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All Journal ACTA VETERINARIA INDONESIANA Indonesian Journal of Pharmaceutical Science and Technology Pharmacon FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Lumbung Farmasi : Jurnal Ilmu Kefarmasian
. Yulianita, .
Department Of Pharmacy And Biology, Faculty Of MIPA – Pakuan University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Mathematics Medicine & Pharmacology Veterinary

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EKSTRAKSI FLAVONOID DAUN MENIRAN MENGGUNAKAN PELARUT NATURAL DEEP EUTECTIC SOLVENT BERBASIS KOLIN KLORIDA-ASAM DENGAN ULTRASOUND ASSISTED EXTRACTION Yulianita .; Zaldy Rusli; Usep Suhendar; Zulfa Masrani
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4294

Abstract

Penggunaan pelarut organik masih umum digunakan untuk menarik senyawa aktif, diantaranya adalah flavonoid yang berperan dalam kesehatan manusia sebagai antioksidan, antikanker, dan antidepresan. Akan tetapi, penggunaan pelarut organik sebenarnya berbahaya bagi kesehatan, karena dapat mempengaruhi sistem saraf pusat dan perifer, sistem reproduksi, menginduksi kanker, dan lain-lain.  Penelitian ini bertujuan untuk menentukan pelarut terbaik dari beberapa kombinasi Natural Deep Eutectic Solvent (NADES) dan metode ekstraksi daun meniran terhadap kadar flavonoid.Pengujian kadar flavonoid dilakukan dengan metode penambahan AlCl3. Hasil penelitian diperoleh kadar flavonoid terbaik pada pelarut NADES 2 yaitu kombinasi Kolin Klorida-Asam Oksalat dengan kondisi ekstraksi optimum pada suhu 48oC, waktu 60 menit dan rasio pelarut NADES:Air 90% sebesai 1,4161% . Berdasarkan penelitian ini, diketahui bahwa ekstraksi menggunakan pelarut NADES tersebut lebih baik dibandingkan metode konvensional dan kombinasi pelarut NADES lainnya. 
Formulasi Transfersom Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius. R) dengan Variasi Konsentrasi Fosfolipid dan Tween 80 Sebagai Pembentuk Vesikel Rini Ambarwati; Yulianita Yulianita
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.7630

Abstract

ABSTRAKPandan    wangi    merupakan    tanaman yang  sering  dimanfaatkan  daunnya  sebagai  bahan  tambahan makanan,  umumnya  sebagai bahan pewarna hijau dan pemberi aroma. Ekstrak daun pandan wangi mengandung senyawa flavonoid yang memiliki aktivitas sebagai agen Depigmentasi. Untuk meningkatkan efektivitas dari ekstrak daun pandan wangi maka akan dibuat nanopartikel. Salah satu teknologi nanopartikel adalah transfersom. Penelitian ini bertujuan untuk menentukan formula yang paling baik dan stabil dari transfersom yang mengandung ekstrak daun pandan wangi dengan melakukan karakterisasi transfersom berdasarkan variasi konsentrasi dari fosfolipid dan tween 80. Transfersom dibuat dalam 3 formula yaitu Formula 1 (F1) dengan perbandingan fofolipid:surfaktan (90:10), F2 (85:15),dan F3 (80:20). Karakterisasi transfersom yang dilakukan meliputi distribusi ukuran partikel, zeta potensial, efisiensi penjerapan, indeks deformabilitas, dan morfologi vesikel. Hasil penelitian menunjukan bahwa formula transfersom terbaik adalah F3 (80:20), dengan rata-rata ukuran partikel 437,77 ±2,25nm, nilai rata-rata PDI (0,393±0,034), Efisiensi Penjerapan (74,172%), zeta potensial (1,35 mV±0,27), deformabilitas (12,646) dan morfologi vesikelnya berbentuk sfheris sesuai kriteria vesikel yang diharapkan. Kata kunci : Daun Pandan Wangi; Transfersom; Nanopartikel; Fospolipid.ABSTRACTPandan is a plant whose leaves are often used as food additives, generally as a green coloring agent and flavoring agent. Pandan leaf extract contains flavonoid compounds which have activity as depigmentation agents. To increase the effectiveness of the fragrant pandan leaf extract, nanoparticles will be made where the particle size will be smaller so that it can improve the delivery quality of drug compounds for the better. One of the nanoparticle technologies is transfersome. This study aimed to determine the best and most stable formula of transfersomes containing pandan leaf extract by characterizing transfersomes based on variations in the concentration of phospholipids and tween 80. Transfersomes were made in 3 formulas, namely Formula 1 (F1) with a ratio of phospholipids: :10), F2 (85:15), and F3 (80:20). The transfersome characterizations included particle size distribution, zeta potential, adsorption efficiency, deformability index, and vesicle morphology. The results showed that the best transfersome formula was F3 (80:20), with an average particle size of 437.77 ±2.25nm, an average PDI value (0.393±0.034), Adsorption Efficiency (74.172%), zeta potential ( 1.35 mV±0.27), deformability (12.646) and the morphology of the vesicles was spherical in shape according to the expected vesicle criteria.Keywords : Pandan Wangi Leaves; Transfersome; Nanoparticle; Phospoliphid.
Histopathological Alterations in Ovarian and Uterine Treated with Extract and Fraction of Kebar Grass (Biophytum petersianum) Nina Herlina; Mulyati Effendi; Wilda Nurhikmah; Yulianita Yulianita; Fitri Aninda
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.4599

Abstract

Kebar grass (Biophytum petersianum) is being used traditionally by the people of West Papua to increase fertility. The effects of extracts and fractions of Kebar grass on the estrus cycle duration and estrus phase in rats were evaluated. The present work was designed to investigate the effects of administration of kebar grass extract and its fraction on the histopathological changes in the ovaries and uterine of rats. The female rats were treated with carboxy methyl cellulose sodium (CMC sodium) 1 % (group I), ethynile estradiol (group II), extract kebar grass (group III),  n-hexane fraction (group IV), ethyl acetate fraction (group V), and water fraction (group VI) of kebar grass via gavage daily for 7 days. At days 7th and 14th, 3 rats in each group were euthanized.  Uterine and ovarian collected and weighed. Hematoxylin-Eosin staining and the paraffin technique were used for histological preparation. Data were analyzed by One Way ANOVA followed by the Duncan test. The Kebar grass has an effect to increase ovarian and uterine weight, increasing most of the number of follicles especially primary follicle and uterine thickness. The treatment with ethyl acetate fraction of kebar grass (group V) constantly showed more effective results than the other kebar grass treatment.
AKTIVITAS ANTIJAMUR EKSTRAK ETANOL 50% DAN ETANOL 96% DAUN PACAR KUKU Lawsonia inermis L TERHADAP Trichophyton mentagrophytes Oom Komala; Yulianita .; Fuji Raka Siwi
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 19, No 1 (2019): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v19i1.1657

Abstract

Trichopyton mentagrophytes is a type of fungus that belongs to a group of dermatophytes, and a disease that causes dermatophytosis (ringworm), this fungus likes parts that contain keratin substances such as skin, hair / hair, nails or horns. This study aims to determine the antifungal activity of 50% and 96% ethanol extract. KHM testing was made with a concentration of 2.5%, 5%, 7.5% and 10% with the dilution method to determine KHM. Whereas in testing the width of the inhibitory area (LDH) was carried out after getting the MIC value at concentrations of 10%, 25% and 50% with disc diffusion method to determine the effective LDH and qualitative phytochemical testing. The results showed that 96% ethanol solvent at a concentration of 50% could inhibit the fungus Trichopyton mentagrophytes compared to 50% ethanol as seen from the inhibition zone formed in the width of the inhibitory area. Secondary metabolite compounds found in 50% ethanol extract and 96% ethanol are flavonoids, alkaloids, saponins, tannins, quinones and terpenoids.
EFEKTIVITAS STIMULANSIA KOMBINASI SARI UMBI BIT DAN BUAH APEL TERHADAP KETAHANAN FISIK DAN KADAR Hb TIKUS PUTIH Sprague Dawley Moerfiah .; Yulianita .; Deni Setiawan
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 19, No 1 (2019): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v19i1.1658

Abstract

Human physical exercise is influenced by hemoglobin levels in the blood, stimulant testing of underlying fatigue should be tested for Hb levels. This study aims to determine the increase in stimulation and hemoglobin levels of white rats using beetroot and apple juice. The method used for stimulant testing was the endurance test using a rotarod and for measuring Hb levels using the sahli method with a hemometer. The data observed were the duration of resistance on rotarod stick which were rotated, the experimental animals used were 25 animals divided into 5 treatment groups with each group of 5 rats namely: group of beetroot and apple (1: 1) (2.8g: 0.63mg / 200gBB), comparison (2: 1) of (5.6g: 0.63mg / 200gBB), comparison (1: 2) of (2.8g: 1.26mg / 200gBB), negative control (-) (CMC-Na 0.5%) and positive  control (+) caffeine 20 mg / 200g BB. Dosage treatment is carried out in one day.The results showed that the combination of beetroot and apple juice had an increase in stimulant and hemoglobin levels of white rats with the most effective dose for stimulant enhancement and Hb levels were found in the second dose compared to beetroot and apple juice (2: 1) 5.6 g / 200gBB: 0.63 g / 200gBB.
GRANOLA BAR YANG DIFORTIFIKASI DENGAN PROTEIN DAGING KERANG SEBAGAI SNACK SEHAT BAGI ANAK BERKEBUTUHAN KHUSUS Sata Yoshida Srie Rahayu; Tri Aminingsih; Yulianita .
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 18, No 2 (2018): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v18i2.1655

Abstract

Flour of Anodonta woodiana meat may be added in the manufacture of food products such as granola bar. The aim of addition is to increase the nutritional value on snacks needed by children with special needs through fortification. This research method was done by making products granola bar in three formulas: without the addition of shells flour, the addition of 2.8 gram, and 5.6 gram. Granola bar were made for consumption by children (7-9 years old) and teenager (10-18 years old). Tests performed included organoleptic test. The results of organoleptic test between three formulas of produced granola bar have different characteristics in flavor parameter. The results of the analysis of parameters of color, aroma, and flavor tested by analysis of variance software showed that the most preferred formula is the second formula with the addition 2.8 gram of mussel meat flour. This granola bar snack is a healthy snack that is safe for consumption by children with special needs, because it is made from ingredients that do not contain flavorings, dyes and artificial preservatives.
Optimasi Ultrasound Assisted Extraction Senyawa Flavonoid dari Daun Meniran Menggunakan Natural Deep Eutectic Solvent Rusli, Zaldy; Yulianita, .; Amalia, Nanda Putri
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9136

Abstract

Meniran (Phyllanthus niruri) merupakan salah satu tanaman yang banyak digunakan sebagai bahan dalam pengobatan tradisional. Meniran mengandung senyawa flavonoid yang dapat bertindak sebagai antioksidan. Ekstraksi senyawa flavonoid umumnya menggunakan pelarut organik, namun penggunaan pelarut organik dapat membahayakan bagi manusia dan lingkungan, sehingga mendorong penggunaan pelarut lain yang lebih ramah lingkungan, salah satunya adalah Natural Deep Eutectic Solvent (NADES). Penelitian ini bertujuan untuk menentukan kombinasi NADES dari kolin klorida dengan beberapa gula alkohol dan menentukan kondisi ekstraksi optimum yang dapat menghasilkan esktrak dengan kadar flavonoid terbaik. Kombinasi NADES yang digunakan adalah kolin klorida dan beberapa gula alkohol. Ekstraksi dilakukan dengan metode Ultrasound Assisted Extraction (UAE). Analisis kadar flavonoid dilakukan dengan menggunakan metode kolorimetri dengan pereaksi AlCl3. Hasil penelitian menunjukkan bahwa kombinasi NADES 1 yaitu Kolin Klorida-Gliserol menghasilkan kadar flavonoid terbaik dibandingkan dengan kombinasi NADES lainnya dengan kadar flavonoid sebesar 1,965 mg QE/g ekstrak cair dengan kondisi optimum yang didapatkan pada waktu 42 menit, suhu 60 °C dan rasio NADES 90 %.
Co-Authors Amalia, Nanda Putri D Prasetyorini Deni Setiawan E Mulyati Effendi, E Mulyati Ekas Mara Firdayani Fitri Aninda Fuji Raka Siwi Lusi Agus Setiani MOERFIAH . Mulyati Effendi Najwa Rokhmah, Nisa Nina Herlina Novi Fajar Utami Novi Novitasari Oom Komala Rini Ambarwati Rini Ambarwati SATA YOSHIDA SRIE RAHAYU Septia Andini Tri Aminingsih Tri Aminingsih usep suhendar Widya fitriyani Wilda Nurhikmah Zaldy Rusli Zaldy Rusli Zulfa Masrani