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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Dedicators Community Jurnal Kesehatan Islam : Islamic Health Journal Journal of Pharmaceutical Care Anwar Medika Soeropati: Journal of Community Service Caring : Jurnal Pengabdian Masyarakat East Asian Journal of Multidisciplinary Research (EAJMR) Jurnal Kedokteran Komunitas (Journal of Community Medicine) Jurnal Farmasi Sains dan Praktis JURNAL PENGABDIAN PENDIDIKAN MASYARAKAT (JPPM) Prosiding Seminar Nasional Pengabdian Masyarakat KOPEMAS
Anita Puspa Widiyana
Universitas Islam Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Kesehatan Islam : Islamic Health Journal

 1 
HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS SENYAWA TURUNAN BENZIMIDAZOL TERTAUTKAN 1,2,3-TRIAZOL SEBAGAI INHIBITOR ENZIM α-GLUKOSIDASE Intan Nurkholidah; Anita Puspa Widiyana; Yoni Rina Bintari
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 1 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i1.19847

Abstract

ABSTRAK Penemuan obat diabetes mellitus sedang banyak dilakukan akibat meningkatnya angka penderita diabetes mellitus. Peneliti menemukan penghambatan terhadap enzim α-glukosidase berperan penting dalam mencegah diabetes komplikasi dan mengontrol gula darah. Senyawa yang berpotensi menjadi inhibitor enzim α-glukosidase yaitu turunan benzimidazol tertautkan 1,2,3-triazol. Hubungan Kuantitatif Struktur-Aktivitas (HKSA) menjadi metode yang digunakan untuk mengetahui hubungan parameter hidrofobik (LogP dan LogS), elektronik (Etotal dan EHOMO), dan sterik (MW dan Vw) dari senyawa turunan benzimidazol tertautkan 1,2,3-triazol dengan aktivitas sebagai inhibitor enzim α-glukosidase. Parameter HKSA dan kriteria lipinski ditentukan menggunakan website online ADMET Lab 2.0 (https://admetmesh.scbdd.com/). Kriteria lipinski menunjukkan seluruh senyawa memenuhi syarat aturan sehingga senyawa turunan benzimidazol tertautkan 1,2,3-triazol dapat menjadi obat aktif jika diberikan per oral. Persamaan HKSA terbaik ditentukan dengan mempertimbangkan nilai r, nilai r2, nilai p, nilai F, dan nilai S, sehingga persamaan yang paling terbaik yaitu -LogIC50 = -0.308 LogP -0.009 Etotal +0.196, dengan n= 15, r = 0.887; r2 = 0.787; F = 12.954; p = 0.004; S = 0.103. Persamaan menunjukkan adanya hubungan parameter Log P dan Etotal dengan aktivitasnya, semakin kecil Log P dan Etotal maka semakin besar aktivitas senyawa turunan benzimidazol tertautkan 1,2,3-triazol sebagai inhibitor enzim α-glukosidase. Kata Kunci: Benzimidazol; Triazol; HKSA; Enzim α-glukosidase
EFEKTIFITAS PELATIHAN TENTANG PENCEGAHAN SCABIES DAN MENINGKATKAN PERILAKU HIDUP BERSIH DAN SEHAT PADA SANTRI MENERAPKAN MODEL FOTOKIMIA DAN TRAFIC GAME HERBAL Sri Herlina; Majida Ramadhan; Anita Puspa Widiyana; Dwi Praseyto, Hamdani; Sayidati Nabila; Wardah; Ahmad Asyari Fasya
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 2 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i2.23090

Abstract

ABSTRACT The problem of students who live in dormitories often experience itching due to the transmission of scabies disease caused by the Sarcoptes scabiei mite, poor sanitation environments, such as hanging dirty clothes and bedding which serve as preferred living habitat other than in human skin. Scabies mites can survive 2-3 days in the external environment of the body, especially on fabrics such as clothes, towels, and mattresses. The personal hygiene of students and the habits of students do not apply Clean and Healthy Living Behavior, such as the habit of littering. Toilets are poorly maintained and do not wash their hands when consuming snacks; even allowing clogged drains can cause puddles at risk of falling due to slippery floors causing accidents for students, even though the management of the boarding school has given directions and appeals to students, but the application is still low. The method of implementing training activities is carried out by means of active interaction, active discussion, and role play with students and direct practice of waste treatment using a modified model of photochemical technology and a rapid sand filter. Increasing the understanding of students managerially using the herbal game traffic method approach is expected to be able to increase awareness and sensitivity in solving these problems. The results of the analysis of students' knowledge can understand that the cleanliness of clothes, towels, and tools can affect the transmission of scabies. The level of understanding of students is 0.43%. In PKM training activities, there are 98% of students who have increased their understanding of healthy and nutritious nutrition and can be developed in Islamic boarding schools as healthy snacks, while the practice of herbal games is still a model for problem recognition, and herbal solutions are said to be rarely applied by 40% to prevent scabies, both using herbal preparations and the application of clean and healthy living behaviors. Keywords: Santri, herbal game traffic, scabies, rapid sand filler, photochemistry
Co-Authors Ahmad Asyari Fasya Alhabsyi, Mochammad Alfian Bachtiar Rifai Pratita Ihsan Chasan Arfisa Damayanti, Dini Sri Diah Royani Meisani Didi Nurhadi Illian Didi Nurhadi Illian Doti Wahyuningsih Dwi Praseyto, Hamdani Efriza Fahmi Triyoga Erna Sulistyowati Eva Putri Arfiani Faizah Dwi Qurrotul Aini Galih Satrio Putra Husain Latuconsina Husain Latucosina Ike Widyaningrum Intan Nurkholidah Luthfi Ahmad Muchlashi Luthfi Ahmad Muchlashi M Josie Yusuf Majida Ramadhan Majida Ramadhan Mellany Ika Sulistyowaty Muhammad Fahmi Hidayatullah Nabilah, Sayidati Nour Athiroh Abdoes Sjakoer Nour Athiroh Abdoes Sjakoer Nugroho Wibisono Rahmatullah, Muhammad Ali Ramadhan, Majida Rhomah, Alfiyah Cahyani Rofiq, Muhammad Fadlan Sayidati Nabila Shinta Kusumawati Sri Herlina Tutuk Budiati VALENTINA YURINA Wardah Wardhani, Baiq Sofia Yoni Rina Bintari Yudi Purnomo