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Effectiveness of MIST with hydroxyapatite and β-tricalcium phosphate in alveolar bone density and osteocalcin level improvement during treatment of infrabony pockets Aulida Arum Mubarokah; Ahmad Syaify; Sri Pramestri Lastianny
Majalah Kedokteran Gigi Indonesia Vol 8, No 2 (2022): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.63524

The minimally invasive surgical technique (MIST) is a method for periodontal regenerative treatment by minimizing trauma so it can preserve vascular supply of the interdental papillae. This study aims to determine the effectiveness of the MIST method with the addition of a combination of hydroxyapatite and β-tricalcium phosphate (HA + β-TCP) in treatment of infrabony pockets in terms of alveolar bone density and osteocalcin levels of gingival crevicular fluid. The study sample was taken from 20 teeth with infrabony pockets (n = 20), which were divided into two groups: 10 teeth treated with MIST and the other group with open flap debridement (OFD). Both groups received combination of HA + β-TCP. The osteocalcin levels of gingival crevicular fluid were checked on day-0 prior to the flap surgery, day-7 and day-14 after flap surgery using the Human Osteocalcin Elisa Kit. Radiological evaluation of alveolar bone density at day-0 and day-90 was done using cone beam computed tomography. Data of osteocalcin levels were analyzed using two-way ANOVA and continued with LSD Post Hoc test, while data of alveolar bone density reduction were analyzed using the Independent t-test parametric test. The results showed that there was no significant difference (p > 0.05) in the values of alveolar bone density between the MIST and OFD groups on day-0 and day-90, while the osteocalcin levels in both groups showed an increase from day-0 to day-7 and a decrease from day-7 to day-14. There was a significant difference (p < 0.05) on day-0 and 7 and day-7 and 14 between MIST and OFD groups. The MIST method with HA + β-TCP was effective and further increases alveolar bone density and osteocalcin levels of gingival crevicular fluid.

Differences in levels of bone morphogenetic protein-2 in periodontitis patients with and without type 2 diabetes mellitus Pritama, Muhammad Fauzi Adityawan; Syaify, Ahmad; Suryono, Suryono
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.83286

Periodontitis is characterized by gingival bleeding, periodontal pocket formation, damage to the connective tissue attachment, and alveolar bone resorption. One of the risk factors that can increase the occurrence of periodontitis is diabetes mellitus (DM). In Indonesia, the incidence and prevalence of periodontitis are higher in patients with type 2 DM. In the present study, BMP-2 expression in periodontitis patients with and without type 2 DM was evaluated. We performed a descriptive analytical cross-sectional study in 40 respondents with stages II-III grades B-C chronic periodontitis. They were divided into a chronic periodontitis group with type 2 DM and a chronic periodontitis group without DM. Crevicular fluid of the gingival sulcus of the central maxillary anterior teeth from each respondent was taken using paper points for 5 minutes and placed in an Eppendorf tube. Each tube was labelled according to its group. All of the samples were examined by BMP-2 ELISA kit and measured by BioRad microplate reader with a wavelength of 450 nm. Data were analysed using SPSS 16.0 program. The independent sample t-test was used to compare the BMP-2 among two groups. The results of the study revealed the BMP-2 level in periodontitis patients with type 2 DM was 63.1 pg/ml, while in periodontitis patients without DM was 66.8 pg/ml. BMP-2 levels in periodontitis patients with type 2 DM were significantly lower than those in periodontitis patients without DM (p < 0.05).

HERBAL THERAPY SUPPRESS INTERLEUKIN-1β IN PERIODONTITIS AND TYPE 2 DIABETES MELLITUS Padang, Lastry Ruth; Syaify, Ahmad; Karina, Vincensia Maria
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 12, No 1 (2025): Vol 12 No 1 (Juni 2025)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v12i1.1764

Background: Interrelated pathological conditions such as periodontitis and Type 2 Diabetes Mellitus (T2DM) still be the mistery to solve. The production of secondary metabolites due to hyperglycemia conditions, namely AGEs, contributes to inflammation that arises in periodontal tissue. Periodontal inflammation is exacerbated by systemic dysregulation resulting in periodontitis being one of the potential complications aggravating the condition of T2DM. Excessive production of pro-inflammatory cytokines damages periodontal tissue and pancreas B cells and thus leads to insulin resistance. Many approach have been conducted to break the relationship between these two diseases, especially from the inflammatory pathway. Herbal therapy is one of the potential treatment to manage the bidirectional relationship. Objective: The aim of this study is to elaborate the effects of herbal therapy on decreasing IL-1β cytokines as potential targeted therapeutic targets for both periodontitis and type 2 diabetes condition.Methods: Literature research done from 2013 to 2023 to find relevant articles. Result: Several herbal therapies effective in decreased Interleukin-1β and correlated to systemic and periodontal condition. Conclusion:Herbal therapy is effectively decreasing Interleukin-1β as a potential therapeutic target in periodontitis and Diabetes Mellitus Type 2 management.

THE EFFECT OF NANOEMULSION MOUTHWASH CONTAINING CITRONELLA OIL (Cymbopogon winterianus) AND LEMON OIL (Citrus limon) ON THE NUMBER OF MACROPHAGES IN PREGNANT RAT MODEL INDUCED BY GINGIVITIS Rahman, Friska Ani; Sunarintyas, Siti; Syaify, Ahmad
Jurnal Medali Vol 7, No 2 (2025): Media Dental Intelektual August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.162-168

Background: Pregnancy gingivitis is known to affect high-risk pregnancies. Therefore, preventive treatments are necessary, one of them being use of mouthwash. Citronella oil and lemon oil have been proven to have anti-inflammatory properties. The aim of this study was to investigate the effectiveness of a nanoemulsion mouthwash combining citronella oil (Cymbopogon winterianus) and lemon oil (Citrus limon), on macrophage counts in a pregnant rat model induced with gingivitis. Method: Female Sprague Dawley rats were confirmed to be pregnant, followed by ligation of both lower incisor teeth, and then mouthwash application. The rats were routinely fed a moist diet and drinking water containing 10% sucrose. Mouthwash application was performed twice daily (morning and evening) over 7 day. Histological evaluation was conducted by counting the number of macrophages in hematoxylin-eosin preparations. Result: The results showed a reduction in the number of macrophages with the administration of the nanoemulsion mouthwash combining citronella oil and lemon oil. The Mann -Whitney test revealed a significant difference compared to the control group (p<0.05). Conclusion: The nanoemulsion mouthwash with 1% citronella oil and 2,77% lemon oil may help reduce the number of macrophages in pregnant rats with gingivitis.

Effectiveness of Non-Surgical Procedures for the Treatment of Black Triangle Cases in the Aesthetic Zone on the Height of the Interdental Papilla: Narrative Review Yusuf, Muhammad; Syaify, Ahmad; Karina, Vincensia Maria
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.306-313

Background: The black triangle is a cervical embrasure to the proximal contact that is not filled with gingival tissue. Until, the treatment of black triangle cases has evolved to offer non-surgical procedures such as hyaluronic acid injection, Injectable Platelet Rich Fibrin (i-PRF), and photobiomodulation therapy. Various studies have also reported the use of hyaluronic acid, i-PRF and photobiomodulation therapy to increase the height of the interdental papillae.Method: Literature searches were carried out systematically from various international databases such as PubMed, ScienceDirect, Google Scholar, and Semantic Scholar. The literature selection stages are carried out through the process of identifying articles, screening, and fulfilling inclusion criteria. A total of 52 articles were published in 2012 – 2022 and have met the criteria for data extraction examination of various clinical parameters from the black triangle case.Result: The results of the review showed that the use of hyaluronic acid injection, i-PRF and photobiomodulation therapy showed significant treatment results in cases of black triangle class I and II. Conclusion: It was reported that the non-surgical procedure for the treatment of black triangle cases produce better result and predictable results, an easy technique, more effective time than surgical procedures and reduced discomfort and met the aesthetic demands of patients based on clinical parameters after 6 month injection.

Osteocalcin levels in gingival crevicular fluid periodontitis patient with and without type 2 Diabetes Mellitus Wildan, Muhammad Nabeel; Syaify, Ahmad; Herawati, Dahlia
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.214-221

Background: Diabetes Mellitus (DM) is a systemic disease with a high prevalence in Indonesia. Periodontitis is a complication of DM with frequent occurrences. Periodontitis with DM causes greater bone damage than non-DM periodontitis because its conditions can affect osteoblast and osteoclast activity. Osteocalcin (OC), mostly synthesized by osteoblasts, regulates the activity of bone formation and turnover so that it can be a marker of bone formation and turnover to see the severity of the disease. OC can be found in gingival crevicular fluid (GCF). This study aimed to determine osteocalcin levels in gingival crevicular fluid periodontitis patients with uncontrolled type 2 Diabetes Mellitus and non-Diabetes Mellitus.Method: Samples used in this study were gingival crevicular fluid taken from 20 samples of periodontitis patients with DM type 2 (DMT2P) and 20 samples of periodontitis non-DM patients. The OC levels were analyzed using ELISA Kit Osteocalcin then statistical tests were carried out.Result: The results showed that the OC level of the DMT2P group was 0.369 Â± 0.140 while the periodontitis non-DM group was 0.664 Â± 0.141.Conclusion: The OC levels of periodontitis patients with DM are lower than periodontitis patients non-DM.

Effectiveness of Non-Surgical Procedures for the Treatment of Black Triangle Cases in the Aesthetic Zone on the Height of the Interdental Papilla: Narrative Review Yusuf, Muhammad; Syaify, Ahmad; Karina, Vincensia Maria
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.306-313

Background: The black triangle is a cervical embrasure to the proximal contact that is not filled with gingival tissue. Until, the treatment of black triangle cases has evolved to offer non-surgical procedures such as hyaluronic acid injection, Injectable Platelet Rich Fibrin (i-PRF), and photobiomodulation therapy. Various studies have also reported the use of hyaluronic acid, i-PRF and photobiomodulation therapy to increase the height of the interdental papillae.Method: Literature searches were carried out systematically from various international databases such as PubMed, ScienceDirect, Google Scholar, and Semantic Scholar. The literature selection stages are carried out through the process of identifying articles, screening, and fulfilling inclusion criteria. A total of 52 articles were published in 2012 – 2022 and have met the criteria for data extraction examination of various clinical parameters from the black triangle case.Result: The results of the review showed that the use of hyaluronic acid injection, i-PRF and photobiomodulation therapy showed significant treatment results in cases of black triangle class I and II. Conclusion: It was reported that the non-surgical procedure for the treatment of black triangle cases produce better result and predictable results, an easy technique, more effective time than surgical procedures and reduced discomfort and met the aesthetic demands of patients based on clinical parameters after 6 month injection.

Osteocalcin levels in gingival crevicular fluid periodontitis patient with and without type 2 Diabetes Mellitus Wildan, Muhammad Nabeel; Syaify, Ahmad; Herawati, Dahlia
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.214-221

Background: Diabetes Mellitus (DM) is a systemic disease with a high prevalence in Indonesia. Periodontitis is a complication of DM with frequent occurrences. Periodontitis with DM causes greater bone damage than non-DM periodontitis because its conditions can affect osteoblast and osteoclast activity. Osteocalcin (OC), mostly synthesized by osteoblasts, regulates the activity of bone formation and turnover so that it can be a marker of bone formation and turnover to see the severity of the disease. OC can be found in gingival crevicular fluid (GCF). This study aimed to determine osteocalcin levels in gingival crevicular fluid periodontitis patients with uncontrolled type 2 Diabetes Mellitus and non-Diabetes Mellitus.Method: Samples used in this study were gingival crevicular fluid taken from 20 samples of periodontitis patients with DM type 2 (DMT2P) and 20 samples of periodontitis non-DM patients. The OC levels were analyzed using ELISA Kit Osteocalcin then statistical tests were carried out.Result: The results showed that the OC level of the DMT2P group was 0.369 Â± 0.140 while the periodontitis non-DM group was 0.664 Â± 0.141.Conclusion: The OC levels of periodontitis patients with DM are lower than periodontitis patients non-DM.

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