Article Per Year (5 Year)
p-Index From 2020 - 2025
1.8
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Manuntung Cendekia Journal of Pharmacy Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Indonesian Journal of Global Health research Jurnal Farmasi Benzena Pharmaceutical Scientific Journal Bencoolen Journal of Pharmacy
Pratimasari, Diah
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
OPTIMASI ZAT WARNA BUNGA TELANG (Clitoria ternatea) SEBAGAI PEWARNA ALAMI PADA SIRUP PARASETAMOL Pratimasari, Diah; Lindawati, Novena Yety
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.39 KB)

Abstract

One of the most developed pharmaceutical preparations for paracetamol is a syrup. An important additional substance required in the formulation of the syrup is a coloring agent. Telang flower (Clitoria ternatea) is one of the plants that has been proved to contain anthocyanins. Anthocyanin is a compound which can be used as a coloring agent. Thus, it is important to further explore telang flower?s potential as a natural coloring agent in paracetamol syrup preparation. This research was started with the extraction of the dye or anthocyanin content in the telang flower. The extraction was performed by ethanol with maceration method. Paracetamol syrups were prepared in four different formulations (F1, F2, F3, and F4). F1, F2, and F3 contained three increased concentrations of telang extract of 0.25%, 0.5% and 1.0%, respectively, while F4 was added with the synthetic food coloring agent, as a control. Each formula was evaluated based on its physical properties parameters including organoleptic observation, pH, density viscosity, and color stability test using spectrophotometry. The results of organoleptic, pH, density viscosity, and color stability parameters showed that telang extract with the concentration of 0.25% and 1% possessed more stable result than 0,5% concentration in the paracetamol syrup preparations.
Diuretic Effectiveness Test and Thin Layer Chromatography (TLC) Profile of Ethanol Extract of Brazilian Spinach Leaves (Althernanthera sisso hort) Widhiastuti, Christina Dwi; Pratimasari, Diah; Amin, Muhammad Saiful
BENCOOLEN JOURNAL OF PHARMACY Vol. 4 No. 2 (2024): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v4i2.36405

Abstract

Hypertension is one of the diseases with the highest prevalence in the world. The group of hypertension drugs that are often used are diuretics. Brazilian spinach is a plant that has the potential to be developed as a diuretic. It is suspected that the contents of Brazilian spinach leaves used as a diuretic are alkaloids, flavonoids and saponins. This study aims to determine the presence of flavonoids and the diuretic effect of ethanol extract of Brazilian spinach leaves as a diuretic in male white rats. The research method is laboratory experimental and descriptive. Phytochemical screening includes alkaloids, phenolics, flavonoids, saponins, tannins, steroids/triterpenoids. Confirmation of the content of flavonoid compounds using the Thin Layer Chromatography (TLC) method. The subjects were 25 male white rats, divided into 5 groups. Positive control group, negative control, Brazilian spinach ethanol extract with 156.25 mg, 312.5 mg, and 625 mg. Rat urine volume was measured at 1-6 hours, pH, diuresis latency. The research results showed that the ethanol extract of Brazilian spinach leaves contained alkaloids, phenolics, flavonoids, tannins, saponins and steroids. Statistically, giving ethanol extract of Brazilian spinach leaves has a good diuretic effect at a dose of 625 mg/200gBW because the significant value shows P<0.05 or there is a difference
Pembuatan madu lemu (madu, albumin lele, dan ekstrak temulawak) sebagai makanan tinggi protein untuk pencegahan stunting Sa'ad, Muhammad; Ariyanti, Lilik; Semartini, Atur; Pratimasari, Diah
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 6 No. 2 (2025)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v6i2.23746

Abstract

Stunting masih menjadi permasalahan kesehatan serius di Indonesia, termasuk di Desa Polokarto, Sukoharjo, Jawa Tengah. Salah satu upaya pencegahan stunting adalah dengan meningkatkan asupan protein hewani, salah satunya melalui konsumsi albumin ikan. Bahan tersebut dapat dikombinasikan dengan madu untuk memperbaiki rasa dan temulawak sebagai penambah nafsu makan, menjadi produk fungsional bernama Madu Lemu. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan penyuluhan dan pelatihan kepada kader posyandu di Desa Polokarto mengenai pemanfaatan bahan alam tinggi protein serta teknik pembuatan Madu Lemu. Kegiatan dilaksanakan selama Juli–Agustus 2024 kepada 36 kader yang terbagi dalam 12 kelompok. Metode yang digunakan adalah service learning dengan evaluasi melalui instrumen pretest dan posttest. Hasil menunjukkan peningkatan pengetahuan signifikan dari skor rata-rata 62,58 menjadi 95,16. Kegiatan ini terbukti efektif meningkatkan pemahaman kader tentang bahan alam bergizi tinggi dan keterampilan membuat produk Madu Lemu. Para kader juga telah meneruskan pelatihan ini di tingkat RT. Upaya ini merupakan langkah strategis dalam mendukung penurunan angka stunting secara berkelanjutan di tingkat desa.
Identifikasi Kualitatif Ekstrak, Fraksi n-Heksan, Fraksi Etil Asetat, Fraksi Air Herba Bandotan (Ageratum conyzoides L.) Palupi, Dwi Ayu; Pratimasari, Diah; Dhurhania, Crescentiana Emy
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v14i1.333

Abstract

Bandotan (Ageratum conyzoides L.) is a plant that grows in subtropical and tropical regions and has high growth and adaptability. Some studies have shown that Bandotan herb has good activity as an antibacterial, anti-inflammatory, antioxidant, and antidiabetic agent. Existing research is limited to the content and activity of Bandotan herb extracts. However, some extracts that undergo fractionation are known to enhance their activity. Therefore, this study aims to identify the flavonoid and phenolic compounds in the polar, semi-polar, and non-polar fractions of Bandotan herb. The research started with macerating the Bandotan herb using ethanol as a solvent and concentrating it to obtain a thick extract. This thick extract was then suspended in warm water and fractionated successively using n-hexane and ethyl acetate solvents. The extracts and fractions obtained were analyzed for their content using tube tests and Thin Layer Chromatography (TLC). The tube test results indicated that the extract, ethyl acetate fraction, and water fraction were positive for flavonoids, while the n-hexane fraction was negative for flavonoids. TLC results showed variations in the compound profiles among the extract and its different fractions.
UJI ANTIINFLAMASI TOPIKAL SEDIAAN KRIM FRAKSI ETIL ASETAT DAUN JOHAR (Cassia siamea L.) TERHADAP MENCIT PUTIH Nandia Apriyanti, Audri; Pratimasari, Diah; Wisnu Kusuma, Eka
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 1 (2023): Jurnal Farmasi (Journal of Pharmacy), April 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/es2f1c91

Abstract

Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n- hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti- inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage
Identifikasi Kualitatif Ekstrak, Fraksi n-Heksan, Fraksi Etil Asetat, Fraksi Air Herba Bandotan (Ageratum conyzoides L.) Ayu Palupi, Dwi; Pratimasari, Diah; C.E. Dhurhania
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/kk6rmd70

Abstract

Bandotan (Ageratum conyzoides L.) is a plant that grows in subtropical and tropical regions and has high growth and adaptability. Some studies have shown that Bandotan herb has good activity as an antibacterial, anti-inflammatory, antioxidant, and antidiabetic agent. Existing research is limited to the content and activity of Bandotan herb extracts. However, some extracts that undergo fractionation are known to enhance their activity. Therefore, this study aims to identify the flavonoid and phenolic compounds in the polar, semi-polar, and non-polar fractions of Bandotan herb. The research started with macerating the Bandotan herb using ethanol as a solvent and concentrating it to obtain a thick extract. This thick extract was then suspended in warm water and fractionated successively using n-hexane and ethyl acetate solvents. The extracts and fractions obtained were analyzed for their content using tube tests and Thin Layer Chromatography (TLC). The tube test results indicated that the extract, ethyl acetate fraction, and water fraction were positive for flavonoids, while the n-hexane fraction was negative for flavonoids. TLC results showed variations in the compound profiles among the extract and its different fractions.
Uji Aktivitas Antibakteri Ekstrak Etanol dan Fraksi Etil Asetat Beras Hitam (Oryza Sativa L.) Terhadap Bakteri Staphylococcus aureus dan Escherichia coli: Jurnal Farmasi (Journal of Pharmacy), October 2025 Umi Fathonah, Yuliana; Wahyudi, Didik; Pratimasari, Diah
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/adx0af97

Abstract

Beras hitam (Oryza Sativa L.) merupakan beras lokal yang memproduksi antosianin dengan intesitas tinggi pada aleuron dan endospremia sehingga warna beras menjadi ungu pekat menjadi hitam. Beras hitam memiliki kandungan kimia flavonoid, tanin, dan alkoloid. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol dan fraksi etil asetat beras hitam (Oryza Sativa L.) terhadap bakteri Staphylococcus aureus dan Escherichia coli. Serbuk beras hitam dimaserasi menggunakan etanol 96%, kemudian difraksinasi menggunakan pelarut etil asetat. Pengujian aktivitas antibakteri ekstrak etanol dan fraksi etil asetat dilakukan dengan menggunakan metode difusi cakram. Pengujian metode difusi dengan menggunakan konsentrasi 25%,30%, dan 35% menggunakan kontrol positif Ciprofloxacin 5µg terhadap bakteri Staphylococcus aureus dan Escherichia coli. Hasil pengujian aktivitas antibakteri menunjukkan ekstrak etanol dan fraksi etil asetat beras hitam dapat menghambat pertumbuhan bakteri dengan adanya daya hambat. Fraksi etil asetat konsentrasi 35% merupakan fraksi teraktif dengan rata-rata diameter zona hambat sebesar 17,47 mm pada bakteri Staphylococcus aureus sedangkan pada bakteri Escherichia coli rata-rata diameter zona hambat fraksi etil asetat sebesar 14,52 mm. Berdasarkan uji analisis data one way anova, masing-masing konsentrasi ekstrak etanol dan fraksi etil asetat menunjukkan adanya perbedaan bermakna dalam aktivitas antibakteri dan tidak memiliki kemampuan aktivitas antibakteri setara dengan kontrol positif Ciprofloxacin dengan nilai sig.(P<0.05).
FORMULASI SEDIAAN KRIM EKSTRAK DAUN TURI (Sesbania grandiflora L)Poir DAN UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Pratiwi, Rifka Septya; Pratimasari, Diah; Setiawan, Iwan
Cendekia Journal of Pharmacy Vol 8, No 3 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i3.319

Abstract

Radikal bebas dapat berpotensi menimbulkan kerusakan sel dalam kulit. Salah satu tanaman yang memiliki kandungan senyawa metabolit sekunder dengan potensi sebagai antioksidan adalah daun turi (Sesbania grandiflora L)Poir. Penelitian ini bertujuan untuk memfomulasi eksrak daun turi menjaadi sediaan krim dan mengetahui aktivitas antioksidan krim ekstrak daun turi (Sesbania grandiflora L) Poir menggunakan metode DPPH. Daun turi diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%,selanjutnya ekstrak dibuat sediaan krim dengan konsentrasi formula I (perbandingan asam stearat : TEA yaitu 10:2), formula II (perbandingan asam stearat : TEA yaitu 15:3) dan formula III (perbandingan asam stearat : TEA yaitu 20:4) dengan diuji kontrol kualitas fisik, ekstrak skrining fitokimia dan dilakukan pengujian aktivitas antioksidan dengan metode DPPH. Hasil pengujian didapatkan rendemen 8,36%, hasil kualitas fisik krim yang homogen, tipe krim minyak dalam air dengan nilai pH, daya sebar, daya lekat, viskositas yang memenuhi persyaratan dan memiliki stabilitas yang baik. Hasil pengujian ekstak skrining fitokimia daun turi positif mengandung flavonoid, tanin, saponin, alkaloid, steroid dan terpenoid. Krim ekstrak daun turi memiliki aktivitas antioksidan dengan nilai IC50 Formula I 54,529 ppm, Formula II 54,450 ppm, dan Formula III 50,474 ppm memiliki kategori yang kuat dalam aktivitas antioksidan
UJI AKTIVITAS LILIN AROMATERAPI KOMBINASI MINYAK ESENSIAL KEMANGI (Ocimum Basillicum) DAN KENANGA (Cananga Odorata) SEBAGAI RELAKSASI TERHADAP MENCIT PUTIH JANTAN Chotimah, Intan Kusnul; Pratimasari, Diah; Kusuma, Eka Wisnu
Cendekia Journal of Pharmacy Vol 8, No 2 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i2.239

Abstract

Pemakaian bahan alam untuk aromaterapi cenderung meningkat, diantaranya adalah minyak esensial kemangi dan kenanga yang memiliki potensi meningkatkan efek terapi komplementer sebagai relaksasi. Kandungan kimia utama dalam tanaman kemangi dapat menekan stres melalui efek fisik dan psikisnya sehingga menimbulkan perasaan tenang dan nyaman dari geraniol (21,23%) dan sitral(43,45%) serta kenanga dengan kandungan senyawa linalool (12,79%) dapat merangsang saraf pusat untuk menurunkan tingkat stres. Tujuan penelitian ini untuk mengetahui efek kombinasi minyak esensial kemangi dan kenanga dalam sediaan lilin aromaterapi, serta evaluasi sifat fisik lilin. Metode destilasi uap air digunakan untuk mengambil minyak esensial daun kemangi dan bunga kenanga. Kombinasi minyak esensial kemudian diformulasi dalam bentuk sediaan lilin aromaterapi dengan konsentrasi kemangi:kenanga, F1 1:2, F2 1,5:1,5, F3 2:1 dan formula kontrol negatif tanpa konsentrasi. Lilin diuji sifat fisiknya meliputi uji organoleptis, titik leleh, waktu bakar, dan hedonik. Pengujian relaksasi dilakukan dengan menggunakan metode TST (Tail Suspension Test) untuk diukur immobility time masing-masing kelompok data dianalisis menggunakan SPSS. Hasil penelitianmenunjukkan bahwa dari keempat formula menunjukkan F2 memiliki sifat fisik yang paling baik sesuai standar dan pada uji One-way Anova terdapat perbedaan yang signifikan pada rata-rata antara formula, dan disimpulkan ada efektivitas lilin yang paling cepat yang dapat merelaksasi mencit.
Formulation and Physical Assessment of Different Topical Products using Bandotan Herb (Ageratum conyzoides L.) Extract Andriani, Disa; Pratimasari, Diah
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.4335

Abstract

Bandotan (Ageratum conyzoides L.) is one of the Asteraceae family plants that has bioactive compound components in the form of polyphenol compounds, terpenoids, and alkaloids. 70% ethanol extract of bandotan herb (Ageratum conyzoides L.) is known to have antioxidant activity. This makes herba bandotan has the potential to be develooped into cosmetic preparations to prevent premature aging of the skin. This study aims to determine the herba bandotan topical preparation that has the best physical properties. Bandotan herb was extracted with 70% ethanol in the amount of 1: 10 at 28˚C for 24 hours using the shaking method at 100 rpm. The ethanol liquid filtrate obtained was then evaporated to obtain a thick extract. Thick bandotan extract is then made into gel, cream, and lotion preparations and evaluated. The resulting % yield of bandotan herb extract was 11.3%. The concentration of 1%, 3% and 5% bandotan herb active substances in the preparation affects the organoleptics, viscosity, spreadability and adhesiveness of the preparation. The best topical preparations of bandotan herb extract that meet the requirements of the pH test, viscosity test, spreadability test, and adhesion test is cream preparations.
Co-Authors Andriani, Disa Ariyanti, Lilik Ayu Palupi, Dwi C.E. Dhurhania Chotimah, Intan Kusnul Dhurhania, Crescentiana Emy Didik Wahyudi Disa Andriani Fachry Abda El Rahman Iwan Setiawan Kusuma, Eka Wisnu Muhammad Sa'ad Nandia Apriyanti, Audri Novena Yety Lindawati, Novena Yety Palupi, Dwi Ayu Pratiwi, Rifka Septya Semartini, Atur Umi Fathonah, Yuliana Widhiastuti, Christina Dwi Wisnu Kusuma, Eka