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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Kesehatan Keperawatan
Laela Hayu Nurani
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Other

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Efektivitas Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Sirih untuk Mempercepat Penyembuhan Luka Fase Proliferasi pada Model Mencit Diabetik Eka Sakti Wahyuningtyas; Nasruddin Nasruddin; Heni Setyowati Esti Rahayu; Heni Lutfiyati; Isabella Meliawati Sikumbang; Laela Hayu Nurani; Afiana Rohmani; Nia Salsabila; Gela Setya Ayu Putri
Jurnal Ilmiah Kesehatan Keperawatan Vol 15, No 2 (2019): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM UNIVERSITAS MUHAMMADIYAH GOMBONG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jikk.v15i2.378

Abstract

The continued increase in the number of people with Diabetes Mellitus (DM) in Indonesia is a serious problem. One of the big problems for people with Diabetes Mellitus (DM) is the emergence of complications of diabetic wounds. To date the strategy for treatment of diabetic wounds has been limited to the use of wound dressing, cell therapy and oxygen therapy. The problem is that the strategy is not fully successful. Thus, it is very important to look for new strategies to improve the quality of diabetic wound healing, such as by applying a combination of plasma medicine and local natural product, like the extraction of Daun sirih (Piper betle) leaves. Plasma medicine is a relatively new and multidisciplinary study involving plasma science, biomedical, pharmaceutical and other health sciences aimed at applying plasma to therapeutic health. Plasma is the fourth phase of matter, after the solid, liquid and gas phase. The medical aspects of plasma are related to the ability of plasma to produce biological molecules Reactive Oxygen and Nitrogen Species (RONS). If RONS is controlled in the right dosage it can be efficacious for health therapy. This study intends to examine the effects of combinative treatment of plasma medicine and Piper betel leaf extract for proliferation phase of wound healing in diabetic small animal model. This study used male Balb c mice with acute wounds which were divided into 5 groups, namely groups of untreated normal mice (ND-TP), groups of untreated diabetic mice (D-TP), groups of diabetic mice wounds with Piper betel leaf extract (DS ), the wound group of diabetic mice with plasma medicine (DP) and the wound group of diabetic mice with plasma medicine and Piper betel leaf (DPS). The plasma medicine was treated on wound with condition non-contact style (the plasma jet did not touch the wound) with a distance of plasma jet reactor nozzle to the surface of wound about 20 mm, for 2 minutes, every day. Macroscopic observation of wounds is carried out every day from day 0 to 7. On day 7 it was seen that the size of the wound area for D-P-S was smaller than the other groups. The results of this study indicated that Piper betel leaf extract can potentially be used to optimize the performance of plasma medicine in accelerating diabetic wound healing during the proliferation phase. Further investigation, however, is important to be conducted to study the effect for all phases of wound healing and its mechanism histo-pathologically.
Jatropha curcas L. Leaf Extract Effects on Blood Pressure and Lipid Levels in Hypertensive Rats with High-Fat Diet Moch. Saiful Bachri; Wiki Yuli Anita; Putri Dwi Lestari; Desi Eko Wulansari; Dwi Retno Nengtyas; Muhammad Ma'ruf; Sapto Yuliani; Wahyu Widyaningsih; Laela Hayu Nurani; Daru Estiningsih; Vivi Sofia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.61-70

Abstract

Background: One of the main risk factors for cardiovascular diseases such as coronary atherosclerotic heart disease (CAHD) is dyslipidaemia or high levels of low-density lipoprotein (LDL) and triglycerides (TG) and low levels of high-density lipoprotein (HDL). Hypertension is also a cause of cardiovascular disease. One potential plant to lower LDL levels and blood pressure is Jatropha curcas, which is known to contain saponins, polyphenols, and flavonoids. Objective: The purpose of this study was to determine the effect of the ethanol extract of Jatropha curcas leaves (EEJCL) on blood pressure, LDL levels, and HDL levels in hypertensive rats given a high-fat diet. Methods: This study is an experimental study with a pretest-posttest control group design on male Wistar strain rats. Rats were divided into seven groups, namely the normal group, control group (induced with NaCl and given a high-fat diet), Captopril group, Simvastatin group, and EEJCL groups given doses of 1.8, 2.7, and 4.05 g/kg BW. The data obtained were analysed using the One-Sample Kolmogorov-Smirnov Test, Homogeneity of Variance, One-Way ANOVA, and Tukey Test. Results: The results showed that the administration of EEJCL could significantly lower LDL levels and blood pressure and increase HDL levels (p < 0.05) at doses of 1.8, 2.7, and 4.05 g/kg BW, and the dose of 4.05 g/KgBW was the most optimal dose. Conclusion: EEJCL has a potential for development in the treatment of hypertension and dyslipidaemia.
STANDARISASI SIMPLISIA BAWANG DAYAK (Eleutherine bulbosa (Mill.) Urb) MELALUI ANALISIS PARAMETER SPESIFIK DAN NON-SPESIFIK Kaffah, Silmi; Silmi Kaffah; Moch. Saiful Bachri; Laela Hayu Nurani; Wahyu Widyaningsih; Muhammad Ma’ruf; Danang Prasetyaning Amukti
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2520

Abstract

Bawang dayak (Eleutherine bulbosa (Mill.) Urb) merupakan bahan alami berupa serbuk kering yang diperoleh dari umbi tanaman ini. Standardisasi sangat penting untuk memastikan konsistensi kualitas, keamanan, dan kemanjuran bagi konsumen. Tujuan penelitian ini adalah untuk mengevaluasi mutu bawang dayak yang diperoleh dari kota Sintang, Kalimantan Barat berdasarkan uji parameter spesifik dan non spesifik. Pengujian dilakukan dengan mengukur parameter non spesifik dan parameter spesifik. Hasil uji parameter non spesifik menunjukkan bahwa Simplisia memiliki kadar air sebesar 9,10%, kadar abu total 0,57%, dan kadar sari larut etanol 5,46%, menunjukkan stabilitas dan kemurnian yang baik. Uji parameter spesifik menunjukkan bahwa kandungan flavonoid total adalah 3,57 mg QE/g dan kandungan fenolik total adalah 2,05 mg GAE/g, yang menunjukkan potensi kapasitas antioksidan dan aktivitas farmakologis. Penelitian ini dapat disimpulkan bahwa umbi bawang dayak memenuhi standar mutu berdasarkan uji parameter spesifik dan non spesifik, layak digunakan sebagai bahan baku obat herbal. Penelitian lebih lanjut diperlukan untuk mengoptimalkan penggunaannya dalam formulasi farmasi.
Co-Authors Afiana Rohmani Danang Prasetyaning Amukti Daru Estiningsih Desi Eko Wulansari Dwi Retno Nengtyas Eka Sakti Wahyuningtyas Gela Setya Ayu Putri Heni Lutfiyati Heni Setyowati Esti Rahayu Isabella Meliawati Sikumbang Kaffah, Silmi Moch. Saiful Bachri Muhammad Ma'ruf Nasruddin Nasruddin Nia Salsabila Putri Dwi Lestari Sapto Yuliani Silmi Kaffah Vivi Sofia Wahyu Widyaningsih Wiki Yuli Anita