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Correlation between Levels of Serum Amylase, Lipase and Triglyceride in Acute Pancreatitis Patients Govindarajan, Gunalan; Tristina, Nina
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.809 KB)

Background: Acute pancreatitis is an inflammation of pancreas associated with reversible pancreatic parenchymal injury. Studies in several countries indicate that the levels of amylase and lipase are usually elevated among patients with acute pancreatitis. Furthermore, hyperlipidemia, mainly high levels of triglycerides, may present in acute pancreatitis. The aim of this study was to determine the levels of serum amylase and lipase as well as their correlation with serum triglyceride level in acute pancreatitis patients.Methods: A retrospective study was conducted on medical records of 48 acute pancreatitis patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2007to 2011. Data collected from the medical records were age, sex, levels of serum amylase, lipase and triglyceride. The distribution of data was determined using Shapiro-Wilk test. The correlation between serum pancreatic enzyme and triglyceride was analyzed using Spearman-rank test.Results: Most patients had increased levels of serum amylase and lipase in this study. However, no correlation between serum amylase and triglyceride (p-value = 0.312) was found. Furthermore, there was no correlation between serum lipase and triglyceride (p-value = 0.241).Conclusions: The levels of serum amylase and lipase increase in most patients with acute pancreatitis with no significant correlation between serum pancreatic enzymes (amylase and lipase) and triglyceride.Keywords: Acute pancreatitis, amylase, lipase, triglycerideÂ DOI: 10.15850/amj.v2n1.420Â Â Â Â

Creatine Phosphokinase and Visual Analogue Scale as Indicators for Muscle Injury in Untrained Bodybuilders Shanmugam, Suresh; Farenia, Reni; Tristina, Nina
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

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Background: Skeletal muscle is a vital tissue in the human body to enable breathing, walking and performingÂ several sports activities. However, this muscle is persistently injured throughout every sports session. SomeÂ exercises demand a muscle injury occurrence in order to build a stronger muscle through an adaptationÂ process namely bodybuilding exercise. Importantly, every muscle injury should occur within a physiologicalÂ range which can be identified by several biomarkers as well as pain scale. The aim of this study was toidentify changes on the level of Creatine phosphokinase (CPK) and Visual analogue scale (VAS) between preÂ and post training sessions and the correlation between these two indicators.Methods: This was an observational analytical cross sectional comparison study which was conducted inÂ October 2012 and the subjects were adult untrained bodybuilders at the Jatinangor fitness center. The dataÂ was obtained by measuring serum CPK and marked VAS. The data were analyzed by t-test, Wilcoxonâs testÂ and Spearmanâs correlation.Results: Both CPK and VAS increased significantly by 296 U/L and 19.9 mm respectively. There was a strongÂ positive significant correlation between VAS and CPK (p=0.01, r = 0.711).Conclusion: The healthy untrained bodybuilders chosen in this study experienced a mild (<2000 U/L)Â muscle injury throughout the training sessions with general increased CPK levels and VAS measurement.Â [AMJ.2015;2(1):147â52]

Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013 Fauzi, Afiq Syazwan; Sumardi, Uun; Tristina, Nina
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.74 KB)

Background: Sepsis is a continuous disease which begins with systemic inflammatory response syndromeÂ (SIRS), seen in association with a large number of clinical conditions. These include infectious insults thatÂ produce SIRS, such as pancreatitis, ischemia, multiple traumas and tissue injury, hemorrhagic shock, immunemediatedÂ organ injury, and the exogenous administration of such putative mediators of the inflammatoryÂ process as tumor necrosis factor and other cytokines. A frequent complication of SIRS is the development ofÂ organ system dysfunction, including such well-defined clinical conditions as acute lung injury, shock, renalÂ failure, and multiple organ dysfunction syndrome (MODS). Hence, this study was conducted to identify theÂ pathogen profile that often causes sepsis.Methods: A retrospective study was performed to 152 medical records of patients diagnosed as sepsisÂ from Internal Medicine Department Dr. Hasan Sadikin General Hospital from January 2013 to DecemberÂ 2013. The variables observed from the medical records were age, sex, comorbidity, main infection, cultureÂ sample, type of gram bacteria, resistant bacteria, and antibiotic susceptibility test. After data collection wasÂ completed, the data were analyzed using computer. The data were presented in percentage.Results: Sepsis in male was higher than female. Highest comorbid was chronic kidney disease (CKD). TheÂ main infection was health care acquired pneumonia (HCAP). Highest pathogen that caused sepsis wasÂ Escherichia coli and highest multidrug-resistant organism (MDRO) was extended spectrum beta-lactamase(ESBL) Escherichia coli.Conclusions: The most common pathogen that causes sepsis is Escherichia coli. [AMJ.2016;3(2):200â5]DOI:Â 10.15850/amj.v3n2.785

Correlation between Serum Uric Acid and HbA1c Levels in Patients with Type 2 Diabetes Mellitus Nugraha, Rifan; Tristina, Nina; Miftanurachman, Miftanurachman
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Althea Medical Journal

Background: Indonesia ranks fourth among countries with the highest number of diabetics. Increasing evidence suggests that hyperuricemia is an independent risk factor for impaired fasting glucose (IFG) and type 2 diabetes. Some observational studies have identified elevated uric acid concentration as a risk factor for diabetes, while others have found an inverse relationship. The present study was conducted to discover the strength and the direction of the correlation. Methods: This study was an analytical cross-sectional study conducted from May to October 2014. The study subjects were 56 medical records of new outpatients diagnosed with T2DM in the Internal Medicine Polyclinic who underwent laboratory examination at the Clinical Pathology Unit of Dr. Hasan Sadikin General Hospital, January-December 2013. Result: The correlation between HbA1c and uric acid levels on the whole subject revealed a weak but significant negative correlation (r=-0.354, p=0.007). There was an insignificant negative correlation in male subjects (r=-0.405, p=0.120); in female subjects (r=-0.319, p=0.05), the correlation was a weak but insignificant negative correlation.Conclusions: There is a weak correlation between HbA1c and uric acid levels in patients with Diabetes Mellitus type 2.

Correlation between Levels of Serum Amylase, Lipase and Triglyceride in Acute Pancreatitis Patients Gunalan Govindarajan; Nina Tristina
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.809 KB)

Background: Acute pancreatitis is an inflammation of pancreas associated with reversible pancreatic parenchymal injury. Studies in several countries indicate that the levels of amylase and lipase are usually elevated among patients with acute pancreatitis. Furthermore, hyperlipidemia, mainly high levels of triglycerides, may present in acute pancreatitis. The aim of this study was to determine the levels of serum amylase and lipase as well as their correlation with serum triglyceride level in acute pancreatitis patients.Methods: A retrospective study was conducted on medical records of 48 acute pancreatitis patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2007to 2011. Data collected from the medical records were age, sex, levels of serum amylase, lipase and triglyceride. The distribution of data was determined using Shapiro-Wilk test. The correlation between serum pancreatic enzyme and triglyceride was analyzed using Spearman-rank test.Results: Most patients had increased levels of serum amylase and lipase in this study. However, no correlation between serum amylase and triglyceride (p-value = 0.312) was found. Furthermore, there was no correlation between serum lipase and triglyceride (p-value = 0.241).Conclusions: The levels of serum amylase and lipase increase in most patients with acute pancreatitis with no significant correlation between serum pancreatic enzymes (amylase and lipase) and triglyceride.Keywords: Acute pancreatitis, amylase, lipase, triglyceride DOI: 10.15850/amj.v2n1.420

Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013 Afiq Syazwan Fauzi; Uun Sumardi; Nina Tristina
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.74 KB)

Background: Sepsis is a continuous disease which begins with systemic inflammatory response syndrome (SIRS), seen in association with a large number of clinical conditions. These include infectious insults that produce SIRS, such as pancreatitis, ischemia, multiple traumas and tissue injury, hemorrhagic shock, immunemediated organ injury, and the exogenous administration of such putative mediators of the inflammatory process as tumor necrosis factor and other cytokines. A frequent complication of SIRS is the development of organ system dysfunction, including such well-defined clinical conditions as acute lung injury, shock, renal failure, and multiple organ dysfunction syndrome (MODS). Hence, this study was conducted to identify the pathogen profile that often causes sepsis.Methods: A retrospective study was performed to 152 medical records of patients diagnosed as sepsis from Internal Medicine Department Dr. Hasan Sadikin General Hospital from January 2013 to December 2013. The variables observed from the medical records were age, sex, comorbidity, main infection, culture sample, type of gram bacteria, resistant bacteria, and antibiotic susceptibility test. After data collection was completed, the data were analyzed using computer. The data were presented in percentage.Results: Sepsis in male was higher than female. Highest comorbid was chronic kidney disease (CKD). The main infection was health care acquired pneumonia (HCAP). Highest pathogen that caused sepsis was Escherichia coli and highest multidrug-resistant organism (MDRO) was extended spectrum beta-lactamase(ESBL) Escherichia coli.Conclusions: The most common pathogen that causes sepsis is Escherichia coli. [AMJ.2016;3(2):200–5]DOI: 10.15850/amj.v3n2.785

Correlation between Serum Uric Acid and HbA1c Levels in Patients with Type 2 Diabetes Mellitus Rifan Nugraha; Nina Tristina; Miftanurachman Miftanurachman
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Indonesia ranks fourth among countries with the highest number of diabetics. Increasing evidence suggests that hyperuricemia is an independent risk factor for impaired fasting glucose (IFG) and type 2 diabetes. Some observational studies have identified elevated uric acid concentration as a risk factor for diabetes, while others have found an inverse relationship. The present study was conducted to discover the strength and the direction of the correlation. Methods: This study was an analytical cross-sectional study conducted from May to October 2014. The study subjects were 56 medical records of new outpatients diagnosed with T2DM in the Internal Medicine Polyclinic who underwent laboratory examination at the Clinical Pathology Unit of Dr. Hasan Sadikin General Hospital, January-December 2013. Result: The correlation between HbA1c and uric acid levels on the whole subject revealed a weak but significant negative correlation (r=-0.354, p=0.007). There was an insignificant negative correlation in male subjects (r=-0.405, p=0.120); in female subjects (r=-0.319, p=0.05), the correlation was a weak but insignificant negative correlation.Conclusions: There is a weak correlation between HbA1c and uric acid levels in patients with Diabetes Mellitus type 2.

Creatine Phosphokinase and Visual Analogue Scale as Indicators for Muscle Injury in Untrained Bodybuilders Suresh Shanmugam; Reni Farenia; Nina Tristina
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.344 KB)

Background: Skeletal muscle is a vital tissue in the human body to enable breathing, walking and performing several sports activities. However, this muscle is persistently injured throughout every sports session. Some exercises demand a muscle injury occurrence in order to build a stronger muscle through an adaptation process namely bodybuilding exercise. Importantly, every muscle injury should occur within a physiological range which can be identified by several biomarkers as well as pain scale. The aim of this study was toidentify changes on the level of Creatine phosphokinase (CPK) and Visual analogue scale (VAS) between pre and post training sessions and the correlation between these two indicators.Methods: This was an observational analytical cross sectional comparison study which was conducted in October 2012 and the subjects were adult untrained bodybuilders at the Jatinangor fitness center. The data was obtained by measuring serum CPK and marked VAS. The data were analyzed by t-test, Wilcoxon’s test and Spearman’s correlation.Results: Both CPK and VAS increased significantly by 296 U/L and 19.9 mm respectively. There was a strong positive significant correlation between VAS and CPK (p=0.01, r = 0.711).Conclusion: The healthy untrained bodybuilders chosen in this study experienced a mild (<2000 U/L) muscle injury throughout the training sessions with general increased CPK levels and VAS measurement. [AMJ.2015;2(1):147–52]

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