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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Plasma - Jurnal Kesehatan Universa Medicina Sebatik Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Folia Medica Indonesiana
Mirna Widiyanti
Balai Litbang Biomedis Papua. Jl. Kesehatan No. 10 Dok II, Jayapura, Papua.
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Universa Medicina

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Low body mass index increases risk of anemia in patients with HIV-AIDS receiving antiretroviral therapy Widiyanti, Mirna; Ubra, Reynold; Fitriana, Eva
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.221-227

Abstract

BackgroundIn acquired immunodeficiency syndrome (AIDS) cases, cytopenias of all major blood cell lines were increasingly recognized in patients with HIV infection. Anemia commonly occurs during HIV infection and has been associated with increased progression to AIDS and decreased survival. The aim of this study was to determine the prevalence of anemia and associated risk factors in adults with HIV-AIDS receiving antiretroviral therapy (ART). MethodsA cross sectional study was conducted involving 90 adults with HIV-AIDS. Sociodemographic data were collected using a questionnaire. In all patients, CD4+ lymphocyte counts were performed by means of a PIMA analyzer, while hemoglobin was determined using a Sysmex hematology analyzer. The WHO cutoff value of hemoglobin was adjusted to altitude to define anemia. Mild to moderate anemia was defined as hemoglobin 8-13 g/dL for men and 8-12 g/dL for women. Severe anemia was defined as hemoglobin 8 g/dL. Data was analyzed by using logistic regression test.ResultsThere were 90 subjects with HIV-AIDS in this study. Anemia was found in 50 subjects (55.6%), consisting of 12.2% with mild anemia and 43.4% with moderate to severe anemia. Multiple logistic regression showed that an important risk factor for anemia was low body mass index (BMI) between <17-18.5 (OR=4.20; 95% CI=1.23-14.36). However, the CD4 <350 cells/mm3 was not a significant risk factor for anemia (OR=1.03; 95% CI=0.21-5.04).ConclusionsLow BMI increases the risk of anemia in subjects with HIV receiving ART. Better screening for anemia and infectious diseases, and modified harm reduction strategy for injection drug users are primary needs in HIV patients.
Habit of cooking pork on hot stones as main risk of cysticercosis Sandy, Semuel; Oktavian, Antonius; Kawulur, Hanna S; Widiyanti, Mirna; Sasto, Iman HS; Maladan, Yustinus
Universa Medicina Vol 37, No 2 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.88-96

Abstract

BackgroundCysticercosis is an infectious disease caused by the larval form of Taenia solium (cysticercus cellulosae) and has been ranked as the most important food-borne parasite of humans in terms of public health, socioeconomic and trade impact. Cysticercosis is still a health problem in Papua and is inseparable from socio-cultural factors, hygiene and environmental sanitation. The aim of this study was to investigate the seroprevalence of cysticercosis and the risk factors that contribute to cysticercosis.MethodsA cross-sectional study was conducted in March-November 2016 involving 800 subjects. Demographic data and risk factors were collected using questionnaires. Cysticercosis serological examination was performed by means of the magnetic microsphere bead immunoassay technique coupled with rT24H recombinant protein to detect serum rT24H cysticercosis specific antibodies. The data obtained were analyzed by bivariate test (chi-square) and logistic regression.ResultsCysticercosis seroprevalence in Papua was 3.6% (284/7 874). The logistic regression analysis found that the risk factors playing the role of predictor were cooking pork with hot stones [OR=3.06; 95%CI: 2.19-4.28; p=0.000], nail hygiene [OR=2.05; 95%CI: 1.57-2.67; p=0.000], consumption of raw vegetables or salads [OR=0.52; 95%CI: 0.30-0.91; p=0.022], use of river water for washing foods [OR= 1.92; 95%CI: 1.39-2.64; p=0.000].ConclusionsCooking pork with hot stones was the main risk factor of cysticercosis. Suspected cases of T. solium in pigs should be confirmed by molecular methods. Both taeniasis and human cysticercosis should be notifiable and surveillance in animals should be improved.
Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy Widiyanti, Mirna; Hadi, Moch Irfan; Kumalasari, Mei Lina Fitri; Natalia, Evi Iriani; Purba, Dedi Ananta; Adiningsih, Setyo
Universa Medicina Vol. 39 No. 2 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.121-127

Abstract

BackgroundThe body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).MethodsAn analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.ResultsAmong the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). ConclusionsBody mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.
Co-Authors Adiningsih, Setyo Adiningsih, Setyo Ahmadi, Ferry Antonius Oktavian Betty Roosihermiatie DASUKI DASUKI Dina Bisara Lolong Eva Fitriana, Eva Holy A. Wibowo Hotma Hutapea, Hotma Hutapea, Hotma Martogi Lorensi Iman HS Sasto, Iman HS Kawulur, Hanna S Kridaningsih, Tri Nury Maladan, Yustinus Maria Holly Herawati Mei Lina Fitri Kumalasari Moch. Irfan Hadi Natalia, Evi Iriani Permata, Ria Yuda Purba, Dedi Ananta Raflizar Raflizar Reynold Ubra, Reynold Rokhmad, Muhammad Fajri Semuel Sandy Supratikta, Hadi Veruswati, Meita Wike, Irawati