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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan El-Hayah : Jurnal Biologi STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Health Notions Journal Of Vocational Health Studies Padjadjaran Journal of Dental Researchers and Students
Amandia Dewi Permana Shita
Fakurtas Kedokteran Gigi Universitas Jember Jl Kalimantan 37 Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Hafiedz Maulana; Nuzulul Hikmah; Amandia Dewi permana Shita; Nur Permatasari; Sri Widyarti
Journal of Tropical Life Science Vol. 4 No. 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.
Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Nuzulul Hikmah; Amandia Dewi Permana Shita; Hafiedz Maulana
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL ≥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).
Uji antibakteri ekstrak daun singkong (manihot esculenta crantz) terhadap fusobacterium nucleatum dan aggregatibacter actinomycetemcomitans Antibacterial activity test of cassava leaves extract (manihot esculenta crantz) against fusobacterium nucleatum and aggregatibacter actinomycetemcomitans Zahara Meilawaty; Amandia Dewi Permana Shita; Rendra Chriestedy Prasetya; Agustin Wulan Suci Dharmayanti; Rido Tri Andika Firdyansyach; Dhea Ayu Dewanti
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 3 (2022): Desember 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i3.37875

Abstract

ABSTRAKPendahuluan: Prevalensi periodontitis di Indonesia masih terbilang tinggi. Data Riskesdas 2018 menunjukkan persentase kasus periodontitis di Indonesia sebesar 74,1%. Periodontitis merupakan penyakit inflamasi pada jaringan periodontal yang disebabkan oleh mikroorganisme spesifik seperti Fusobacterium nucleatum dan Aggregatibacter actinomycetemcomitans. Perawatan suportif menggunakan antibiotik, seperti metronidazole, diperlukan dalam perawatan periodontitis tetapi penggunaan antibiotik dapat memberikan efek samping sehingga perlu digantikan oleh tanaman herbal yang memiliki efek samping minimal, yaitu daun singkong (Manihot esculenta crantz). Penelitian ini bertujuan untuk menganalisis daya antibakteri ekstrak daun singkong terhadap Fusobacterium nucleatum dan Aggregatibacter actinomycetemcomitans. Metode: Jenis penelitian in vitro experimental laboratories dengan rancangan penelitian post test only control group design. Daun singkong yang sudah teridentifikasi di ekstrak dengan metode maserasi. Ekstrak kasar yang didapatkan kemudian dijadikan ke dalam beberapa dosis (6,25; 12,5; 25; 50; 100; dan 200 µg/mL). Kelompok dosis tersebut kemudian diuji menggunakan metode disk diffusion dan dibandingkan dengan kontrol positif yaitu metronidazole dan kontrol negatif yaitu propilen glikol.Data hasil penelitian diuji normalitasnya menggunakan uji Shapiro Wilk dan uji homogenitas menggunakan Levene test. Selanjutnya dilakukan uji Mann Whitney untuk melihat perbedaan antara dua kelompok sampel. Hasil: Terdapat zona jernih pada sekeliling kertas cakram dengan ekstrak daun singkong dosis 200 µg/mL yang menandakan adanya hambatan pertumbuhan dari F. nucleatum dan A. actinomycetemcomitans. Hasil statistik terlihat adanya perbedaan yang bermakna antara kelompok ekstrak daun singkong dosis 200 µg/mL dan kontrol positif (p=0,009) untuk F. Nucleatum, dan p=0,05 untuk A. actinomycetemcomitans. Simpulan: Ekstrak daun singkong dapat menghambat pertumbuhan dari F. nucleatum dan A. actinomycetemcomitans.Kata kunci: ekstrak daun singkong; fusobacterium nucleatum; aggregatibacter actinomycetemcomitans; antibakteriABSTRACTIntroduction: The prevalence of periodontitis in Indonesia is relatively high. The 2018 RISKESDAS data shows that the percentage of periodontitis cases in Indonesia is 74.1%. Periodontitis is an inflammatory disease of the periodontal tissue caused by specific microorganisms or groups of microorganisms such as Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. Supportive care using antibiotics, such as metronidazole, is required to treat periodontitis. However, antibiotics can have side effects, so they need to be replaced by herbal plants with minimal side effects, namely cassava leaves (Manihot esculenta Crantz). This study aims to analyze the antibacterial effect of cassava leaf extract against Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. Methods: This study was an in vitro laboratory experimental study with a post-test only control group design. The identified cassava leaves were extracted by the maceration method. The crude extract obtained was then made into several doses. The dose group was then tested using the disk diffusion method and compared with the positive control, metronidazole, and the negative control, propylene glycol.The research data were tested for normality using the Shapiro Wilk test and the homogeneity test using the Levene test. Then the Mann Whitney test was carried out to see the difference between the two sample groups Results: The results showed a clear zone around the disc paper with a 200 µg/ml dose of cassava leaf extract, which indicates the growth inhibition of F. nucleatum and A. actinomycetemcomitans. The statistical results showed a significant difference between the 200 µg/ml group and the positive control(p= 0,009 for F. Nucleatum; p=0,05 for A. actinomycetemcomitans). Conclusion: Cassava leaves extract can inhibit the growth of F. nucleatum and A. actinomycetemcomitans.Keywords: cassava leaf extract; fusobacterium nucleatum; aggregatibacter actinomycetemcomitans; antibacterial 
Radiographic analysis of teeth calcification of breastfed rat cubs of mothers consuming excessive Arabica coffee Apriyono, Dwi Kartika; Shita, Amandia Dewi Permana; Fatimatuzzahro, Nadie; Prasetya, Rendra Chriestedy; Umaimah, Ulfa
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.80243

Abstract

Lack of nutrient intake, especially calcium, can inhibit tooth development because calcium is the major component of the inorganic material that forms enamel and dentin. Caffeine in coffee can decrease calcium levels in the body. Arabica coffee has a very high caffeine content compared to other types of coffee. Excessive caffeine consumption can cause the inhibition of PTH secretion. As a result, the nursing mother's body cannot absorb calcium optimally. This makes the baby lack calcium intake which is used for the dental calcification process. This study analyzes radiographic images of tooth calcification of rat cubs during lactation period from rat mothers which consumed excess doses of Arabica coffee. Forty-eight breastfeeding rat mothers (n = 48) were divided into a control group and a treatment group. The control group consisted of 24 rat mothers that were given aquadest. The treatment group consisted of 24 nursing rat mothers, which were given coffee orally at a dose of 2.7 grams/200 grams/day. After the rat mothers gave birth (H + 1 to H + 18), every 4 rat cubs were euthanized, then the mandibular bones were X-rayed. Dental calcification was viewed and analyzed based on radiographic images. The teeth of rat cubs whose mothers consumed excess doses of Arabica coffee experienced a delay in the calcification stage compared to the teeth of normal rat cubs. Consumption of Arabica coffee by nursing mothers can cause a delay in the stage of dental calcification in rat cubs.
The potential of cassava leaves extract in gingival fibroblasts of periodontitis of rats with ovarian dysfunction Shita, Amandia Dewi Permana; Meilawaty, Zahara; Rothschildi, Dhesyarmani Putri; Dharmayanti, Agustin Wulan Suci; Hamzah, Zahreni
Padjadjaran Journal of Dentistry Vol 33, No 3 (2021): November
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no3.29611

Abstract

Introduction: The prevalence of periodontitis has reached 42.8% in Indonesia. One contributing factor is Porphyromonas gingivalis. The ovarian dysfunction caused by ovariectomy procedures may also cause periodontitis. Post ovariectomy conditions resemble menopause, lowering the production of estrogen and progesterone hormones, leaving patients vulnerable to periodontitis. To prevent the side effects of the treatment, herbal ingredients are commonly used. The extract of cassava leaves is known to have pharmacological effects as an antioxidant and, thus, can be applied as a medicine for periodontitis.      Methods: A total of 21 rats were divided into three groups, (1) control: healthy rats; (2) Group P.1: P. gingivalis-induced rats; (3) Group P.2: ovariectomized rats. Groups P.1 and P.2 were further divided into three subgroups that were administered cassava leaves extract at a dosage of 179.2 mg/ kg BW, aquades and vitamin C. Rats were euthanized at day eight after the initial treatment to collect left mandibular first molar. The mandibular sections were immunohistochemically stained to quantify SOD expression using light microscope while the Image J software was used. Fibroblast cells expressing SOD are characterized by brown coloration in the cytoplasm and darker nucleus. Results: In periodontitis conditions, either due to P.gingivalis induction or ovarian dysfunction, fibroblast cells in rats given cassava leaves extract expressed higher SOD than rats given aquades, but still lower than rats given vitamin C. The result of the one way ANOVA test showed p value of 0,00, which means that there is a significant difference in all groups. Conclusion: Cassava leaves extract demonstrated the potential to increase the antioxidant expression in P. gingivalis-induced and ovarian dysfunction rats.
Inhibition of namnam (Cynometra cauliflora L.) leaves extract on the growth of Porphyromonas gingivalis Ulpiyah, Zakiyya; Shita, Amandia Dewi Permana; Wahyukundari, Melok Aris
Padjadjaran Journal of Dentistry Vol 31, No 2 (2019): July 2019
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.961 KB) | DOI: 10.24198/pjd.vol31no2.18540

Abstract

Introduction: Porphyromonas gingivalis growth should be prevented to minimise inflammation in periodontal tissues. Antibacterial herbs need to be considered because there are side effects caused by synthetic antibacterial drugs. Namnam (Cynometra cauliflora L.) leaves are known for having antibacterial effects. The purpose of this research was analysing the inhibition potential, and the highest inhibition concentration of namnam leaves extract on the growth of Porphyromonas gingivalis. Methods: 24 samples were divided into 6 groups. The positive control group was given 0.2% chlorhexidine, and the treatment group was given various concentrations (100%, 80%, 60%, 40%, and 20%) of namnam leaves extract. The disc which spilled by various concentrations of namnam leaves extracts and 0.2% chlorhexidine was placed on a medium which has been inoculated by P. gingivalis, then incubated at 37ºC for 48 hours. The inhibition zone was measured using a vernier calliper. Results: The concentration of 100% had the highest average inhibition zone value, which was 11.43 mm. The content in namnam leaves extracts which serve as antibacterial were tannins, flavonoids, triterpenoids, saponins and quinones. Conclusion: Namnam leaves extract can inhibit the growth of P. gingivalis. 100% of namnam leaves extract has the highest antibacterial inhibition zone.Keywords: Antibacterial, Namnam leaves extract, periodontal disease, Porphyromonas gingivalis
MANDIBULAR RADIOGRAPHIC ANALYSIS FOR GENDER DETERMINATION OF DOWN SYNDROME SUFFERERS Rendra Chriestedy Prasetya; Amandia Dewi Permana Shita; Nadie Fatimatuzzahro; Nuzulul Hikmah; Hafiedz Maulana; Indonesia Koes Wijayaningrat; Adinda Febriyanti; Dwi Kartika Apriyono
Journal of Vocational Health Studies Vol. 9 No. 2 (2025): November 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I2.2025.130-138

Abstract

Background: Natural disasters frequently occur in Indonesia, creating a need for effective victim identification. Gender identification is a crucial initial step, as it can narrow the search space by 50% during individual identification. The corpus and ramus mandible are an organ that plays an important role in gender prediction with a high predictive accuracy. However, the Down syndrome mandibular size is different from that of normal people. Purpose: To analyze the difference in corpus length and total height of the mandibular ramus between individuals with down syndrome and those without, as a step to gender determination. Method: This observational cross-sectional study involved 12 individuals with down syndrome and 12 individuals without, aged 10 – 17 years. The mandibular corpus length was measured through panoramic radiography from the gonion to the menton point. The mandibular ramus was measured from the apex of the condyle to the gonion point using the Clinicview application. Data were analyzed using the T-test with SPSS Ver. 26 software. Result: The length of the mandibular corpus differs significantly (p-value = 0.000) between Down syndrome with normal people. The length of the mandibular corpus in down syndrome does not differ significantly (p-value > 0.000) between males and females. The total height of the mandibular ramus does not differ significantly between down syndrome and non-down syndrome groups, both in males and females. Conclusion: The corpus length and the mandibular ramus's total height cannot be used as indicators of gender determination in down syndrome.
Co-Authors Adinda Febriyanti Agustin Wulan Suci Dharmayanti Ari Tri Wanodyo Handayani Dhea Ayu Dewanti Dwi Kartika Apriyono Dyah Indartin Setyowati Hafiedz Maulana Indonesia Koes Wijayaningrat Lutfi Meiga Sari Luthfia Choirunnisa Melok Aris Wahyukundari, Melok Aris Muflikhah, Dewi Muhamad Martin Widayat Nadie Fatimatuzzahro Nungky Tias Susanti Nur Permatasari Nur Permatasari Nuzulul Hikmah Oktavia Nur Vitasari Paramudibta Lungit Kuncaraningtyas Pudji Astuti PUDJI ASTUTI Purwanto Purwanto Rendra Chriestedy Prasetya Rido Tri Andika Firdyansyach Rothschildi, Dhesyarmani Putri Shabrina Widya Ardiningrum Sri Widyarti Sulistyani Sulistyani Sulistyani Sulistyani Swasthi Prasetyarini Tecky Indriana Ulpiyah, Zakiyya Umaimah, Ulfa Zahara Meilawaty Zahreni Hamzah