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All Journal The International Journal of Tropical Veterinary and Biomedical Research Narra X
Zulkifli, Baidillah
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Veterinary

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Isolation and identification of pathogenic bacteria isolated from aceh cattle liver infected by Fasciola gigantica based on microbiological and biochemical assay Sari, S.Si, M.Si, Wahyu Eka; Zamzami, Rumi Sahara; Hambal, Muhammad; Ferasyi, Teuku Reza; Qomariah, Annisa Nurul; Riandi, Lian Varis; Muttaqien, Muttaqien; Zulkifli, Baidillah
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 2 (2024): Vol. 9 (2) November 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i2.43996

Abstract

Fasciolosis is a disease caused by fluke infestation Fasciola gigantica and Fasciola hepatica. Usually, these flukes infect ruminants such as cattle, goats, sheep and wildlife. Infestation F. gigantica can cause a decrease in the immune response, so that livestock become more susceptible to infection with other microorganisms. The emergence of microorganisms such as bacteria can cause foodborne disease for those who consume liver infestation by F. gigantica. This study aims to see the presence of pathogenic bacteria in the liver of cattle infestation by F. gigantica. Isolation of bacteria present in beef liver was conducted by culturing it on culture media such as blood agar media. Blood agar media can be used to determine pathogenic bacteria. Pathogenic properties of bacteria are seen based on the ability of bacteria to hemolyze blood on blood agar media. Based on the results of the hemolysis test on blood agar media, four colonies were found that were potentially pathogenic, namely alpha hemolysis (isolate S2-A) and beta hemolysis (isolate S1.1-A, S2-B, and S3-A). Furthermore, the results of bacterial identification were based on morphological observations and Gram staining tests as well as biochemical tests and spore staining, isolate S2-A identified as bacteria Staphylococcus sp., while isolates S1.1-A, S2-B, and S3-A were identified as bacteria Bacillus sp. Thus, it can be concluded that in the liver of cattle infestation by F. gigantica, bacteria are found that have the potential to be opportunistic pathogens.
The number of Leydig cells in highfat diet-fed rats after administration of kepok banana peel extract Zulkifli, Baidillah; Akmal, Muslim; Wahyuni, Sri; Gholib, Gholib; Adam, Mulyadi; Zainuddin, Zainuddin; Lubis, Triva Murtina; Usrina, Nora; Nirmala, Fadya
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v7i2.30689

Abstract

The impact of free radicals on testicular Leydig cells can result in the disruption of male reproductive health. The present study aimed to evaluate the effects of a high-fat diet on Leydig cells and the potential of kepok banana peel extract as a medication to mitigate these effects. In total of 20 adult male Wistar rats were assigned to five groups and treated with standard feed (P1), high-fat feed (P2), high-fat feed with simvastatin (P3), and high-fat feed with banana peel extract at doses of 100 and 200 mg/kg BW (P4 and P5). After 60 days of treatment, the number of Leydig cells was determined using HE staining methods. Data were analyzed using an One Way ANOVA test. The results showed that the administration of 100 mg/kg BW of kepok banana peel extract (P4) was able to maintain the number of Leydig cells and counteract the negative effects of a high-fat diet. These findings suggest that kepok banana peel extract may have the potential as a herbal medicine for supporting male reproductive health.
The Role of Gut Microbiota-derived Tryptophan Metabolites in Mycobacterium tuberculosis Infection: A Mini-Review Maulina, Novi; Hayati, Zinatul; Hasballah, Kartini; Zulkarnain, Zulkarnain; Zulkifli, Baidillah
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v7i2.30165

Abstract

The gut microbiota has a major contribution in human physiology and influences disease pathogenesis, including in tuberculosis (TB) lung infection. Gut-lung axis has demonstrated the interplay of these two organs, mediated by metabolites produced by the gut microbes or derived from host molecules transformation. Tryptophan (Trp) is one of the essential aromatic amino acids catabolized as kynurenine, serotonin (5-hydroxytryptamine), and indole derivatives, including indole propionic acid (IPA), via 3 pathways. The latter was microbiota-derived Trp catabolism, which has known to have an immunomodulatory role, as ligands for Aryl hydrocarbon Receptor (AhR). Intriguingly,Mycobacterium tuberculosisrequired Trp as a nitrogen source, especially in CD4+ T cells-generated stress, to survive in the phagosome of macrophage and to cause disease. Recently, IPA is identified as a new anti-mycobacterial compound, which is specific and has broad spectrum of anti-mycobacterial activity. The structural similarity of this gut microbiota-derived metabolite and Trp allows IPA to inhibit the TrpE anthranilate synthase in Trp biosynthesis pathway in Mtb. In this review, wesummarize findings from recent work by focusing on the role of Trp metabolites in host cells in TB infection.A better understanding of this chemical signal could potentially serve as a novel strategy for managing this chronic inflammatory disease.
Chemometric-empowered spectroscopic techniques in pharmaceutical fields: A bibliometric analysis and updated review Zulkifli, Baidillah; Fakri, Fajar; Odigie, Joan; Nnabuife, Loveday; Isitua, Chinwe C.; Chiari, Williams
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.80

Abstract

Undeniable increase in pharmaceutical demand has encouraged researchers to develop analytical techniques to analyze drugs and monitor their effects. Chemometrics enabled simple spectroscopic approaches (such as infrared or UV spectroscopy) to analyze complex samples, including drug formulations, excreted fluids and tissues of living organisms. The aim of this study was to evaluate the research trend of this combinatorial technique utilized for pharmaceutical-related sample analysis using a bibliometric analysis. Bibliometric data of published literature from the Scopus database on March 14, 2023 were retrieved using the keyword combinations of "multivariate", "chemometrics", "pattern recognition", "drug", "pharmaceutical" and "spectroscopy". Network visualization analysis was performed using VOSviewer on the co-occurring keywords and authorships, presenting data such as top cited papers (n=10). The literature review was performed based on the research trend revealed by the clusters that emerged in the network visualization. The analysis revealed that the first paper was published in 1973 (n=1) and a total of 3544 records have been published as of March 14, 2023, comprising original research articles (n=3144, 88.71%) and review articles (n=232, 6.55%). The keyword “chemometrics” with Total Link Strength (TLS) of 826 emerged as the most abundant, followed by “metabolomics” (TLS=388), “Raman spectroscopy” (TLS=280), “metabonomics” (TLS=272), “nuclear magnetic resonance” or “NMR” (TLS=271), and “multivariate analysis” (TLS=254). Network visualization revealed that the research falls into two general categories: (1) drug toxicity and efficacy monitoring and (2) quality control of drug manufacturing. The top cited paper (n=3269) was a review article published in 1999 describing the utility of nuclear magnetic resonance combined with multivariate statistics for metabolite profiling of biological samples. The chemometric-empowered spectroscopy techniques were expected to provide objective measurement during clinical studies and monitoring of therapeutic effects.
Diagnosis of ehrlichiosis and anaplasmosis in fila brasileiro dog Usrina, Nora; Zulkifli, Baidillah; Hidayat, Farah Amalia; Daniel, Daniel; Nurliana, Nurliana; Roslizawaty, Roslizawaty; Athaillah, Farida; Yusriani, Yenni
The International Journal of Tropical Veterinary and Biomedical Research Vol 10, No 1 (2025): Vol 10 (1) May 2025
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v10i1.45754

Abstract

Background and Aim: Canine ehrlichiosis and anaplasmosis are significant tick-borne diseases with global distribution and high clinical relevance in veterinary medicine. This case report presents a ten-year-old male Fila Brasileiro dog exhibiting clinical signs of anorexia and lethargy for three consecutive days.Materials and Methods: Physical examination revealed fever (40.3 C), pale mucous membranes, and a body condition score of 3/5. A complete blood count (CBC) showed leukocytosis, neutrophilia, eosinophilia, microcytic anemia, and thrombocytopenia. Further confirmation using a SNAP 4Dx rapid test detected antibodies against Ehrlichia spp. and Anaplasma spp., leading to a definitive diagnosis of ehrlichiosis and anaplasmosis. Treatment involved fluid therapy using intravenous 0.9% sodium chloride and doxycycline at a dose of 250 mg per day for 21 days.Results : The hematological findings align with typical abnormalities observed in dogs with these infections, including reduced erythrocyte and platelet counts, which are associated with immune-mediated destruction and bone marrow suppression. These pathogens also alter neutrophil function to evade the host immune response, contributing to prolonged inflammation and disease progression. The hematological profile presented here demonstrates a rare combination of microcytic anemia and eosinophilia, which may suggest an atypical host immune response not commonly described in previous literature.Conclusion: This case highlights the importance of early diagnosis through hematological and serological examinations and emphasizes the need for routine tick prevention to reduce the risk of tick-borne diseases in dogs.
Histology and histomorphometry of the skin in the ventral abdominal region of domestic fowl (Gallus gallus domesticus), duck (Anas platyrhynchos), and doves (Columba livia) Zainuddin, Zainuddin; Rahmi, Erdiansyah; Akmal, Muslim; Masyitha, Dian; Ismail, Ismail; Hamny, Hamny; Pratiwi, Siska; Zulkifli, Baidillah
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 1 (2024): Vol. 9 (1) May 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i1.40134

Abstract

This study aims to determine the histological and histomorphometric characteristics of the skin of domestic fowl (Gallus gallus domesticus), ducks (Anas platyrhynchos), and doves (Columba livia) in the ventral abdominal region. Each study sample consisted of six individuals. The samples were processed into histological preparations with a thickness of 5 m and then stained using Haematoxylin-Eosin (HE). The results showed that the histological structure of the skin of domestic fowl, ducks, and doves is relatively thin compared to the structure of mammalian skin and consists of the epidermis, dermis, and hypodermis (subcutis). The histomorphometric data analysis showed that the thickness of the epidermal layer of the skin in the ventral abdominal region of domestic fowl, ducks, and doves was not significantly different (P0.05), but there were significant differences (P0.05) in the thickness of the dermis and hypodermis. It can be concluded that a similarity exists in the histological structure of the skin of domestic fowl, ducks, and doves, but differences are observed in the histomorphometric properties of the skin in the ventral abdominal region of these birds.
The relationship between incidence of pediculosis capitis and quality of life among female students at Madrasah Ulumul Quran (MUQ) Sigli Mulki, Putria; Asrizal, Cynthia Wahyu; Maryam, Tjut; Hajar, Sitti; Putra, Teuku Romi Imansyah; Zulkifli, Baidillah
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 1 (2024): Vol. 9 (1) May 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i1.40124

Abstract

Pediculosis capitis is an ectoparasitic disease that lives on the human scalp and caused by Pediculus humanus capitis. This incident is categorized as a neglected case, but the impact is quite significant. The incident can give a negative impact, including physical, psychological, social and school perceptions or learning impairment. This study aimed to determine the relationship between the incidence of pediculosis capitis with the quality of life of female students of Madrasah Ulumul Quran Sigli. This research is an observational analytic study with a cross-sectional approach. The samples were collected by the total sampling method. The results obtained from 155 respondents who met the inclusion criteria found that 124 respondents (80%) had pediculosis capitis and 31 respondents (20%) with no pediculosis capitis. Statistical analysis using the chi square test obtained a p value of 0.000 (0.05). The conclusion was found that there was a relationship between the incidence of pediculosis capitis and the quality of life of female students of Madrasah Ulumul Quran Sigli.
Herbal flavonoids in preserving testicular physiology under oxidative stress: A bibliometric analysis of systematic reviews Zulkifli, Baidillah; Fakri, Fajar; Gholib, Gholib; Akmal, Muslim; Adam, Mulyadi; Sabri, Mustafa; Lubis, Triva Murtina; Zainuddin, Zainuddin; Zulfitri, Zulfitri; Admi, Masda; Syah, Nanda Yulian; Usrina, Nora; Fajri, Fauzan
The International Journal of Tropical Veterinary and Biomedical Research Vol 8, No 2 (2023): Vol. 8 (2) November 2023
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v8i2.36616

Abstract

Herbal antioxidants have gained attention recently as possible treatments for disorders of male reproductive function linked to oxidative stress because of their ability to neutralize free radicals.The investigation into herbal flavonoids for preserving oxidative stress-impaired testicular physiology has been effectively conducted through the visualization of bibliometric analysis. Bibliometric data of published papers collected from the PubMed and Scopus databases in 2018-2023. Network visualization was performed using VOSviewer software on the set keywords that occur (n=15). The literature review was conducted according to the research trends identified by the clusters that appeared in the network visualization. The result revealed that a total of 266 records have been published based on the specified search set keywords since 2018. Through the analysis of keywords, inclusion and exclusion criteria, and the relevant content of papers, 11 articles were identified as suitable for conducting a literature review. Network visualization revealed that the research falls into two general categories: (1) toxicity to the testicles caused by oxidative stress and (2) prevention of oxidative stress impact on tissue through herbal medicine. Examination of the paper's content revealed that certain antioxidant compounds from plants can stabilize free radicals in the testicles. These antioxidants include vitexin, diosmin, hesperidin, phenolic acids, naphthoquinones, fisetin, pachypodol, sciadopitysin, carvacrol, and morin. However, further research is needed to compare active antioxidant content in different herbal plants and identify optimal concentrations for therapeutic effects.
A Descriptive Study of Knowledge, Attitude, and Awareness of Basic Life Support Among the Students of the Faculty of Veterinary Medicine Jasa, Zafrullah Khany; Putra, Teuku Romi Imansyah; Al-Mathari, Alif; Farhana, Rika; Zulkifli, Baidillah
The International Journal of Tropical Veterinary and Biomedical Research Vol 8, No 2 (2023): Vol. 8 (2) November 2023
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v8i2.35835

Abstract

Basic life support (BLS) is a first-aid measure performed to restore vital organ functions in cardiac or respiratory arrest patients. This research was conducted on the students of the Veterinary Medicine Faculty in the 2018th and 2019th entry years from November 15th 30th, 2021. This study was a descriptive observational study using a cross-sectional research design. Two hundred two respondents in this study were selected by stratified random sampling. Data from respondents were collected using an online questionnaire via Google Forms. The results of this study indicated that most respondents were 20 years old (46.5%), female (65.8%), and the number of respondents from each generation was the same. The data analysis of the respondents' basic life support showed that they possessed a minimal level of knowledge (60.9%), good attitude (66.8%), and good awareness (56.9%). According to these findings, most students had positive attitudes and awareness of basic life support. The aspect of knowledge about basic life support practices among these students falls into the poor category; therefore, there is a need to step up the socialization and training process.
Diagnosis and medical treatment of otitis externa in a ragdoll cat: A case report Usrina, Nora; Habibie, Maulana; Darmawi, Darmawi; Amiruddin, Amiruddin; Zulkifli, Baidillah; Yusriani, Yenni
The International Journal of Tropical Veterinary and Biomedical Research Vol 8, No 2 (2023): Vol. 8 (2) November 2023
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v8i2.35836

Abstract

Otitis is a disease that is often found due to the cat's ears being unclean and causing earwax to build up along with fluid. Otitis is caused by inflammation of the epithelium of the ear canal and also surrounding structures such as the external auditory meatus and pinna. A 3-month-old Ragdoll cat, male, with white and black hair on the ears, was examined with complaints of head tilting and frequent head shaking, pus in the ears, and inflammation. Clinical examination revealed erythema. The ear wax swab examination results showed an Otodectes cynotis mite infection. The results of the bacterial culture examination showed the presence of Klebsiella sp bacterial infection. The animal was diagnosed with otitis externa. Treatment for otitis externa is given by Dexamethasone, Erlamycetin (Chloramphenicol 1%), Ivermectin, and lidocaine. The accumulated earwax is also cleaned using a cotton bud and saline. Five days after therapy the cat showed recovery.
Co-Authors Al-Mathari, Alif Amiruddin Amiruddin asrizal, cynthia wahyu Athaillah, Farida Chiari, Williams Daniel Daniel Darmawi . Dian Masyitha Erdiansyah Rahmi Faisal Mustafa Fajar Fakri Fajri, Fauzan Farhana, Rika Gholib Gholib, Gholib Habibie, Maulana Hamny Hamny Hidayat, Farah Amalia Isitua, Chinwe C. Ismail Ismail Jasa, Zafrullah Khany Kartini Hasballah Maryam, Tjut Masda Admi Maulina, Novi Muhammad Hambal Mulki, Putria Mulyadi Adam, Mulyadi Muslim Akmal Muttaqien Muttaqien, Muttaqien Nanda Yulian Syah Nirmala, Fadya Nnabuife, Loveday Nora Usrina NURLIANA NURLIANA Odigie, Joan Qomariah, Annisa Nurul Riandi, Lian Varis Roslizawaty Roslizawaty, Roslizawaty Sari, S.Si, M.Si, Wahyu Eka Siska Pratiwi SITTI HAJAR Sri Wahyuni Teuku Reza Ferasyi Teuku Romi Imansyah Putra Triva Murtina Lubis Yenni Yusriani Zainuddin, Zainuddin Zamzami, Rumi Sahara Zinatul Hayati Zulfitri Zulfitri, Zulfitri Zulkarnain Zulkarnain