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All Journal PROSIDING SEMINAR NASIONAL JURNAL KIMIA SAINS DAN APLIKASI Jurnal Matematika & Sains The Journal of Pure and Applied Chemistry Research Jurnal Ilmiah Arena Tekstil Indonesian Journal of Chemistry Jurnal Kartika Kimia Fullerene Journal of Chemistry ALKIMIA : Jurnal Ilmu Kimia dan Terapan Amina Warta AKAB Journal Serambi Engineering (JSE) al Kimiya : Jurnal Ilmu Kimia dan Terapan
Muhammad Ali Zulfikar
Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Social Sciences

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A Deep Overview of Anticoagulant Drugs: Recent Synthesis and Their Activity Assay Engrid Juni Astuti; Slamet Ibrahim; Muhammad Ali Zulfikar; Sophi Damayanti
Indonesian Journal of Chemistry Vol 24, No 2 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.87252

Abstract

During the unprecedented COVID-19 pandemic, anticoagulant drugs have emerged as a crucial component of treatment alongside antivirus medications. Patients with severe COVID-19 frequently have critical conditions marked by blood clot development, necessitating the administration of anticoagulants. This review aims to provide a comprehensive overview of various anticoagulant drugs, their synthesis methods, and assays employed to predict their anticoagulant activity. Notable anticoagulant categories frequently utilized include oral anticoagulants heparin, non-vitamin K antagonists, and vitamin K antagonists. In recent years, the development of new anticoagulants has seen a shift towards a multifaceted approach that combines in silico prediction with in vitro and in vivo assays. In silico prediction techniques play a pivotal role in the initial screening process. This integrated approach has yielded promising results, paving the way for the synthesis of novel anticoagulant candidates, as substantiated by a battery of in vitro, in vivo, and ex-vivo tests.
Kinetic Adsorption Study of Cd(II) Metal Ions Using Glutaraldehyde-Crosslinked Thiosemicarbazide-Modified Poly (vinyl alcohol) Hannifa Puspawardhani Rifa’i; Muhammad Ali Zulfikar
Jurnal Serambi Engineering Vol. 9 No. 3 (2024): Juli 2024
Publisher : Faculty of Engineering, Universitas Serambi Mekkah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cd(II) metal ions are commonly found in water bodies and are non-essential and carcinogenic, leading to lung cancer. Thus, it is crucial to remove Cd(II) metal ions from water. Adsorption is one effective separation method due to its relative simplicity and cost-effectiveness. In this work, the adsorption kinetics study of Cd(II) metal ions using PVA.cl.GA-TSC were examined. Polyvinyl alcohol (PVA) was crosslinked with glutaraldehyde and subsequently modified with thiosemicarbazide (TSC). The resulting PVA.cl.GA-TSC was characterized using FTIR. The adsorption process was carried out in a batch system at room temperature. The study revealed that the adsorption kinetics of Cd(II) metal ions with PVA.cl.GA-TSC followed a pseudo-second-order kinetic model, with a rate constant of 0.4 × 10⁻³ g.mg⁻¹.min⁻¹. In the kinetics data, an intra-particle diffusion model was also performed to understand the adsorption reaction mechanism. The intra-particle diffusion model indicated that the rate-determining step was governed by the intra-particle diffusion stage, with a rate constant of 0.387 mg.g-1min-1/2.
Sintesis Membran Komposit Berbahan Dasar Kitosan dengan Metoda Sol-Gel sebagai Membran Fuel Cell Pada Suhu Tinggi Nila Tanyela Berghuis; Muhammad Ali Zulfikar; Deana Wahyuningrum
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 7, No 1 (2020): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v7i1.6614

Abstract

Kitosan adalah polisakarida kationik yang terdiri dari residu glukosamin dan N-asetil glukosamin yang terikat oleh ikatan β-1,4 glikosidik. Keberadaan gugus alkohol bebas pada kerangka kitosan dapat dimanfaatkan sebagai gugus pembentuk matrik dengan atom lainnya, dalam penelitian ini adalah silika (Si). Kondisi ini dapat dimanfaatkan sebagai bahan dasar sintesis membran sel bahan bakar (Fuel Cell). Sintesis kitosan dilakukan dengan mendeasetilasi kitin yang bersumber dari limbah kulit udang. Membran komposit kitosan-TEOS (Tetraetilortosilikat) telah berhasil disintesis dengan menggunakan variasi nilai konsentrasi kitosan terhadap jumlah TEOS. Membran komposit kitosan-TEOS disintesis dengan menggunakan metoda sol-gel dan pembalikan fasa. Kitosan dan membran komposit yang dihasilkan kemudian dikarakterisasi sifat kimia dan fisika nya yaitu penentuan derajat deasetilasi, penentuan berat molekul rata-rata (Mv), persen kelarutan, analisis struktur dengan menggunakan FTIR, uji ketahanan suhu, analisis morfologi dengan menggunakan SEM, dan kapasitas pertukaran ion (KPI). Hasil karakterisasi menunjukkan derajat deasetilasi kitosan sebesar 79,31% dengan nilai berat molekul rata-rata (Mv) 1,16 x 107 g/mol dan persen kelarutan 1% (v/v) asam asetat. Hasil pengukuran FTIR membran menunjukkan terdapat puncak 1377 cm-1 yang merupakan puncak dari eter siklik, puncak 3454 cm-1 yang merupakan puncak dari O-H, puncak pada 1662-1666 cm-1 yang merupakan puncak dari C=O asetamida, dan 3454-3500 cm-1 yang merupakan puncak N-H, sedangkan puncak 904 cm-1 dan 1091,7 cm-1 menunjukkan adanya ikatan silang antara Si-OH dan Si-O-C (alifatik). Uji ketahanan membran terhadap suhu sebesar 120oC sedangkan nilai konduktivitas ionik terbesar dimiliki oleh tipe membran CTSN-1,5 dengan nilai 0,114 meq/g. Hasil analisis SEM menunjukkan bahwa membran mempunyai struktur yang rapat.
Sintesis dan Karakterisasi Titanium Oksida Dalam Cairan Ion 1-Butil-3-Metil Imidazolium Klorida dengan Metode Hidrotermal Enriyani, Riri; Zulfikar, Muhammad Ali; Alni, Anita
Jurnal Kartika Kimia Vol 5 No 1 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i1.111

Abstract

In this study, TiO2 was synthesized using the hydrothermal method which the solvent used was a mixture of 1-butyl-3-methyl imidazolium chloride ion (BMIM Cl) with water in a ratio of 3:7 v/v. Ionic liquid of 1-butyl-3-methyl imidazole was synthesized with methyl imidazole and chlorobutane as precursors and then characterized using 43 MHz NMR. TiO2 which had been synthesized with BMIM Cl : water (3:7 v/v) was then characterized using XRD, SEM, UV-Vis/DR and BET then compared the results with TiO2 synthesized with water solvent. Based on of XRD analysis was obtained that TiO2 was synthesized by BMIM Cl : water (3:7 v/v) and water solvent produced anatase and brochite crystals where the crystal size of TiO2 synthesized with BMIM Cl : water (3:7 v/v) as solvent was smaller that is 17.70 nm and which is synthesized with water solvent is about 20.35 nm. Based on the SEM characterization data, the morphological structure was more homogeneous. Based on the characterization data using UV-Vis/DR and BET, it was obtained that TiO2 synthesized with BMIM Cl : water (3:7 v/v) had a bigger band gap and larger surface area and pores than TiO2 synthesized by water solvent.
Co-Authors Abdul Wahab Mohammad Afdal Bahri Ana Hidayati Mukaromah Anita Alni Anita Alni Anita Alni, Anita Buchari Buchari Deana Wahyuningrum Deana Wahyuningrum Engrid Juni Astuti Enriyani, Riri Halimah Fahri Handajaya Rusli, Handajaya Hannifa Puspawardhani Rifa’i Herlina H Indah Permata Cantika Iwan Syahjoko Saputra Lasmaryna Sirumapea Ledyastuti, Mia M. Bachri Amran Muh. Amin Muhamad Nasir Muhammad Yudhistira Azis, Muhammad Yudhistira Mustapa Mustapa Nila Tanyela Berghuis Rachmawati Rachmawati Rino R. Mukti Riri Enriyani Slamet Ibrahim - Sophi Damayanti Tikarahayu Putri Umma, Reza Roisatul Wulan Septiani