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All Journal JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Ika Yuni Astuti
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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REVIEW ON PHOTOSENSITIZER POTENTIAL OF NATURAL DYES FOR ANTIMICROBIALS USING PHOTODYNAMIC INACTIVATION Ayu Mulyani; Ika Yuni Astuti; Djalil, Asmiyenti Djaliasrin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1291

Abstract

Infectious diseases still threaten human life, with incidents continuing to increase every year. The increase in antibiotic resistance in recent years has been one of the causes. This incident triggered research to find alternative antibacterial therapies. One such alternative therapy is Photodynamic Inactivation (PDI). This paper reviews the application of PDI for treating diseases caused by microorganisms, especially dermatitis,  periodontitis, blood transfusions, and foodborne diseases, emphasizing the use of natural dyes as photosensitizers. The source for this article was obtained from several indexed databases, such as the National Center for Biotechnology Information (NCBI), Elsevier, and Google Scholar, from 2002 to 2024. The keywords used included “photodynamic therapy", “photodynamic inactivation (PDI)”, "antimicrobial photodynamic therapy (aPDT)", “laser-activated disinfection”, “photoactive disinfection”, “LED”, “natural photosensitizer”, “curcumin”, “riboflavin”, “hypericin”, “chlorophyll and chlorophyllin. Original (clinical and experimental) studies, case series, case reports, and reviews were also included. Letters to the editor and commentaries are excluded. After reviewing 148 relevant articles, 57 were selected. Full texts were read, and data were extracted and entered into tables. The review demonstrated that natural photosensitizers, such as curcumin, hypericin, riboflavin, and chlorophyll derivatives, have the potential to reduce the number of microorganisms in PDI therapy. Photosensitizers can be obtained from several natural sources. Using the PDI procedure, the ROS produced have been proven to effectively inhibit pathogenic microorganisms and can be widely used to treat diseases caused by microorganisms. Keywords: curcumin, hypericin, riboflavin, chlorophyllin derivatives, PDI, natural dye, antimicrobial.
PERBANDINGAN PROFIL KANDUNGAN KIMIA EKSTRAK AIR, EKSTRAK HIDROTROPI, DAN EKSTRAK ETANOL RAMUAN JAMU SAINTIFIK PENURUN KADAR GULA DARAH SERTA UJI STABILITASNYA: CHEMICAL CONTENT PROFILE COMPARISON OF WATER EXTRACT, HYDROTROPIC EXTRACT, AND ETHANOLIC EXTRACT OF SCIENTIFIC JAMU FOR LOWERING BLOOD SUGAR LEVEL AND ITS STABILITY TEST Sasmita, Sasmita; Retno Wahyuningrum; Ika Yuni Astuti
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1801

Abstract

Scientific jamu for lowering blood sugar are used in the form of decoction preparations, so it is less practical. The method of using scientific herbal medicine which is still traditional has several disadvantages, namely it is impractical and reduces the level of patient compliance which can result in a decrease in the effectiveness of scientific jamu. Based on this, the development of scientific herbal medicine into a more modern dosage form is very important to do. The selection of the right extraction method and solvent will produce an extract with the most optimal active constituent in producing pharmacological effects, so that it can increase the effectiveness of research in the context of drug discovery and development. In this study, the chemical content profiles of 3 (three) different types of extracts were compared, namely water extract, hydrotropic extract, and ethanol extract. The three types of extracts were then compared for their yield values, total flavonoid levels, andrographolide, cinnamaldehyde, and curcumin. The total flavonoid levels were determined by the UV-Vis spectrophotometry method, the andrographolide, cinnamaldehyde, and curcumin levels were determined by the densitometry thin layer chromatography (TLC) method. The extract with the best chemical content profile was subjected to forced degradation tests. The results showed that the ethanol extract produced the highest yield compared to the water extract and hydrotrope extract, which was 4.48%. The ethanol extract also provided the best chemical content profile, namely the total flavonoid content of 16.15 ± 0.96 mg QE / g, andrographolide content of 2.14 ± 0.12%, cinnamaldehyde content of 8.22 ± 0.31%, and curcumin of 6.46 ± 0.80%. In the forced degradation test, the total flavonoid content in the ethanol extract decreased due to several conditions, such as hydrolysis, oxidation, thermal, and photolytic.   Keywords:  Extraction, Forced degradation, Hydrotropic, Scientific jamu
Optimization of Gel Formulation and Antibacterial Activity against Cutibacterium acnes from Combined Extracts of Caesalpinia sappan and Carthamus tinctorius Using Simplex Lattice Design Azizah, Umi Hani; Ika Yuni Astuti; Aktsar Roskiana
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.13175

Abstract

Acne vulgaris remains a common dermatological disorder in which Cutibacterium acnes plays a central role, while concerns over antibiotic resistance highlight the need for safe natural alternatives. This study aimed to develop and optimize a topical gel formulation containing combined extracts of Caesalpinia sappan and Carthamus tinctorius with antibacterial activity against C. acnes. An experimental design was employed using the Simplex Lattice Design (SLD) method to optimize the proportions of Carbopol 940 and triethanolamine as gelling and stabilizing agents. The prepared gels were evaluated for physical characteristics, stability, hedonic properties, and antibacterial activity using the agar diffusion method. The optimized formulation, with a desirability value of 0.931, demonstrated appropriate viscosity, spreadability, and pH within the physiological range. Stability testing through six freeze–thaw cycles confirmed no significant changes in organoleptic or physicochemical parameters. Hedonic evaluation indicated good acceptance regarding odor, texture, and non-irritating properties, though color preference was slightly lower. Antibacterial assays showed that both the optimized gel and combined extracts produced strong inhibition zones against C. acnes, comparable to clindamycin as a positive control. These findings confirm that the combination of C. sappan and C. tinctorius extracts, when optimized through statistical design, can yield a stable and effective herbal gel with strong antibacterial activity. This research highlights the potential of integrating traditional medicinal plants with modern formulation approaches to develop safe, natural, and sustainable alternatives for acne management.
Co-Authors Adi Garnadi Rahman Aktsar Roskiana Asmiyenti Djaliasrin Djalil Ayu Mulyani Azizah, Umi Hani Binar Asrining Dhiani Binar Asriningdhiani Dian Pratiwi Didik Setiawan Diniatik Dwi Hartanti Dwi Saesar Nur Syafril Endang Sari Faesol Amin Fendi Nugroho Feni Nurul Hidayanti Frisky Almuksiti Gigih Iryoto Indri Hapsari Iskandar Soedirman Iskandar Sudirman Kristanti Kristanti Luthvia Novita Sari Nimas Mahataranti Nova Astrit Natalia Pri Iswati Utami Ranti Kartikasari Reny Apriani Retno Wahyuningrum Sasmita Sasmita Suparman Suparman Tri Setyo Bayuaji Umi Hidayati Unik Fajriyah Wahyunita Yulia Sari Wiranti Sri Rahayu Yohanes Khristantyo