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All Journal Jurnal Ilmiah Farmasi e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi UNEJ e-Proceeding Journal of Islamic Pharmacy Jurnal Ilmu Kefarmasian Indonesia Farmasis: Jurnal Sains Farmasi Pharmaceutical Sciences and Research (PSR)
Fransiska Maria Christianty
Fakultas Farmasi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

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Preventive Effects of Alpha-Lipoic Acid on Lipopolysaccharide-Induced Endothelial Dysfunction in Rats Christianty, Fransiska Maria; Suharjono,; Susilo, Imam; Khotib, Junaidi
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endothelial dysfunction has been considered as one of the key initial events in the pathogenesis of atherosclerosis and other cardiovascular diseases (CVDs). Several studies imply that chronic inflammation and oxidative stress play a critical role in endothelial dysfunction. The present study was designed to evaluate the preventive effect of alpha-lipoic acid (ALA) on lipopolysaccharide (LPS) induced endothelial dysfunction in rat based on malondialdehyde (MDA) level and vascular cell adhesion molecules-1 (VCAM-1) expression. Thirty Wistar rats were administered ALA for 2 weeks in different doses (30, 60, 120 mg.kg-1 BW) 1 hour before LPS 0.5 mg.kg-1 BW i.p challenge. The LPS was injected on 1st, 4th, and 9th day. MDA plasma level was analyzed with spectrophotometer λ 529 nm, and VCAM-1 expression was determined by immunohistochemistry. Pretreatment with ALA for 14 days could decrease plasma MDA level on LPS-induced endothelial dysfunction in rats. However, only one group of ALA doses, 120 mg.kg-1 BW, showed significant difference with LPS untreated group statistically. It was also found that ALA, in all treatment groups, could attenuate VCAM-1 expression. These findings suggest that ALA had a protective effect against endothelial dysfunction and may potentially prevent vascular inflammatory disease.
Pengetahuan, Sikap, dan Perilaku Penggunaan Suplemen dan Obat Tradisional pada Tenaga Kesehatan di Jember selama Pandemi COVID-19 Dhita Evi Aryani; Antonius Nugraha Widhi Pratama; Ika Norcahyanti; Sinta Rachmawati; Fransiska Maria Christianty; Ema Rachmawati; Gustia Alinda Lintarsari
Pustaka Kesehatan Vol 11 No 2 (2023): Volume 11 No.2, 2023
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v11i2.39268

Abstract

Healthcare workers play the role as the front line in treating COVID-19 patients, so they are at risk of being exposed by this virus therefor it is necessary to always maintain health and increase their immunity. One way is taking supplements or traditional medicines. The behavior of taking supplements or traditional medicines is influenced by knowledge and attitudes. The purpose of this study was to determinate the knowledge, attitudes, and behavior of using supplements and traditional medicines among healthcare workers in Jember during the COVID-19 pandemic. This research was an observational analytic study with a cross-sectional design involving 376 healthcare workers in Jember selected by convenience sampling method.The data collection instruments was questionnaires. The results showed that the majority of respondents had good knowledge (52.1%) and moderate attitudes (59.0%). Sociodemographic factors that influence knowledge are level of education and the type of healthcare worker, while the factors that influence attitudes are age, level of education, type of health worker, and working time. There is a significant relationship (p≤0.05) between knowledge and attitudes which can be concluded that knowledge influences attitudes towards the use of supplements and/or traditional medicines
Analisis Guessability Score dan Pemahaman Piktogram Kefarmasian pada Pasien Tuberkulosis Ema Rachmawati; Dhea Nanda Aliefia; Fransiska Maria Christianty
Jurnal Ilmiah Farmasi 2023: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2023.art3

Abstract

Background: Pharmaceutical pictograms can be used to help tuberculosis patients understand treatment information, especially those with low reading skills.Objective: This study aimed to analyze the guessability score and the level of understanding of pharmaceutical pictograms related to the use of TB drugs.Method: This was an observational study with a cross-sectional design. The sample used was 96 TB patients who were actively undergoing treatment. The guessability score and level of understanding were analyzed descriptively, while the relationship between socio-demographic characteristics and the level of understanding of pharmaceutical pictograms was analyzed using the Chi-square test.Results: The results showed that the guessability score of 23 pictograms tested on respondents varied greatly, with a score range of 29.2%–99%. Meanwhile, the level of respondents' understanding of pharmaceutical pictograms related to TB treatment was in the "fair" category. The Chi-square test showed a significant relationship between the level of respondents’ education and their understanding of pharmaceutical pictograms.Conclusion: The findings of this study demonstrated that not all pictogram images were simple for respondents to understand. It is necessary to choose pictogram images that are easy for respondents to understand or redesign pictogram images so that they can be used to improve the effectiveness of drug information delivery to patients. Intisari Latar belakang: Gambar piktogram kefarmasian dapat digunakan untuk membantu pasien tuberkulosis memahami informasi pengobatan, khususnya untuk pasien dengan tingkat literasi rendah. Tujuan: Penelitian bertujuan untuk mengukur kemampuan menerka (guessability score) dan pemahaman responden terhadap piktogram kefarmasian terkait pengobatan tuberkulosis.Metode: Penelitian observasional cross-sectional terhadap 96 responden pasien TB yang aktif menjalani pengobatan. Guessability score dan tingkat pemahaman dianalisis secara deskriptif, sedangkan hubungan karakteristik sosio-demografi dengan tingkat pemahaman dianalisis dengan uji Chi-square.Hasil: Hasil penelitian menunjukkan kemampuan menerka (guessability score) terhadap 23 gambar piktogram sangat beragam, dengan rentang skor 29,2% – 99%. Sedangkan tingkat pemahaman responden terhadap piktogram kefarmasian terkait pengobatan TB masuk dalam kategori “cukup”. Uji Chi-square menunjukkan adanya hubungan yang signifikan antara tingkat pendidikan terhadap tingkat pemahaman responden.Kesimpulan: Tidak semua gambar piktogram kefarmasian mudah dipahami oleh responden. Untuk itu perlu memilih gambar piktogram yang mudah dipahami reponden atau melakukan desain ulang gambar piktogram sehingga dapat digunakan untuk meningkatkan efektivitas pemberian informasi obat pada pasien.Kata kunci: guessability score, pemahaman, piktogram kefarmasian, tuberculosis
Evaluasi Penggunaan Antibiotik pada Pasien Diare Menggunakan Metode ATC/DDD di Puskesmas Kalisat Kabupaten Jember Rachmawati, Ema; Husnun, Khoiriyah Haifa; Machlaurin, Afifah; Norcahyanti, Ika; Christianty, Fransiska Maria; Aryani, Dhita Evi
FARMASIS: Jurnal Sains Farmasi Vol 5 No 1 (2024): Farmasis: Jurnal Sains Farmasi Vol 5. No. 1 (2024)
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v5i1.8777

Abstract

Pendahuluan: Diare merupakan masih menjadi masalah utama di seluruh dunia dan menjadi penyebab tingginya angka kesakitan dan kematian di segala usia. Sebagian besar kasus diare disebabkan oleh virus bersifat self limiting disease. Namun sayangnya, diare menjadi salah satu penyakit yang rentan menyebabkan overuse dan misuse dari penggunaan antibiotik. Hal tersebut berpotensi meningkatkan resiko terjadinya resistensi antibiotik. Surveilans pola peresepan antibiotik merupakan bagian penting dalam pengendalian resistensi antibiotik dan perlu dilakukan secara secara rutin dari waktu ke waktu. Tujuan: Melakukan evaluasi penggunaan antibiotik pada pasien diare di Puskesmas Kalisat Kabupaten Jember tahun 2021 menggunaakan metode ATC per DDD serta melihat kesesuiaan pemilihan antibiotik berdasarkan PPK tahun 2017. Metode: Penelitian ini merupakan penelitian cross sectional dengan metode retrospektif. Pengambilan data dilakukan terhadap 55 rekam medis pasien diare rawat jalan di Puskesmas Kalisat Kabupaten Jember tahun 2021 yang memenuhi kriteria. Data penggunaan antibiotik dihitung nilai sesuai indikator DDD per 1000 pasien per hari, Drug Utilization (DU) 90 persen serta kesesuaian dengan PPK 2017. Hasil: Karakteristik responden menunjukkan jumlah pasien diare perempuan lebih banyak dibanding pasien laki-laki (63,64 persen vs 36,36 persen). Persentase diare terbanyak terjadi pada kelompok usia 18-25 tahun dan 36-45 tahun dengan persentase masing-masing sebesar 21, 82 persen serta diagnosis paling banyak adalah gastroenteritis akut (GEA) yaitu sebesar 67,27 persen. Total penggunaan antibiotik pada pasien diare sebesar 5,98 DDD per 1000 pasien per hari dengan antibiotik yang sering diresepkan adalah kotrimoksazol dengan nilai 3,59 DDD per 1000 pasien per hari dan menyusun 60,13 persen dari segmen DU 90 persen. Persentase kesesuaian penggunaan antibiotik pada pasien GEA sebesar 94,59 persen. Sedangkan untuk pasien dengan diagnosis disentri, persentase kesesuaian penggunaan antibiotik didapatkan sebesar 38,88 persen. Kesimpulan: Kotrimoxazol paling tinggi diresepkan dalam terapi diare di Puskesmas Kalisat Kabupaten Jember dan menunjukkan persentase 60,13 persen dalam segmen DU 90 persen, sehingga perlu adanya evaluasi terkait ketepatan penggunaan sebagai upaya untuk mengendalikan jumlah peresepan antibiotik tersebut guna mencegah resiko resistensi  antibiotik.
Co-Authors Andrean Roni Antonius Nugraha Widhi Pratama Antonius Nugraha Widhi Pratama Aryani, Dhita Evi Dhea Nanda Aliefia Dhita Evi Aryani Diana Holidah Ema Rachmawati Ema Rachmawati Fifteen Aprila Fajrin Fifteen Aprilia Fajrin Gati Dwi Sulistyaningrum Gustia Alinda Lintarsari Hakimah, Farda Husnun, Khoiriyah Haifa Ika Norcahyanti Imam Susilo Irvina Anggita Baharini Junaidi Khotib Lina Winarti Machlaurin, Afifah Monica Cinuradha Aura Salsabina Nanda Puspasari Sinta Rachmawati Suharjono, Suharjono, Suharjono Wilda Zidni Ilma Yasmin Yasmin Yasmin Yasmin