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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Biomedical Engineering Jurnal Sains dan Teknologi Farmasi Majalah Obat Tradisional Majalah Farmaseutik Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika
Ngatidjan Ngatidjan
Departement Of Pharmacology And Therapy, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Biomedical Engineering

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Carbonated hydroxyapatite inflammation’s responses on local rabbits Aryan Morita; Ngatidjan Ngatidjan; Setyo Purwono
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective: This study aimed to find out the response of mandible inflammation implanted with carbonated hydroxyapatite.  Methods: Sixty local rabbits were divided into three groups, including carbonatedhydroxyapatite (CHA) group; hydroxyapatite (HA) group; and control. Each group divided into 5 sub groups for observation in day-1, 3, 5, 7, and 14. On first day, all rabbits were anesthesized and incised to create cavity in the mandible. CHA or HA powder as much as 0,05 g were put into it. Then it was sutured using silk thread. Von Ebner method for decalcification were used followed by hematoxylin eosin staining to examine the neutrophil and macrophage. Results: The number of neutrophil, macrophage, and edema volumes in CHA group were lower than HA group. There were not any significant difference (p>0,05) between CHA, HA, and control.  Conclusion: There are no mandible inflammation response in CHA implantation and HA.Key Words: CHA; edema volumes; inflammation; macrophages; neutrophils
Co-Authors Afifah Afifah Aryan Morita Dewi, Lucia Vita Inandha Dwi Aris Agung Nugrahaningsih Endang Mahati Erna Kristin Eti Nurwening Sholikhah FARIDA HAYATI Indra Bramanti Jarir At Thobari Lukman Hakim Lukman Hakim Mae Sri Hartati Wahyuningsih Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Ni Made Dwi Sandhiutami Nur Arfian Pratiwi, Woro Rukmi Rul Afiyah Syarif Setyo Purwono Setyo Purwono Sismindan Sismindan Sitarina Widyarini Soni Prabowo Putra Yuniyanti, Mia Munawaroh