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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Cahaya Mandalika Humantech : Jurnal Ilmiah Multidisiplin Indonesia Prosiding Workshop dan Seminar Nasional Farmasi (WSNF) Scientific Journal of Dermatology and Venereology
Eka Indra Setyawan
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Formulation and Effectiveness Test of 96% Ethanol Extract Anti-Acne Serum Cashew Leaves (Anacardium occidentale L.) Mc Seer, Raysha; Rini Dwiastuti; Eka Indra Setyawan
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.99

Abstract

Introduction: Recently, the use of cosmetics to cure acne made from natural ingredients can have a good effect. Cosmetic preparations that are currently developing rapidly are serum preparations because they have better effects, and the moisturizing technology used is based on skin physiology. The natural ingredient in question is cashew leaves, which treat acne caused by Propionibacterium acnes. This research aims to obtain a serum preparation of cashew leaf extract to determine its effectiveness against P. acne and optimize the two ingredients, namely carbopol and triethanolamine (TEA) so that the serum preparation has physical stability that meets predetermined standards. Methods: This research is pure experimental research of a qualitative nature to obtain a serum preparation of cashew leaf extract with effectiveness as an anti-acne and using the factorial design method with the optimization factor for carbopol concentration comparison as a gelling agent and TEA as an alkalizing agent. The physical property parameters observed as a response to the equation are spreadability and viscosity using two-way statistical tests, ANOVA, with IBM SPSS statistics 29.0.1.0 software. Results: The research results obtained indicate the effectiveness of cashew leaf extract serum preparations against bacteria, such as Propionibacterium acnes. Apart from that, there is no significant difference between the formulas in the spreadability parameters, which means there is no influence from variations in carbopol and TEA concentrations on the physical evaluation of spreadability. Meanwhile, there are significant differences between the formulas in the viscosity parameters, there is an influence of variations in the concentration of carbopol and TEA on the physical evaluation of viscosity. Conclusion: Cashew leaf extract serum preparations are effective in treating bacteria Propionibacterium acnes, the cause of acne.
TINJAUAN SISTEMATIS: PENGARUH TOCILIZUMAB TERHADAP FUNGSI LIPOPROTEIN PADA PASIEN RHEUMATOID ARTRITIS DENGAN RESIKO KARDIOVASKULAR Ni Wayan, Antika Sri Devi; I Nyoman Arya Nugraha Wicaksana; Made Ary Sarasmita; Eka Indra Setyawan
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 6 No. 3 (2025)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v6i3.4375

Abstract

Rheumatoid arthritis (RA) merupakan penyakit autoimun yang dapat meningkatkan risiko kardiovaskular dan pengobatan dengan Tocilizumab telah menunjukkan potensi dalam memodulasi fungsi lipoprotein. Penelitian ini bertujuan untuk mengevaluasi pengaruh Tocilizumab terhadap fungsi lipoprotein pada pasien RA dengan risiko kardiovaskular. Tinjauan sistematis ini dilakukan dengan mengikuti pedoman pelaporan sistematis untuk tinjauan dan meta-analisis (PRISMA). Proses penelitian meliputi identifikasi, seleksi, dan analisis data dari berbagai studi yang relevan. Hasil analisis menunjukkan bahwa Tocilizumab dapat berkontribusi dalam perbaikan profil lipoprotein dan mengurangi parameter inflamasi pada pasien RA yang berpotensi menurunkan risiko kardiovaskular. Tocilizumab menunjukkan efek positif terhadap fungsi lipoprotein pada pasien dengan rheumatoid arthritis yang berisiko kardiovaskular. Temuan ini mendukung penggunaan Tocilizumab sebagai terapi yang tidak hanya mengatasi gejala RA, tetapi juga berkontribusi pada pengelolaan risiko kardiovaskular. Penelitian lebih lanjut diperlukan untuk memahami mekanisme yang mendasari efek ini dan untuk mengeksplorasi implikasi klinisnya.
The Pharmacokinetics of Single-Inhaler Triple Therapy in COPD: A Systematic Reviews Arenawati, Sang Ayu Made; Dharmanta, I Nyoman Dwika; Made Ary Sarasmita; Eka Indra Setyawan; Luh Putu Mirah Kusuma Dewi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17960

Abstract

Background: The integration of inhaled corticosteroids, long-acting -agonists, and long-acting muscarinic antagonists into a fixed-dose Single Inhaler Triple Therapy (SITT) represents a pivotal strategy for managing chronic obstructive pulmonary disease (COPD) in patients with persistent symptomatology or frequent exacerbations. Despite the proven clinical efficacy of SITT, data regarding its pharmacokinetic properties across both healthy volunteers and the COPD population appear disjointed, warranting a comprehensive synthesis. Methods: We executed a systematic review following the PRISMA 2020 framework. A rigorous search of electronic databases was undertaken to retrieve clinical and population pharmacokinetic trials examining SITT. Articles were screened against specific inclusion criteria, and methodological quality was scrutinised using standard risk-of-bias instruments. Data synthesis was performed narratively, prioritizing essential pharmacokinetic indicators. Results: The review consolidated data on key metrics, specifically peak plasma concentrations, total systemic exposure, and time to peak. The analysis revealed that systemic bioavailability of the triple combination components is bioequivalent to that of their respective mono- or dual-therapy formulations. Furthermore, no significant drug accumulation was detected following multiple doses. Variations in pharmacokinetic behavior were predominantly linked to patient demographics, disease severity, and inhaler handling proficiency. Conclusion: SITT exhibits a consistent and predictable pharmacokinetic profile characterized by low systemic exposure in both healthy individuals and patients with COPD. These insights reinforce the pharmacological stability and therapeutic viability of single-inhaler regimens in clinical practice.
Co-Authors Arenawati, Sang Ayu Made Damayanti, Novi Amna Dharmanta, I Nyoman Dwika Diah Mawarni Fitriari G. A. Desya Pradnyaswari Gusti Ayu Dian Ratna Dewi I Gusti Ngurah Agung Dewantara Putra I Nyoman Arya Nugraha Wicaksana Izzul Ishfahan Komang Dian Aditya Putra Luh Putu Mirah Kusuma Dewi Mahaswari, Anak Agung Istri Rani Mamarimbing, Merlyn Santa Mc Seer, Raysha Naripradnya, Putu Saradevi Ni Made Ary Sarasmita Ni Wayan, Antika Sri Devi Pande Putu Ayu Laksmi Dewi Pratiwi, Elsa Nanda Ayu Rini Dwiastuti