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All Journal Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research
Mulyadi Adam, Mulyadi
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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The number of Leydig cells in highfat diet-fed rats after administration of kepok banana peel extract Zulkifli, Baidillah; Akmal, Muslim; Wahyuni, Sri; Gholib, Gholib; Adam, Mulyadi; Zainuddin, Zainuddin; Lubis, Triva Murtina; Usrina, Nora; Nirmala, Fadya
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v7i2.30689

Abstract

The impact of free radicals on testicular Leydig cells can result in the disruption of male reproductive health. The present study aimed to evaluate the effects of a high-fat diet on Leydig cells and the potential of kepok banana peel extract as a medication to mitigate these effects. In total of 20 adult male Wistar rats were assigned to five groups and treated with standard feed (P1), high-fat feed (P2), high-fat feed with simvastatin (P3), and high-fat feed with banana peel extract at doses of 100 and 200 mg/kg BW (P4 and P5). After 60 days of treatment, the number of Leydig cells was determined using HE staining methods. Data were analyzed using an One Way ANOVA test. The results showed that the administration of 100 mg/kg BW of kepok banana peel extract (P4) was able to maintain the number of Leydig cells and counteract the negative effects of a high-fat diet. These findings suggest that kepok banana peel extract may have the potential as a herbal medicine for supporting male reproductive health.
HISTOPATHOLOGICAL OVERVIEW OF NEW ZEALAND WHITE PSEUDO-PREGNANT RABBIT UTERUS AFTER OVARY TRANSPLANTATION WITH VARYING DURATION OF OVARIES INSIDE THE UTERUS Nazaruddin, Nazaruddin; Fadillah, Nurul Aini; Melia, Juli; Thasmi, Cut Nila; Roslizawaty, Roslizawaty; Sayuti, Arman; Daud, Razali; Adam, Mulyadi; Syafruddin, Syafruddin
Jurnal Kedokteran Hewan Vol 17, No 4 (2023): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i4.34694

Abstract

This study aims to understand the histopathological changes in the pseudo-pregnant rabbit uterus concerning the duration of ovaries inside the uterus during ovarian transplantation. The study used nine New Zealand White (NZW) pseudo-pregnant female rabbits aged 3-5 years, weighed 1.5-2.9 kg. After a 30-day adaptation period, all rabbits were divided into three treatment groups: K1 (n=3) underwent ovarian transplantation for 3 days, K2 (n=3) for 5 days, and K3 (n=3) for 7 days. Pseudo-pregnant was induced using PMSG and hCG. The rabbits were intramuscularly injected with 100 IU of PMSG, followed by intravenous injection of 75 IU of hCG three days later. Ovary transplantation was performed on the 8th day (day 0 being the day of hCG injection). Uterus was collected after the transplantation procedure according to the respective treatment groups. The results showed that in K1, K2 and K3, there was hyperemia in the endometrial epithelium and infiltration of inflammatory cells. Hyperemia and necrosis were more severe in K1 compared to K2 and K3. In K3, the histopathological appearance of the endometrium tended to be normal, with less damage. In conclusion, the histopathological findings of hyperemia and necrosis in the uterus undergoing ovarian transplantation lasted for 3 days compared to 5 and 7 days.
Co-Authors Arman Sayuti Cut Nila Thasmi, Cut Nila Fadillah, Nurul Aini Gholib Gholib, Gholib Juli Melia Muslim Akmal N. Nazaruddin Nirmala, Fadya Nora Usrina Razali Daud Roslizawaty Roslizawaty, Roslizawaty Sri Wahyuni Syafruddin Syafruddin Triva Murtina Lubis Zainuddin, Zainuddin Zulkifli, Baidillah