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All Journal E-Jurnal Medika Udayana SONDE (Sound of Dentistry) Interdental Jurnal Kedokteran Gigi (IJKG) Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) MDJ (Makassar Dental Journal) Jurnal Kedokteran Universitas Palangka Raya Pharmaceutical Sciences and Research (PSR) Barigas: Jurnal Riset Mahasiswa
Nugrahini, Sintha
Departemen Gigi Dan Mulut, Fakultas Kedokteran, Universitas Palangka Raya, Palangka Raya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Decrease in transverse strength of heat polymerized acrylic resin plate after immersion in 15% betel leaf extract (Piper betle Linn.): Penurunan kekuatan transversal plat resin akrilik polimerisasi panas setelah perendaman dalam larutan ekstrak daun sirih (Piper betle Linn.) 15% Sintha Nugrahini; Helena Jelita; Putu Hanny Ardianingsih
Makassar Dental Journal Vol. 11 No. 1 (2022): Volume 11 Issue 1 April 2022
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v11i1.513

Abstract

The method of chemically cleaning dentures by immersion in an effervescent denture cleanser solution for a long time can affect the transverse strength. Betel leaf extract can be used as a natural disinfectant because it contains essential oils that are antimi-crobial by denaturing cell proteins. This study was intended to examine the decrease in the transverse strength of heat polymeri-rized acrylic resin plates after immersion in 15% betel leaf extract solution. The posttest only control group design study used a sample of 24 HPAR plates, which were divided into 6 groups. The plates were immersed in distilled water for 72 hours to re-duce the residual monomer, immersed in 15% betel leaf extract solution, the positive control group in Fittydent® and the nega-tive control group in aquadest for 1 and 6 hours. The transverse strength was tested using the Universal Testing Machine and the data were analyzed using the one-way Anova test. The results showed the average transverse strength after immersion for 1 hour in 15% betel leaf extract, Fittydent®, and aquadest, respectively, namely 46.512±10.965 MPa, 72.744±22.395 MPa, and 81.522±28.854 MPa; after soaking for 6 hours, respectively, namely 49.171±14.246 MPa, 73.894±25.844 MPa, and 71.860± 17.553 MPa. The LSD test showed that there was a significant difference in transverse strength (p<0.05). It was concluded that the immersion of the HPAR plate in 15% betel leaf extract solution for 1 hour and 6 hours decreased the transverse strength.
Correlation between Neutrophil-Lymphocyte Ratio and Urea Serum in Hemodialysis Patients at Dr. Doris Sylvanus Hospital Nafisy Apritis Sambo; Lia Sasmithae; Sintha Nugrahini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 1 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i1.2076

Abstract

Chronic Kidney Disease (CKD) is a condition characterized by kidney damage for > 3 months, as well as structural or functional abnormalities with or without a decrease in Glomerular Filtration Rate (GFR) < 60 mL/minute/1.73. This damage leads to increased urea levels in the blood, also known as uremia, which can increase the risk of inflammation in CKD patients undergoing hemodialysis (HD). Previous studies revealed that increased urea and Neutrophil-Lymphocyte Ratio (NLR) can be used as inflammatory biomarkers to replace CRP, IL-6, and other indicators. This study aimed to determine the correlation between NLR and serum urea levels in pre- and post-HD CKD patients at Dr. Doris Sylvanus Hospital. An analytical survey method was used with a retrospective design.The process started by taking medical records of patients currently undergoing HD who were selected as respondents. The sample population consisted of 50 (70.4%) males and 21 (29.6%) females. Based on the age group, 43.7% of patients were aged 51-60. The results showed that the average NLR pre- and post-HD were 5.24±4.88 and 10.41±12.31, respectively. The average urea pre- and post-HD were 195.97±77.88 and 120.97±47.4, respectively. The bivariate analysis showed a significant weak correlation between NLR and serum urea level pre-HD (p=0.004 with r =0.338) and post-HD (p=0.039 with r =0.246) in patients.
KARAKTERISTIK KASUS KEKERASAN SEKSUAL TERHADAP PEREMPUAN DI WILAYAH KALIMANTAN TENGAH TAHUN 2015-2020 Aprilia Dwi Sandra; Sintha Nugrahini; Ricka Brillianty Zaluchu
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 4 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Kekerasan seksual adalah tindak kejahatan yang cenderung meningkat setiap tahun dan menjadi masalah global. Kejahatan ini memiliki prevalensi yang tinggi terhadap perempuan serta memberikan dampak buruk bagi mental dan fisik korban. Oleh karena itu, perlu diteliti mengenai kejadian kekerasan seksual di wilayah Kalimantan Tengah menggunakan data Visum et Repertum. Penelitian ini bertujuan untuk mengetahui gambaran temuan forensik pada kasus kekerasan seksual yang dialami korban. Penelitian ini dilakukan dengan metode deskriptif kualitatif dengan pendekatan retrospektif berdasarkan hasil Visum et Repertum sebanyak 134 data sesuai dengan kriteria inklusi pada total populasi yang diambil dari Rumah Sakit Umum Daerah dr. Doris Sylvanus dan Rumah Sakit Bhayangkara Tingkat III Palangka Raya Data dianalisis menggunakan Microsoft Excel 2021 untuk mendapatkan usia korban kekerasan seksual, lokasi robekan hymen, jenis luka, lokasi luka anogenital, dan penyebab luka. Hasil penelitian menunjukkan selama tahun 2015-2020 kasus kekerasan seksual di wilayah Kalimantan Tengah didominasi oleh remaja awal sebanyak 46,7%, robekan hymen terbanyak pada arah jarum jam tiga 15,8%, temuan luka terbanyak luka lecet baru (luka yang ditemukan beberapa jam sampai beberapa hari pasca kejadian) 46%, lokasi luka terbanyak terdapat pada genitalia eksterna 76%, dan penyebab luka terbanyak oleh benda tumpul 87%. Kata kunci: forensik, kekerasan seksual, visum et repertum DOI : 10.35990/mk.v6n4.p340-351
HUBUNGAN USIA, BODY MASS INDEX (BMI), DAN FREKUENSI GERAKAN REPETITIF DENGAN KEJADIAN CARPAL TUNNEL SYNDROM (CTS) PADA WANITA DENGAN KEBIASAAN MENCUCI PAKAIAN MENGGUNAKAN TANGAN DI DESA MUARA UNTU KABUPATEN MURUNG RAYA PROVINSI KALIMANTAN TENGAH Lestari, Noor Reza Indah; Nugrahini, Sintha; Mutiasari, Dian; Balyas, Abi Bakring; Komara, Nisa Kartika
E-Jurnal Medika Udayana Vol 13 No 1 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i01.P18

Abstract

Sebagian besar wanita di Desa Muara Untu masih mencuci pakaian menggunakan tangan hampir setiap hari. Kecepatan tangan, posisi tangan yang ekstrim, gerakan berulang dengan tekanan dalam waktu yang lama dan genggaman pada saat mengucek pakaian yang menggunakan kekuatan adalah salah satu faktor resiko terjadinya Carpal Tunnel Syndrome. Penelitian ini bertujuan untuk mengetahui hubungan usia, Body Mass Index, dan frekuensi gerakan repetitif dengan kejadian Carpal Tunnel Syndrome pada wanita yang mencuci pakaian menggunakan tangan di Desa Muara Untu Kabupaten Murung Raya Provinsi Kalimantan Tengah. Penelitian ini merupakan studi korelasi yang menggunakan desain Cross Sectional. Instrumen dalam penelitian ini adalah kuesioner Boston-Carpal Tunnel Questionare (BCTQ) dan kuesioner pemeriksaan fisik Phalen’s test. Berdasarkan analisis bivariat ditemukan bahwa hubungan usia dengan Carpal Tunnel Syndrom menghasilkan koefisien korelasi 0,318 dengan probabilitas 0,001, hubungan Body Mass Index dengan kejadian Carpal Tunnel Syndrome menghasilkan koefisien korelasi 0,111 dengan probabilitas 0,210, dan hubungan frekuensi gerakan repetitif dengan kejadian Carpal Tunnel Syndrome menghasilkan koefisien korelasi 0,077 dengan probabilitas 0,385. Kesimpulannya adalah terdapat hubungan yang signifikan antara usia dengan kejadian Carpal Tunnel Syndrome dan tidak terdapat hubungan yang signifikan antara Body Mass Index dan frekuensi gerakan repetitif dengan kejadian Carpal Tunnel Syndrome.
Analisis Kandungan Boraks (Natrium Tetraborate) Pada Kerupuk Yang Beredar di Pasar Besar Kota Palangka Raya Noor Sulaiman, Reza; Augustina, Indria; Ratnasari, Arini; Immanuela Toemon, Agnes; Nugrahini, Sintha
Jurnal Kedokteran Universitas Palangka Raya Vol 12 No 1 (2024): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

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Abstract

The addition of Food Additives containing chemical active substances has been widely used in daily life. Many food producers still use them as hazardous food additives that can lead to health problems. This study aims to determine the presence of borax and measure the levels found in unbranded crackers sold in the Palangka Raya City Main Market. This research is a descriptive study with a cross-sectional design. The research sample consisted of 41 unbranded crackers sold in the Palangka Raya City Main Market, selected using a sampling technique with total sampling based on inclusion and exclusion criteria. The research instruments used were the borax easy kit test and sp-300 spectrophotometer. Data processing techniques used descriptive analysis with data presentation in the form of percentage values. The results of this study identified borax in 41 samples of unbranded crackers sold in the Palangka Raya City Main Market, with 4 samples containing borax in each coriander cracker sample. Sample 1 was found to contain 37.74 grams of borax, sample 2 contained 33.62 grams of borax, sample 4 contained 61.63 grams of borax, and sample 7 contained 15.57 grams of borax.
Hubungan Kualitas Tidur dengan Konsentrasi pada Mahasiswa preklinik Fakultas Kedokteran Universitas Palangka Raya Tahun 2022 Muhtazah, Farida; Kahanjak, Donna; Nugrahini, Sintha
Barigas: Jurnal Riset Mahasiswa Vol. 1 No. 1 (2023): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v1i1.8034

Abstract

Concentration is centralization of the mind, motivation towards something with the addition of feeling worried, depressed, and panic so as not to hinder one's readiness. One of the factors that make it difficult to concentrate is the quality of sleep. Students can experience concentration problems, especially medical students because of the limited quality and quantity of sleep. Therefore, researchers are interested in conducting research on the relationship between sleep quality and concentration in preclinical students at the Faculty of Medicine, University of Palangka Raya. This study used an analytic observation method with a cross-sectional design. The research sample was 212 preclinical students in 2019, 2020 and 2021 who met the inclusion and exclusion criteria. Sampling technique with proportionate stratified random sampling. The instruments in this study were the Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess sleep quality and the Stroop Test to assess concentration. This study showed that out of 212 samples, 55 people had good sleep quality and 157 had poor sleep quality. Only 39 people with good sleep quality had good concentration. There are 120 students with poor sleep quality but have good concentration. The results of the analysis showed with the Chi Square P Value test (0.416 > 0.05) that there was no significant relationship or relationship between sleep quality and concentration in preclinical students at the Faculty of Medicine, University of Palangka Raya.
Efektivitas infusa daun kalakai (Stenochlaena palustris (Burm.F) Bedd) terhadap kadar kolesterol total pada tikus putih galur wistar yang diinduksi CCl4 Saloh, Rachel Sarita; Carmelita, Austin Bertilova; Nugrahini, Sintha; Balyas, Abi Bakring; Adnyana, I Gde Hary Eka
Barigas: Jurnal Riset Mahasiswa Vol. 2 No. 3 (2024): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v2i3.12183

Abstract

Cholesterol can be attacked by CCl4 by increasing lipid peroxidation, where CCl4 causes an increase in acetate transport into the liver, resulting in an increase in substrate (acetate) which causes cholesterol synthesis to also increase. Based on previous research, the kalakai plant (Stenochlaena palustris (Burm.F) Bedd) has good antioxidants to ward off free radicals. Objective: To determine the potential of kalakai leaf infusion to prevent the increase in total cholesterol levels induced by CCl4. Method: True experimental research with a post test only control group design, using 24 white male Wistar rats weighing 200-250 g, divided into three treatment groups and a negative (-) group induced by CCl4. Treatment groups I, II, II were given kalakai leaf infusion at a dose of 300 mg/kgBW, 400 mg/kgBW, 500 mg/kgBW. This research was conducted for 15 days. Research Results: In the normality and homogeneity test, the sig>0.05 value was obtained, so it can be concluded that the data is normally and homogeneously distributed. Then the data can be continued for Oneway ANOVA hypothesis testing, and a value of sig>0.05 is obtained. Based on the research results, there was no effect from the kalakai leaf infusion and the hypothesis was rejected.
Gastroprotective Potential of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema canescens Jack)-Ultrasonic Assisted Extraction in Rats Induced with Absolute Ethanol Savitri, Dilasari; Trinovita, Elsa; Widayati, Ratna; Handayani, Septi; Nugrahini, Sintha
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Peptic ulcer disease is a gastrointestinal disorder associated with significant morbidity and mortality. Enhancing the quality of life of patients with peptic ulcers often involves integrating conventional treatments with complementary alternative therapies. One such alternative therapy is herbal remedies, which local communities have long recognized. Sungkai leaves (Peronema canescens Jack) contain various bioactive components, including flavonoids, alkaloids, saponins, tannins, steroids, and phenolic compounds. This study aimed to assess the gastroprotective properties of sungkai leaf extract (Peronema canescens Jack) by analyzing the average size of gastric lesions in male Wistar rats exposed to absolute ethanol. The research used a true experimental design with a posttest-only control group approach involving six treatment groups, each consisting of four rats. Gastroprotective activity was macroscopically evaluated by measuring the average size of the gastric lesions. Statistical analyses were conducted using the Kruskal-Wallis and Mann-Whitney tests for post hoc comparisons. Results showed that the normal group had an average lesion size of 0 mm, the negative control group had 115.37±50.53 mm, and the positive control group had 7.40±2.57 mm. For the groups treated with sungkai leaf extract, the 100 mg/kgBW dose resulted in 6.86±3.83 mm lesions, the 200 mg/kgBW dose in 9.65±10.27 mm, and the 400 mg/kgBW dose in 29.50±19.68 mm. Statistical analysis using SPSS 26 revealed a significant difference between the groups,with a Kruskal-Wallis test result of p=0.002. These findings show that sungkai leaf extract exhibits gastroprotective activity compared with omeprazole, as seen by the smaller average size of gastric lesions in male Wistar rats treated with absolute ethanol.
Co-Authors Adnyana, I Gde Hary Eka Aprilia Dwi Sandra Arini Ratnasari Augustina, Indria Austin Bertilova Carmelita, Austin Bertilova Balyas, Abi Bakring Dewi Farida Nurlitasari Dewi, Intan Kemala Dian Mutiasari, Dian Elsa Trinovita Handayani, Septi Helena Jelita Helena Jelita I Made Agus Astika Immanuela Toemon, Agnes Kadek Dwi Dessy Sapitri Kahanjak, Donna Komara, Nisa Kartika Lestari, Noor Reza Indah Lia Sasmithae Muhtazah, Farida Nafisy Apritis Sambo Noor Sulaiman, Reza Putu Hanny Ardianingsih Ricka Brillianty Zaluchu Saloh, Rachel Sarita Savitri, Dilasari Widayati, Ratna Wirayuni, Kadek Ayu