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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Pengabdian Masyarakat Tjut Nyak Dhien
Vivi Sofia
Universitas Tjut Nyak Dhien
Religion Chemistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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The relationship between NFκβ-p65 and PGE2 gene expression in osteoarthritis synoviocyte cells after mesenchymal stem cell Wharton Jelly Treatment Vivi Sofia
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1826.816 KB) | DOI: 10.12928/pharmaciana.v10i2.15926

Abstract

The genes involved in cartilage degradation in the pathogenesis of osteoarthritis ( OA) are the Nuclear Factor Kappa Beta (NFĸβ) gene, which plays a vital role in modulating cartilage damage involving activation of pro-inflammatory cytokines, including prostaglandin E2 (PGE2). This pure experimental research aimed at analyzing the relationship between the expression of NFĸβ genes after administration of mesenchymal stem cells in osteoarthritis synoviocytes in vitro from Wharton's Jelly (WJ-MSCs). The samples were isolated from synovial tissues of patients with osteoarthritis who underwent Total Knee Replacement (TKR) surgery and then divided into six treatment groups, each with four replicates. Groups I and II were the synoviocyte-control classes of 24h and 48h (synoviocytes, incubated for 24 and 48 hours respectively). Groups III and IV were control groups of 24h and 48h WJ-MSCs (mesenchymal stem cells derived from the Wharton's Jelly, incubated for 24 and 48 hours respectively). Finally, Groups V and VI were the 24-hour and 48-hour co-cultural treatment groups (synoviocyte co-culture and WJ-MSCs, Incubated, for 24 and 48 hours respectively). Using qPCR, PGE2 gene and NF NFκβ gene expressions were observed in each population. Tests showed 0.61 and 0.61, respectively, after the administration of WJ-MSCs, the expressions of the NFκβ-p65 and PGE2 genes in the 24h classes. In the 48h group, meanwhile, both numbers fell to 0.15 and 0.47, respectively. These indicate a strong correlation between the NFκβ-p65 gene and PGE2 gene expressions in OA synovial cells after the administration of MSC-WJ (r = 0.903).
PENGARUH NATTOKINASE TERHADAP DAYA KERJA Metformin HCl DALAM MENURUNKAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR M Sandila Okta; Vivi Sofia
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.502 KB) | DOI: 10.12928/pharmaciana.v3i1.420

Abstract

Interaction of modern drug and traditional drug is an issue that needs to beexamined, not least in the treatment of diabetes mellitus. Nattokinase is a nutraceuticalproduct that can be used in conjunction with antidiabetic oral drugs that allows theinteraction. This study aims to determine the effect of Nattokinase against their powerMetformin HCl in decreasing of blood glucose levels male white rats (Rattusnorvegicus) Wistar. This study uses an oral glucose tolerance test with glucose loadingdose of 4.5 g/kg. Animals test used were white male Wistar rats aged 2-3 monthsweighing 150-200 g, 20 rats were divided into 4 groups, each group consisted of 5 rats.Group I as a negative control group was given tween 80 - span 80, group II as a positivecontrol group was given metformin HCl doses of 45 mg/kg, group III was givenNattokinase dose 300 mg/kgBB, group IV given nattokinase 300 mg/kgBB 1 hour thenwere given metformin HCl. 30 minutes later all treatment of groups were given glucose.When treatment is considered as a time at-0. The given of glucose is considered as thetime at-30. Blood sampling via the tail at 0, 30, 60, 120, and 180. Blood glucose levelswas measured with the Easy Touch. The effect of decreasing blood glucose levelsindicated by the value of LDDK0-180 (Regional Area Under the Curve minute 0 tominute 180 of the graph time vs blood glucose levels). The data can be testedstatistically by Kruskal-Wallis and Mann Whitney with a level of 95%. The resultsshowed that administration of Metformin HCl after 1 hour administration Nattokinasecan be decreased 52.22% of Metformin HCl.
Jatropha curcas L. Leaf Extract Effects on Blood Pressure and Lipid Levels in Hypertensive Rats with High-Fat Diet Moch. Saiful Bachri; Wiki Yuli Anita; Putri Dwi Lestari; Desi Eko Wulansari; Dwi Retno Nengtyas; Muhammad Ma'ruf; Sapto Yuliani; Wahyu Widyaningsih; Laela Hayu Nurani; Daru Estiningsih; Vivi Sofia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.61-70

Abstract

Background: One of the main risk factors for cardiovascular diseases such as coronary atherosclerotic heart disease (CAHD) is dyslipidaemia or high levels of low-density lipoprotein (LDL) and triglycerides (TG) and low levels of high-density lipoprotein (HDL). Hypertension is also a cause of cardiovascular disease. One potential plant to lower LDL levels and blood pressure is Jatropha curcas, which is known to contain saponins, polyphenols, and flavonoids. Objective: The purpose of this study was to determine the effect of the ethanol extract of Jatropha curcas leaves (EEJCL) on blood pressure, LDL levels, and HDL levels in hypertensive rats given a high-fat diet. Methods: This study is an experimental study with a pretest-posttest control group design on male Wistar strain rats. Rats were divided into seven groups, namely the normal group, control group (induced with NaCl and given a high-fat diet), Captopril group, Simvastatin group, and EEJCL groups given doses of 1.8, 2.7, and 4.05 g/kg BW. The data obtained were analysed using the One-Sample Kolmogorov-Smirnov Test, Homogeneity of Variance, One-Way ANOVA, and Tukey Test. Results: The results showed that the administration of EEJCL could significantly lower LDL levels and blood pressure and increase HDL levels (p < 0.05) at doses of 1.8, 2.7, and 4.05 g/kg BW, and the dose of 4.05 g/KgBW was the most optimal dose. Conclusion: EEJCL has a potential for development in the treatment of hypertension and dyslipidaemia.
Penyuluhan DAGUSIBU Obat Sebagai Upaya Promotif Kesehatan Bagi Siswa-Siswi SMA Negeri 4 Medan Nilsya Febrika Zebua; Ernawaty Ginting; Yangie Dwi Marga Pinanga; Vivi Sofia; Nurul Karima
ABDIMASKU : Jurnal Pengabdian Masyarakat UTND Vol 3 No 1 (2024): Edisi Januari 2024 - Juni 2024
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/jpmtnd.v3i1.1013

Abstract

Pengetahuan tentang Dagusibu dikalangan remaja saat ini tergolong minim, mereka hanya menganggap bahwa apotek ataupun toko obat merupakan tempat mendapatkan obat, apakah itu golongan obat bebas, bebas terbatas, maupun obat keras, mereka menganggap tidak ada perbedaan diantara keduanya, selain itu pengetahuan tentang penyimpanan obat masih sangat minim mereka dapatkan, mereka menganggap penyimpanan obat dalam bentuk sirup harus disimpan di lemari pendingin. Kebiasaan ini masih saja terjadi, untuk pembuangan obat yang memiliki cara tersendiri juga masih minim diketahui dikalangan remaja, sehingga perlu dilakukan sosialisasi terhadap teknik Dagusibu (Dapatkan, Gunakan, Simpan, dan Buang Obat) dikalangan remaja dalam hal ini dilakukan terhadap siswa-siswa SMA Negeri 4 Medan. Metode pengabdian ini dilakukan secara ceramah, tanya jawab, dan kuesioner untuk menilai pemahaman siswa terkait dengan Dagusibu. Kegiatan ini diikuti oleh 35 orang siswa/i di SMA Negeri 4 Medan pada tanggal 08 November 2023. Pada kegiatan ini menunjukkan bahwa pengetahuan siswa/i di SMA Negeri 4 terkait dengan Dagusibu memiliki tingkatan pengetahuan yang baik, hal ini dapat dilihat dari hasil kuesioner yang dilakukan pada saat sebelum dilakukan sosialisasi dalam bentuk ceramah mengalami kenaikan rata-rata sekitar 19,58% yang awalnya sudah memiliki persentase yang tinggi secara berurut untuk pengetahuan tentang mendapatkan obat dari sumbernya sebanyak 70,7% menjadi 84,3%; menggunakan obat untuk penyakit yang tepat berkisar dari angka 64,8% menjadi 81,9%; menyimpan obat sesuai dengan bentuk sediaannya berkisar dari angka 58,1% menjadi 81,0% dan membuang obat dengan benar berkisar dari 55,2% menjadi 80,0%. Hal ini membuktikan bahwa tingkat pemahaman siswa/i SMA Negeri 4 Medan tentang Dagusibu sangat baik.
Edukasi Obat Generik Dan Obat Paten Untuk Ibu-Ibu Pengajian Masjid Jamik Medan Helvetia Nurul Karima; Nilsya Febrika Zebua; Nerdy Nerdy; Vivi Sofia; Kanne Dachi
ABDIMASKU : Jurnal Pengabdian Masyarakat UTND Vol 3 No 2 (2024): Edisi Juli 2024 - Desember 2024
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/jpmtnd.v3i2.1295

Abstract

Pengabdian masyarakat yang telah dilakukan bertujuan untuk meningkatkan pengetahuan masyarakat khususnya bagi ibu-ibu pengajian masjid jamik terkait dengan perbedaan obat generik dan obat paten. Pengabdian masyarakat dilaksanakan tanggal 10 Juni 2024 di dilakukan dengan cara memberikan edukasi dalam bentuk ceramah terkait perbedaan obat generik dan paten kepada 25 orang ibu pengajian masjid jamik, kecamatan Medan Helvetia, Sumatera Utara. Metode edukasi yang diberikan pemaparan materi dalam bentuk ceramah oleh dosen Universitas Tjut Nyak Dhien dan dilanjutkan dengan sesi tanya jawab. Hasil dari kegiatan pengabdian yang dilakukan bahwa sebagian besar ibu-ibu pengajian masjid jamik masih beranggapan bahwa penggunaan obat generik kurang efektif dibandingkan dari obat paten karena memiliki harga yang lebih mahal. Edukasi yang diberikan dapat meningkatkan pengetahuan bagi Ibu-ibu pengajian masjid jamik dan merubah anggapan mereka terhadap penggunaan obat generik dan obat paten.
Co-Authors Daru Estiningsih Desi Eko Wulansari Dwi Retno Nengtyas Ernawaty Ginting Kanne Dachi Laela Hayu Nurani M Sandila Okta Moch. Saiful Bachri Muhammad Ma'ruf Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Nurul karima Putri Dwi Lestari Sapto Yuliani Wahyu Widyaningsih Wiki Yuli Anita Yangie Dwi Marga Pinanga