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All Journal PHARMACON JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Journal of Asean Studies on Maritime Issues Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ The Studies of Social Sciences Jurnal Lentera Farma
Defny Silvia Wewengkang
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Journal : PHARMACON

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ALGA Halimeda opuntia DARI PERAIRAN DESA POOPOH KABUPATEN MINAHASA Bryan Andrew Tikonuwu; Defny Silvia Wewengkang; Erladys Rumondor
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49364

Abstract

Halimeda opuntia is a genus of seaweed from the Chlorophyta division that contains bioactive compounds that can be utilized in various fields, especially in medicine. This study was conducted with the aim of determining the antibacterial activity of Halimeda opuntia algae extracts obtained from coastal waters of Poopoh Village, Tombariri District, Minahasa Regency against Pseudomonas aeruginosa and Staphylococcus aureus bacteria. Samples were extracted by maceration method using 95% ethanol solvent. Antibacterial activity testing was conducted using the Kirby and Bauer Disc Diffusion method. The results showed that the average diameter of the inhibition zone against Pseudomonas aeruginosa test bacteria was 6.83 mm and for Staphylococcus aureus test bacteria was 8.58 mm, the inhibition zone that arose against these two bacteria was included in the medium inhibition category. Through this study, it can be concluded that ethanol extract has antibacterial activity against test bacteria, especially on Staphylococcus aureus bacteria. Keywords: Algae, Halimeda opuntia, antibacterial activity, Pseudomonas aeruginosa, Staphylococcus aureus
Uji Potensi Antibakteri Ekstrak Spons Stylissa carteri dari Perairan Poopoh Minahasa Terhadap Bakteri Staphylococcus aureus dan Pseudomonas aeruginosa.: Antibacterial Potential Test Of Stylissa Carteri Sponge Extract From Poopoh Minahasa Waters Against Staphylococcus aureus And Pseudomonas aeruginosa Bacteria. Chelinda Tumundo; Defny Silvia Wewengkang; Jumriadi Jumriadi
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49697

Abstract

Kejadian resistensi antibiotik berdampak pada kegagalan pengobatan penyakit infeksi yang dapat berujung pada kematian. Dengan adanya kegagalan pada pengobatan infeksi maka pemilihan terapi akan terbatas, sehingga diperlukan penelusuran terhadap senyawa baru yang berpotensi sebagai antibakteri. Indonesia memiliki biota laut yang sangat melimpah salah satunya spons yang kaya akan senyawa bioaktif yang berpotensi dikembangkan dalam bidang pengobatan sebagai antibakteri. Penelitian ini bertujuan untuk menguji potensi antibakteri dari ekstrak spons Stylissa carteri terhadap bakteri Staphylococcus aureus dan Pseudomonas aeruginosa. Proses maserasi menggunakan etanol 95% sebagai pelarut. Hasil maserat selanjutnya di evaporasi menggunakan suhu 40°C. Pengujian aktivitas antibakteri menggunakan metode difusi agar (Disc Diffusion Kirby Bauer Method). Hasil penelitian menunjukkan bahwa hasil pengukuran rata-rata diameter zona hambat dari ekstrak spons Stylissa carteri pada bakteri Staphylococcus aureus adalah 7,75 mm dan pada bakteri Pseudomonas aeruginosa dengan nilai sebesar 7,25 mm. Dari hasil pengujian aktivitas antibakteri ekstrak spons Stylissa carteri menunjukkan adanya aktivitas antibakteri dengan kategori sedang terhadap bakteri uji. Kata Kunci : Spons Stylissa carteri, Antibakteri, Staphylococcus aureus, Pseudomonas aeruginosa.
Investigating the antibacterial activity of sponge extract Callyspongia aerizusa from the waters of Parentek Beach, Lembone East District, Minahasa Regency Christania Sigarlaki; Defny Silvia Wewengkang; Gerald Edward Rundengan
PHARMACON Vol. 13 No. 3 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55211

Abstract

Callyspongia aerizusa is one type of sponge that grows in the waters of Indonesia, like sponges in general, this species has a porous body and a hard surface like stone. In addition, C. aerizusa can also absorb oxygen from water through the diffusion process. This study aims to determine whether there is antibacterial activity of C. aerizusa sponge extract from Parentek Beach Waters, East Lembean District, Minahasa Regency. This study uses the agar diffusion method (Kirby Bauer diffusion dics) and will see the inhibition zone that will be generated based on its category. Based on the results of the research, C. aerizusa sponge extract has a diameter of inhibition zone produced, namely on Staphylococcus aureus bacteria 8 mm in a concentration of 250 ug and for Eschericia coli bacteria it has no inhibition zone produced
Antibacterial Activity Test of Lissoclinum patella Extract Obtained from the Coastal Waters of Parentek Village, East Lembean District, Minahasa Regency Kiwol, Hilda; Wewengkang, Defny; Rumondor, Erladys
PHARMACON Vol. 13 No. 3 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55990

Abstract

Ascidians are a class of marine tunicates that are included in marine invertebrate organisms. Tunicates (Ascidian) are animals included in the subphylum Urochordata, which have a small bag-like body shape and generally live in marine waters. The body of this animal is covered by a coat (tunic) formed from protein and polysaccharide compounds. This study aims to determine the antibacterial activity of ethanol extract of ascidian Lissoclinum patella against the growth of Staphylococcus aureus and Escherichia coli bacteria. Extraction uses maceration method to extract active compounds from ascidian Lissoclinum patella. The results of the extract were tested whether there was antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria, the test used the Kirby-Bauer agar diffusion method. The results of the test showed antibacterial activity with a marked inhibition zone around the disc paper of the extract test solution on Staphylococcus aureus bacteria with a medium inhibition zone diameter of 7.6 mm and Escherichia coli bacteria with a medium inhibition zone diameter of 6.3 mm.
Co-Authors Abdullah, Surya Sumantri Adithya Yudistira Adrian, Gerild Alfiani Idie Amanda, Turangan Angellia Grace Yetto Anjelina Preysi Wenas, Glori Antasionasti, Irma Atuani, Maria Atuani, Maria T Ayu Widiyani, I Dewa Bawole, Avinda Shania Wiane Brian G. A. Adilan Brigita Putri Tumbelaka Bryan Andrew Tikonuwu Butue, Leobernard Carolus Paulus Paruntu Chelinda Tumundo Chrispawanty Cindhy Ranggatau Christania Sigarlaki Damanis, Frelinsia V.M. DEBY AFRIANI MPILA Deiske Adeliene Sumilat, Deiske Adeliene Diana Graselia Maniagasi Djakatara, Ridwan S. Djakatara, Ridwan Sukardi Eda, Mochamad I. Edi Suryanto Eka Laurensi Awaeh Elly Suoth Erladys M. Rumondor Erladys Melindah Rumondor ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Erladys Rumondor Erladys Rumondor Fatimawali . Gayatri Citraningtyas Gerald Edward Rundengan Gleam Yordan Henki Rotinsulu, Henki Herny E.I. Simbala Hutahaean, Amsaline Idie, Alfiani Ikhrar, Muhammad S. Ikhrar, Muhammad Setiawan Irma Antasionasti Jainer Siampa Jayanto, Imam Jolanda, Shinta Jordan Pangemanan, Christian Josua, Endro Julianri Lebang Julianri Sari Lebang Jumriadi Kantor, Renatry Karlah L. R. Mansauda Katiandagho, Lyone Katili, Syifa Sari Katili, Yuni Irianty Keintjem, Brigieta Kevin R. Mengko Kindangen, Eunike Elizabeth Kiwol, Hilda Komang Ayu May Widyani Kotel, Marcelinda Kotel, Marcelinda N. Latif, Rizky Latif, Rizky Akbar Lintogareng, Anggretsya Lisi, Anastasia Kazia Friany Lonteng, Elur Luntungan, Brigita Michelle Ma'ati, Carlene Macpal, Fransisca Madi, Eveline Manoppo, Cinlye Manoppo, Cinlye J Manoppo, Triska Manumpil, Aprilia Max R.J. Runtuwene Max Runtuwene Meilani Jayanti Meldha, Meldha Natalie D Rumampuk Paat, Englin Meiva Patinggi, Christina Pelealu, Eunike Pitoy, Novia Pitoy, Novia A. Ritan, Yosefa E.H. Rumondor, Erladys Sandrina Sibara, Syalomita Shartika Alda Trivena Rompas Siampa, Jainer Pasca Silap, Gloria Ekaputri Sitti Juliah Nurhamidin Sri Sudewi, Sri Sumare, Chika Wanda Suoth, Josua Suoth, Josua A.T. Tumengkol, Josua Tumigolung, Dea Tumiwa, Pricilia Irene Tumiwa, Priscila Irene Tumundo, Berlian Tasya Turangan, Amanda T. M. Victoria Londa, Lolouren Viocindy Riska Nusaly Viska Fadila Tompunu Waas, Riviani Angela Watupongoh, Cavieta Watupongoh, Cavieta C. A. Wendersteyt, Novira Vita Weny Wiyono Widya Fransiska Rompas Woran, Falinry