyanta Aribawa Rofi, Alina Nur Sabiti, Farroh Bintang Tri Murti Andayani Widiyanto, Dimas