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All Journal Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Ilmiah Manuntung Jurnal Surya Masyarakat JFL : Jurnal Farmasi Lampung Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Jurnal Surya Masyarakat Media Farmasi Indonesia Benzena Pharmaceutical Scientific Journal SWAGATI: Journal of Community Service Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Novena Yety Lindawati, Novena Yety
Academy of National Pharmacy, Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH KOMBINASI EKSTRAK TERPURIFIKASI HERBA SAMBILOTO (Andrographis paniculata (Burm.f.) Nees) DAN HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP TRANSLOKASI PROTEIN GLUT-4 PADA TIKUS DIABETES MELLITUS TIPE 2 RESISTEN INSULIN Nugroho, Agung Endro; Lindawati, Novena Yety; Pramono, Suwijiyo
Majalah Obat Tradisional Vol 19, No 2 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (929.168 KB) | DOI: 10.14499/mot-TradMedJ19iss2pp62-69

Abstract

Herba sambiloto (Andrographis paniculata (Burm. f) Nees) dan herba pegagan (Centella asiatica (L.) Urban) merupakan tanaman obat unggulan yang sedang dikembangkan sebagai obat tradisional salah satunya sebagai antidiabetes. Penelitian bertujuan untuk melihat efek kombinasi ekstrak terpurifikasi herba sambiloto dan herba pegagan terhadap translokasi protein GLUT-4 pada tikus diabetes mellitus tipe 2 resisten dibandingkan dengan penggunaan dari masing-masing ekstrak. Dalam penelitian digunakan 8 kelompok perlakuan dimana 3 kelompok diberi kombinasi ekstrak terpurifikasi herba sambiloto dengan herba pegagan:  kelompok I (912,1: 300); kelompok II (651,5 : 500); kelompok III (390,9 : 700) dalam mg/kg BB;  kelompok IV (ekstrak terpurifikasi herba sambiloto 1303 mg/kg BB); kelompok V (ekstrak terpurifikasi herba   pegagan  1000 mg/kg BB),   kelompok   VI   (kontrol   positif  metformin 45mg/kg BB),   kelompok  VII (kontrol negatif CMC-Na 0,5%), dan kelompok VIII (kontrol normal). Parameter yang diukur data semi kuantitatif translokasi protein GLUT 4 pada sel otot paha (soleus muscle) dengan metode Immunohistochemistry. Hewan uji diabetes mellitus tipe 2 resisten insulin dibuat dengan pembebanan fruktosa (1,8 g/kg BB) dan pakan kaya lemak (campuran pakan pelet 95% dan 5% kuning telur bebek serta lemak babi 5 mL/ 200 g BB) selama 70 hari. Penetapan kondisi resisten insulin hewan uji digunakan 3 parameter meliputi kadar glukosa darah, uji kadar lemak (trigliserida, LDL, kolesterol dan HDL), dan uji daya hipoglikemik glibenklamid yang dibandingkan dengan kontrol normal. Hasil uji resisten insulin dengan analisis statistik Independent Sample-t Test menunjukkan ada perbedaan bermakna (p<0,05) antara tikus normal dengan tikus diit lemak-fruktosa pada hari ke-50 dan ke-70. Hal ini mengindikasikan tikus diit lemak-fruktosa terindikasi DM tipe 2 resisten insulin. Pengaruh kelompok I (kombinasi ekstrak terpurifikasi herba sambiloto dengan herba pegagan (912,1 : 300 mg/kg BB) terhadap translokasi protein GLUT-4 lebih baik jika dibandingkan dengan pengaruh dari masing-masing ekstrak dengan signifikan p<0,05 dengan analisis oneway ANOVA.
UJI TOKSISITAS AKUT KAPSUL BAWANG PUTIH LANANG (Allium sativum Linn) Murtisiwi, Lusia; Lindawati, Novena Yety
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1697.086 KB) | DOI: 10.51352/jim.v2i2.65

Abstract

Garlic (Allium sativum Linn) is evidently active against Mycobacterium tuberculosis. Garlic contains allicin that is able to inhibit the bacteria causing tuberculosis. This dried extract garlic is also qualified as content of capsules of traditional medicine, score of Total Plate Count is1.5 (required not over 10); figures of mold and yeast extract of garlic is 4.102 (required not over 104); does not contain microbial pathogens (uncontaminated with coliform bacteria, Escherichia coli, Salmonella sp, and Staphylococcus aureus); and aflatoxin is not detected (required not more than 30 CPM); the average of moisture content is 2% (required notmore than 10%). Capsule of dried extract garlic (Allium sativum Linn) meets pharmaceutical requirements for traditional medicine capsule dosage form, with9 minutes as disintegrating time (required not more than 15 minutes) and meets the uniformity of weight as required for capsule. Results of the research indicates that dried extract of garlic indose above 48.750 mg/ kg body weightto get LD50in garlic, belongs to ‘relatively harmless’. Dried extract garlic in 4 doses variations do not affect the liver functions of mice, so significant clinical toxicity symptoms that happen on entire animals test have not gained yet
OPTIMASI ZAT WARNA BUNGA TELANG (Clitoria ternatea) SEBAGAI PEWARNA ALAMI PADA SIRUP PARASETAMOL Pratimasari, Diah; Lindawati, Novena Yety
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.39 KB)

Abstract

One of the most developed pharmaceutical preparations for paracetamol is a syrup. An important additional substance required in the formulation of the syrup is a coloring agent. Telang flower (Clitoria ternatea) is one of the plants that has been proved to contain anthocyanins. Anthocyanin is a compound which can be used as a coloring agent. Thus, it is important to further explore telang flower?s potential as a natural coloring agent in paracetamol syrup preparation. This research was started with the extraction of the dye or anthocyanin content in the telang flower. The extraction was performed by ethanol with maceration method. Paracetamol syrups were prepared in four different formulations (F1, F2, F3, and F4). F1, F2, and F3 contained three increased concentrations of telang extract of 0.25%, 0.5% and 1.0%, respectively, while F4 was added with the synthetic food coloring agent, as a control. Each formula was evaluated based on its physical properties parameters including organoleptic observation, pH, density viscosity, and color stability test using spectrophotometry. The results of organoleptic, pH, density viscosity, and color stability parameters showed that telang extract with the concentration of 0.25% and 1% possessed more stable result than 0,5% concentration in the paracetamol syrup preparations.
PENETAPAN KADAR TOTAL FLAVONOID EKSTRAK ETANOL KACANG MERAH (Phaseolus vulgaris L.) SECARA SPEKTROFOTOMETRI VISIBEL Lindawati, Novena Yety; Ma'ruf, Sabilla Hudzaifah
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.027 KB) | DOI: 10.51352/jim.v6i1.312

Abstract

Red kidney bean is one of the string beans that contain highest-fiber with a concentration 26.3 gram/100 gram substance. Red kidney bean contains flavonoid tannin steroid/triterpenoid and coumarin. The Flavonoid in red kidney bean has anti-diabetes activity. This research aims to determine total flavonoid content in the red kidney bean extract. Extraction is done using the maceration method with 70% ethanol solvent. The extract which is got is used for qualitative and quantitative analysis. Quercetin used as a standard solution. The qualitative analysis of flavonoid using TLC, Wilstater Cyanidin by forming a red complex and NaOH by a forming yellow complex. The Quantitative analysis was using colorimetry method with reagent AlCl3 to form complexes between AlCl3 and keto groups. Quantitative analysis continued with Visible Spectrophotometry on a wavelength of 430.0 nm and operating time at the 27th minute. The results of the qualitative test showed that the extract was positive flavonoids. The average concentrations of total flavonoids were 0,4733% extract with a variation coefficient value of 1,2%.
Formulasi dan Uji Antiinflamasi Sediaan Hidrogel Ekstrak Jahe Merah (Zingiber officinale) Setiawan, Iwan; Lindawati, Novena Yety; Amalia, Bevy
Media Farmasi Indonesia Vol. 13 No. 1 (2018): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.017 KB)

Abstract

ABSTRAKJahe merah (Zingiber officinale) merupakan tanaman yang sudah banyak diteliti dan memiliki kemampuan antiinflamasi terutama dalam menghambat proses denaturasi protein yang terjadi pada proses inflamasi. Penelitian ini ekstrak jahe merah diaplikasikan ke dalam sediaan hidrogel dengan basis gelling agent natrium karboksimetilselulosa. Sediaan hidrogel kemudian dilakukan uji stabilitas hingga hari ke 21 dan dievaluasi terhadap daya anti inflamasi kepada hewan uji tikus jantan galur wistar. Hasil penelitian pada sediaan hidrogel ekstrak jahe merah ini menunjukkan hasil stabilitas fisik yang baik, pH, viskositas, daya sebar dan daya lekat yang baik dan memenuhi persyaratan sediaan gel. Hasil uji daya anti inflamasi pada hewan uji tikus jantan galur wistar pada hidrogel ekstrak jahe merah dengan basis gelling agent CMC Na memberikan perbedaan yang bermakna dengan kontrol (P< 0,05).
Alternatif Pengobatan Hipertensi dalam Program Pengabdian Masyarakat STIKES Nasional di Desa Kwarasan, Grogol, Sukoharjo Lindawati, Novena Yety; Nugroho, Danie; Ardanaputri, Geffa Yusinda; Saputri, Maria Oktafiani Ari; Mohollana, Mohollana; Triastuti, Rika; Murdianningsih, Sari
Jurnal Surya Masyarakat Vol 6, No 1 (2023): November 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.6.1.2023.98-103

Abstract

Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg on two measurements with an interval of five minutes in a state of sufficient rest, calm. Treatment of hypertension can use medicinal plants, namely bay leaves and soursop leaves. Bay leaves and soursop leaves have antioxidant activity that can counteract free radicals so that they can lower blood pressure, while bay leaves themselves contain flavonoids that can reduce the risk of cardiovascular disease. This activity program uses the method of giving local seminars and workshops directly to the PKK group in Kwarasan Village, Grogol District, Sukoharjo Regency. The results of real work lecture program showed an increase in participants' knowledge which was evaluated through an average increase in the pretest score from 86 to 94 during the posttest as well as an increase in the skills of participants in workshop activities.
AKTIVITAS ANTIGLIKASI EKSTRAK DAUN KENIKIR (Cosmos caudatus Kunth) DENGAN METODE SPEKTROFOTOMETRI UV-VIS: ANTI-GLICATION ACTIVITY OF KENIKIR (Cosmos caudatus Kunth) LEAF EXTRACT USING SPECTROPHOTOMETRY UV-VIS METHOD Lindawati, Novena Yety; Aisyah, Nurul
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1559

Abstract

Kenikir merupakan jenis sayuran yang sering dikonsumsi mentah sebagai lalapan dan dimasak sebagai sayur. Senyawa flavonoid dan fenolik yang terdapat pada daun kenikir dapat digunakan sebagai antiglikasi. Glikasi sendiri merupakan penyebab terjadinya komplikasi pada penderita diabetes. Reaksi glikasi akan membentuk senyawa berbahaya Advanced Glycation End Products (AGEs) sehingga memperburuk kondisi penderita diabetes. Antiglikasi sangat dibutuhkan untuk mencegah produksi Advanced Glycation End Products (AGEs). Mengetahui aktivitas antiglikasi pada ekstrak daun kenikir merupakan tujuan penelitian ini. Dalam penelitian ini digunakan metode spektrofotometri UV-VIS. Hasil ekstrak daun kenikir direaksikan dengan 2,4-dinitrofenilhidrazin (DNPH) dan BSA terglikasi dianalisis menggunakan Spektrofotometri pada panjang gelombang 450 nm. Hasil penelitian menujukkan ekstrak etanol daun kenikir memiliki aktivitas antiglikasi dengan rata-rata nilai  sebesar 295,047 ppm dengan koefisien variasi sebesar 0,850%.
Pengembangan dan Pengolahan Ikan Tongkol (Euthynnus affinis) Dengan Kombinasi Sayuran Lokal yang Berpotensi Mencegah dan Mengendalikan Stunting pada Masyarakat Desa Bakipandeyan Lindawati, Novena Yety; Ovikariani, Ovikariani; Athifa, Luthfi Nur; Angelia, Putu Tia; Yuliyani, Rinda Susan; Delasafira, Arfi
Jurnal Surya Masyarakat Vol 7, No 1 (2024): November 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.7.1.2024.81-87

Abstract

Stunting is the condition of toddlers who experience failure to grow or have a body condition that is shorter than their age standard due to malnutrition, inadequate recurrent infections in the first 1,000 days of life. Bakipandeyan Village, Baki, Sukoharjo is one of the assisted villages that pays attention to the prevention and control of stunting. This encourages the holding of community service activities aimed at preventing and controlling stunting in children aged 0-24 months. This activity program uses seminar and workshop methods directly to mothers with children aged 0-24 months, health workers, and PKK cadres by considering the status of stunting and malnutrition in the Bakipandeyan village area, Baki, Sukoharjo. The results of community service showed an increase in participants' knowledge which was evaluated through an average increase in pretest scores from 79.77 to 93.86 at posttest as well as an increase in participants' skills in workshop activities. The results of the partner satisfaction questionnaire showed that people who gave good to very good appreciation reached 95%, so this activity was appropriate, satisfying and accepted by the people of Bakipandeyan Village, Baki, Sukoharjo.
Pelatihan Pembuatan Jamu Kunir Asem dan Jamu Saintifik Hipertensi Susilowati, Susilowati; Lindawati, Novena Yety; Ramadhan, Taufiq; Nurwiyanti, Dyah Kartika; Yolanda, Lola; Latifiana, Nabila Adiesty Putri; Putri, Wichita Azzahra Sheika; Sari, Amalia Vita
Jurnal Peduli Masyarakat Vol 6 No 4 (2024): Jurnal Peduli Masyarakat: Desember 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v6i4.4733

Abstract

Hipertensi merupakan kondisi dimana tekanan darah berada di atas nilai normal yaitu >140 mmHg untuk tekanan sistolik dan >90 mmHg untuk tekanan diastolik. Menduduki urutan pertama setiap tahunya. Penggunaan ramuan herbal sebagai tatalaksana non farmakologi penyakit hipertensi sangat membantu mengatasi hipertensi. Pengenalan jamu saintifik dan optimalisasi herbal di Desa Gajahan masih kurang dan belum mendapat edukasi mengenai ramuan jamu saintifik sebagai alternatif menurunkan tekanan darah, maka dilakukan pengenalan jamu saintifik, dengan harapan dapat mengurangi angka hipertensi di Desa Gajahan. Kegiatan dilakukan dengan penyuluhan dan pelatihan pembuatan jamu kunir asem dan jamu saintifik. Sasaran kegiatan adalah kader kesehatan PKK Desa Gajahan, Surakarta. Hasil dari kegiatan ini menunjukan ada peningkatan pemahaman masyarakat dalam memahami jamu saintifik serta dalam pembuatanya, hal ini ditunjukan dengan kenaikan nilai postest yang signifikan <0,05. Hasil tingkat kepuasan masyarakat dapat dilihat dari antusiasme audiens dalam mengikuti kegiatan ini, dengan nilai kepuasan mencapai nilai 97,6%.
PENJERNIHAN MINYAK JELANTAH MENJADI LILIN AROMATIK PALMAROSA DAN LEMON SEBAGAI PENCEGAHAN DBD Utami, Nastiti; Lindawati, Novena Yety; Pramesti, Erika Diyah; Sari, Fitri Atrika; Chotimah, Intan Kusnul; Widya, Selsa Rizky; Alifya, Zhausan Dina
SWAGATI : Journal of Community Service Vol. 1 No. 1 (2023): March
Publisher : Universitas AMIKOM Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24076/swagati.2023v1i1.1018

Abstract

This community service was held on January 21, 2023 at the Inclusion Studio (Anugerah Aulia) Cemani Village, Grogol District, Sukoharjo Regency with 30 participants. This community service was carried out through 3 stages, the preparation stage, the implementation stage, and the evaluation stage. The purpose of this activity is to increase public knowledge about the prevention of dengue hemorrhagic fever by utilizing aromatik candles as mosquito repellents and motivating the community by using used cooking oil to create new businesses as an increase in micro, small and medium enterprises in Cemani Village. This activity was successful by obtaining an average pretest score of 44.58%, after counseling and workshops, community knowledge increased with an average posttest score of 90.83%.
Co-Authors Agung Endro Nugroho Alifya, Zhausan Dina Amalia, Bevy Angelia, Putu Tia Anggraini, Truly Ardanaputri, Geffa Yusinda Athifa, Luthfi Nur Chotimah, Intan Kusnul Dany Hexa Grosny Ralphsody Delasafira, Arfi Estikawati, Indriani Fitrianingsih, Natasya Hanindita Iwan Setiawan Latifiana, Nabila Adiesty Putri Ma'ruf, Sabilla Hudzaifah Mohollana, Mohollana Murdianningsih, Sari Murtisiwi, Lusia Nugroho, Danie Nurul Aisyah Nurwiyanti, Dyah Kartika Ovikariani, Ovikariani Pramesti, Erika Diyah Pratimasari, Diah Putri, Wichita Azzahra Sheika Rahmawati, Anggita Ramadhan, Taufiq Riska Anggraini, Riska Saputri, Maria Oktafiani Ari Sari, Amalia Vita Sari, Fitri Atrika Susilowati Susilowati SUWIJIYO PRAMONO Triastuti, Rika Utami, Nastiti Widya, Selsa Rizky Yolanda, Lola Yuliyani, Rinda Susan