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Effects of Morning’s Prayer Routines in The Congregation on Random Blood Sugar Levels of Elderly at Al Wahyu Mosque Rungkut Surabaya Indri Ngesti Rahayu; Lani Diana; R. Varidianto Yudo Tjahjono
Denta Journal Kedokteran Gigi Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2
Publisher : Universitas Hang Tuah

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Background: Increased health problems in the elderly occur because of the aging process that causes many changes in their body. One of the changes istheincrease in blood glucose more than normal and at risk of diabetes mellitus. Morning prayer can be a religious coping and regular physical activity that lowers blood sugar levels. Objective: to analyze the effect of the morning prayer routines in the congregation on random blood sugar levels of the elderly at Al-Wahyu Mosque Rungkut Surabaya. Method:This study was an observational analytic study with a cross-sectional design using 30 respondents. The group studied was the congregation of the morning prayers of the Al Wahyu MosqueRungkut Surabaya which was over 45-year-old which undergoes random blood sugar levels measurement. Results:The Independent t-testmethodshowedthat the value of signification was 0,000 (p<0,05) which means that there is the influence of the morning prayer’s routines in the congregation on random blood sugar levels of the elderly at Al-Wahyu Mosque Rungkut Surabaya. Conclusion:Elderly people who routinely carry out the morning prayer routines in the congregation have lower blood sugar levels than elderly people who are not routine.

Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.

PENGARUH HbA1c TERHADAP SINDROMA MATA KERING PADA PASIEN DIABETES MELLITUS DI SURABAYA NI WAYAN WIWIN OKTORI; VARIDIANTO YUDO TJAHJONO; SRI ARIANI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Diabetes mellitus is a public health problem experienced by many countries and becomes a serious problem, affecting health in the world. Various complications of DM related to the surface of the eye is dry eye syndrome. Dry eye syndrome is an eye disorder with symptoms of discomfort, pain, dryness and foreign body sensation in the eye. The level of glycosylated hemoglobin (HbA1c) is one indicator of DM and it is stated that the prevalence of dry eye syndrome is significantly higher in DM sufferers than in healthy individuals. The Aim of this study to know the effect of HbA1c on dry eye syndrome in patients with diabetes mellitus Method :. This study used a cross sectional method and the sampling method used was purposive sampling. Samples taken as many as 34 people are patients with diabetes mellitus aged 18-55 years who have HbA1c results seen from medical records at the Public Health Center Jagir Surabaya. The research data was taken using the Dry Eye Questionnaire (DEQ), interviews and Schirmer Test I. The research data was then analyzed using a contingency test. Result: The significance value of the HbA1c test with the Schirmer I Test showed p = 0.026; that’s means a significant effect between HbA1c levels on dry eye syndrome with the Schirmer I Test and the significance value of the HbA1c test with the DEQ questionnaire shows p <0.001; that’s means a significant effect between HbA1c levels on dry eye syndrome and DEQ questionnaire, performed on patients with diabetes mellitus in Jagir Health Center, Surabaya City Conclusion: There is an influence of HbA1c levels on dry eye syndrome

Efek Pemberian Oksigen Hiperbarik Pada Efektivitas Ekstrak Cacing Tanah (Lumbricus terrestris) Terhadap Pertumbuhan Salmonella Typhi Secara In Vitro VARIDIANTO YUDO TJAHJONO; RETNO BUDIARTI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.341

Background: Typhoid fever is an infectious disease of the small intestine caused by the bacterium Salmonella typhi, and causes a fairly high mortality rate. These bacteria have developed resistance to many antibiotics. Earthworm extract (ECT) has been widely used as an alternative to treat typhoid fever. Hyperbaric oxygen therapy (OHB) has been used to treat various diseases and can suppress the growth of bacteria. Objective: To determine the effect of hyperbaric oxygen (OHB) 3 ATA on the effectiveness of earthworm (Lumbricus terrestris) extract on the growth of Salmonella typhi in vitro. Methods: This experimental study used the post-test only control group design method. Thirty-six samples of S.typhi bacteria in liquid medium (broth) were divided into four groups. The first group (K-) was not given any treatment, the second group (P1) was given earthworm extract, the third group (P2) was given hyperbaric oxygen 3 ATA, and the fourth group (P3) was given a combination of earthworm extract and hyperbaric oxygen 3 ATA. The results of bacterial growth in each group were calculated in colony forming units (CFU) / ml and analyzed statistically. Results: The growth of S.typhi bacteria in the first group (K-) was 108.51 x 106 CFU/ml, the second group (P1) was 483 CFU/ml, the third group was 1.4 x 106 CFU/ml, and the fourth group (P3) was 215 CFU/ml. The fourth group (P3) had the smallest number of bacterial growth and had a significant difference compared to the first (P1) and third (P3) groups (p = 0.001; p < α ; α = 0.05), but the difference was not significant compared to the second group (P1 ) (p = 0.308; p > α; α = 0.05). Conclusion: Giving earthworm extract (ECT) with hyperbaric oxygen (OHB) 3 ATA (combination) was most effective in inhibiting the growth of Salmonella typhi bacteria compared to giving earthworm extract (ECT) alone or giving hyperbaric oxygen (OHB) 3 ATA alone.

STUDI EKSPERIMENTAL: PENURUNAN PROFIL NETROFIL DAN TNF-α SETELAH PEMBERIAN EKSTRAK TERIPANG EMAS (STICHOPUS HERMANNI) R. Varidianto Yudo Tjahjono; Prawesty Diah Utami; Herin Setianingsih
Surabaya Biomedical Journal Vol 1 No 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.23

Latar Belakang: Vaginitis candida adalah penyakit infeksi jamur yang diderita hampir setiap wanita di dunia. Meningkatnya jumlah netrofil dan kadar faktor nekrosis tumor alfa (TNF-α) merupakan ciri khas dari penyakit ini. Ekstrak teripang emas (Stichopus hermanni) telah banyak diteliti terutama untuk anti jamur dan bakteri, anti peradangan , anti oksidan dan lain-lain. Tujuan: Membandingkan profil netrofil dan TNF-α antara kelompok kontrol dengan kelompok studi lain yang mendapatkan ekstrak teripang emas (S.hermanni) melalui studi eksperimental menggunakan mencit coba. Metode: Penelitian eksperimental dengan desain “post-test only control group design”. Unit eksperimentalnya terdiri dari 24 mencit BALB/c yang diinokulasi C.albicans per vaginam dan dibagi menjadi empat grup terdiri dari : (K-) kelompok yang tidak mendapatkan perlakuan; (P1)kelompok yang mendapatkan ekstrak S.hermanni dosis 8,5mg/kgBB; (P2) kelompok dengan dosis ekstrak 17mg/kgBB; dan (P3) kelompok dengan dosis ektrak 34 mg/kgBB. Jumlah netrofil dilihat dari pemeriksaan mikroskopis jaringan mukosa vagina. Kadar sitokin TNF-α dilihat dari pemeriksaan ELISA sampel darah. Hasil: Hasil pengamatan profil netrofil pada jaringan mukosa vagina mencit coba menunjukkan bahwa kelompok P2 mengalami penurunan netrofil tertinggi namun secara statistic tidak signifikan penurunannya (p=0,156; p>α). Pengamatan profil TNF-α padai serum darah mencit pada kelompok P2 menunukkan penurunan yang signifikan dibanding kelompk lain (p=0,001; p< α). Perbedaan ini terutama bila dibandingkan kelompok K- (p=0,004; p< α) dan kelompok P1(p=0,004; p< α) Kesimpulan: Pemberian ekstrak S.hermanni terbukti mampu menurunkan profil netrofil dan kadar TNF-α pada mencit coba, dengan dosis efektifnya sebesar 17 mg/kgBB.

Pengaruh Ekstrak Daun Kelor (Moringa oleifera L.) Terhadap Pertumbuhan Escherichia coli Pada Media Agar Nutrient AULIA CEMPAKASARI; VARIDIANTO YUDO TJAHJONO; PRAJOGO WIBOWO; LESTARI DEWI
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.402

Diare adalah defekasi cair lebih dari 3 kali dalam 24 jam dan merupakan penyakit yang sering terjadi di Negara dengan sanitasi buruk, dengan prevalensi tertinggi yang disebabkan oleh bakteri Escherichia coli. Ekstrak daun kelor (Moringa oleifera L.) yang banyak dijumpai di daerah tropis seperti Indonesia, diharapkan dapat efektif dalam menghambat aktivitas bakteri Escherichia coli karena menyimpan sumber metabolit sekunder yang bersifat antibakteri seperti flavonoid, tannin dan alkaloid. Penelitian ini merupakan penelitian eksperimental laboratorium dengan menggunakan bakteri Escherichia coli yang dibagi menjadi 6 kelompok perlakuan yaitu kontrol negatif, konsentrasi 25%, konsentrasi 50%, konsentrasi 75%, konsentrasi 100% dan kontrol positif yang masing-masing kelompok dilakukan 4 kali pengulangan. Hasil penelitian menunjukkan pada konsentrasi 25% memiliki diameter zona hambat 6,99 mm, pada konsentrasi 50% memiliki diameter zona hambat 7,27 mm, pada konsentrasi 75% memiliki diameter zona hambat 7,91 mm, dan pada konsentrasi 100% memiliki diameter zona hambat 8,90 mm. Pada uji Kruskal-Wallis menunjukkan adanya perbedaan signifikan dari 6 kwlompok perlakukan dengan nilai signifikasi 0,001 (p<0,05). Uji Mann-Whitney U di dapatkan bahwa kelompok control negative tidak memiliki perbedaan yang signifikan terhadap kelompok konsentrasi 25%, 50% dan 75% dengan nilai signifikasinya >0,05 (p>0,05). Hasil penelitian uji daya hambat ekstrak daun kelor kelor (Moringa oleifera L.) terhadap pertumbuhan bakteri Escherichia coli pada media agar nutrient dengan beberapa kelompok perlakuan yang berbeda telah dilakukan dan disimpulkan bahwa Ekstrak daun kelor (Moringa oleifera L.) dapat menghambat pertumbuhan bakteri Escherichia coli pada media agar.

Karakteristik Pasien Stroke Di Klinik Rehabilitasi Medik Rspal Dr. Ramelan Surabaya Periode Januari – Juni 2024 Febrian, Amellia Ika; Jauhar, Tamam; Wijayaningrum, Lena; Tjahjono, Varidianto Yudo
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 3 (2025): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v5i3.271

Stroke adalah kelainan neurologi yang menjadi faktor penyebab kematian terbanyak kedua di dunia. Penderita stroke umumnya berusia diatas 50 tahun dan banyak yang berasal dari negara berkembang. Stroke bisa terjadi karena banyak faktor, seperti penyakit penyerta, pola hidup buruk, lingkungan yang kurang sehat, dan kurangnya aktivitas fisik. Meskipun stroke banyak terjadi di usia lanjut, namun faktor risiko tersebut banyak didapatkan ketika usia muda yang dapat meningkatkan risiko stroke di usia mendatang. Penelitian ini bertujuan untuk mengetahui karakteristik pasien stroke di klinik Rehabilitasi Medik RSPAL dr. Ramelan Surabaya periode Januari – Juni 2024. Metode penelitian yang digunakan adalah deskriptif dengan pengambilan sampel menggunakan metode total sampling. Populasi penelitian adalah seluruh pasien stroke yang memiliki rekam medis lengkap. Data yang dilihat antara lain usia, jenis kelamin, penyakit penyerta berupa hipertensi dan diabetes mellitus. Berdasarkan data yang diperoleh dari rekam medis didapatkan 70 sampel dengan variabel penelitian hipertensi, diabetes mellitus, usia, dan jenis kelamin. Distribusi pasien stroke dengan faktor risiko hipertensi berjumlah 53 orang. Distribusi pasien stroke dengan faktor risiko diabetes mellitus berjumlah 24 orang. Distribusi pasien stroke dengan faktor usia mayoritas termasuk dalam usia ≥45 tahun sebanyak 66 orang. Distribusi pasien stroke dengan faktor risiko jenis kelamin mayoritas pada laki-laki sebanyak 47 orang. Kesimpulan penelitian ini yaitu faktor risiko yang mendominasi kejadian stroke pada pasien stroke di Klinik Rehabilitasi Medik RSPAL dr. Ramelan Surabaya periode Januari – Juni 2024 adalah memiliki hipertensi, berjenis kelamin laki-laki, dan berusia ≥45 tahun

STUDI EKSPERIMENTAL: PENURUNAN PROFIL NETROFIL DAN TNF-α SETELAH PEMBERIAN EKSTRAK TERIPANG EMAS (STICHOPUS HERMANNI) R. Varidianto Yudo Tjahjono; Prawesty Diah Utami; Herin Setianingsih
Surabaya Biomedical Journal Vol. 1 No. 2 (2022): January
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.23

Latar Belakang: Vaginitis candida adalah penyakit infeksi jamur yang diderita hampir setiap wanita di dunia. Meningkatnya jumlah netrofil dan kadar faktor nekrosis tumor alfa (TNF-α) merupakan ciri khas dari penyakit ini. Ekstrak teripang emas (Stichopus hermanni) telah banyak diteliti terutama untuk anti jamur dan bakteri, anti peradangan , anti oksidan dan lain-lain. Tujuan: Membandingkan profil netrofil dan TNF-α antara kelompok kontrol dengan kelompok studi lain yang mendapatkan ekstrak teripang emas (S.hermanni) melalui studi eksperimental menggunakan mencit coba. Metode: Penelitian eksperimental dengan desain “post-test only control group design”. Unit eksperimentalnya terdiri dari 24 mencit BALB/c yang diinokulasi C.albicans per vaginam dan dibagi menjadi empat grup terdiri dari : (K-) kelompok yang tidak mendapatkan perlakuan; (P1)kelompok yang mendapatkan ekstrak S.hermanni dosis 8,5mg/kgBB; (P2) kelompok dengan dosis ekstrak 17mg/kgBB; dan (P3) kelompok dengan dosis ektrak 34 mg/kgBB. Jumlah netrofil dilihat dari pemeriksaan mikroskopis jaringan mukosa vagina. Kadar sitokin TNF-α dilihat dari pemeriksaan ELISA sampel darah. Hasil: Hasil pengamatan profil netrofil pada jaringan mukosa vagina mencit coba menunjukkan bahwa kelompok P2 mengalami penurunan netrofil tertinggi namun secara statistic tidak signifikan penurunannya (p=0,156; p>α). Pengamatan profil TNF-α padai serum darah mencit pada kelompok P2 menunukkan penurunan yang signifikan dibanding kelompk lain (p=0,001; p< α). Perbedaan ini terutama bila dibandingkan kelompok K- (p=0,004; p< α) dan kelompok P1(p=0,004; p< α) Kesimpulan: Pemberian ekstrak S.hermanni terbukti mampu menurunkan profil netrofil dan kadar TNF-α pada mencit coba, dengan dosis efektifnya sebesar 17 mg/kgBB.

The Effect of Providing Basic Life Support Materials Using the Audiovisual Method on the Knowledge and Skills of Cardiopulmonary Resuscitation Bayu Aji Sadewa; Angela Puspita; R. Varidianto Yudo Tjahjono; Titut Harnanik
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1073

Cardiac arrest is a leading cause of death worldwide, including in the United States and Indonesia, with most cases triggered by coronary heart disease. Successful resuscitation largely depends on rapid interventions such as cardiopulmonary resuscitation (CPR) and defibrillation, as survival chances decrease by approximately 10% for every minute without intervention. Basic Life Support (BLS) has been proven to improve resuscitation outcomes; however, knowledge and skills related to BLS remain limited, including among medical students. This study aimed to analyze the effect of providing BLS training using audiovisual methods on the knowledge and skills of students who are members of the Medical Assistance Team (Tim Bantuan Medis/TBM), Faculty of Medicine, Universitas Hang Tuah Surabaya, in performing cardiopulmonary resuscitation (CPR). A cross-sectional study was conducted at the Faculty of Medicine, Universitas Hang Tuah, Surabaya, Indonesia, from June to September 2025. A total of 21 TBM students were selected using a total sampling technique. The dependent variables were knowledge and skills in performing CPR, while the independent variable was BLS training delivered using audiovisual methods. Data were collected using questionnaires that had been tested for validity and reliability. Data analysis was performed using the Wilcoxon signed-rank test for knowledge levels and the McNemar test for CPR skills. The Wilcoxon signed-rank test showed that knowledge levels were significantly improved after the provision of BLS training using audiovisual methods (p = 0.020). The McNemar test demonstrated that CPR skills were also significantly improved after the audiovisual BLS training (p = 0.008). There is a significant effect of audiovisual-based Basic Life Support (BLS) training on improving both CPR knowledge and skills among TBM students.

Effect of Ethanol Extract of Sea Pandan Fruit (Pandanus Tectorius) on Blood Glucose Levels in Male White Rats (Rattus Norvegicus) Induced by Dexamethasone Ghifara Kireina Annisa; Nita Pranitasari; R. Varidianto Yudo Tjahjono; Roostantia Indrawati
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1214

Diabetes mellitus is a metabolic disorder with increased blood glucose due to decreased insulin production or sensitivity. Chronic hyperglycemia can lead to endothelial dysfunction and vascular complications. Dexamethasone as a synthetic glucocorticoid can cause hyperglycemia through increased gluconeogenesis and insulin resistance. The antioxidant content in sea pandanus (Pandanus tectorius) has the potential to lower blood glucose levels. This study aims to determine the effect of ethanol extract of sea pandan fruit on blood glucose levels of male white rats (Rattus norvegicus) induced by dexamethasone. This study aims to determine the effect of ethanol extract of sea pandan fruit (Pandanus tectorius) on blood glucose levels in male white rats (Rattus norvegicus) induced by dexamethasone. Experimental research with a post test only control group on 30 mice grouped into 3 groups. Namely, K(-) which was only given standard feed, K(+) which was induced by dexamethasone at a dose of 5 mg/KgBB, and KP which was induced by dexamethasone at a dose of 5 mg/KgBB and given Pandanus tectorius fruit extract at a dose of 100 mg/KgBB, then at the end of the study a blood sample was taken to measure blood glucose levels and then terminated. The sample was selected using simple random sampling technique. The data was analyzed using the One Way Anova test. In the results of the study, the average blood glucose level K(-) = 170.37 was obtained; K(+) = 274.62; KP = 243. In the One Way Anova parametric test, a significant result was obtained which was 0.005 (p<0.05). Then in the Post Hoc Games-Howell test, K(-) and K(+) had a significance of 0.001 (p<0.05), while the K(-) and KP groups as well as K(+) and KP showed no significant results. This suggests that ethanol extract of Pandanus tectorius fruit did not successfully inhibit the increase in blood glucose levels in dexamethasone-induced white rats. The administration of ethanol extract of Pandanus tectorius fruit as a therapy was able to reduce the blood glucose level of male Rattus norvegicus induced by dexamethasone compared to a K(+) positive control of 31.62 mg/dL (11.5%).

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