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All Journal Jurnal Kesehatan Lingkungan indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Damianus Journal of Medicine Journal of Medicine and Health Indonesian Journal of Global Health research Cermin Dunia Kedokteran JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of General Procedural Dermatology and Venereology Indonesia Journal of Urban Health Research Journal of Medicine and Health
Lorettha Wijaya
Fakultas Kedokteran Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia
Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Eruptive Xanthoma in Acute Pancreatitis: A Systematic Review of Case Reports Yonatan, Eric Ricardo; Alexander, Leonardo; ., Valencia; Wijaya, Lorettha
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202510-18

Abstract

Background: Eruptive xanthoma is a skin lesion caused by localized lipid deposits in the dermis, characterized by an eruption of yellow papules typically present on the buttocks, shoulders, and extensor skin surfaces of the extremities. Eruptive xanthoma is associated with acute pancreatitis as a result of hypertriglyceridemia or other lipid disorders. This study aims to discuss several case reports of patients with eruptive xanthomas and acute pancreatitis to provide descriptions and similarities between cases.Methods: This systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Case reports about eruptive xanthoma and acute pancreatitis are included in this systematic review. The literature search was done using PubMed, EBSCOHost, ProQuest, and Google Scholar. Critical evaluation for case reports by Joanna Briggs Institute is used for risk of bias assessment.Results: A literature search identified 6 case reports after eliminating irrelevant and duplicated studies. All assessed case reports reported similar dermatologic manifestations of eruptive xanthoma. Majority of patients reported severe acute abdominal pain as the main symptom of acute pancreatitis. All studies showed an increased level of lipid profiles, and other diagnostic workups support the diagnosis of eruptive xanthoma and acute pancreatitis. Risk of bias in case reports included was acceptable.Conclusion: Eruptive xanthomas can be found in patients with acute pancreatitis with correlation to hypertriglyceridemia and lipid disorders. Proper recognition, diagnosis, and treatment for eruptive xanthoma and acute pancreatitis should be kept in mind for practitioners.Keywords: Eruptive xanthoma, acute pancreatitis, systematic review
Polusi Udara dan Dermatitis Atopik: Suatu Tinjauan Literatur Wikanto, Jessica Rosemary; Wijaya, Lorettha; Dewantara, Jason; Lopulalan, Anastasya Anjeli; Regina, Regina
Jurnal Kesehatan Lingkungan Indonesia Vol 24, No 3 (2025): Oktober 2025
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.65719

Abstract

Latar belakang: Polusi udara di Indonesia saat ini cukup tinggi seiring dengan meningkatnya urbanisasi dan industrialisasi. Paparan polusi udara dapat merusak fungsi perlindungan kulit dan diduga berhubungan dengan dermatitis atopik. Studi ini bertujuan untuk mengulas perkembangan studi pengaruh polusi udara terhadap dermatitis atopik.Metode: Studi ini merupakan tinjauan literatur dengan menggunakan basis data Pubmed, ClinicalKey, EBSCO, dan ProQuest yang terbit dalam 5 tahun terakhir dan berbahasa Inggris. Kata kunci yang digunakan adalah “particulate matter AND atopic dermatitis”.Hasil: Hasil studi menunjukkan bahwa polusi udara dapat merusak sawar kulit dan memicu respon peradangan, sehingga memicu dermatitis atopik. Paparan polusi udara pada masa prenatal dan usia dini berhubungan dengan peningkatan insidensi dermatitis atopik pada anak-anak. Paparan jangka pendek terhadap kadar polutan tinggi dapat meningkatkan risiko kekambuhan dermatitis atopik. Prevalensi dermatitis atopik juga terus mengalami peningkatan di negara-negara berkembang.Simpulan: Studi ini menyimpulkan bahwa polusi udara dapat menjadi pemicu ataupun memperparah gejala dermatitis atopik. ABSTRACT Title: Air pollution and atopic dermatitis: A literature reviewBackground: Currently, air pollution in Indonesia is quite high along with increasing urbanization and industrialization. Exposure to air pollution may cause damage to skin protective function and may be related to atopic dermatitis. This paper aims to review the progress of studies concerning the relationship between air pollution and atopic dermatitis. Method: Studies, which were published in English within the last 5 years, were obtained through databases (Pubmed, ClinicalKey, EBSCO, and ProQuest). The keywords used are“particulate matter AND atopic dermatitis”Result: Results show that air pollution may damage skin barrier and trigger inflammatory response, thereby inducing atopic dermatitis. Prenatal and early childhood exposure to air pollution were associated with increasing incidence of atopic dermatitis in children. Acute exposure to high pollutant causes the increase of atopic dermatitis relapse. The prevalence of atopic dermatitis is also increasing in developing countries. Conclusion: This study concluded that air pollution may trigger or worsen the symptoms of atopic dermatitis. 
Wound Healing Potency of Edible Bird’s Nest Alysia, Jessica; Stella, Maureen Miracle; Widjaja, Maureen; Wijaya, Lorettha
Indonesian Journal of Global Health Research Vol 7 No 1 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i1.4065

Abstract

Edible bird's nest (EBN) or swiftlet's nest has recently been used extensively in regenerative medicine. This study aims to give a more thorough overview on the efficacy of EBN as a wound-healing agent. Method: We searched literature through several databases: Google Scholar, PubMed, Proquest, JSTOR, EBSCOhost, and SAGE. The keywords used were "bird nest, scar, wound healing" and their synonyms. The inclusion criteria were original articles written in English and assessed the effects of EBN in the wound healing process. We found 9 in vitro studies and 4 in vivo studies reporting wound healing effect of EBN, both macroscopically and microscopically. EBN could increase wound healing process through several mechanisms, such as cell proliferation, anti-oxidants, anti-inflammation, increased collagen synthesis, and tissue hydration. EBN has the potential to be used as a natural bioactive agent to increase the wound healing process.
Terapi Kombinasi Montelukast dan Desloratadin pada Pasien Urtikaria Akut yang Tidak Responsif dengan Antihistamin dan Kortikosteroid Regina, Regina; Wijaya, Lorettha; Stella, Maureen Miracle
Bahasa Indonesia Vol 24 No 1 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i1.3220

Abstract

Introduction: Urticaria is a common skin disease, characterized by localized edema that appears suddenly and disappears within 24 hours. Antihitamin-H1 is the drug of choice for urticaria which is sometimes combined with systemic corticosteroids. The use of montelukast in cases of urticaria is still rarely reported. Case Report: A 21-year-old woman came with complaint of itchy bumps all over her body with a dominant burning sensation since 5 days ago. Complaint remained unchanged even after administering up to four doses of desloratadine and a combination of 16 mg methylprednisolone. The complaint finally improved after the patient was given montelukast 10 mg per day combined with desloratadine 5 mg twice a day. Discussion: Leukotriene is a lipid mediator that can increase vasopermeability and vasodilation in the skin. The improvement in symptoms that occurred after the combination therapy of montelukast and desloratadine proved the involvement of leukotrienes in the pathogenesis of this patient's case of acute urticaria. Conclusion: Combination therapy with montelukast and desloratadine may be useful in some cases of acute urticaria. Further studies with sufficient control may be conducted to determine the effectiveness of montelukast in combination with antihistamines for cases of acute urticaria.  
Effects of Coffee Consumption on Acne Vulgaris Severity in Atma Jaya Medical Students in Jakarta, Indonesia Natasha, Tiffanie; Wijaya, Lorettha; Djuartina, Tena; Arieselia, Zita
Journal of Urban Health Research Vol. 3 No. 1 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i1.5467

Abstract

Introduction: Acne vulgaris is a common multifactorial skin disease. With diet as one of the possible factors, the rising habit of coffee consumption may have its own effects on acne. In present time, there is a lack of study between coffee consumption and acne vulgaris as well as the relationship between the two topics. This study aimed to analyze the effects of coffee consumption on acne severity. Methods: A cross-sectional study was conducted from September to December 2022 on 106 Atma Jaya medical students in Jakarta, Indonesia, who has acne and consumed coffee in the past month when the study was performed. The students were asked to fill a questionnaire about demographic and filtering questions along with questions about coffee consumption in the past month based on Diet History Questionnaire III (DHQ III). Acne lesion observations on the face, upper back, and chest were then performed on every individual to calculate acne severity based on Global Acne Grading System (GAGS). Results: Students who only drank black coffee tend to have lower acne severity score (mean±SD: 19.69±5.68) than those who drank coffee mixtures beverages (mean±SD: 25.41±5.11) (p-value<0.001). There was a significant negative correlation between acne severity scores and amount of black coffee consumed (p-value=0.001). On the other hand, there was a significant positive correlation between acne severity scores and amount of coffee mixtures beverages consumed (p-value<0.001). Conclusion: The results of this study show that the types and amount of coffee consumed had significant effects on acne vulgaris severity in medical students. Keywords: acne vulgaris - black coffee - coffee mixtures
Drug-induced hypersensitivity syndrome with liver injury due to phenytoin: A case report Wijaya, Lorettha; Adevita, Stella; Alvianto, Steven; Christiani, Yoseveline; Cahyadi, Alius; Yolanda, Raesa
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Drug-induced hypersensitivity syndrome (DIHS) is a rare and severe systemic drug reaction characterized by skin involvement, internal organ complications, and hematologic disorders. Management of this condition is challenging due to its wide range of cutaneous manifestations and 10% mortality rate. Case Illustration: A 52-year-old male presented with widespread redness throughout his body with a prior history of regular phenytoin consumption. The rash continued to spread despite the patient’s abrupt discontinuation of the suspected medication. He was diagnosed with atypical DIHS according to J-SCAR criteria and was given high-dose corticosteroid. Drastic clinical improvement was observed after nine days of therapy, and complete resolution of the rash was achieved after 14 days. The steroid was stopped after four weeks, and no relapse was observed after four months of follow-up. Discussion: Discontinuing the suspected medication is the first crucial step in DIHS management. No specific pharmaceutical strategy has been established for this syndrome; however, systemic corticosteroids have been frequently prescribed as a first-line therapy. Steroids need to be tapered off slowly over 6–8 weeks, even upon clinical resolution, to prevent relapse. In the current case, the steroid was tapered off slowly over four weeks. The lack of relapse observed after steroid discontinuation could be due to the fact that the patient stopped consuming the suspected medication immediately. Conclusion: Education on the consequences of prescribing high-risk medications is important. Early detection and prompt cessation of offending medications are needed for better DIHS outcomes.
Co-Authors ., Valencia Adevita, Stella Adji, Aryani Alexander, Leonardo Alius Cahyadi Alvianto, Steven Alysia, Jessica Arief Budiyanto Audrey Melanie Audrey Melanie Catherine Patricia Soetedjo Christiani, Yoseveline Dewantara, Jason Erwin Jawan Gabriela Christy Indwiani Astuti Lopulalan, Anastasya Anjeli Maria Clarissa Wiraputranto Mustofa Mustofa Natasha, Tiffanie Nurdjannah J. Niode Poppy Kristina Sasmita Putri, Devita Putri, Marcelina Grace Tjondro Raesa Yolanda, Raesa Regina Regina Regina Regina Stella, Maureen Miracle Tena Djuartina, Tena Veronica Veronica Widjaja, Maureen Wikanto, Jessica Rosemary Yonatan, Eric Ricardo Yunisa Astiarani Zita Arieselia