Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Sari Pediatri Paediatrica Indonesiana Media Medika Muda Jurnal Health Sains
Noor Wijayahadi
Department Of Pharmacology, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Published : 22 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : JURNAL GIZI INDONESIA

 1 
Efektivitas ekstrak umbi sarang semut (myrmecodia pendens merr.& perry) sebagai penurun kadar glukosa darah tikus sprague dawley yang diabetes mellitus Raya, Maxianus Kopong; Legowo, Anang M.; Wijayahadi, Noor
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 2 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.674 KB) | DOI: 10.14710/jgi.4.2.138-144

Abstract

Background : Diabetes Mellitus (DM) is a disease associated with pancreatic β cell damage and causes hyperglycemia Antioxidants were effective in reducing the state of hyperglycemia that was triggered by free radicals. Sarang semut contains flavonoids and tannins that act as antioxidants.Objective : The purpose to analyze the effectiveness of sarang semut stem extract as lowering blood glucose on diabetic white male Sprague Dawley rats. Method : True experimental with 30 rats which divided into five groups : negative control (DM+ water), positive control (DM+glibenklamid) and 3 treatment groups of DM + water extract of  sarang semut stem powder 90 mg/200gBW, 180 mg/200g BW and 360/200g BW respectively. DM was induced by 65mg/kgBW Streptozotocin and 230 mg/kgBW Nicotinamide intraperitonealy. Extract was given by sonde. The data was analyzed by Kruskall-Wallis and Mann-Whitney. Results : IC50 value of  sarang semut stem extract were 6,56-10,07 mg/ml in powder and 9,12-15,62 mg/ml whole. The average rats weight alteration on groups of negative control, positive control,  and 3 treatment groups of DM + water extract of  sarang semut stem powder 90 mg/200gBW, 180 mg/200g BW and 360/200g BW before and after treatment were -7,60± -0,40; 25,80±0,51; 16,40±0,44; 17,20±1,28 dan 19,20±0,06 gram respectively (ρ=0,001). The average fasting blood glucose level on groups of negative control, positive control,  and 3 treatment groups of DM + water extract of  sarang semut stem powder 90 mg/200gBW, 180 mg/200g BW and 360/200g BW before and after treatment were 3,33±2,42; -122,44±-0,51; -79,42±-11,38; -94,08±-11,97 and -134,66±-2,59 mg/dL respectively (ρ=0,001). Conclusion : The IC50­ value in sarang semut stem powder was higher than a whole form. Dose of 360 mg/200g BW lowered blood glucose better than 90 and 180 /200g BW dosage.
Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum Damayanti, Kusmadewi Eka; Wijayahadi, Noor; Puruhita, Niken
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 1 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.446 KB) | DOI: 10.14710/jgi.4.1.63-66

Abstract

Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats. Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day. Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05).Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats. 
Pengaruh ekstrak buah naga daging merah (Hylocereus polyrhizus) terhadap berat badan, indeks fagositosis makrofag dan produksi nitrit oksida makrofag (Studi pada mencit BALB/c yang diinfeksi Salmonella typhimurium) Kusdalinah, Kusdalinah; Johan, Andrew; Wijayahadi, Noor
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.684 KB) | DOI: 10.14710/jgi.2.2.73-77

Abstract

Background: Salmonella typhimurium has ability to avoid the phagosome and escape from the trap-free in cytoplasm.Macrophage was activated to phagocyte microbe and produced microbicidal agent nitric oxide (NO).Polyphenolic compounds are proved as an immunomodulatory agent.Hylocereus polyrhizus contains high level of polyphenols and thus increases appetite.Objective: Proving the effects various doses (6 mg, 12 mg, and 24 mg/20 g mice’s weight) of Hylocereus polyrhizus extract to increase weight, increase macrophage phagocytosis and NO production of macrophage.Methods:True experiment research for fourteen day on males BALB/c mice, post-test only controlled group design.The treatment groups were  a dose of 6 mg/day (X1), 12 mg/day (X2), and 24 mg/day (X3), whereas the control group (K) was not given the extract of Hylocereus polyrhizus.All treatment and control groups were infected by Salmonella typhimurium intraperitoneally 105 CFU in tenth day.Results: Weight in the treatment group was higher than the control group (p=0.037). Index of macrophage phagocytosis was higher in the treatment group compared to the control group but it was not significant (p=0.154). Macrophage NO production was higher in the treatment group compared to the control group but was not significant (p=0.332).Conclusion: Weight increased significantly.Increasing of macrophage phagocytosis index and macrophage NO production were not significant.
Co-Authors Abdul Khanis Agus Priyatno Alfarizi, Rizki Anang M Legowo Andreas Arie Setiawan Andreas Arie Setiawan Andrew Johan Diniafelsa Wola Edwin Tohaga Elvi Suryati Erwin Kresnoadi Evangga Yudha Perdana Fairuz Azmila Purnomo Fathur Nur Kholis Fuadi Fuadi Hartantyo Hartantyo Ika Pawitra Miranti Indra Wijaya Iva-Yuana Iva-Yuana Kamilah Budhi Kamilah Budhi R Kamilah Budhi Rahardjani Ken Shinta Kis - Djamiatun Kusdalinah Kusdalinah Kusmadewi Eka Damayanti Meira Dewi Mochamad Ali Sobirin Muhammad Sholeh Kosim Mundhofir, Farmaditya Eka Putra Niken Puruhita Novi Angriyani Putri, Syifa Nurisma Rachmatu Bill M Rahmi - Wirman Rahmi Isma Asmara Putri Raya, Maxianus Kopong Renni Yuniati Rifki Agung Rina Pratiwi Rudy Handoyo Satrio Adi W Sulistiyati Bayu U Tjahjono Tjahjono Tjipta Bahtera Tjipta Bahtera Tjipta Bahtera Tun Paksi Sareharto Vega Karlowee Yora Nindita