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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Yumary: Jurnal Pengabdian kepada Masyarakat JIPP Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Amalia Khairunnisa, Amalia
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Religion Humanities Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Antioxidant Assay of Kefir Peanut (Arachis hypogaea L.) with Variations in Concentration and Fermentation Time Viogenta, Pratika; Khairunnisa, Amalia; Kartinah, Nani; Rahmadati, Erfiza
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87814

Abstract

Kefir is a processed beverage produced through pasteurized milk fermentation using a starter from kefir grains. These grains contain groups of lactic acid bacteria and yeast. Peanuts can be used as a raw material for kefir products and Arachis hypogaea L. has antioxidant activity due to a high nutritional content namely vegetable oil, protein, minerals, and essential fatty acids. This study aimed to determine the highest antioxidant activity with variations in concentration and time fermentation of peanut kefir (Arachis hypogaea L.). This research on the antioxidant activity test method used the DPPH method with UV-Vis spectrophotometry. The results of testing the antioxidant activity of peanut kefir with variations in the concentration of kefir grains of 0%, 1%, 2%, and 3% had IC50 values of 64.929 ppm, 57.675 ppm, 54.742 ppm, and 51.870 ppm, respectively. The one-way ANOVA test showed a significant difference between the IC50 value and the concentration of kefir grains. The highest antioxidant in 3% concentration determined the fermentation time with 0, 12, 24, 36, 48, and 60 hours variations. The results of testing the antioxidant activity of kefir peanut with variations in the fermentation time it was had IC50 values of 64.319 ppm respectively, 62.609 ppm, 59.376 ppm, 56.321 ppm, 51.870 ppm, and 51.384 ppm. The one-way ANOVA test results showed no significance in the 0 with 12 hours completion time and 48 with 60 hours. The research results on peanut kefir show that kefir grains of 3% and the duration of fermentation for 48 hours have strong antioxidant activity.
Penetapan Kadar Fenolik Total dan Uji Aktivitas Antioksidan Fraksi dari Ekstrak Etanol Daun Cempedak (Artocarpus integer) dengan Metode DPPH Rizki, Muhammad Ikhwan; Sari, Anna Khumaira; Kartika, Dewi; Khairunnisa, Amalia; Normaidah
MPI (Media Pharmaceutica Indonesiana) Vol. 4 No. 2 (2022): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v4i2.4937

Abstract

Daun cempedak (Artocarpus integer) dimanfaatkan secara tradisional oleh masyarakat Kalimantan Selatan dalam pengobatan. Golongan fenolik terkandung dalam ekstrak daun cempedak dan memiliki kemampuan sebagai antioksidan. Fraksi dari ekstrak daun cempedak belum pernah ditetapkan kadar fenolik total dan akivitas antioksidannya. Penelitian ini bertujuan untuk mengetahui fraksi dari ekstrak daun cempedak yang mengandung kadar fenolik dan aktivitas antioksidan tertinggi. Penelitian dimulai dengan pengeringan daun segar menggunakan lemari pengering, pembuatan serbuk simplisia, proses ekstraksi secara maserasi, pengeringan ekstrak dengan lemari pengering, dan proses fraksinasi dengan pelarut n-heksan, etil asetat dan aquadest. Penetapan kadar fenolik total dapat dilakukan dengan reagen Folin-Ciocalteu dan menggunakan baku pembanding asam galat. Aktivitas antioksidan dilakukan menggunakan metode DPPH berdasarkan nilai IC50 dan dengan pembanding kuersetin. Kadar fenolik total pada fraksi n-heksan 9,352 ± 0,113% b/b, fraksi etil asetat 12,595 ± 0,415% b/b, dan fraksi aquadest 9,992 ± 0,485% b/b ekivalen asam galat. Fraksi n-heksan, etil asetat, dan aquadest masing-masing memiliki nilai IC50 sebesar 89,192 ± 2,91 bpj (kuat), 64,754 ± 2,803 bpj (kuat), dan 82,247 ± 23,034 bpj (kuat). Kesimpulan dari penelitian ini bahwa fraksi etil asetat memiliki kadar fenolik total tertinggi dan aktivitas antioksidan paling kuat dibandingkan fraksi n-heksan dan fraksi aquadest dari ekstrak daun cempedak. Cempedak (Artocarpus integer) leaves are traditionally used by people in South Kalimantan as medicine. The phenolic group contained in cempedak leaf extract has known as an antioxidant. The fraction of cempedak leaf extract has never been determined for total phenolic content and antioxidant activity. This study aimed to determine the fraction of cempedak leaf extract that contains the highest levels of phenolic and antioxidant activity. The study started with drying of fresh leaves using a drying cabinet, simplicia powder preparation, maceration extraction, extract drying, and fractionation with n-hexane, ethyl acetate and aquadest as solvents. Determination of total phenolic content was obtained with Folin-Ciocalteu reagent and gallic acid as a standard for comparison. Antioxidant activity was measured using the DPPH method based on the IC50 value and comparison with quercetin. The total phenolic content of the n-hexane, ethyl acetate and aquadest fraction were 9.352 ± 0.113% w/w, ethyl acetate fraction 12.595 ± 0.415% w/w, and aquadest fraction 9.992 ± 0.485% w/w equivalent gallic acid, respectively. The n-hexane, ethyl acetate, and aquadest fractions showed IC50 values of 89.192 ± 2.91 ppm (strong), 64.754 ± 2.803 ppm (strong), and 82.247 ± 23.034 ppm (strong), respectively. The conclusion of this study was that the ethyl acetate fraction had highest total phenolic content and strongest antioxidant activity compared to n-hexane and aquadest fraction from cempedak leaf extract.
Uji Flavonoid Total dan Antioksidan Kulit Batang Balik Angin (Alphitonia excelsa (Fenzl) Reis Ex. Endl) Hadi, Samsul; Muliana, Ana; Khairunnisa, Amalia
MPI (Media Pharmaceutica Indonesiana) Vol. 4 No. 2 (2022): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v4i2.5208

Abstract

Alphitonia excelsa merupakan salah satu tanaman yang berpotensi sebagai antioksidan dan telah digunakan secara turun temurun di masyarakat sebagai terapi berbagai macam penyakit. Hal tersebut mendasari tujuan penelitian ini, yaitu menentukan aktivitas antioksidan dan total flavonoid kulit batang A. excelsa. Metode yang di gunakan dalam pengujian antioksidan adalah peredaman terhadap radikal 2,2-difenil-1-pikrilhidrazil (DPPH), sedangkan pengujian flavonoid total dengan AlCl3 dilakukan secara kolorimetri. Hasil yang didapatkan dari penelitian ini adalah nilai IC50 aktivitas antioksidan A. excelsa sebesar 37,00 ± 1,46 μg/ml (bpj) dan flavonoid total senilai 1,17% ± 0.04 QE (quercetin equivalent). Berdasarkan nilai tersebut dapat disimpulkan bahwa kulit batang A. excelsa memiliki kemampuan antioksidan yang sangat kuat. Alphitonia excelsa is a plant that potential to be tested for its antioxidant ability and has been used as medicine. This underlies the purpose of this study, namely to determine the antioxidant activity and total flavonoids of the stem bark of A. excelsa. The method used in antioxidant evaluaion was 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, while the total flavonoid assay with AlCl3 was carried out colorimetrically. The results obtained from this study were the IC50 value of the antioxidant activity and total flavonoids of A. excelsa, with the value of 37.00 ± 1.46 μg/ml and 1.17% ± 0.04 quercetin equivalent, respectively. Based on these values, it can be concluded that the stem bark of A. excelsa has a very strong antioxidant capacity.
Matoa Leaf Serum (Pometia pinnata Forst) : Physical Characteristics and Antioxidant Activity Khairunnisa, Amalia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.49154

Abstract

Matoa Leaf (Pometia pinnata Forst) has antioxidant activity that inhibits free radicals. This research aims to determine the physical characteristic and antioxidant activity of facial serum Matoa leaves (P. pinnata Forst.) with concentrations of the ethanol extract F1 (1%), F2 (3%), and F3 (5%). The physical characteristics tested included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesivity. Antioxidant activity was determined by the DPPH method. The organoleptic results showed that the serum had a yellowish-brown to greenish-brown color, a distinctive aroma of extract, a slightly viscous liquid, and homogeneity. pH test results in F1, F2, and F3 were 6.93±0.02, 5.66±0.02, and 5.05±0.01. Viscosity test results in F1, F2, and F3 were 2983.3±76.3 cP, 3200±50 cP, and 3950.0±50.0 cP. Spreadability test results in F1, F2, and F3 were 5.33±0.05 cm, 5.06±0.05 cm, and 5.03±0.05 cm. Adhesivity test results in F1, F2, and F3 were 1.3±0.04 seconds, 1.89±0.07 seconds, and 2.43±0.09 seconds. Antioxidant activity values in F1, F2, and F3 were 206,445±2,900 ppm (very weak), 149,464±4,025 ppm (moderate), and 49,204±0.383 ppm (very strong). This research concludes that increasing the concentration of the extract increases color and aroma intensity, viscosity, and adhesivity, and decreases the pH value, spreadability, and IC50 value of facial serum.
Penerapan Simple Water Filter pada Masyarakat Desa Benua Raya, Kecamatan Bati-Bati, Kabupaten Tanah Laut Ramadhan, Hafiz; Forestryana, Dyera; Hasymi, Liana Fitriani; Sutomo, Sutomo; Khairunnisa, Amalia; Istikowati, Wiwin Tyas
Yumary: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 3 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v5i3.3660

Abstract

Purpose: The aim of this community service is a form of disaster preparedness to prevent health problems through the implementation of simple water filters in Benua Raya Village, Bati-Bati District, Tanah Laut Regency. Methodology: Activities were carried out by implementing Clean and Healthy Living Behavior (PHBS) counseling and training on making simple water filters for community mothers and Posyandu cadres with a total of 52 people on September 18th, 2024. Results: The activity results showed that participants knew and understood the importance of PHBS, especially using clean and suitable water for daily life and when affected by natural disasters as a form of disease prevention. The percentage of knowledge before the activity was 80.77%-94.23%, which increased after the activity to 96.15%-100%. The level of knowledge and skills of participants in making simple water filters also increased from 44.23%-48.08% to 88.46%-94.23%. Conclusions: This activity concludes that counseling and training on making simple water filters can increase the awareness of the people of Benua Raya Village to implement PHBS and can be one of the family preparedness efforts in obtaining clean water when a flood disaster occurs. Limitations: The activity was only attended by Posyandu cadres and housewives. Contribution: The counseling, education, and training activities for the Benua Raya Village community need to be carried out consistently because they contribute to increased awareness of Clean and Healthy Living Behavior.
Skrining senyawa Combretum Indicum sebagai inhibitor Caspase 3 secara In Silico Hadi, Samsul; Salma, Salma; khairunnisa, Amalia; Kamelia, Suci
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.3999

Abstract

Osteoarthritis ialah gangguan sendi degeneratif yang ditandai dengan erosi cartilage artikular. Salah satu protein yang mempunyai peran besar dalam penyakit ini adalah caspase sub type 3. Sehingga tujuan dari penelitian ini adalah skrining senyawa belanda yang berpotensi sebagai inhibitor caspase 3. Metode dari penelitian ini menggunakan seanyawa yang terkandung dalam Combretum indicum, data ini kemudian dilakukan docking menggunakan software PLANTS. Hasil dari penelitian ini adalah scor docking dari masing masing senyawa yaitu Isatin Sulfonamide -90,8975; Casuariin -92,4942; asquisqualic acid -90,8911; 1-desgalloyleugeniin -100,988; arachidonic acid -63,4613; Punicalin -88,2142; linoleic acid - 97,4111; gallic acid -59,1281; Rutin-95,3717; ellagic acid -63,6793; methyl ursolate -77,5611; flavogallonic acid -80,8221; Quisqualic acid -63,1281; brevifolin carboxylic acid -71,5203; Trigonelline-59,8987; Quercetin -74,4091; quinoline-4-carbonitrile -61,5971; β-sitosterol -87,3881; Pedunculagin-86,843 Lupeol -76,4221; Punicalagin -82,1754; linalool -67,8673; Eugeniin -100,7541.Oleh karena itu senyawa yang berpotensi sebagai inhibitor caspase 3 adalah Rutin, linoleic acid, asquisqualic acid, Eugenin, Casuariin, 1-desgalloyleugeniin.
Pengaruh Religiusitas dan Konsep Diri Terhadap Kesadaran Diri pada Wanita Pengguna Khimar Khairunnisa, Amalia; Rozi, Fahrul
Jurnal Ilmiah Penelitian Psikologi Vol 5 No 1 (2019): 2019
Publisher : Psikologi UHAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jippuhamka.v5i1.9250

Abstract

Fashion merupakan fenomena yang sangat cepat dalam perkembangannya, salah satu fashion yang berkembang sangat cepat adalah fashion busana. Busana berfungsi untuk menutupi seluruh bagian tubuh dari kepala hingga kaki yang juga berfungsi sebagai pembeda antar umat beragama, dalam agama Islam salah satu busana yang sedang ramai diperbincangkan adalah khimar yang pada dasarnya penutup kepala yang digunakan menjulur hingga menutupi dada. Dalam penggunaannya khimar digunakan karena adanya evaluasi diri sehingga menimbulkan kesadaran diri pada diri individu. Kesadaran diri dalam penggunaan khimar dapat timbul karena adanya sikap religiusitas yang membuat individu berkomitmen dengan agama yang dianutnya serta adanya konsep diri yang membuat individu mampu mempersepsikan segala hal yang terjadi didalam kehidupannya. Oleh karena itu penelitian ini bertujuan untuk Mengidentifikasi hubungan yang signifikan antara religiusitas dengan kesadaran diri pada wanita pengguna khimar, mengidentifikasi hubungan yang signifikan antara konsep diri dengan kesadaran diri pada wanita pengguna khimar, dan mengidentifikasi pengaruh yang signifikan antara religiusitas dan konsep diri terhadap kesadaran diri pada wanita pengguna khimar. Metode peneliatan yang digunakan adalah metode penelitian kuantitatif, populasi dalam penelitian ini adalah seluruh wanita pengguna khimar usia 18-40 tahun. Dengan sampel dalam penelitian ini yaitu 150 responden wanita pengguna khimar usia 18-40 tahun. Subjek penelitian diambil secara acak atau Non Probability Sampling dan menggunakan teknik Purposive Sampling. Alat pengumpulan data yang digunakan adalah Skala Religiusitas, Personal Self-Concept (PSC) Questionnaire, dan Self-Conscioussness Scale Revised (SCS-R). Skala Religiusitas yang terdiri dari 12 item valid dan 1 item tidak valid dengan (kefisien alpha α = 0.907), Personal Self-Concept (PSC) Questionnaire terdiri dari 12 item valid dan 6 item tidak valid dengan (koefisien alpha α = 0.736), dan Self-Conscioussness Scale Revised (SCS-R) terdiri 19 item valid dan 4 item tidak valid dengan (koefisien alpha α = 0.857). Analisis data menggunakan teknik Multiple Regresi. Berdasarkan hasil analisa Multiple Regresi diketahui nilai íŸ Unstandradize Religiusitas sebesar 0.031 memiliki probability values 0.683 (p>0.05). Dan pada íŸ Unstandradize Konsep Diri sebesar 0.456 memiliki probability values 0.000 (p<0.05). Dan pengaruh Religiusita dan Konsep Diri terhadap Kesadaran diri memiliki koefisien R2 sebesar 0.202 yang menunjukkan kontribusi variabel Religiusitas dan Konsep Diri terhadap Kesadaran Diri sebesar 20,2% dan sisanya 79,8% dipengaruhi oleh variabel lain, koefisien F sebesar 18,642 dengan probability values sebesar 0.000 (p<0.05).
Co-Authors Anna Khumaira Sari Dewi Kartika Fahrul Rozi Forestryana, Dyera Kamelia, Suci Liana Fitriani Hasymi Muhammad Ikhwan Rizki Muliana, Ana Nani Kartinah Normaidah, Normaidah Rahmadati, Erfiza Ramadhan, Hafiz Salma Salma Samsul Hadi Sutomo Sutomo Viogenta, Pratika Wiwin Tyas Istikowati