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All Journal Journal of Biomedicine and Translational Research Jurnal Analis Kesehatan Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Sehat Indonesia (JUSINDO)
Nuroh Najmi
Anatomy Pathology, Department Of Oral Biology Faculty Of Dentistry Universitas Padjadjaran, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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EFEK PENGGUNAAN OBAT KUMUR PADA PENATALAKSANAAN DENTURE STOMATITIS Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25059

Abstract

Kolonisasi jamur Candida pada mukosa yang memakai gigi tiruan dan plat akrilik gigi tiruan, khususnya Candida albicans adalah faktor etiologi utama denture stomatitis.  Pemeliharaan kebersihan gigi dan mulut dan pemeriksaan rongga mulut secara berkala akan mencegah sebagian besar kasus kandidiasis oral. Penelitian ini bertujuan untuk menentukan efek penggunaan obat kumur pada penatalaksanaan denture stomatitis.  Desain penelitian ini adalah studi literatur (narrative review). Pencarian artikel menggunakan database jurnal penelitian PubMed pada bulan Oktober-November 2023. Kriteria inklusi penelitian meliputi artikel dalam bahasa Inggris, artikel publikasi pada 10 tahun terakhir, dan artikel uji klinis. Kriteria eksklusi penelitian meliputi uji hewan, penelitian in vitro, penelitian yang tidak diterbitkan. Nistatin pastiles lebih efektif dalam mengobati denture stomatitis. Obat kumur klorheksidin lebih efektif terhadap C. albicans. Indocyanine green mediated photodynamic therapy pada penggunaan obat kumur kombinasi nistatin. Obat kumur kitosan-kurkuminoid bebas alkohol dapat berfungsi sebagai alternatif terapi topikal yang aman dan potensial dalam mengobati denture stomatitis. Penggunaan obat kumur nistatin, klorheksidin, indocyanine green (ICG), kitosan-kurkuminoid bebas alcohol dapat menurunkan jumlah mikroorganisme pada gigi tiruan. Obat kumur dapat mencegah dan mengobati denture stomatitis.
HUBUNGAN KESEHATAN GIGI DAN MULUT DAN PRODUK SUSU Najmi, Nuroh; Kuswandani, Faisal; Rafisa, Anggun; Balafif, Felisa Febriane
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25062

Abstract

Susu mengandung latosa dan kalsium yang penting bagi tubuh serta tambahan nutrisi lainnya.  Produk susu juga dapat melindungi rongga mulut terhadap berbagai masalah gigi seperti karies dan penyakit periodontal. Perlindungan ini berkaitan dengan senyawa seperti fosfor, kalsium, dan protein. Pada beberapa kasus terdapat individu alergi produk susu dan individu dengan intoleransi laktosa. Sehingga asupan nutrisi yang terkandung di dalam susu akan berkurang. Penambahan bakteri probiotik menjadi salah satu cara untuk membantu dan menambah fungsi serta manfaat.  Menambahkan probiotik pada produk susu dapat menjadi strategi pendukung dalam pencegahan dan pengobatan penyakit mulut utama termasuk karies gigi, penyakit periodontal, dan kandidiasis
Quorum Sensing and the Transition from Symbiosis to Dysbiosis in Periodontal Biofilms: A Scoping Review Febriane Balafif, Felisha; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Introduction: Quorum sensing (QS), a bacterial cell communication system, has emerged as a key regulator of community level biofilm dynamics, yet its role in mediating this ecological transition has not been systematically synthesized. This scoping review aimed to map and synthesize evidence published over the last decade on the role of quorum sensing in driving the transition from symbiosis to dysbiosis in periodontal biofilms. Methods: A scoping review was conducted in accordance with the PRISMA-ScR guidelines. Searches were performed in PubMed, Scopus, and Web of Science for studies published between 2016 and 2025 that investigated quorum sensing mechanisms in periodontal or subgingival biofilms using in vitro, ex vivo, or in vivo models. Data were charted and analyzed descriptively. Results: Sixty one studies met the inclusion criteria. Autoinducer-2 mediated signaling emerged as the most consistently reported quorum sensing pathway in periodontal biofilms. Quorum sensing was shown to regulate interspecies communication, biofilm maturation, metabolic cooperation, and coordinated virulence expression. Evidence indicated that quorum sensing primarily drives dysbiosis through functional reprogramming of microbial communities rather than through numerical dominance of specific pathogens. Several studies also linked quorum sensing activity to enhanced host inflammatory responses and alveolar bone loss in experimental models. Conclusion: Quorum sensing as a central ecological mechanism orchestrating the transition from symbiosis to dysbiosis in periodontal biofilms. By coordinating community wide microbial behavior, host and microbe interactions, quorum sensing contributes to sustained dysbiosis and periodontal inflammation.
Vitamin Deficiencies among Adult Patients with Recurrent Aphthous Stomatitis: A Systematic Review Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of the oral mucosa characterized by recurrent, painful ulcerations that significantly impair quality of life. Although its etiology is multifactorial, nutritional factors, particularly vitamin deficiencies, have been proposed as potential contributors through their roles in immune regulation, epithelial integrity, and wound healing. Evidence regarding vitamin status in adults with RAS, however, remains inconsistent. This systematic review aimed to synthesize and critically evaluate available evidence on vitamin levels in adult patients with recurrent aphthous stomatitis. A comprehensive literature search was conducted in PubMed and Scopus for studies published between January 2015 and December 2025, following PRISMA 2020 guidelines. Eligible studies included adult participants (≥18 years) diagnosed with RAS and reported serum or salivary vitamin levels. Observational and interventional studies were considered. Data were extracted on study characteristics, vitamin assessment methods, and key findings, and were analyzed descriptively. Seven studies met the inclusion criteria. Vitamin D was the most frequently investigated micronutrient, followed by vitamin B12 and other hematinic parameters. Several studies reported lower vitamin D levels in patients with RAS compared with controls, while others found similarly high rates of deficiency in both groups. Associations between vitamin levels and clinical severity of RAS were generally weak, although vitamin D deficiency was linked to increased ulcer multiplicity in one study. Vitamin B12 deficiency was primarily observed in populations with concomitant iron deficiency anemia rather than in otherwise healthy adults with RAS. Current evidence suggests that vitamin deficiencies, particularly vitamin D, may function as modifying or aggravating factors in adult RAS rather than direct causal agents. Further high-quality studies are required to clarify their clinical relevance and therapeutic implications.
Malnutrition and oral Health in Elderly: a Narrative Review Anggraini, Jamas Ari; Najmi, Nuroh; Rafisa, Anggun; Febriane Balafif, Felisa; Sari, Kartika Indah
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

The aging process is generally defined as the accumulation of various changes that occur in cells and tissues as we age. According to the World Health Organization (WHO), an elderly individual is defined as a person who has reached or surpassed 60 years of age. Changes in conditions experienced by the elderly are not only physical changes, but also social and psychological changes. These changes influence each other and interact with other factors, which have an impact on the health conditions of the elderly, including appetite regulation which indirectly also has an impact on nutritional status in elderly. As we already know, nutrition is an important component for the elderly that affects the entire aging process and the general health condition of the elderly, including their oral health. Oral health and nutrition themselves have a multidirectional relationship. This relationship is manifested in the oral cavity, including plaque formation, dental caries, periodontal disease and other oral conditions. It is imperative for clinicians to comprehend the interplay between oral health and nutrition, as this knowledge is crucial for the effective management of elderly patients. This article focuses on the relationship between nutrition an oral health and its impact on older adults.
Soy Isoflavone Mediated Modulation of IL-1β Related Inflammatory Pathways in Oral Mucosal Cells: A Scoping Review of Experimental Studies Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Balafif, Felisha Febriane
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Background: Soy isoflavones, particularly genistein, have been widely studied for their anti-inflammatory properties. However, evidence regarding their modulatory effects on interleukin-1β (IL-1β)–related inflammatory pathways in oral mucosal tissues remains limited. Objective: This scoping review aimed to map the available experimental evidence on the effects of genistein on inflammatory responses associated with IL-1β in the oral cavity. Methods: A scoping review was conducted following a comprehensive literature search of PubMed and ScienceDirect databases. Articles published in English between 2016 and 2026 were screened using predefined keywords related to soy isoflavones, genistein, IL-1β, inflammation, and oral or periodontal tissues. Original experimental studies focusing on inflammatory modulation in oral or periodontal contexts were included. Results: From the literature search, only one experimental study met the inclusion criteria. The included study investigated a genistein-loaded folic acid–modified liposome-hydrogel composite for periodontitis treatment. The findings demonstrated that genistein exerted anti-inflammatory effects by modulating inflammatory cytokines, including IL-1β, and inhibiting the TLR4/MyD88/NF-κB signaling pathway. The study also reported improved inflammatory regulation through macrophage phenotype modulation and interaction with periodontal ligament stem cells. Conclusion: Current experimental evidence on the role of genistein in modulating IL-1β–related inflammation in the oral cavity is scarce. The limited findings suggest that genistein has potential anti-inflammatory effects in periodontal inflammation; however, further well-designed experimental studies focusing specifically on oral mucosal cells and inflammatory pathways are needed to support its therapeutic application.
Co-Authors Achmad Syawqie Agus Rohmat Hidayat Anggraini, Jamas Ari Anggun Rafisa Anis Setyowati APRIANI Apriani Apriani Bahjah, Firda Hanan Balafif, Felisa Febriane Balafif, Felisha Faisal Kuswandani Faisal Kuswandani Falisha Febriane Balafif Febriane Balafif, Felisa Felisha Febriane Balafif Fifi Veronica Hanna Goenawan Ina Hendiani Jennifer Putri Kuswandani , Faisal Murti, Evivana Pranika Nurwijayanti Otih Yuningsih Rizky Farida Berlian Ronny Lesmana Sari, Kartika Indah Setyawati, Rina Stephanie Yessica