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Ekstrak Kulit Pisang Kepok (Musa paradisiaca) Menurunkan Kadar AST pada Tikus Putih yang Diinduksi Diet Tinggi Lemak STEFANUS DJONI HUSODO; ASAMI RIETTA KUMALA; INDRI NGESTI RAHAYU
HANG TUAH MEDICAL JOURNAL Vol 18 No 2 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v18i2.122

ABSTRACT Background. Non-alcoholic fatty liver disease (NAFLD) is closely related to the incidence of obesity and dyslipidemia. Increased levels of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) are the most frequently performed liver function tests that can be used as a benchmark for suspicion of NAFLD. Banana peels contain flavonoids and phenolics which are antioxidants that can function as hepatoprotectors. Aim. Proving the effect of Kepok banana peel extract on AST and ALT of Wistar rats induced high fat diet. Method. experimental study with a post-test only control group design, with four treatment groups. There is negative control group only given four weeks standard diet (K-), positive control group only given four weeks high-fat diet (K+), and two treatment group where the rats were given two weeks high-fat diet then were given two weeks high-fat diet plus Kepok banana peel extract at a dose of 200 mg/kg BW (K1) and 400 mg/kg BW (K2). Result. the highest mean AST levels were in the negative control group and the lowest was the K2 group. Meanwhile, the highest mean of ALT was in the positive control group and the lowest was the K2 group. Based on the Kruskal Wallis test, the significance of the AST variable was not different (p>0,05), but the ALT variable was significantly different (p<0,05). Significant differences from the Mann Whitney-U test (p<0,05) were obtained between the negative control group and the positive control, the negative control group with K2 and the positive control group with the K2 group). Conclusion. The administration of Kepok banana peel extract (Musa paradisiaca formatypica) showed a significant decrease in ALT levels in Wistar strain white rats induced by a high-fat diet, but it was not significant for AST levels

Profil Penderita Covid-19 dengan Komorbid Penyakit Jantung Koroner di Rumah Sakit Umum Haji Surabaya SHERINA AYU PITALOKA; STEFANUS DJONI HUSODO; RIAMI
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.157

Background : COVID-19 is an illness caused by a new version of corona virus that still has connections with the family of SARS virus. COVID-19 first emerged in Wuhan and spread through contaminated individual contact, droplets, fomites. COVID-19 appear in Indonesia on 2020. Risk factor of COVID-19 exposure is comorbidity like heart disease. Coronary heart disease is a chronical inflammation characterized by the narrowing of coronary artery supplying oxygen. Coronary heart disease as comorbidity, worsens the clinical conditions of COVID-19 patients. Method : This is descriptive research with approach of quantitive method using secondary data. Population are medical records of COVID-19 patients with coronary heart disease comorbid ity in Haji Surabaya Public Hospital on 1st June 2020 to 31st August 2021. Total sampling is used in which all samples are included if in accordance to inclusion criteria in certain periods of time. Variables include age, gender, blood pressure, temperature, BMI, hemoglobin, RBC, WBC, platelet, hematokrit, PPT, aPTT, D-dimer, ECG. Collected data are analyzed descriptively and presented in tables. Results : Research shows COVID-19 patients with coronary heart disease comorbidity profile in Haji Public Hospital Surabaya often happens to age range of 56 – 65 years old, often in man, with normal vital signs. BMI affected fragility of exposure and risk factor of COVID-19 as well as coronary heart disease. CBC shows normal score rate and PPT, APTT majority normal. Abnormality in d-dimer status of patients increased, indicating increase in coagulation activity, abnormality in ECG interpretation shows abnormality of heart functions.

Pengaruh Latihan Submaksimal pada Intensitas Terlatih dan Tidak Terlatih Terhadap Kadar Eritrosit Darah Tikus Putih (Rattus norvegicus) Betina Galur Wistar HUSODO, STEFANUS DJONI; ERIC MAYO DAGRADI; AMIRIL MU’MININ
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.474

Penurunan aktivitas fisik serta perubahan gaya hidup dan pola makan yang tidak sehat di masa kini mengakibatkan semakin berkembangnya penyakit degeneratif dan penyakit infeksi. Eritrosit tubuh terutama eritrosit sangat berhubungan dengan terjadinya penyakit degeneratif. Untuk mendapatkan eritrosit yang baik dengan kadar eritrosit yang memadai dapat dilakukan dengan beberapa hal, salah satunya adalah olahraga dengan intensitas cukup dan teratur. Olahraga yang sesuai dengan kemampuan tubuh dapat mengaktifkan kerja eritrosit sehingga dapat meningkatkan eritrosit dan mencegah terjadinya penyakit degeneratif dan penyakit infeksi. Penelitian ini bertujuan untuk mengetahui pengaruh latihan submaksimal dengan intensitas terlatih dan tidak terlatih terhadap kadar eritrosit darah pada tikus putih betina galur wistar. Penelitian ini adalah penelitian eksperimen dengan menggunakan post test only control group design. Objek dalam penelitian ini adalah 25 tikus putih betina (Rattus norvegicus) galur wistar yang dibagi menjadi 5 kelompok. Hasil analisis statistik dengan uji One Way Anova yaitu p=0.034 Dari hasil uji didapatkan perbedaan yang bermakna antar kelompok perlakuan. hasil uji antar kelompok pada tabel 5.6 pada penelitian ini menunjukkan kelompok K1 dan K2 signifikan dengan nilai 0,46, kelompok K2 dan kelompok K3 signifikan dengan nilai 0,33, kelompok K2 dan kelompok K4 signifikan dengan nilai 0,19. Dapat disimpulkan terdapat perbedaan bermakna pada kadar eritosit antara latihan submaksimal intensitas terlatih dan tidak terlatih. Kata kunci : latihan submaksimal, terlatih, tidak terlatih, eritrosit

Patin sebagai sumber omega 3 untuk menurunkan faktor resiko terjadinya MAFLD karena DM tipe 2 Rahayu, Indri N.; Kumala, Asami Rietta; Taruna, Dody; Husodo, Stefanus Djoni; Dagradi, Eric Mayo; Sukmana, Judya
Surabaya Biomedical Journal Vol 3 No 1 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.114

Diet asam lemak tak jenuh ganda (PUFA) telah diteliti dan terbukti dapat memodulasi peradangan, namun, hanya sedikit beberapa penelitian yang fokusnya pada patobiologi PUFA dengan menggunakan diet isokalori dan isolipid namun belum dapat dijelaskan apakah patologi terkait tersebut disebabkan oleh komposisi diet PUFA, metabolisme lipid, atau obesitas, karena sebagian besar penelitian membandingkan diet dengan yang diberi makan ad libitum. Stres oksidatif dan mitokondria hati berperan dalam patogenesis penyakit hati berlemak nonalcohol. Omega-3 PUFA memiliki peran protektif yang potensial terhadap kerusakan sel oksidatif yang diinduksi ROS pada tikus organ, terutama di hati. Atenuasi hepatic fibrosis oleh EPA (asam eicosapentaenoic) secara signifikan berhubungan dengan kadar ROS hati. EPA juga menekan peningkatan kadar ROS hati dan penurunan penanda oksidatif serum, seperti 8-isoprostan dan feritin. Ikan patin memiliki kandungan asam lemak tak jenuh ganda omega 3 serta selenium yang merupakan antioksidan sehingga dapat menghambat terjadinya progresifisitas kejadian NAFLD maupun MAFLD. Mekanismenya antara lain melalui jalur penghambatan stress oksidatif yang merupakan patofisiologi terjadinya NAFLD maupun MAFLD.

Exploring the Threads of Youth: Stress, BMI, and Menstrual Health in Hang Tuah 2 Senior High School, Sidoarjo Adiwinoto, Ronald Pratama; Ulwani, Qulistan Balqis; Wijayaningrum, Lena; Husodo, Stefanus Djoni; Gustam, Tasalina Yohana Parameswari; Prasetya, Hanung; Adnyana, I Made Dwi Mertha
Journal of Current Health Sciences Vol. 5 No. 1: 2025
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/jchs.202597

Background: Menstrual cycle disorders are common problems among adolescent girls and are associated with reproductive health issues. Factors such as Body Mass Index (BMI) and stress are believed to influence menstrual irregularities. This study aims to examine the relationship between BMI, stress, and menstrual cycle irregularities as a preventive measure to maintain optimal menstrual health. Method: This observational analytical study utilized a non-probability sampling technique. Data analysis was conducted using Spearman’s Rho Correlation test and Cross Tabulation test at a significance level of 0.05. Results: The analysis showed a significant positive correlation between BMI and menstrual irregularities (p = 0.010, r = 0.258) and between stress and menstrual irregularities (p = 0.001, r = 0.480). Stress exhibited a stronger association with menstrual irregularities than BMI. Conclusion: This study highlights the relationship between BMI and stress with menstrual irregularities in female adolescents at SMA Hang Tuah 2 Sidoarjo. These findings emphasize the need for targeted interventions addressing nutritional and psychological support to improve menstrual health. Monitoring BMI and managing stress are essential strategies to enhance reproductive health in adolescents. Further research is recommended to explore effective interventions to address these factors and improve adolescent well-being.

Patin sebagai sumber omega 3 untuk menurunkan faktor resiko terjadinya MAFLD karena DM tipe 2 Rahayu, Indri N.; Kumala, Asami Rietta; Taruna, Dody; Husodo, Stefanus Djoni; Dagradi, Eric Mayo; Sukmana, Judya
Surabaya Biomedical Journal Vol. 3 No. 1 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.114

Diet asam lemak tak jenuh ganda (PUFA) telah diteliti dan terbukti dapat memodulasi peradangan, namun, hanya sedikit beberapa penelitian yang fokusnya pada patobiologi PUFA dengan menggunakan diet isokalori dan isolipid namun belum dapat dijelaskan apakah patologi terkait tersebut disebabkan oleh komposisi diet PUFA, metabolisme lipid, atau obesitas, karena sebagian besar penelitian membandingkan diet dengan yang diberi makan ad libitum. Stres oksidatif dan mitokondria hati berperan dalam patogenesis penyakit hati berlemak nonalcohol. Omega-3 PUFA memiliki peran protektif yang potensial terhadap kerusakan sel oksidatif yang diinduksi ROS pada tikus organ, terutama di hati. Atenuasi hepatic fibrosis oleh EPA (asam eicosapentaenoic) secara signifikan berhubungan dengan kadar ROS hati. EPA juga menekan peningkatan kadar ROS hati dan penurunan penanda oksidatif serum, seperti 8-isoprostan dan feritin. Ikan patin memiliki kandungan asam lemak tak jenuh ganda omega 3 serta selenium yang merupakan antioksidan sehingga dapat menghambat terjadinya progresifisitas kejadian NAFLD maupun MAFLD. Mekanismenya antara lain melalui jalur penghambatan stress oksidatif yang merupakan patofisiologi terjadinya NAFLD maupun MAFLD.

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