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All Journal Medali Jurnal : Media Dental Intelektual The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia Majalah Obat Tradisional Dental Journal (Majalah Kedokteran Gigi) JIKG (Jurnal Ilmu Kedokteran Gigi) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah
Ahmad Syaify, Ahmad
Department Of Periodontology, Faculty Of Dentistry, Universitas Gadjah Mada
Dentistry Health Professions Medicine & Pharmacology Public Health

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Effectiveness of MIST with hydroxyapatite and β-tricalcium phosphate in alveolar bone density and osteocalcin level improvement during treatment of infrabony pockets Aulida Arum Mubarokah; Ahmad Syaify; Sri Pramestri Lastianny
Majalah Kedokteran Gigi Indonesia Vol 8, No 2 (2022): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.63524

Abstract

The minimally invasive surgical technique (MIST) is a method for periodontal regenerative treatment by minimizing trauma so it can preserve vascular supply of the interdental papillae. This study aims to determine the effectiveness of the MIST method with the addition of a combination of hydroxyapatite and β-tricalcium phosphate (HA + β-TCP) in treatment of infrabony pockets in terms of alveolar bone density and osteocalcin levels of gingival crevicular fluid. The study sample was taken from 20 teeth with infrabony pockets (n = 20), which were divided into two groups: 10 teeth treated with MIST and the other group with open flap debridement (OFD). Both groups received combination of HA + β-TCP. The osteocalcin levels of gingival crevicular fluid were checked on day-0 prior to the flap surgery, day-7 and day-14 after flap surgery using the Human Osteocalcin Elisa Kit. Radiological evaluation of alveolar bone density at day-0 and day-90 was done using cone beam computed tomography. Data of osteocalcin levels were analyzed using two-way ANOVA and continued with LSD Post Hoc test, while data of alveolar bone density reduction were analyzed using the Independent t-test parametric test. The results showed that there was no significant difference (p > 0.05) in the values of alveolar bone density between the MIST and OFD groups on day-0 and day-90, while the osteocalcin levels in both groups showed an increase from day-0 to day-7 and a decrease from day-7 to day-14. There was a significant difference (p < 0.05) on day-0 and 7 and day-7 and 14 between MIST and OFD groups. The MIST method with HA + β-TCP was effective and further increases alveolar bone density and osteocalcin levels of gingival crevicular fluid.
Differences in levels of bone morphogenetic protein-2 in periodontitis patients with and without type 2 diabetes mellitus Pritama, Muhammad Fauzi Adityawan; Syaify, Ahmad; Suryono, Suryono
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.83286

Abstract

Periodontitis is characterized by gingival bleeding, periodontal pocket formation, damage to the connective tissue attachment, and alveolar bone resorption. One of the risk factors that can increase the occurrence of periodontitis is diabetes mellitus (DM). In Indonesia, the incidence and prevalence of periodontitis are higher in patients with type 2 DM. In the present study, BMP-2 expression in periodontitis patients with and without type 2 DM was evaluated. We performed a descriptive analytical cross-sectional study in 40 respondents with stages II-III grades B-C chronic periodontitis. They were divided into a chronic periodontitis group with type 2 DM and a chronic periodontitis group without DM. Crevicular fluid of the gingival sulcus of the central maxillary anterior teeth from each respondent was taken using paper points for 5 minutes and placed in an Eppendorf tube. Each tube was labelled according to its group. All of the samples were examined by BMP-2 ELISA kit and measured by BioRad microplate reader with a wavelength of 450 nm. Data were analysed using SPSS 16.0 program. The independent sample t-test was used to compare the BMP-2 among two groups. The results of the study revealed the BMP-2 level in periodontitis patients with type 2 DM was 63.1 pg/ml, while in periodontitis patients without DM was 66.8 pg/ml. BMP-2 levels in periodontitis patients with type 2 DM were significantly lower than those in periodontitis patients without DM (p < 0.05).
HERBAL THERAPY SUPPRESS INTERLEUKIN-1β IN PERIODONTITIS AND TYPE 2 DIABETES MELLITUS Padang, Lastry Ruth; Syaify, Ahmad; Karina, Vincensia Maria
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 12, No 1 (2025): Volume 12 No 1, Juni 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v12i1.1764

Abstract

Background: Interrelated pathological conditions such as periodontitis and Type 2 Diabetes Mellitus (T2DM) still be the mistery to solve. The production of secondary metabolites due to hyperglycemia conditions, namely AGEs, contributes to inflammation that arises in periodontal tissue. Periodontal inflammation is exacerbated by systemic dysregulation resulting in periodontitis being one of the potential complications aggravating the condition of T2DM. Excessive production of pro-inflammatory cytokines damages periodontal tissue and pancreas B cells and thus leads to insulin resistance. Many approach have been conducted to break the relationship between these two diseases, especially from the inflammatory pathway. Herbal therapy is one of the potential treatment to manage the bidirectional relationship.  Objective: The aim of this study is to elaborate the effects of herbal therapy on decreasing IL-1β cytokines as potential targeted therapeutic targets for both periodontitis and type 2 diabetes condition.Methods: Literature research done from 2013 to 2023 to find relevant articles. Result: Several herbal therapies effective in decreased Interleukin-1β and correlated to systemic and periodontal condition. Conclusion:Herbal therapy is effectively decreasing Interleukin-1β as a potential therapeutic target in periodontitis and Diabetes Mellitus Type 2 management.
THE EFFECT OF NANOEMULSION MOUTHWASH CONTAINING CITRONELLA OIL (Cymbopogon winterianus) AND LEMON OIL (Citrus limon) ON THE NUMBER OF MACROPHAGES IN PREGNANT RAT MODEL INDUCED BY GINGIVITIS Rahman, Friska Ani; Sunarintyas, Siti; Syaify, Ahmad
Jurnal Medali Vol 7, No 2 (2025): Media Dental Intelektual August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.162-168

Abstract

Background: Pregnancy gingivitis is known to affect high-risk pregnancies. Therefore, preventive treatments are necessary, one of them being use of  mouthwash. Citronella oil and lemon oil have been proven to have anti-inflammatory properties. The aim of this study was to investigate the effectiveness of a nanoemulsion mouthwash combining citronella oil (Cymbopogon winterianus) and lemon oil (Citrus limon),  on macrophage counts in a pregnant rat model induced with gingivitis. Method: Female Sprague Dawley rats were confirmed to be pregnant, followed by ligation of both lower incisor teeth, and then mouthwash application. The rats were routinely fed a moist diet and drinking water containing 10% sucrose. Mouthwash application was performed twice daily (morning and evening) over 7 day. Histological evaluation was conducted by counting the number of macrophages in hematoxylin-eosin preparations. Result: The results showed a reduction in the number of macrophages with the administration of the nanoemulsion mouthwash combining citronella oil and lemon oil. The Mann -Whitney test revealed a significant difference compared to the control group (p<0.05). Conclusion: The nanoemulsion mouthwash with 1% citronella oil and 2,77% lemon oil may help reduce the number of macrophages in pregnant rats with gingivitis.
Co-Authors Aulida Arum Mubarokah Beta Widya Oktiani Dahlia Herawati Dewi Nurdiana Edi Karyadi Indi Kusumawati Ivan Arie Wahyudi Kwartarini Murdiastuti Marsetyawan HNES Marsetyawan HNES Nungky Devitaningtyas Nur Rahman Ahmad Seno Aji Osa Amila Hafiyyah Padang, Lastry Ruth Pritama, Muhammad Fauzi Adityawan Rahman, Friska Ani Shinta Ferronika Siti Sunarintyas Sri Budi Barunawati Sri Pramestri Lastianny, Sri Pramestri Sudibyo Sudibyo Suryono Suryono Suryono Suryono Vincensia Maria Karina