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Ekspresi Phosphatase Regenerating Liver-3 dan E-Cadherin pada Kanker Serviks Stadium Awal dan Lanjut Lokoregional ARIFUDDIN, SHARVIANTY; ASKANDAR, BRAHMANA; MISKAD, UPIK ANDERIANI
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : "Dharmais" Cancer Center Hospital

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Tujuan: untuk menyelidiki hubungan antara ekspresi PRL-3 dan E-Cadherin dengan stadium, jenis histopatologi, dan derajat diferensiasi kanker serviks. Metode: penelitian ini merupakan studi analitik dengan pendekatan potong lintang di beberapa rumah sakit pendidikan Bagian Obstetri dan Ginekologi, Makassar, mulai Januari hingga Juni 2011. Ekspresi PRL-3 dan E-Cadherin diperiksa dengan pengecatan imunohistokimia pada 16 kanker serviks stadium awal dan 15 stadium lanjut lokoregional. Hasil: ekspresi PRL-3 tidak berbeda bermakna antara kanker serviks stadium awal dengan stadium lanjut lokoregional, antara berbagai jenis histopatologik dan derajat diferensiasi (p>0,05). Ekspresi E-Cadherin juga menunjukkan tidak ada perbedaan bermakna antara berbagai stadium, jenis histopatologi, dan derajat diferensiasi (p>0,05). Tidak didapatkan korelasi bermakna antara ekspresi PRL-3 dengan E-Cadherin pada penelitian ini. Kesimpulan: tidak ada hubungan antara ekspresi PRL-3 dan E-Cadherin dengan stadium, jenis histopatologi, dan derajat diferensiasi kanker serviks.Kata Kunci: Kanker serviks stadium awal, kanker serviks stadium lanjutlokoregional, adenokarsinoma, karsinoma sel skuamosa, derajat diferensiasi, PRL-3, E-Cadherin.

The Risk of Infection Human Papilloma Virus Infection in Acceptors of Depot Medroxyprogesterone Acetate Contraceptions Aras, Baharuddin; Tahir, Mardiah; Arifuddin, Sharvianty; Hartono, Eddy; Chalid, Maisuri T.
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Cervical cancer is the second most prevalent cancer inwomen around the world and the most common cancer in womencausing death. This study aims to analyze the connection betweeninfection of human papilloma virus (HPV) 16/18 and cervicalchanges in the acceptors of Depot Medroxyprogesterone Acetate(DMPA) Contraceptions and nonacceptors of Depot MedroxyprogesteroneAcetate (DMPA) Contraceptions.Methods: The research was conducted at the Public ServiceInstitution of Dr. Wahidin Sudirohusodo hospital, and privatemidwife clinics for seven months from December 2015 to June 2016.The research design is cross-sectional with. The samples were fortyacceptors of Depot Medroxyprogesterone Acetate (DMPA) and fortynon-acceptors of Depot Medroxyprogesterone Acetate (DMPA)contraception. Prevalence of HPV 16/18 and cervical cytologychanges were examine using the polymerase chain reaction andliquid base cervical cytology.Results: The results showed there was no significant relationshipbetween long-term use of DMPA contraceptives with HPV 16 and 18.There was no significant relationship between long-term use ofDMPA contraceptives with cervical cytology changes. There was nosignificant relationship between HPV 16 and 18 infections with theoccurrence of cervical cytology changes in long-term use of DMPAcontraceptives.Conclusion: The long-term use of DMPA contraceptive does notincrease the risk of HPV 16 and 18 infections. Also does not causecervical cytology changes that lead to cervical malignancy.Keywords: cervical cytology changes, Depot MedroxyprogesteroneAcetate (DMPA) contraception, HPV 16/18 infection

Endoglin Expression (CD105) in Ephithelial Ovarian Cancer Jumsa, Rizkinov; Rambulangi, John; Arifuddin, Sharvianty; Miskad, Upik
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: Endoglin ( CD105 ) is one of the factors that play a role in vascular development , angiogenesis and vascular homeostasis. The aim of this research is to address the endoglin expression (CD105) in primary tumor and metastasis tumor (omentum) and their relation with clinicopathological factor: stadium, differentiation level, and histological epithelial ovarian cancer. Method: The research was performed at Public Service Hall of Dr. Wahidin Sudirohusodo Hospital and educational networking hospital of Obstetrics and Gynecology Departement of Medical Faculty Hasanuddin University Makassar. The research design is cross sectional with 55 samples consisting of 55 samples of primary tumor and 55 matastasis tumor. Imunohistochemistry examination was performed to all samples. Result:The results show a significant relation between endoglin (CD105) at omentum metastasis tumor and stadium and cell differentiation level of epithelial ovarian cancer. There is no significant relation between endoglin (CD105) expression at primary tumor of ovarian cancer and stadium and differentiation and type of histopathological cell. In addition, there is no significant relation between endoglin expression (CD105) at omentum metastasis tumor and type of histophatological cell of ovarian cancer. There is a significant correlation (strong category) between endoglin expression at omentum metastasis tumor and endoglin expression at primary tumor of epithelial ovarian cancer. Conclusion: Endoglin expression in ovarian cancer metastatic tumor to omentum is correlated to clinical stage and differentiation level of ovarian cancer. And endoglin is one of the pro angiogenic and pro metastasis factors. Keywords:epithelial ovarian cancer, endoglin expression, CD105, immunohistochemistry  

PENGARUH SUPLEMENTASI VITAMIN E TERHADAP KADAR PROSTAGLANDIN (PGF2Α) DAN INTENSITAS NYERI HAID (DYSMENORRHEA) PRIMER PADA REMAJA PUTRI Hutagaol, Iin Octaviana; Arifuddin, Sharvianty; Syamsudin, Saidah
The Southeast Asian Journal of Midwifery Vol 4 No 2 (2018): The Southeast Asian Journal of Midwifery
Publisher : Asosiasi Pendidikan Kebidanan Indonesia

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Painful menstruation (dysmenorrhoe) caused by a primary phase endometrium secretion producing excessive prostaglandin F2 alpha . The research aimed at investigating the effect of vitamin E supplementation on the prostaglandin content (PGF2α) and the primary (dysmenorrhea )intensity. This was a quasi experiment reseacrh with the pre-post test control group design The research result indicates that the average PGF2α content in the intervention group who is given the vitamin E is lower than control group who is given the vitamin E is lower than the control group who is given the placebo. The pain intensity median in the intervention group who is given the vitamin E is lower than the control group who is given the placebo. There is the effect of the vitamin E supplementation on the PGF2a and the pain intesity (dysmenorrhoe). Based on the paired T- test, the PGF2aof the intervention group is (p=0.000) and the cotrol group is (p=0,0.158) with a=0.05. Based on Wilcoxon sign test, the menstrual pain intensity of the intervention group is (p=0.000) and the control group is (p=0.480)..

The Risk of Infection Human Papilloma Virus Infection in Acceptors of Depot Medroxyprogesterone Acetate Contraceptions Aras, Baharuddin; Tahir, Mardiah; Arifuddin, Sharvianty; Hartono, Eddy; Chalid, Maisuri T.
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Cervical cancer is the second most prevalent cancer inwomen around the world and the most common cancer in womencausing death. This study aims to analyze the connection betweeninfection of human papilloma virus (HPV) 16/18 and cervicalchanges in the acceptors of Depot Medroxyprogesterone Acetate(DMPA) Contraceptions and nonacceptors of Depot MedroxyprogesteroneAcetate (DMPA) Contraceptions.Methods: The research was conducted at the Public ServiceInstitution of Dr. Wahidin Sudirohusodo hospital, and privatemidwife clinics for seven months from December 2015 to June 2016.The research design is cross-sectional with. The samples were fortyacceptors of Depot Medroxyprogesterone Acetate (DMPA) and fortynon-acceptors of Depot Medroxyprogesterone Acetate (DMPA)contraception. Prevalence of HPV 16/18 and cervical cytologychanges were examine using the polymerase chain reaction andliquid base cervical cytology.Results: The results showed there was no significant relationshipbetween long-term use of DMPA contraceptives with HPV 16 and 18.There was no significant relationship between long-term use ofDMPA contraceptives with cervical cytology changes. There was nosignificant relationship between HPV 16 and 18 infections with theoccurrence of cervical cytology changes in long-term use of DMPAcontraceptives.Conclusion: The long-term use of DMPA contraceptive does notincrease the risk of HPV 16 and 18 infections. Also does not causecervical cytology changes that lead to cervical malignancy.Keywords: cervical cytology changes, Depot MedroxyprogesteroneAcetate (DMPA) contraception, HPV 16/18 infection

Endoglin Expression (CD105) in Ephithelial Ovarian Cancer Jumsa, Rizkinov; Rambulangi, John; Arifuddin, Sharvianty; Miskad, Upik
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: Endoglin ( CD105 ) is one of the factors that play a role in vascular development , angiogenesis and vascular homeostasis. The aim of this research is to address the endoglin expression (CD105) in primary tumor and metastasis tumor (omentum) and their relation with clinicopathological factor: stadium, differentiation level, and histological epithelial ovarian cancer. Method: The research was performed at Public Service Hall of Dr. Wahidin Sudirohusodo Hospital and educational networking hospital of Obstetrics and Gynecology Departement of Medical Faculty Hasanuddin University Makassar. The research design is cross sectional with 55 samples consisting of 55 samples of primary tumor and 55 matastasis tumor. Imunohistochemistry examination was performed to all samples. Result:The results show a significant relation between endoglin (CD105) at omentum metastasis tumor and stadium and cell differentiation level of epithelial ovarian cancer. There is no significant relation between endoglin (CD105) expression at primary tumor of ovarian cancer and stadium and differentiation and type of histopathological cell. In addition, there is no significant relation between endoglin expression (CD105) at omentum metastasis tumor and type of histophatological cell of ovarian cancer. There is a significant correlation (strong category) between endoglin expression at omentum metastasis tumor and endoglin expression at primary tumor of epithelial ovarian cancer. Conclusion: Endoglin expression in ovarian cancer metastatic tumor to omentum is correlated to clinical stage and differentiation level of ovarian cancer. And endoglin is one of the pro angiogenic and pro metastasis factors. Keywords:epithelial ovarian cancer, endoglin expression, CD105, immunohistochemistry  

Kepatuhan Konsumsi Tablet Zat Besi (Fe) terhadap Hemoglobin Ibu Hamil Trimester III selama Tiga Bulan di Puskesmas Poasia dan Puskesmas Lepo-Lepo Kota Kendari Andriani, Andriani; Manapa, Esther Sanda; Nontji, Werna; Syamsuddin, Saidah; Syafar, Muhammad; Arifuddin, Sharvianty
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

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Latar belakang: Tablet zat besi (Fe) paling efektif untuk meningkatkan kadar hemoglobin dan dapat menurunkan prevalensi anemia sebesar 20-25% akibat kekurangan zat besi selama trimester III zat besi yang tidak mencukupi dapat ditularkan ke janin yang sedang berkembang. Ketidakpatuhan ibu hamil dalam mencukupi kebutuhan zat besi berpotensi terjadinya anemia, bayi lahir prematur dan kematian janin. Tantangan yang perlu dibenahi yaitu bagaimana menganjurkan ibu hamil untuk patuh konsumsi tablet besi (Fe) sesuai dengan anjuran bidan dan tenaga kesehatan lainnya. Tujuan penelitian: Untuk mengetahui kepatuhan konsumsi tablet zat besi (Fe) terhadap hemoglobin ibu hamil trimester III selama tiga bulan di Puskesmas Poasia dan Puskesmas Lepo-Lepo Kota Kendari. Metode: Penelitian ini menggunakan desain Quasi Experiment dengan rancangan non randomized control group pretest-posttest metode pengambilan sampel menggunakan teknik purposive sampling besar sampel dalam penelitian ini berjumlah 140 yang terdiri dari 70 intervensi dan 70 kontrol, data dianalisis menggunakan uji Mann Whitney. Hasil: Penelitian menunjukkan terjadi peningkatan rerata skor hemoglobin pada kelompok intervensi yakni pretest 1,40 posttest 1,57. Hasil uji statistik diperoleh nilai p=0,000 (p<0,05) yang menunjukkan ada perbedaan yang signifikan rerata skor hemoglobin. Nilai rerata skor pretest pada kelompok kontrol sebesar 1,07 dan posttest 1,67. Hasil uji statistik diperoleh nilai p=0,000 (p<0,05) yang menunjukkan ada perbedaan yang signifikan rerata skor hemoglobin pada pretest dan posttest untuk kelompok kontrol. Hasil menunjukkan terjadi selisih rerata lebih tinggi kelompok intervensi dari pada kelompok kontrol. Kesimpulan:Terdapat perbedaan rerata skor peningkatan hemoglobin pada ibu hamil trimester III pada kelompok intervensi dan kelompok kontrol.

Pengaruh Model Continuity of Care dalam Asuhan Kehamilan dan Persalinan terhadap Luaran Bayi Baru Lahir Foranci, Yoki; Nontji, Werna; Arifuddin, Sharvianty
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.7470

The aim of this research is to analyze the influence of the continuity of care model in pregnancy and childbirth care on the outcomes of newborn babies. The research method used is quasi-experimental with the Posttest-Only Control Design method. The research was carried out in the working area of the Weru and Danowudu Bitung Community Health Centers, North Sulawesi, from 16 March to 16 June 2023. The population was 173 respondents and the sampling technique, namely consecutive sampling, obtained 70 pregnant women divided into 2 groups, 35 each for the intervention group and 35 for the intervention group. for the control group. The results of the research show that the probability value in the chi-square test is 0.007 in the intervention and control groups, where this value is smaller than the standard significant value of 0.05, which means there is a significant influence from the results of the Continuity of Care model in pregnancy and delivery care on the outcomes of new babies. born. The conclusion obtained is that the influence of continuity of care in pregnancy and childbirth care can influence the outcomes of newborn babies. So to improve and maintain the quality of services for pregnant women, giving birth, BBL, it is necessary to provide continuous midwifery care. Keywords: ANC, Continuity of Care, Pregnant Women, Baby Outcomes

Basil Seeds Infused Water Increases Hemoglobin Levels in Adolescent Women in Jember Widiyanti, Febrina Artha; Arifuddin, Sharvianty; Ahmad, Mardiana; Hadju, Veny; Nontji, Werna; Aryandy, Andi
Jurnal Kesehatan dr. Soebandi Vol 11 No 2 (2023): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v11i2.507

Anemia is a condition of decreased hemoglobin levels, hematocrit and erythrocyte count and requires the availability of sufficient iron and protein so that hemoglobin synthesis can be carried out. Basil seeds are a good source of micronutrients and have excellent antioxidant potential for health and can be used as an attractive beverage with various benefits. This study aims to determine the effect of giving Basil Infused Water on increasing Hemoglobin levels which is expected to be a solution to prevent anemia in young women as a preparation for becoming a mother so that complications do not occur during a future pregnancy. Materials and This research was conducted at the Nuris Islamic Boarding School, Jember Regency. This research is a Quasy Experiment with a blinded pre-post test group design . The sample used was 52 young women. Sampling by purposive sampling in accordance with the inclusion criteria. Data analysis using statistical tests paired T-test and Independent T-Test . The study showed that there was an increase in hemoglobin levels in young women after being given intervention in the form of basil infused water for 90 days with a total of three times a week. The statistical test results showed that there was a mean difference of 1.6423 gr/dl and statistically significant with p = 0.000 where p <0.05 which means there was an increase in hemoglobin levels before and after being given basil seeds infused water . Keyword: Basil Seeds, Hemoglobin, Adolescent Women

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