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Crohn Disease: Patofisiologi, Diagnosis, dan Penatalaksanaan Nurul Utami, Herdiana; Ira Munirah; Latifah Mukhlisatunnafsi; Marwa Zileikhadira Manzalina; Yusra Pintaningrum; Jaini Rahma
Lombok Medical Journal Vol. 2 No. 2 (2023): Lombok Medical Journal Volume 2 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i1.2340

Abstract

ABSTRAK Penyakit Crohn adalah kondisi radang usus idiopatik kronis, ditandai dengan lesi, yang dapat memengaruhi seluruh saluran cerna mulai dari mulut hingga anus. Insiden tahunan penyakit crohn mencapai 3 hingga 20 kasus per 100.000 dengan usia rata-rata 30 tahun. Patofisiologi penyakit crohn didasarkan pada peradangan jaringan oleh respons imun yang tidak dapat dikendalikan terhadap antigen bakteri. Penegakan diagnosis dengan Computed tomography (CT), magnetic resonance imaging (MRI), dan ultrasonografi menjadi standar diagnosis dari penyakit crohn. Prognosis dari penyakit crohn ini tergantung dari komplikasi yang muncul seperti fistula dan bowel obstruction usus serta kondisi remisi dari pasien, ataupun tingkat respon tiap pasien terhadap pengobatan sehingga dalam menangani penyakit crohn adalah mengobati kondisi peradangan aktif hingga cepat mengalami remisi dan mempertahankannya selama mungkin. Kata Kunci: crohn disease; patofisiologi; diagnosis; penatalaksanaan; prognosis ABSTRACT Crohn's disease is a chronic idiopathic inflammatory bowel condition, characterized by lesions, which can affect the entire gastrointestinal tract from the mouth to the anus. The annual incidence of Crohn's disease is 3 to 20 cases per 100,000 with a median age of 30 years. The pathophysiology of Crohn's disease is based on tissue inflammation by an uncontrollable immune response to bacterial antigens. Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography have become the standard for the diagnosis of Crohn's disease. The prognosis of Crohn's disease depends on complications such as enteric fistula and intestinal neoplasia and the condition of remission of the patient, or the level of response of each patient to treatment so that in treating Crohn's disease is to treat the active inflammatory condition until it goes into remission quickly and maintain it as long as possible. Keyword: crohn disease; pathophysiology; diagnosis; treatment; prognosis
Enterokolitis Nekrotik: Patofisiologi, Diagnosis dan Tatalaksana Iftinan, Yumna; Ranti Filarma Negara Purnama; Lale Srigading Udayanti; Izza Ahmad Muharis; Jannatul Cahya Admiyanti; Yusra Pintaningrum
Lombok Medical Journal Vol. 2 No. 2 (2023): Lombok Medical Journal Volume 2 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i1.2390

Abstract

Enterokolitis nekrotik (EKN) merupakan kondisi peradangan pada usus dan lebih banyak ditemukan pada bayi lahir prematur. Kejadian EKN meningkat pada anak dengan berat badan lahir <1500 gram dan usia kehamilan <28 minggu. Patofisiologi EKN belum dipahami sepenuhnya, namun mekanisme yang dapat berkaitan dengan terjadinya penyakit yaitu invasi bakteri intraluminal melalui TLR-4 dan mengaktifkan reaksi inflamasi. Selain itu, gangguan mikrosirkulasi usus serta disbiosis juga dikatakan berkaitan dengan proses terjadinya penyakit. Penegakan diagnosis dan stadium penyakit dilakukan dengan Bell’s Modifed Staging Criteria, terdiri dari fase ringan, sedang dan parah. Akibat buruknya prognosis EKN, pemberian tatalaksana harus dilakukan secara adekuat.
Heart-type Fatty Acid-binding Protein (H-FABP) sebagai Diagnostik Awal dan Prognostik Infark Miokard Akut Ni Made Utami Wulandari; Putu Wika Pramesti Iswari; Yusra Pintaningrum
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2622

Abstract

Acute myocardial infarction (AMI) remains one of the leading causes of mortality and morbidity worldwide. Early diagnosis and accurate prognosis are vital to improve patient outcomes. Heart-type Fatty Acid-binding Protein (H-FABP) has emerged as a potential biomarker for AMI. H-FABP is a cytoplasmic protein encoded by the FABP3 gene, situated on chromosome 1 in the human genome. It plays a crucial role in active fatty acid metabolism and is implicated in the absorption, cellular metabolism, and/or transport of polyunsaturated fatty acids (PUFAs). During the pathogenesis of acute coronary syndrome (ACS), H-FABP is rapidly released into the circulation when myocardial ischemic injury occurs. Its early detection, around 1-2 hours after AMI, with a peak at 5-10 hours, and normalization within 24-36 hours, makes H-FABP an ideal candidate for early diagnostic and prognostic evaluation in AMI patients. Despite its excellent prognostic value, H-FABP's diagnostic sensitivity outweighs its specificity for AMI. This review discusses the potential of H-FABP as an early diagnostic and prognostic marker for AMI and emphasizes further studies and research are needed regarding the use of H-FABP as a diagnostic and/or prognostic marker for AMI.
Varises Esofagus Shofa Rona Alya Nuha; Ratu Asyifa Sukma Ayu; Sastraningsih Setiawati; Suci Nurjanah; Yusra Pintaningrum
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2762

Abstract

Varises esofagus adalah pelebaran vena submucosa pada distal esofagus akibat hipertensi portal pada pasien sirosis hati. Varises esofagus merupakan salah satu bentuk komplikasi dari penyakit sirosis hati, yaitu penyakti gambaran perubahan patologis dari stadium akhir fibrosis hepatik yang berlangsung progresif dan ditandai dengan terbentuknya nodul regenerative. Terdapat beberapa terapi yang dapat diberikan kepada pasien dengan varises esofagus, seperti terapi farmakologi dan terapi endoskopi dilakukan terutama untuk upaya mencapai homeostatis pada kasus perdarahan varises. Terapi endoskopi terdiri dari skleroterapi dan ligasi. Skleroterapi adalah metode pengobatan dimana agen sklerosis (etanolamina oleat) akan disuntikkan ke dalam varises untuk menghambat hemodinamik. Sebaliknya, teknik ligasi dilakukan untuk memblokir aliran darah varises secara fisik dan memicu fibrosis
A Original Research Hubungan Indeks Massa Tubuh (IMT) dan Low Density Lipoprotein Cholesterol (LDL-C) dengan Tekanan Darah pada Pasien Poli Jantung di RSUD Provinsi NTB Lendi Leskia Putri; Yusra Pintaningrum; Fitriannisa Faradina Zubaidi
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2959

Abstract

Hypertension is one of the leading causes of death worldwide. According to data from the World Health Organization (WHO) in 2019, hypertension affects more than 22% of the global population. The results from Riskesdas indicate an increasing prevalence of hypertension in Indonesia, from 25.8% to 34.1%. Body Mass Index (BMI) has a significant impact on the occurrence of hypertension, where individuals with excess BMI and obesity have a higher risk of developing hypertension. The increase in hypertension cases is also caused by dyslipidemia. LDL-C ratio is a strong predictor of atherosclerosis plaque formation, which can lead to increased blood vessel resistance and elevated blood pressure. This study aims to analyze the relationship between Body Mass Index (BMI) and Low Density Lipoprotein Cholesterol (LDL-C) with Blood Pressure. The design of this study was correlational research design with a cross sectional approach. The population in this study were all patients of polyclinic cardiology RSUD Provinsi NTB (November 2022-January 2023), with the sampling technique used was consecutive sampling, where size of sample is 28 peoples. Obtained data are analyzed using Spearman method. Overall there were 28 subjects. There were 4 (14.3%) subjects with underwight range, 7 (25%) with healthy weight range, 16 (57.2%) with overweight range, and obesity range. While for LDL-C levels, there were 8 (28.5%) with optimal, Fairly good, Borderline high, High, and very high. 5 (18%) out of 28 respondents have optimal BP, 7 (25%) with normal BP whereas in high BP were 57%. Stastistical analysis shows that there was no relationship between the value of BMI with blood pressure with p-value 0,765 (p>0,05; r = 0,059). there was no relationship between LDL-C with blood pressure (r = 0,044; p = 0,823).
Co-Authors A.A.S.M. Meiswaryasti Putra Basuki Rahmat Fitriannisa Faradina Zubaidi Hairu Nurul Mutmainah I Gede Yasa Asmara Iftinan, Yumna Ilsa Hunaifi Ira Munirah Izza Ahmad Muharis Jaini Rahma Jannatul Cahya Admiyanti KETUT ANGGA ADITYA PUTRA PRAMANA Lale Srigading Udayanti Latifah Mukhlisatunnafsi Lendi Leskia Putri Marwa Zileikhadira Manzalina Ni Made Utami Wulandari Nurul Utami, Herdiana Putu Wika Pramesti Iswari Ranti Filarma Negara Purnama Ratu Asyifa Sukma Ayu Rina Lestari Romi Ermawan, Romi Sastraningsih Setiawati Shofa Rona Alya Nuha Suci Nurjanah yanna indrayana