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All Journal Jurnal Kedokteran Diponegoro Media Medika Muda
Fathur Nur Kholis
Department Of Internal Medicine, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Medicine & Pharmacology

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Air Pollution Exposure and Physical Exhaustion in Relation to GSH:GSSG Ratio of Online-Based Motorcycle Drivers Nabilla Nurcahya Junior; Dodik Pramono; Fathur Nur Kholis; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.33245

Abstract

Background: Online motorcycle drivers work more than 10 hours a day, surpassing the international working hour regulations. Working hours are directly proportional to air pollution exposure generating reactive oxygen species (ROS). On the other hand, physical exercise also contributes to the generation of ROS due to greater oxygen utilization by mitochondria. The ratio of GSH to GSSG represents the oxidative stress level in body tissues.Objective: This study aimed to analyze the relationship between the length of air pollution exposure and the level of physical exhaustion to GSH:GSSG ratio of online motorcycle drivers.Methods: This research was a cross-sectional study of 16 male online motorcycle drivers. The GSH:GSSG ratio was assessed by ELISA with cyclic DTNB reaction principle. Length of air pollution exposure and level of physical exhaustion data were obtained from the interview. Statistical analysis was done to determine the correlation between variables.Results: The mean GSH:GSSG ratio in studied population is 0.69 ± 0.26, lower than 1 value of GSH:GSSG ratio represents high oxidative stress condition. Based on the correlation test, there are no correlation between length of air pollution exposure (r = -0.464, p = 0.070) and level of physical exhaustion (r = -0.439, p = 0.089) to GSH:GSSG ratio in online motorcycle drivers.Conclusion: Our findings suggested that online motorcycle drivers have a high level of oxidative stress, length of air pollution exposure, and status of physical exhaustion, which is not associated with the GSH:GSSG ratio.
Effects of Garcinia Mangostana Linn Pericarp Extract and Physical Exercise on Atheroembolic Histopathologic Features Kidney in Wistar Rats with Metabolic Syndrome Perdana, Evangga Yudha; Miranti, Ika Pawitra; Kholis, Fathur Nur; Wijayahadi, Noor; Setiawan, Andreas Arie
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42578

Abstract

Background: Renal atheroembolism is an under-recognized cause of renal failure. Atheroembolism is caused by cholesterol crystals from ulcerated atherosclerotic plaques and is influenced by inflammation and endothelial dysfunction. The formation of complicated atherosclerotic lesions is a prerequisite for the development of cholesterol crystal emboli. The exact incidence of atheroembolism remains unclear due to frequent underdiagnosis. In a previous report, the rate of embolism in the kidney among patients dying after surgery for acute atherosclerosis of the aorta was 77%. Non-pharmacological therapeutic management (such as diet and physical exercise) is an important factor in preventing and reducing the risk of atherogenesis. Prior research suggests that controlling body weight, primarily through physical exercise, is a critical factor in preventing and reducing the risk of atherogenesis, in addition to medication adherence and other therapeutic management alternatives. Another study found that mice with metabolic syndrome given Garcinia mangostana pericarp can reduce inflammatory cell infiltration, thereby reducing physiological symptoms, metabolic syndrome, liver disorders, and cardiovascular symptoms. The combination of physical exercise and metabolic supplements in the treatment was even able to significantly reduce atheroma plaque area as well as the incidence of plaque rupture, and prolong survival time. Objective: To investigate the effect of Garcinia Mangostana Linn Pericarp administration along with Physical Exercise on the histopathologic features of renal atheroembolism in Wistar rats with metabolic syndrome. Methods: This study is a true experimental study with research subjects in the form of male Rattus norvegicus Wistar rats which were randomly divided into 3 groups. All groups were induced metabolic syndrome through the administration of a diet similar to the "Western" purified atherogenic diet patent Envigo® formulated as a high fat diet (20 - 23% BW; 40 - 45% kcal from fat), saturated fatty acids (SFA >60% of total fatty acids), and drinking tap water ad libitum. However, in group K (no additional treatment), P1 (garcinia pericarp extract 800 mg / kg / day with physical exercise), and P2 (nanoemulsion garcinia pericarp extract 50 mg / kg / time of administration with physical exercise). Results: In the group treated with garcinia pericarp extract 800 mg/kg bw/day with physical exercise and the group with nanoemulsion 50 mg/kg bw/day with physical exercise, there were no fatty streaks, inflammation, and impaired myocyte coherence. There was 0-5% fibrous connective tissue, one layer of foam cell layer and myocyte-lipid, no cholesterol crystal embolism was found. Conclusion: The administration of Garcinia Mangostana Linn pericarp extract and/or nanoemulsion with physical exercise can have an effect on the histopathological picture of the kidneys of Wistar rats with metabolic syndrome, although there was no difference in effect between the two treatments.
Co-Authors Agus Layanto Amelia, Sesa Andreas Arie Setiawan, Andreas Arie Ayudyah Nurani Bernardus Parish Budiono Charles Limantoro Djuara P Lubis Dodik Pramono Dwi Lestari Partiningrum Dwi Ngestiningsih Fanti Saktini Felicia Angga Putriani Friska Anggraini Helena Silitonga Hariyana, Bambang Ika Pawitra Miranti Ivona Oliviera Josephine Natalie K. Heri Nugroho HS, K. Heri Ksatriaputra, Alesandro Lusiana Batubara Muhammad Agung Wibowo Wicaksono Nabilla Nurcahya Junior Noor Wijayahadi Nugroho, Trilaksana Nurul Eka Putri Nyoman Suci Widyastiti Perdana, Evangga Yudha Rakhma Yanti Hellmi Sofyan Rais Addin Valencia Fabiana Yosef Purwoko