Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Indonesian Journal of Tropical and Infectious Disease Farmasains : Jurnal Ilmiah Ilmu Kefarmasian ad-Dawaa : Journal of Pharmaceutical Sciences Journal Pharmacy of Tanjungpura
Hafrizal Riza, Hafrizal
Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Tanjungpura, Pontianak
Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
EFFECT OF FREE ALKALOID AND NON-FREE ALKALOID ETHANOL 70% EXTRACT OF JUSTICIA GENDARUSSA BURM F. LEAVES AGAINST REVERSE TRANSCRIPTASE HIV ENZYME IN VITRO AND CHEMICAL COMPOUND ANALYSIS Prajogo, Bambang; Widiyanti, Prihartini; Riza, Hafrizal
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 7 (2015)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v5i7.1203

Abstract

HIV-AIDS is a global problem and the deadliest disease in the world. One of HIV and AIDS prevention strategy can be done with traditional medicine research program from natural resource that has anti-HIV AIDS activity. It has been found that 70% ethanol extract of Justicia gendarussa Burm.f leaves, alkaloid free and alkaloid non-free, has a strong inhibitory activity against HIV reverse transcriptase enzyme, as an effort to find a solution in the face of HIV AIDS prevalence that is still high with problem of HIV-AIDS treatment such as side effects and resistances. Justicia gendarussa had already known for having an effect anti-HIV and therefore we were looking at the mechanism of inhibition of HIV Reverse Transcriptase enzyme. Both types of extracts were tested in vitro using ELISA technique and analysed chemical content of Gendarusin A as anti-HIV using high performance liquid chromatography. ELISA test results obtained percent inhibition, respectively for 254.2, 254.2, 235.6, and 279.7 for the concentration of 5 ppm, 10 ppm, 15 ppm and 20 ppm of free alkaloid extract and 169.0, 164.0, 130.5 and 369.5 for the concentration of 5 ppm, 10 ppm, 15 ppm and 20 ppm of non-free-alkaloid extract. The results of high performance liquid chromatography obtained Gendarusin A in the free-alkaloid extract at retention time 8.402 minutes and non-free alkaloid extract at retention time 8.381. Therefore, these results concluded that the Justicia gendarussa Burm.f can be a useful resource for the isolation and development of new anti-HIV.
Pengaruh Metode Pengeringan terhadap Aktivitas Antioksidan Ekstrak Etanol Daun Physalis angulata L. Luliana, Sri; Riza, Hafrizal; Iswahyudi, Ilham
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 5 No 1 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.264 KB) | DOI: 10.22236/farmasains.v5i1.1231

Abstract

Proses pengeringan diperlukan untuk mempertahankan mutu suatu simplisia. Penelitian ini bertujuan untuk mengetahui pengaruh metode pengeringan terhadap aktivitas antioksidan daun ciplukan (Physalis angulata L.). Pengujian aktivitas antioksidan dilakukan terhadap metode pengeringan dengan menggunakan angin, matahari tidak langsung dan oven, serta sampel segar tanpa pengeringan. Aktivitas antioksidan diuji menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Nilai IC50 sampel pengeringan angin, matahari tidak langsung, oven dan segar berturut-turut adalah 46,42 ± 3,37; 34,33 ± 2,24; 77,91 ± 3,44 and 57,63 ± 4,33 ?g/ml. Berdasarkan data hasil penelitian, kami menyimpulkan bahwa terdapat perbedaan signifikan (p<0,05) pada nilai aktivitas antioksidan tiap sampel yang dikeringkan dengan metode yang berbeda.
EVALUASI PENGGUNAAN STATIN UNTUK PENCEGAHAN RISIKO KARDIOVASKULAR ATEROSKLEROSIS PADA PASIEN DISLIPIDEMIA DENGAN DIABETES MELITUS TIPE 2 Isandora, Yesica; Nurmainah, Nurmainah; Riza, Hafrizal
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lini pertama pengobatan dislipidemia adalah statin untuk pencegahan risiko penyakit Atherosclerotic Cardiovascular Disease (ASCVD). Penggunaan statin pada pasien dislipidemia dengan komorbid diabetes melitus tipe 2 masih belum tepat, sehingga berisiko tinggi terjadinya ASCVD. Penelitian ini untuk mengetahui persentase ketepatan penggunaan statin berdasarkan perbedaan risiko ASCVD dan jenis statin yang digunakan pada penderita dislipidemia dengan diabetes melitus tipe 2 di RSUD Sultan Syarif Mohamad Alkadrie Pontianak. Penelitian observasional menggunakan rancangan potong lintang bersifat deskriptif. Pengumpulan data cara retrospektif yaitu data rekam medik, data laboratorium, dan data resep obat pasien rawat jalan dislipidemia dengan diabetes melitus tipe 2 di RSUD Sultan Syarif Mohamad Alkadrie Pontianak periode Januari – Juni 2019. Sampel yang memenuhi kriteria inklusi dan ekslusi sebanyak 47 pasien. Penelitian ini menunjukkan bahwa pasien dislipidemia dengan diabetes melitus tipe 2 yang memiliki risiko ASCVD < 7,5 % sebanyak 31,91 % dengan penggunaan statin 27,65 % tepat, 4,25 % tidak tepat. Pasien dengan risiko ASCVD ?7,5% sebanyak 68,08 %, penggunaan statin masih belum tepat. Jenis statin yang digunakan pada penelitian ini yaitu simvastatin 10 mg dan 20 mg, serta atorvastatin 20 mg. Kesimpulan dari penelitian ini pasien dengan risiko tinggi ASCVD mendapatkan statin dengan dosis yang tidak tepat berdasarkan pedoman ACC/AHA 2013.
Analisis Perbandingan Metode Autodock 4.2 dan Autodock Vina dalam Memprediksi Interaksi Thiazolidinedione dengan Reseptor PPARG Reynaldi, Muhammad Andre; Faradilla, Aulia; Sari, Rafika; Riza, Hafrizal; Najini, Robby
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.47852

Abstract

Introduction: Molecular docking simulation is an in silico method that plays a role in drug discovery and analyzing drug interactions with receptors. The method using Autodock 4.2 and Autodock Vina is widely used in molecular docking simulations, especially for analyzing interactions that occur between ligands and receptors. Aims: This study was aims to compare the Autodock 4.2 and Autodock Vina methods in simulating the docking of thiazolidinedione against PPARG in terms of bond energy and type of interaction parameters. Methods: The method used in this research was molecular docking simulation using Autodock 4.2 and Autodock Vina. The two methods compared the interaction results and binding affinity scores in the thiazolidinedione group against PPARG. Result: The results of this study show that the interactions using the Autodock 4.2 and Autodock Vina methods have similar amino acids that are bound and the same active site. The binding affinity score also shows that the best are troglitazone, pioglitazone, native ligand and rosiglitazone. Conclusion: Based on the results of this study, it shows that molecular docking simulations using the Autodock 4.2 and Autodock Vina methods thiazolidinedione with PPARG have similar docking score patterns and almost the same types of interactions.
EFFECT OF FREE ALKALOID AND NON-FREE ALKALOID ETHANOL 70% EXTRACT OF JUSTICIA GENDARUSSA BURM F. LEAVES AGAINST REVERSE TRANSCRIPTASE HIV ENZYME IN VITRO AND CHEMICAL COMPOUND ANALYSIS Prajogo, Bambang; Widiyanti, Prihartini; Riza, Hafrizal
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 1 (2016)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.42 KB) | DOI: 10.20473/ijtid.v6i1.1203

Abstract

HIV-AIDS is a global problem and the deadliest disease in the world. One of HIV and AIDS prevention strategy can be done with traditional medicine research program from natural resource that has anti-HIV AIDS activity. It has been found that 70% ethanol extract of Justicia gendarussa Burm.f leaves, alkaloid free and alkaloid non-free, has a strong inhibitory activity against HIV reverse transcriptase enzyme, as an effort to find a solution in the face of HIV AIDS prevalence that is still high with problem of HIV-AIDS treatment such as side effects and resistances. Justicia gendarussa had already known for having an effect anti-HIV and therefore we were looking at the mechanism of inhibition of HIV Reverse Transcriptase enzyme. Both types of extracts were tested in vitro using ELISA technique and analysed chemical content of Gendarusin A as anti-HIV using high performance liquid chromatography. ELISA test results obtained percent inhibition, respectively for 254.2, 254.2, 235.6, and 279.7 for the concentration of 5 ppm, 10 ppm, 15 ppm and 20 ppm of free alkaloid extract and 169.0, 164.0, 130.5 and 369.5 for the concentration of 5 ppm, 10 ppm, 15 ppm and 20 ppm of non-free-alkaloid extract. The results of high performance liquid chromatography obtained Gendarusin A in the free alkaloid extract at retention time 8.402 minutes and non-free alkaloid extract at retention time 8.381. Therefore, these results concluded that the Justicia gendarussa Burm.f can be a useful resource for the isolation and development of new anti-HIV.
ANALYSIS OF THE INTERACTION OF ALICIN BINDINGS ON PPARG USING MOLECULAR DYNAMICS SIMULATION Reynaldi, Muhammad Andre; Faradilla, Aulia; Nurbaeti, Siti Nani; IH, Hariyanto; Fajriaty, Inarah; Riza, Hafrizal
Journal Pharmacy Of Tanjungpura Vol 1, No 2 (2024): APRIL
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Allicin is one of the compounds contained in garlic which previous research predicted could be obtained using PPARG (Peroxisome Proliferatr Activated Receptor Gamma). However, short research requires further analysis, namely molecular dynamics. This research aims to analyze the interaction of allicin binding to PPARG used molecular dynamics. The dynamic molecular method used Gromac 2023 software with the chemical structure of allicin obtained from Pubchem data, while PPARG data was obtained from RCSB website. The results obtained from this study indicate that allicin interacts with similar amino acids as pioglitazone. However, its energy affinity is not as great as pioglitazoe. Based on the results of this research, it shows that allicin is predicted to be able to interact with PPARG in a molecular dynamic mannerKeywords: Allicin, PPARG, Molecular dynamics.
Co-Authors Bambang Prajogo Fajriaty, Inarah Faradilla, Aulia Hariyanto IH Isandora, Yesica Iswahyudi, Ilham Luliana, Sri Muhammad Andre Reynaldi Najini, Robby Nurmainah Nurmainah Prihartini Widiyanti Rafika Sari Siti Nani Nurbaeti