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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Prosiding University Research Colloquium Jurnal Farmasi Klinik dan Sains Usadha Journal of Pharmacy
Naelaz Zukhruf Wakhidatul Kiromah
Universitas Muhammadiyah Gombong
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology

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FORMULATION AND EVALUATION OF HANDSANITIZER GANITRI LEAVE EXTRACT (Elaeocarpus ganitrus Roxb) Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Jurnal Farmasi Klinik dan Sains Vol 2, No 1 (2022): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v2i1.815

Abstract

Ganitri (Elaeocarpus ganitrus Roxb.) is one of the traditional medicinal plants that grows in Kebumen Regency, every part of the plant can cure various diseases. The leaves are known to contain carbohydrates, alkaloids, flavonoids, saponins, steroids, glycosides and anthraquinones which show antibacterial activity. Research on the development of pharmaceutical preparations from ganitri leaves has never been done. Seeing the large number of ganitri plants that grow and their great potential, this study aims to develop a pharmaceutical formulation in the form of a Hand Sanitizer.The results showed that formula 1 in the hand sanitizer spray preparation with a concentration of 1% ganitri (Elaeocarpus ganitrus Roxb.) leaf ethanol extract and 5% aloe vera had the best physical evaluation of the preparation. The data from the physical evaluation were analyzed statistically, namely the pH test and the viscosity test. The results of the normality test data and homogeneity test data with P> 0.05, which means that the data is normally distributed and homogeneous. The results of the ANOVA test showed that in the pH test there was no significant difference because the significance value was p> 0.05, while in the viscosity test the significance value was P < 0.05, it could be concluded that the average concentration of each formula in the viscosity test had a significant difference and systemically proven. Formulas 1, 2 and 3 had the diameter of inhibition against all test bacteria with the best inhibition in formula 2 of 18 mm on e.coli bacteria, 17.19 mm on s. aureus bacteria and 17 mm on shigella bacteria.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN LULUR KRIM EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) DENGAN METODE DPPH (1,1-diphenyl-2-pikrilhidrazil) Irma Nusa Mazidah; Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati
Jurnal Farmasi Klinik dan Sains Vol 4, No 1 (2024): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v4i1.1293

Abstract

Tanaman daun sirih merah (Piper crocatum Ruiz & Pav) merupakan salah satu tanaman yang mempunyai aktivitas antioksidan karena memiliki kandungan senyawa flavonoid. Untuk membuat sediaan lulur krim antioksidan dari daun sirih merah (Piper crocatum Ruiz & Pav) dengan metode DPPH (1,1-diphenyl-2-pikrilhidrazil) yang dapat diformulasikan sebagai bahan aktif dalam sediaan lulur krim untuk membantu menjaga kesehatan kulit. Ketiga formula dengan variasi trietanolamin yang berbeda yaitu F1 2%, F2 3% dan F3 4% diuji sifat fisiknya dengan parameter uji organoleptis, homogenitas, viskositas, daya sebar dan daya lekat. Dari parameter uji tersebut F1 dengan trietanolamin 2% sebagai formula dengan uji fisik yang baik kemudian di uji DPPH (1,1-diphenyl-2-pikrilhidrazil). Hasil dari penelitian ini menunjukan F1 memiliki aktivitas antioksidan sedang dengan nilai sebesar 117,69 ppm, vitamin C sebagai kontrol prositif memiliki aktivitas antioksidan sangat kuat dengan nilai IC50 sebesar 6,449 ppm. Formula lulur krim ekstrak etanol 90% daun sirih merah (Piper crocatum Ruiz & Pav.) memiliki nilai IC50 dengan kategori sedang.
Uji Aktivitas Ekstrak Etanol Daun Sirih Hijau(Piper betle L.) Bakteri Klebsiella Pneumonia Penyebab Ulkus Diabetik Septi Wahyuni; Titi Pudji Rahayu; Naelaz Zukhruf Wakhidatul Kiromah
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.19173

Abstract

Daun sirih hijau (Piper betle L ) merupakan tanaman obat yang memiliki khasiat sebagai pengobatan salah satunya antibakteri dan dapat digunakan sebagai alternatif pengobatan ulkus diabetik. Ulkus diabetik merupakan salah satu komplikasi penyakit diabetes melitus dengan adanya luka terbuka pada kulit. Senyawa yang memiliki aktivitas antibakteri pada daun yaitu senyawa fenol. Bakteri Klebsiella pneumonia penyebab ulkus diabetik. Tujuan Penelitian, Untuk mengetahui aktivitas antibakteri dan mengetahui konsentrasi ekstrak daun sirih hijau  dengan menggunakan pelarut etanol 96% terhadap bakteri Klebsiella pneumonia penyebab ulkus diabetik. Penelitian ini menggunakan metode difusi (paper disc) untuk uji antibakteri. Media yang digunakan NA. Kontrol positif yang digunakan ciprofloxacin, seri konsentrasi ekstrak yang digunakan 3%, 5% dan 7,5%. Diameter zona hambat diamati kemudian dianalisis menggunakan uji statistik One Way Anova. Hasil Penelitian, Uji aktivitas antibakteri ekstrak etanol 96% daun sirih hijau   terhadap bakteri Klebsiella pneumonia penyebab ulkus diabetik yaitu 9,37 pada konsentrasi 7,5%. Kesimpulan, Ekstrak etanol daun sirih hijau mempunyai daya hambat terhadap bakteri Klebsiella pneumonia   penyebab ulkus diabetik.Kata kunci:Daun sirih hijauUlkus diabeticCiprofloxacinPaper disc
Uji Aktivitas Ekstrak Etanol dan Akuades Umbi Rumput Teki (Cyperus rotundus L.) Sebagai Repellent Terhadap Nyamuk Aedes aegypti Naelaz Zukhruf Wakhidatul Kiromah; Siti Inayah; Satria Eta Mulyana; Zalsa Billa; Syifa Churrohmah; Rizki Nur Azizah
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.19174

Abstract

The dengue virus is one of the causes of Dengue Fever (DF) and is transmitted through the bite of Aedes aegypti mosquitoes. The tuber of the nutgrass plant contains flavonoid compounds known to have insect-repellent activity. This research aims to determine the repellent activity and % protection value of 96% ethanol and water extracts of nutgrass tubers (Cyperus rotundus L.). The research was conducted using male white rats with a repellent test method, and the data generated is the percentage of protection. The concentrations of 1.5%, 3%, and 6% of nutgrass tuber 96% ethanol extract exhibited repellent activity with percentage protection values of 42.7%, 54.02%, and 73.84%, respectively. The aqueous extract of nutgrass tubers showed percentage protection values of 46.34%, 58.66%, and 72.94%, respectively. These results were statistically significant (p<0.05). The research findings indicate that a concentration of 6% provides the highest protection against mosquito bites for both extracts.
Co-Authors Arnika Dwi Asti Asriani Tangawuningsih Ayu Fatimah Ayu Nissa Ainni Chondrosuro Miyarso Findi Maretha H Herniyatun Hijan Dzulfadhli Utomo Indah Rachmawati Irma Nusa Mazidah Laeli Fitriyati Leni Melisa Noviani Pratiwi Nur Ambarwati Rizka Hidayatus Sholihah Rizki Nur Azizah Rokhania Eka Pravitasari Saniati Hasanah Satria Eta Mulyana Septi Wahyuni Sinta Wahyu Septiani Siti Inayah Sukma Edhie Febrialfiyan Syifa Churrohmah Titi Pudji Rahayu Uswatun Hasanah Uswatun Hasanah Venny Septiana Rahayu Yayu Krisdiyanti Zalsa Billa