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All Journal Jurnal Pangan dan Gizi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences METAMORFOSA Journal of Biological Sciences Cannarium (Jurnal Ilmu-ilmu Pertanian) Jurnal Pangan dan Agroindustri Jurnal Keteknikan Pertanian Tropis dan Biosistem Jurnal Ilmiah Universitas Batanghari Jambi JITIPARI (Jurnal Ilmiah Teknologi dan Industri Pangan UNISRI) AGRITEKNO, Jurnal Teknologi Pertanian Jurnal Teknologi Pertanian Andalas Journal of Tropical AgriFood Agrica: Journal of Sustainable Dryland Agriculture Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Teknologi Pangan CHEMTAG Journal of Chemical Engineering JURNAL AGROTEKNOSAINS Jurnal Riset Teknologi Pangan Dan Hasil Pertanian (RETIPA) Journal of Food and Agricultural Product Jurnal Ilmiah Pangan Halal Rona Teknik Pertanian Jurnal Ilmu-Ilmu Pertanian
Jatmiko Eko Witoyo
Institut Teknologi Sumatera
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Social Sciences Other

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Kajian Bioinformatika Penghambatan Alosterik Asemanan Dan Glukomanan Terhadap C-JUN NH2 Terminal Kinase (JNK) Dewi Ratih Tirto Sari; Reni Ustiatik; Jatmiko Eko Witoyo; Gabriella Chandrakirana Krisnamurti; Yohanes Bare
SPIZAETUS: JURNAL BIOLOGI DAN PENDIDIKAN BIOLOGI Vol 2, No 2 (2021): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v2i2.47

Abstract

cJun NH2 terminal Kinase (JNK) merupakan protein kinase family MAPK yang berperan dalam j alur pensinyalan penyakit metabolisme, salah satunya dalam regulasi faktor resiko obesitas. Penelitian in bertujuan untuk mengeksplorasi potensi asemanan dan glukomanan dalam menghambat JNK sebagai antidiabetes.metode pendekatan molecular docking digunakan untuk mengidentifikasi interaksi antara senyawa asemanan dan glukomanan terhadap protein JNK. Asemanan dan glukomanan berikatan di sisi aktif yang berbeda satu sama lain. Residu sisi aktif asemanan berada di close gate protein JNK, sedangkan glukomanan menunjukkan sisi aktif jalur ikatan inhibitor dari JNK. Asemanan dan glukomanan menghambat aktivitas JNK dengan berikatan di sisi non-katalitik dan diprediksi penghambatan protein JNK oleh kedua senyawa secara alosterik yang dapat merubah konformasi protein JNK. Selain itu, asemanan berikatan dengan kuat terhadap protein JNK dengan jenis ikatan hydrogen, interaksi hidrofobik dan elektrostatik dengan energi ikatan yang lebih rendah dari glukomanan – JNK. Penelitian disimpulkan bahwa senyawa asemanan dan glukomanan berpotensi sebagai antiobesitas dengan peranannya sebagai inhibitor terhadap protein JNK.
Extraction Methods and Bioactivity of Essential Oils from Kesum Leaves (Persicaria odorata): A Short Review Panggulu Ahmad Ramadhani Utoro; Jatmiko Eko Witoyo; Dikianur Alvianto; Nelsy Dian Permatasari
SPIZAETUS: JURNAL BIOLOGI DAN PENDIDIKAN BIOLOGI Vol 3, No 3 (2022): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v3i3.82

Abstract

Persicaria odorata (Synonym of Polygonatum odoratum and Polygonum minus) leaves, locally known as Kesum leaves, is one of Indonesia's biodiversity species, particularly on Kalimantan Island, and it is contained a high concentration of essential oils. The extraction of essential oil from Kesum leaves commonly uses various methods, including solvent extraction, steam distillation, hydro-distillation, supercritical fluid extraction, microwave-assisted extraction, ultrasonic-assisted extraction, and so on, with various extract characteristics produced. Several studies reported that Kesum leaves essential oil has numerous advantages, including anti-bacterial, hepatoprotective, anti-tyrosinase, antioxidant properties, and so on. Future research will require additional and new techniques, particularly non-thermal extraction technology and other bioactivity tests, to improve yield and maintain the essential oil composition of Kesum leaves. 
In Silico Screening of Syzygium myrtifolium Flavonoid Compoinds as Anti-bacterial Activity: In Silico Screening of Syzygium myrtifolium Flavonoid Compounds Nelsy Dian Permatasari; Jatmiko Eko Witoyo; Masruri; Sudarminto Setyo Yuwono; Simon Bambang Widjanarko
Journal of Tropical Life Science Vol. 12 No. 3 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.03.02

Abstract

Bacterial infection and antibiotic resistance are popular issues nowadays. Several pre[1]vious reports performed antibacterial screening activities involving natural herbs and synthetic drugs. Alanine racemase and transglycosylase are essential proteins for peptidoglycan membrane synthesis in bacteria and an alternative target for antibacterial performance. This study identified six flavonoid compounds in Syzygium myrtifolium to perform the antibacterial activity. In silico study was conducted for modelling flavonoids – protein complexes. Five flavonoids from S. myrtifolium were taken out of he canonical smiles from the PubChem database and modelled three-dimensional structure using ChemDraw and molView. Targeted protein, alanine racemase and transglycosylase were downloaded from Protein Data Bank with ID 4WR3 and 1SLY. Ligands and proteins were interacted by Molegro virtual Docker 5.0 and visualized by Discovery studio version 21.1.1. Five flavonoids showed inhibition with alanine racemase and transglycosylase in the same active sites of control and sodium benzo[1]ate. According to the binding energy, calopiptin performed the lowest binding energy value in alanine racemase complexes, while 2-Propanone, 1,3-bis(5-nitro-2-furanyl) showed the lowest value of four other flavonoids at transglycosylase complexes. The type of interactions were electrostatic, hydrogen bonds, hydrophobic interactions and unfavorable ones. Low binding energy and varied interaction types indicated tight of ligand-protein interaction. In summary, five flavonoids inhibited alanine racemase and transglycosylase, and the peptidoglycane membrane synthesis in bacteria might be inferred.
Tinjauan literatur singkat bioaktivitas ekstrak daun matoa (Pometia pinnata) dari Indonesia dan aplikasinya pada produk pangan Panggulu Ahmad Ramadhani Utoro; Jatmiko Eko Witoyo; Muhammad Alwi
Journal of Tropical AgriFood Volume 4, Nomor 2, Tahun 2022
Publisher : Jurusan Teknologi Hasil Pertanian Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35941/jtaf.4.2.2022.9293.67-76

Abstract

Pometia pinnata merupakan tumbuhan tropis yang berasal dari famili Sapindaceae tersebar luas di daerah Indonesia yang dimanfaatkan masyarakat sebagai obat tradisional yang dikenal sebagai daun matoa. Daun matoa mengandung banyak senyawa bioaktif seperti saponin, terpenoid, flavonoid, alkaloid, tanin dan kumarin. Ekstraksi komponen biaoaktif daun matoa umumnya menggunakan metode maserasi dengan berbagai pelarut, antara lain etanol, aquadest, n-hexane, ethyl acetate, dan lain-lain, dengan berbagai jumlah komponen bioaktif yang dihasilkan. Beberapa penelitian melaporkan bahwa daun matoa memiliki banyak manfaat, antara lain sebagai penurun tekanan darah, membantu mengobati diabetes, penyakit perut (diare dan disentri), penyakit ginekologi, dan saat ini daun matoa dikembangkan sebagai suplemen atau fortifikasi pada susu. Penelitian yang akan datang diharapkan dan membutuhkan inovasi baru, terutama mengenai teknologi fortifikasi pangan yang dapat diaplikasikan dengan ekstrak daun matoa, untuk meningkatkan hasil dan ekonomi tanaman matoa.
Virtual Prediction of Zerumbone Compound in Lempuyang as Anti-Bacterial Agent Through In-Silico Approach Jatmiko Eko Witoyo; Nelsy Dian Permatasari; Panggulu Ahmad Ramadhani Utoro
Metamorfosa: Journal of Biological Sciences Vol 10 No 2 (2023)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2023.v10.i02.p11

Abstract

A native herbaceous plant of Southeast Asia, lempuyang is also widely distributed in Indonesia. This plant's primary bioactive component, Zerombone, has a variety of bioactivities, including an anti-bacterial effect. Typically, transglycosylase and alanine racemase were necessary proteins for forming peptidoglycan membranes and are now frequently used as anti-bacterial targets. Thus, using an in-silico approach, this work assessed the interactions between the zerumbone and the protein targets. The PubChem database was searched for the zerumbone compound (CID 5470187). Transglycosylase (PDB code: 1SLY), alanine racemase (PDB code: 4WR3), and the control protein target were also obtained from the PDB database. The Molegro Virtual Docker 5.0 version and the Discovery Studio application 21.1.1 versions were used to interface with and visualize the protein target and zerumbone compound. The result demonstrated that, like the control, the zerumbone compound in lempuyang blocks the active sites of the transglycosylase and the alanine racemase. The zerumbone-alanine racemase complexes additionally showed lower energy binding than other complexes. In conclusion, zerumbone in lempuyang can be a new candidate for anti-bacterial agents by inhibiting the synthesis of membrane peptidoglycan via suppressing transglycosylase and alanine racemase activities.
Local Legumes from Dry Land of East Nusa Tenggara: Diversity, Nutritional Composition, and Their Use in Society – A Literature Study Hyldegardis Naisali; Jatmiko Eko Witoyo; Panggulu Ahmad Ramadhani Utoro
JITIPARI Vol 8 No 2 (2023)
Publisher : Universitas Slamet Riyadi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/jitipari.v8i2.9054

Abstract

East Nusa Tenggara (ENT) is a province in Indonesia with diverse flora, including the diversity of local legumes. It has been extensively explored and reported in various scientific publications, especially the types of legumes, their nutritional composition, and their uses in local communities. However, few literature studies still comprehensively review the types of legumes, their nutritional composition, and their utilization in the local community of ENT. So, this literature review aims to briefly review the diversity, chemical composition, and use of local legumes from the dry lands of ENT. Various studies reported that Glycine max, Arachis hypogaea, Vigna radiata (L.) R. Wilczek, Cajanus cajan, Vigna unguiculata, Phaseolus lunatus, Vigna umbellata, Lablab purpureus (L.) Sweet, Mucuna pruriens (L.) DC, Phaseolus vulgaris L, Psopocarpus tetragonolobus (L.) DC, and Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep nuts are commonly found in the ENT region, either cultivated by the local community or grown wild. Generally, local legumes in ENT have a relatively complete nutritional composition, which varies depending on the type of bean. The ENT's local people use local beans as a mixture of rice/corn and function as sources of protein. Future research is needed to explore the functional characteristics of each ENT local bean. In addition, it is necessary to develop formulations and other food products to utilize ENT's local legumes to diversify legume-based local food.
Kajian Pustaka Karakteristik Fisiko-Kimia Jagung dari Nusa Tenggara Timur, dan Produk Turunan Tradisionalnya Hyldegardis Naisali; Jatmiko Eko Witoyo; Panggulu Ahmad Ramadhani Utoro; Nelsy Dian Permatasari
AGRICA Vol. 16 No. 2 (2023): December
Publisher : Agriculture Faculty of Flores University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/agr.v16i2.3006

Abstract

Corn is a carbohydrate-based food source in the East Nusa Tenggara (ENT) region and is the second staple food after rice. Corn has been a hereditary food ingredient in the ENT region from generation to generation with various local names. However, comprehensive literature studies discussing productivity, diversity, physicochemical characteristics, and traditional corn derivative products from ENT are still rare and limited. The purpose of writing this article is to review corn from ENT by emphasizing aspects of productivity, variety, physicochemical characteristics, and its traditional derivative products from various scientific sources. Literature studies showed that ENT's estimated corn production in 2021 is 750,166 tons from the three cultivated types: local, superior free-range, and hybrid. ENT's local corn has a variety of physical diversity, especially regarding grain color. Regarding chemical characteristics, ENT's local corn has a relatively complete nutritional and mineral content and is suitable for food. The local people of ENT have many traditional derivative products from corn with a total of >10 types of food, which are still sustainable from generation to generation and are processed simply with maintaining local wisdom. One famous traditional and ethnic food from ENT is "Jagung bose".
Review Keragaman dan Metode Pengolahan Umbi-Umbian Lokal Nusa Tenggara Timur Hyldegardis Naisali; Panggulu Ahmad Ramadhani Utoro; Jatmiko Eko Witoyo
Jurnal Pangan dan Gizi Vol 13, No 2 (2023): Kajian Pangan dan Gizi
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jpg.13.2.2023.1-17

Abstract

East Nusa Tenggara (ENT) is one of Indonesia's regions with a dry climate with low annual rainfall and a diversity of local tuber flora biodiversity, which has been communicated in various scientific publications. However, information on the diversity and utilization of local tubers is still partial in certain areas in ENT. This article aims to briefly review the diversity and use of local ENT tubers by local communities. The method used in preparing this article is the study of literature from various scientific journals and books related to local tubers. Several studies reported that Manihot esculenta and Ipomoea batatas are local tubers widely cultivated in almost all areas of ENT. Colocasia esculenta, Solanum tuberosum, Canna edulis, Dioscorea esculenta, Dioscorea bulbifera, and Amorphophallus muelleri Blume are local tubers which have begun to be cultivated in a limited manner in several areas in ENT. Apart from that, many wild minor tubers are found around yards and forests in almost all areas of ENT, such as Dioscorea alata, Amorphophallus paeoniifolius, and Dioscorea hispida. Local tubers, both cultivated and growing wild in ENT, function as an alternative source of carbohydrates during the lean season. The method of processing local tubers by the oENT's people into food is still straightforward and traditional: boiling, burning, and frying or processing them into tuber flour.
Phytochemicals - Bioactivity of Avicennia marina Leaves Extract, and Its Application in Food Products: A Brief Literature Review Jatmiko Eko Witoyo; Panggulu Ahmad Ramadhani Utoro
Rona Teknik Pertanian Vol 16, No 2 (2023): Volume No. 16, No. 2, Oktober 2023
Publisher : Department of Agricultural Engineering, Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17969/rtp.v16i2.31752

Abstract

Abstract. Avicennia marina (A. marina) is a tropical and non-tropical biodiversity that grows along the coast worldwide, including Indonesia. A. marina, known as the "gray mangrove" tree, is a mangrove plant of the Avicenniaceae family. A widely used plant part is A. marina leaves, which are further processed into A. marina leaves extracts. Various studies on A. marina leaves, extract, and their application to food products have been extensively researched and communicated in various scientific papers. So, this study aims to provide an overview of the current knowledge on A. marina leaves extract, focusing on its phytochemical-bioactivity and application in food products. Various studies have reported that A. marina leaves extract contains polyphenols, flavonoids, steroids, terpenoids, alkaloids, cardiac glycosides, saponins, tannins, anthraquinones, and other phytochemical compounds based on phytochemical screening. Several recent studies also reported that A. marina leaves extracts to have many benefits due to their biological activities, including antioxidant, anti-bacterial, anti-fungal, anti-cancer activities, and so on. The application of A. marina leaves in the food product is reported to be able to increase the specific nutritional value, such as chocolate bars and noodles. In addition, the water extract of A. marina leaves can maintain the quality of fishery products, especially fresh fish, and acts as a natural bio-formalin or bio-preservation. In future research, the application and supplementation of water extract of A. marina leave in other food products need to be studied further. In addition, other food process engineering must be applied and evaluated to produce extract of A. marina leaves with maintained bioactive compounds and their bioactivity Fitokimia - Bioaktivitas Ekstrak Daun Avicennia marina dan Aplikasinya pada Produk Pangan: Tinjauan Literatur SingkatAbstrak. Avicennia marina (A. marina) merupakan keanekaragaman hayati tropis dan non-tropis yang tumbuh di sepanjang pantai di seluruh dunia, termasuk Indonesia. A. marina, yang juga dikenal sebagai pohon "bakau abu-abu", adalah tanaman bakau dari keluarga Avicenniaaceae. Bagian tanaman yang banyak dimanfaatkan adalah daun A. marina, yang selanjutnya diolah menjadi ekstrak daun A. marina. Berbagai penelitian mengenai daun A. marina, ekstrak, dan aplikasinya pada produk pangan telah banyak diteliti dan dikomunikasikan dalam berbagai karya ilmiah. Oleh karena itu, penelitian ini bertujuan untuk memberikan gambaran umum tentang pengetahuan terkini tentang ekstrak daun A. marina, dengan fokus pada fitokimia-bioaktivitas dan aplikasinya pada produk pangan. Berbagai penelitian telah melaporkan bahwa ekstrak daun A. marina mengandung polifenol, flavonoid, steroid, terpenoid, alkaloid, cardiac glycosides, saponin, tanin, antrakuinon, dan senyawa fitokimia lain berdasarkan skrining fitokimia. Beberapa penelitian terbaru juga melaporkan bahwa ekstrak daun A. marina memiliki banyak manfaat karena aktivitas biologisnya, seperti aktivitas antioksidan, anti-bakteri, anti-jamur, dan anti-kanker. Aplikasi daun A. marina pada produk makanan, seperti pada chocolate bars dan mie, dilaporkan dapat meningkatkan nilai gizinya secara spesifik. Selain itu, ekstrak air daun A. marina dapat menjaga kualitas produk perikanan, terutama ikan segar, dan berperan sebagai bio-formalin atau pengawet alami. Pada penelitian selanjutnya, aplikasi dan suplementasi ekstrak air daun A. marina pada produk pangan lain perlu dikaji lebih lanjut. Selain itu, rekayasa proses pangan lain perlu diterapkan dan dievaluasi untuk menghasilkan ekstrak daun A. marina dengan senyawa bioaktif dan bioaktivitas yang terjaga.
Recent Trends in Porang Research via Bibliometrics Analysis Approach Jatmiko Eko Witoyo; Eva Ni’maturohmah; Panggulu Ahmad Ramadhani Utoro
Jurnal Ilmiah Universitas Batanghari Jambi Vol 23, No 3 (2023): Oktober
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v23i3.3903

Abstract

Porang is a native Indonesian plant with many benefits and has been widely studied by researchers in Indonesia. However, bibliometrics analysis of porang research is still limited. So, this study aims to establish a bibliometric analysis to know the recent trends in porang research. Data were taken from Scopus using Publish or Perish (PoP) software from 2012 to 2022 and processed further using Microsoft Excel and VOSViewer to determine the bibliometric mapping of porang research. The information on publication trends, authors, keywords, journal sources, numbers of publications, author productivity, and citations was analyzed descriptively. The 164 articles were retrieved from the Scopus database using PoP software from 2012 to 2022. The tendency for the number of publications was increased throughout the observation period, with the highest of annual publications in 2022 with 44 articles. Different trends are shown in the fluctuating number of citations each year, and the highest number of citations was found in 2014, with 91 citations. Food Research, Journal of Tropical Life Science, and IOP Conference Series: Earth and Environmental Science are the journals and conference papers that publish the most articles related to porang research, with 4, 4, and 43 articles, respectively, with Wardhani being the most productive as the first author. The “glucomannan”, “Amorphophallus muelleri" and “Amorphophallus oncophyllus” were the most title keyword in porang research, with 35, 18, and 18 occurrences, respectively.
Co-Authors Aditya Wahyu Nugraha Afifah, Amalia Alvianto, Dikianur Bambang Dwi Argo Bare, Yohanes Brahmanti, Ajeng Astrini Cavendish, Amedeo Devita, Wilda Harlia Dewi Ratih Tirto Sari Endo Pebri Dani Putra Eva Ni’maturohmah Gabriella Chandrakirana Krisnamurti Hamaisa, Atika Hyldegardis Naisali Jaya Mahar Maligan Khoirina, Adhian Dini Khoirina Kurniawan, Randy Yusuf Masruri Masruri Masruri Muhammad Alwi Nelsy Dian Permatasari Ni'maturohmah, Eva Pamungkas, Bangkit Puji Putra Pangestuti, Martasari Beti Panggulu Ahmad Ramadhani Utoro Permatasari, Nelsy D Pratama, Borneo Satria Putra, Tamam Athallah Rhely Rahayu, Lisa F Ristianti, Wigi Putri Saraswati, Ayu R SARASWATI, Ayu Rahayu Sari, Yanti SIMON BAMBANG WIDJANARKO Sudarminto Setyo Yuwono Susilo, Donor Utomo M. Ustiatik, Reni Utoro, Panggulu A R Yunira, Eka Nur'azmi