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All Journal snimed Jurnal Ilmiah Farmasi Media Penelitian dan Pengembangan Kesehatan Journal of Educational, Health and Community Psychology Disease Prevention and Public Health Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Sari Pediatri Universa Medicina Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Refleksi Pembelajaran Inovatif Jurnal Aisyah : Jurnal Ilmu Kesehatan Automata JK Unila (Jurnal Kedokteran Universitas Lampung) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Ika Fidianingsih
Departemen Histologi, Fakultas Kedokteran, Universitas Islam Indonesia, Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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METILASI CPG ISLAND GEN DAPK P ADA LEUKEMIA LIMFOBLASTIK AKUT Ika Fidianingsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 5, No 1, (2013)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Abstract

Metilasi CpG island atau hipermetilasi pada promoter gen adalah penambahan gugus metil pada basa sitosin yang mendahului basa guanin yang menyebabkan penurunan ekspresi Tumor Supressor Gen (TSG) sehingga menimbulkan kejadian kanker. DAPK adalahSerin-Treonin kinase yang tergantung pada Calsium atau Calmodulin yang berpartisipasi dalam berbagai jalur signal kehidupan, autofagi dan apoptosis. Pada kasus Leukemia Limfoblastik Akut (LLA) terdapat metilasi CpG island gen DAPK. Meskipun :frekuensinya tidak tinggi, tetapi hal ini menunjukkan adanya keterlibatan proses epigenetik (DNA metilasi) dalam proses perkembangan terbentuknya leukemia.
PERSONALIZED MEDICINE UNTUK PENDERITA KANKER, MUNGKINKAH? Ika Fidianingsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 5, No 2, (2013)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Studi Toksisitas Nanopartikel Organ Limpa pada Hewan Percobaan, Tinjauan Scoping Review Dodi Faras Ilmiawan Sutomo; Dwi Nur Ahsani; Ika Fidianingsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1082

Abstract

Nanotechnology has been developing in the medical field, but some nanoparticles have toxic effects on the body, including the spleen. This scoping review represents an attempt to take stock of existing research results related to the presence or absence of toxicity to the spleen caused by nanoparticles involving experimental animals. A scoping review was conducted to synthesize and map the toxicity of nanoparticles. It has been searched on PubMed databases for spleen or lien and toxic or toxicity, and nanoparticles or dendrimers or "metal nanoparticles" or “magnetite nanoparticles” or nanoshells or “multifunctional nanoparticles” or nanocapsules or nanoconjugates or nanodiamonds or nanogels or nanospheres. Seventeen studies met our inclusion criteria. In conclusion, it showed that 13 nanoparticles could cause toxicity in rodent spleen and as many as 4 nanoparticles did not cause toxicity in rodent spleen.
Consumption of Cassava Extract (Manihot Esculenta) Improves Pancreatic Histology and Seminiferous Tubules in Wistar Rats Induced Diabetes Mellitus with Streptozotocin Prasetyo, Mohamad Rizki Adi; Ghalib, Qoit Muhammad Abdul; Ahsani, Dwi Nur; Fidianingsih, Ika
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3022.987 KB) | DOI: 10.30604/jika.v8i2.1929

Abstract

Diabetes Mellitus (DM) can damage various organs, which are the pancreas and the testes, which cause infertility. Therefore, alternative treatment is needed, including cassava (Manihot Esculenta) which contains polyphenol antioxidants that can reduce free radicals caused by hyperglycemia. The objectives of the study were to determine the effect of cassava consumption on the histological pancreas and testes of Wistar rats induced with streptozotocin. This study was an experimental study posttest only control group design. Experimental animals were divided into four treatment groups, namely healthy controls (K1), DM aqua dest (K2), DM metformin (K3), and DM cassava (K4). The treatment was given after successful DM induction. The histology of the pancreas was the area of the islets of Langerhans. The histology of the testes was the thickness of the seminiferous tubule epithelium. The analysis used a one-way ANOVA test. The average area of Langerhans Island, respectively, namely 6482,95±117.71 m2, 2597.49±137.25 m2, 2746.93± 172.07 m2, and 3307.00 ± 368.51 m2 (p-value = 0.000). The mean epithelial thickness of the seminiferous tubules was 19.62±1.12 m, 15.59 ±0.46m, 17.05±1.42m, and 18.09±0.52m (K4) (p-value = 0.000). In conclusion, the consumption of cassava extract (Manihot esculenta) can improve the histological picture of the pancreas and increase the thickness of the seminiferous tubule. Abstrak: Diabetes Mellitus (DM) dapat merusak berbagai organ yaitu pankreas dan testis yang menyebabkan kemandulan. Oleh karena itu, diperlukan pengobatan alternatif antara lain ubi kayu (Manihot Esculenta) yang mengandung antioksidan polifenol yang dapat meredam radikal bebas akibat hiperglikemia. Tujuan penelitian adalah untuk mengetahui pengaruh konsumsi singkong terhadap gambaran histologi pankreas dan testis tikus Wistar yang diinduksi dengan streptozotocin. Penelitian ini merupakan penelitian eksperimental post-test only control group design. Hewan coba dibagi menjadi empat kelompok perlakuan yaitu kontrol sehat (K1), DM aqua dest (K2), DM metformin (K3), dan DM singkong (K4). Perlakuan diberikan setelah induksi DM berhasil. Histologi pankreas yang akan diamati adalah area pulau Langerhans. Histologi testis adalah ketebalan epitel tubulus seminiferus. Analisis menggunakan uji one way ANOVA. Rata-rata luas Pulau Langerhans berturut-turut yaitu 6482,95±117,71 m2, 2597,49±137,25 m2, 2746,93 m2±172,07, dan 3307,00m2±368,51 (p-value = 0,000). Ketebalan epitel rata-rata tubulus seminiferus adalah 19.62±1.12m, 15.59±0.46 m, 17.05±1.42m, and 18.09±0.52 m (K4) (p-value = 0,000). Kesimpulannya, konsumsi ekstrak singkong (Manihot esculenta) dapat memperbaiki gambaran histologis pankreas dan meningkatkan ketebalan epitel tubulus seminiferus.
Wound healing activity of topical Phaleria macrocarpa extract in type 2 diabetic rats Sulistyoningrum, Evy; Rosmelia, Rosmelia; Fidianingsih, Ika; Narantika, Shindy Galuh; Cleopatra, Neysa Nurprahutri; Azzahra, Fathimah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.136-147

Abstract

BackgroundHyperglycemia interrupts wound healing, causing persistent and non-healing wounds. Phaleria macrocarpa extract (PME) has anti-diabetic, anti-inflammatory, antimicrobial, and antioxidant properties. This study aimed to assess P. macrocarpa activity on skin wound healing in diabetic rats. MethodsAn experimental study performed on 25 male Wistar rats. Ointments were prepared by adding vehicle (w/w) to PME at the desired concentration. Diabetes was induced by injecting rats with nicotinamide (NAD) 230 mg/kg and streptozotocin (STZ) 65 mg/kg. After hyperglycemia was confirmed, animals were randomly grouped into: i) normal rats, ii) diabetic rats; iii) diabetic rats + 2.5% ointment; iv) diabetic rats +5% ointment; and v) diabetic rats +10% ointment. Full-thickness skin wounds were induced on the dorsum and treatment was applied daily for 3 and 7 days, respectively. On days 4 and 8, wound closure was measured and animals were sacrificed for tissue samples. Wound healing was evaluated by measuring malondialdehyde (MDA) in tissue homogenates of the dermal wounds and analyzing histological changes by hematoxylin-eosin and Sirius-red staining. ResultsPME 10% ointment improved MDA levels and wound closure of inflammatory and proliferation phases. In inflammatory phase, 5% and 10% ointment reduced inflammation severity compared with diabetic rat group (p<0.05). In proliferation phase, PME 10% ointment group had a higher wound histological score (characterized by epidermal regeneration, fibroblast count, granulation tissue, and angiogenesis), and higher collagen bundle density compared with untreated groups (p<0.05).  ConclusionsTopical P. macrocarpa improves inflammatory and proliferation phases of excision wound healing in type 2 diabetes.
Peningkatan Pengetahuan Perawatan Jenazah di Dusun Babadan Ngemplak Sleman Fidianingsih, Ika
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 7, No 3 (2024): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v7i3.6692

Abstract

Perawatan jenazah sesuai syariat islam bagi jenazah yang beragama islam diperlukan. Ibadah yang sesuai ilmu mendatangkan pahala, memberi ketenangan dan membantu masyarakat. Hasil pengamatan dan observasi menunjukkan masih ditemukan kondisi dimana perawatan jenazah belum sesuai syariat dan pemandian jenazah yang terbuka di padukuhan Babadan Wedomartani Ngemplak Sleman. Pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan sikap masyarakat terhadap perawatan jenazah serta penyediaan penutup jenazah. Metode yang dilakukan adalah koordinasi dengan warga dan pakar di bidang perawatan jenazah, dilanjutkan pelatihan dan praktek perawatan jenazah, tanya jawab setelah sesi penjelasan dan praktek, serta wawancara kepada beberapa warga dilakukan untuk evaluasi kegiatan. Warga jamaah masjid Al Ittihad Babadan yang mengikuti kegiatan pelatihan menyampaikan bahwa kegiatan pelatihan perawatan jenazah ini dirasakan sangat bermanfaat dan meningkatkan pemahaman masyarakat terkait perawatan jenazah secara islam. Selain itu Hasil survey kepuasan penyelenggaraan pelatihan menunjukkan 93,1% warga merasa puas dan 6,9% cukup puas
Co-Authors Adeniar Yusnina Adika Zhulhi Arjana Afiqoh, Ainun Nur Alissa Anna Safira Arif Reynaldi Alifiansyah Azzahra, Fathimah Cleopatra, Neysa Nurprahutri Dadik Subiyanto Dewajani Purnomosari Dodi Faras Ilmiawan Sutomo Dwi Nur Ahsani Eddy Supriyadi Ety Sari Handayani Evy Sulistyoningrum Fuad Khadafianto Ghalib, Qoit Muhammad Abdul Ismaiyah Ismaiyah Izzati Muhimmah Kharisma, Muhammad Khoiriyah, Umatul Kusumawardani, Endah Najmuddin, Abdulhalim Ahmad Narantika, Shindy Galuh Naufal Abdurrahman Nazarudin, Zohan Ninda Devita, Ninda Nurmasitoh, Titis Prasetyo, Mohamad Rizki Adi Raisha Amini Rosmelia Rosmelia Threeyana Ariyati Kadi Utami, Shindy Yudha Wijaya, Diani Puspa Yudha Prasetyo Utomo Zainuri Sabta Nugraha