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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Pendidikan Informatika dan Sains JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JURNAL PENGABDI Chemistry Indonesian Journal of Chemical Research Pharmacology and Clinical Pharmacy Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Acta Chimica Asiana Sasambo Journal of Pharmacy Cermin Dunia Kedokteran Pharmaceutical Sciences and Research (PSR) Journal Pharmacy of Tanjungpura
Hariyanto IH
Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Jl. Prof. Dr. Hadari Nawawi, Pontianak, Kalimantan Barat, 78124, Indonesia Departemen Farmakologi Dan Farmasi Klinik, Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Energy Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences

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Perbedaan Jenis Terapi Antipsikotik terhadap Lama Rawat Inap Pasien Skizofrenia Fase Akut di RSJD Sungai Bangkong Pontianak Ih, Hariyanto; Putri, Rizka A.; Untari, Eka K.
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.331 KB) | DOI: 10.15416/ijcp.2016.5.2.115

Abstract

Skizofrenia adalah salah satu gangguan jiwa berat yang mempengaruhi seseorang dalam berpikir, merasa, dan bertindak. Prevalensi skizofrenia di Kalimantan Barat pada tahun 2013 adalah 0,7 per 1000 penduduk. Penelitian ini bertujuan untuk menentukan ada atau tidaknya perbedaan lama rawat inap pasien antar jenis terapi antipsikotik yang diberikan kepada pasien skizofrenia fase akut di Rumah Sakit Jiwa Daerah (RSJD) Sungai Bangkong periode Januari–Desember 2014. Desain penelitian berupa analisis cross-sectional dengan metode pengumpulan data secara retrospektif. Penelitian ini dilakukan terhadap 98 rekam medik pasien yang menerima terapi antipsikotik. Data dianalisis dengan analisis univariat dan bivariat. Analisis univariat memberikan gambaran karakteristik pasien, sedangkan analisis bivariat bertujuan untuk melihat ada atau tidaknya perbedaan lama rawat inap pasien antar jenis terapi antipsikotik yang diberikan. Hasil penelitian didapatkan bahwa jenis antipsikotik dan adjuvant yang paling banyak digunakan pasien adalah risperidon dan triheksifenidil dengan frekuensi pemakaian masing-masing sebanyak 446 kali (25,32%) dan 340 kali (65,89%). Hasil analisis menggunakan One‑Way ANOVA menunjukkan bahwa lama rawat inap pasien skizofrenia fase akut yang mendapatkan terapi antipsikotik tunggal tipikal, tunggal atipikal, dan kombinasi tidak mengalami perbedaan yang signifikan (p>0,05). Hasil tersebut menunjukkan bahwa lama rawat inap antar jenis terapi antipsikotik tidak berbeda sehingga dapat disimpulkan jenis terapi antipsikotik yang diberikan tidak memengaruhi perbedaan lama rawat inap pasien.Kata kunci: Antipsikotik, jenis terapi, lama rawat inap, skizofreniaDifferent Type of Antipsychotic Therapies on Length of Stay of Acute Schizophrenia Patients in Sungai Bangkong Regional Mental Hospital Pontianak Schizophrenia is one of severe mental disorders that affects how a person thinks, feels, and acts. In 2013, the prevalence of schizophrenia in West Kalimantan was 0,7 per 1000 inhabitants. This study aimed to determine whether there was any difference in patients’ length of stay of inter-type of antipsychotic therapies given to acute phase schizophrenia patients in Sungai Bangkong Regional Mental Hospital in the period of January–December 2014. The study design was a cross-sectional analysis with retrospective data collecting method. This study was carried out to 98 patients’ medical records who received antipsychotic therapy. Data were analyzed with univariate and bivariate analysis. Univariate analysis gave an overview of patients’ characteristics while bivariate analysis was used to see whether there was any difference in patients’ length of stay of inter-type of antipsychotic therapies. The result showed that the most widely used antipsychotic and adjuvant by patients were risperidone and trihexyphenidyl as many as 446 times (25,32%) and 340 times (65,89%), respectively. Analysis result using One-Way ANOVA showed that the length of stay of acute phase schizophrenia patients, treated with typical monotherapy, atypical monotherapy, and polytherapy, had no significant difference (p>0,05). It showed that length of stay of inter-type of antipsychotic therapies were not different, thus it could be concluded that type of antipsychotic therapies didn’t affect the differences in patients’ length of stay.Keywords: Antipsychotic, length of stay, schizophrenia, type of therapies
SKRINING FITOKIMIA DAN ANALISIS KROMATOGRAFI LAPIS TIPIS DARI EKSTRAK ETANOL DAUN BINTANGUR (Calophyllum soulattri Burm. F.) Fajriaty, Inarah; IH, Hariyanto; Andres, Andres; Setyaningrum, Risky
Jurnal Pendidikan Informatika dan Sains Vol. 7 No. 1 (2018): Jurnal Pendidikan Informatika dan Sains
Publisher : IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (451.407 KB) | DOI: 10.31571/saintek.v7i1.768

Abstract

Bintangur (Calophyllum soulattri Burm.F.) oleh masyarakat Indonesia digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui penapisan fitokimia dan profil kromatogram dari daun bintangur. Daun bintangur diekstraksi menggunakan alat Soxhlet dan pelarut etanol 96%. Metabolit sekunder diidentifikasi dengan uji skrining fitokimia dan uji KLT. Alkaloid menggunakan Mayer, Wagner, dan Dragendoff, Flavonoid dengan uji Schinoda, terpenoid/steroid menggunakan Liebermann Burchard, tanin menggunakan FeCl3 dan gelatin, fenolmenggunakan FeCl3, saponin dengan indeks busa, indeks ikan, dan indeks hemolitik, dan quinon dengan NaOH. Pengujian senyawa terpenoid/steroid dan fenol dilanjutkan dengan uji KLT dengan fase diam plat silika gel GF254 dan fase gerak n-heksana:etil asetat (6:4) dan (3:7), sinar UV 254nm dan 366nm serta dengan penampak bercak Libermann Burchard dan FeCl3. Skrining fitokimia menunjukan senyawa flavonoid, steroid, fenol, tanin, dan saponin dengan indeks ikan sebesar 400 kali pengenceran, indeks busa166,67 dan indeks hemolitik 1.176,470. Uji KLT menunjukkan senyawa terpenoid/steroid dan fenol dengan bercak warna biru violet dan biru kehitaman.Kata kunci: Ekstrak Etanol Daun Bintangur (Calophyllum soulattri Burm.F.),               Kromatografi Lapis Tipis (KLT), Skrining Fitokimia
Kejadian Buta Warna pada Pasien Tuberkulosis Paru di Unit Pengobatan Penyakit Paru-Paru (UP4) Pontianak Carissa, Ingrid Devi; Nansy, Esy; IH, Hariyanto; Asroruddin, Muhammad
Cermin Dunia Kedokteran Vol 44, No 4 (2017): Optalmologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.823 KB) | DOI: 10.55175/cdk.v44i4.845

Abstract

Etambutol adalah obat golongan makrolida yang digunakan untuk pengobatan tuberkulosis (TB), memiliki efek samping berupa neuropati optik toksik, salah satu parameternya yaitu buta warna. Penelitian ini bertujuan untuk mengetahui gambaran lama penggunaan etambutol dan kejadian buta warna pada pasien tuberkulosis paru di Unit Pengobatan Penyakit Paru-paru (UP4) Pontianak. Penelitian ini menggunakan metode cross sectional bersifat deskriptif. Pengumpulan data rekam medis dilakukan di Poliklinik Directly Observed Treatment Short-course (DOTS) UP4 Pontianak dan pemeriksaan buta warna di Poliklinik Mata Rumah Sakit Pendidikan Universitas Tanjungpura Pontianak (RSP UNTAN). Total populasi adalah 45 orang. Pasien yang memenuhi kriteria inklusi 24 orang, 11 di antaranya bersedia menjalani pemeriksaan mata, 8 (72,73%) perempuan, dan 3 (27,27%) laki-laki. Pasien pengguna etambutol ≤2 bulan sebanyak 8 orang (72,72%) dan > 2 bulan 3 orang (27,27%). Jumlah pasien TB paru yang buta warna (parsial) sebanyak 2 orang (18,18%), 1 laki-laki (0,09%) pada penggunaan etambutol ≤2 bulan dan 1 perempuan (0,09%) pada penggunaan etambutol > 2 bulan.Ethambutol is macrolide drugs effective for tuberculosis, the side effect is optic neuropathy resulting in color blindness. This study searched colour blindness among pulmonary tuberculosis patients treated with ethambutol in UP4, Pontianak. This study was descriptive crosssectional with prospective data collection.The medical record data collection was done at Directly Observed Treatment Short-Course (DOTS) UP4 unit in Pontianak, the examination for colour blindness was conducted at the Ophthalmology Outpatient Dept., Tanjungpura University Hospital in Pontianak (RSP UNTAN). From total samples of 45 people, 24 met the inclusion criteria, and 11 agreed to undergo colour blindness test, 8 (72.73%) females, and 3 (27,27%) males. Eight (72.73%) persons used ethambutol for ≤2 months and 3 (27.27%) persons for > 2 months. Two (18.18%) persons suffered from partial colour blindness - one male used ethambutol for ≤2 months and one female used ethambutol > 2 months.
SKRINING FITOKIMIA DAN ANALISIS KROMATOGRAFI LAPIS TIPIS DARI EKSTRAK ETANOL DAUN BINTANGUR (Calophyllum soulattri Burm. F.) Inarah Fajriaty; Hariyanto IH; Andres Andres; Risky Setyaningrum
Jurnal Pendidikan Informatika dan Sains Vol. 7 No. 1 (2018): Jurnal Pendidikan Informatika dan Sains
Publisher : IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/saintek.v7i1.768

Abstract

Bintangur (Calophyllum soulattri Burm.F.) oleh masyarakat Indonesia digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui penapisan fitokimia dan profil kromatogram dari daun bintangur. Daun bintangur diekstraksi menggunakan alat Soxhlet dan pelarut etanol 96%. Metabolit sekunder diidentifikasi dengan uji skrining fitokimia dan uji KLT. Alkaloid menggunakan Mayer, Wagner, dan Dragendoff, Flavonoid dengan uji Schinoda, terpenoid/steroid menggunakan Liebermann Burchard, tanin menggunakan FeCl3 dan gelatin, fenolmenggunakan FeCl3, saponin dengan indeks busa, indeks ikan, dan indeks hemolitik, dan quinon dengan NaOH. Pengujian senyawa terpenoid/steroid dan fenol dilanjutkan dengan uji KLT dengan fase diam plat silika gel GF254 dan fase gerak n-heksana:etil asetat (6:4) dan (3:7), sinar UV 254nm dan 366nm serta dengan penampak bercak Libermann Burchard dan FeCl3. Skrining fitokimia menunjukan senyawa flavonoid, steroid, fenol, tanin, dan saponin dengan indeks ikan sebesar 400 kali pengenceran, indeks busa166,67 dan indeks hemolitik 1.176,470. Uji KLT menunjukkan senyawa terpenoid/steroid dan fenol dengan bercak warna biru violet dan biru kehitaman.Kata kunci: Ekstrak Etanol Daun Bintangur (Calophyllum soulattri Burm.F.),               Kromatografi Lapis Tipis (KLT), Skrining Fitokimia
Perbedaan Jenis Terapi Antipsikotik terhadap Lama Rawat Inap Pasien Skizofrenia Fase Akut di RSJD Sungai Bangkong Pontianak Hariyanto Ih; Rizka A. Putri; Eka K. Untari
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3010.589 KB) | DOI: 10.15416/ijcp.2016.5.2.115

Abstract

Skizofrenia adalah salah satu gangguan jiwa berat yang mempengaruhi seseorang dalam berpikir, merasa, dan bertindak. Prevalensi skizofrenia di Kalimantan Barat pada tahun 2013 adalah 0,7 per 1000 penduduk. Penelitian ini bertujuan untuk menentukan ada atau tidaknya perbedaan lama rawat inap pasien antar jenis terapi antipsikotik yang diberikan kepada pasien skizofrenia fase akut di Rumah Sakit Jiwa Daerah (RSJD) Sungai Bangkong periode Januari–Desember 2014. Desain penelitian berupa analisis cross-sectional dengan metode pengumpulan data secara retrospektif. Penelitian ini dilakukan terhadap 98 rekam medik pasien yang menerima terapi antipsikotik. Data dianalisis dengan analisis univariat dan bivariat. Analisis univariat memberikan gambaran karakteristik pasien, sedangkan analisis bivariat bertujuan untuk melihat ada atau tidaknya perbedaan lama rawat inap pasien antar jenis terapi antipsikotik yang diberikan. Hasil penelitian didapatkan bahwa jenis antipsikotik dan adjuvant yang paling banyak digunakan pasien adalah risperidon dan triheksifenidil dengan frekuensi pemakaian masing-masing sebanyak 446 kali (25,32%) dan 340 kali (65,89%). Hasil analisis menggunakan One‑Way ANOVA menunjukkan bahwa lama rawat inap pasien skizofrenia fase akut yang mendapatkan terapi antipsikotik tunggal tipikal, tunggal atipikal, dan kombinasi tidak mengalami perbedaan yang signifikan (p>0,05). Hasil tersebut menunjukkan bahwa lama rawat inap antar jenis terapi antipsikotik tidak berbeda sehingga dapat disimpulkan jenis terapi antipsikotik yang diberikan tidak memengaruhi perbedaan lama rawat inap pasien.Kata kunci: Antipsikotik, jenis terapi, lama rawat inap, skizofreniaDifferent Type of Antipsychotic Therapies on Length of Stay of Acute Schizophrenia Patients in Sungai Bangkong Regional Mental Hospital Pontianak Schizophrenia is one of severe mental disorders that affects how a person thinks, feels, and acts. In 2013, the prevalence of schizophrenia in West Kalimantan was 0,7 per 1000 inhabitants. This study aimed to determine whether there was any difference in patients’ length of stay of inter-type of antipsychotic therapies given to acute phase schizophrenia patients in Sungai Bangkong Regional Mental Hospital in the period of January–December 2014. The study design was a cross-sectional analysis with retrospective data collecting method. This study was carried out to 98 patients’ medical records who received antipsychotic therapy. Data were analyzed with univariate and bivariate analysis. Univariate analysis gave an overview of patients’ characteristics while bivariate analysis was used to see whether there was any difference in patients’ length of stay of inter-type of antipsychotic therapies. The result showed that the most widely used antipsychotic and adjuvant by patients were risperidone and trihexyphenidyl as many as 446 times (25,32%) and 340 times (65,89%), respectively. Analysis result using One-Way ANOVA showed that the length of stay of acute phase schizophrenia patients, treated with typical monotherapy, atypical monotherapy, and polytherapy, had no significant difference (p>0,05). It showed that length of stay of inter-type of antipsychotic therapies were not different, thus it could be concluded that type of antipsychotic therapies didn’t affect the differences in patients’ length of stay.Keywords: Antipsychotic, length of stay, schizophrenia, type of therapies
Analisis Tingkat Pengetahuan dan Perilaku Swamedikasi Diare Selama Pandemi Covid-19 Filomina Dila Putri; Shoma Rizkifani; Hariyanto IH
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13599

Abstract

Diarrhea was determined as one of the Covid-19 symptoms and during the Covid-19 pandemic in 2020, the prevalence of diarrhea increased to 13.05% in district of Rasau Jaya. The limitations of health services during the Covid-19 pandemic led to the increasing of self-medication behavior, including self-medication to overcome those diarrheal symptoms. The object of this study was to determine the level of knowledge and behavior of self-medication for diarrhea in district of Rasau Jaya and the correlation between these knowledge and behavior. We use a cross sectional approach with total of 70 respondents and we use  purposive sampling with a questionnaire measuring instrument for sampling technique as well. Data were measured by statistical tests of Spearman rank correlation. The results showed that  57.14% of respondents have a good level of self-medication knowledge whereas 41.43% and 1.43% of respondents have medium and deficient knowledge, respectively. These results are in line with self-medication behavior that shown 95.71% of respondents have a good level of behavior but only 4.29% of respondents have a deficient level. We found that People in Rasau Jaya had a good level of self-medication knowledge and behavior and there is a correlation between those two.
Kejadian Buta Warna pada Pasien Tuberkulosis Paru di Unit Pengobatan Penyakit Paru-Paru (UP4) Pontianak Ingrid Devi Carissa; Esy Nansy; Hariyanto IH; Muhammad Asroruddin
Cermin Dunia Kedokteran Vol 44, No 4 (2017): Optalmologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i4.845

Abstract

Etambutol adalah obat golongan makrolida yang digunakan untuk pengobatan tuberkulosis (TB), memiliki efek samping berupa neuropati optik toksik, salah satu parameternya yaitu buta warna. Penelitian ini bertujuan untuk mengetahui gambaran lama penggunaan etambutol dan kejadian buta warna pada pasien tuberkulosis paru di Unit Pengobatan Penyakit Paru-paru (UP4) Pontianak. Penelitian ini menggunakan metode cross sectional bersifat deskriptif. Pengumpulan data rekam medis dilakukan di Poliklinik Directly Observed Treatment Short-course (DOTS) UP4 Pontianak dan pemeriksaan buta warna di Poliklinik Mata Rumah Sakit Pendidikan Universitas Tanjungpura Pontianak (RSP UNTAN). Total populasi adalah 45 orang. Pasien yang memenuhi kriteria inklusi 24 orang, 11 di antaranya bersedia menjalani pemeriksaan mata, 8 (72,73%) perempuan, dan 3 (27,27%) laki-laki. Pasien pengguna etambutol ≤2 bulan sebanyak 8 orang (72,72%) dan > 2 bulan 3 orang (27,27%). Jumlah pasien TB paru yang buta warna (parsial) sebanyak 2 orang (18,18%), 1 laki-laki (0,09%) pada penggunaan etambutol ≤2 bulan dan 1 perempuan (0,09%) pada penggunaan etambutol > 2 bulan.Ethambutol is macrolide drugs effective for tuberculosis, the side effect is optic neuropathy resulting in color blindness. This study searched colour blindness among pulmonary tuberculosis patients treated with ethambutol in UP4, Pontianak. This study was descriptive crosssectional with prospective data collection.The medical record data collection was done at Directly Observed Treatment Short-Course (DOTS) UP4 unit in Pontianak, the examination for colour blindness was conducted at the Ophthalmology Outpatient Dept., Tanjungpura University Hospital in Pontianak (RSP UNTAN). From total samples of 45 people, 24 met the inclusion criteria, and 11 agreed to undergo colour blindness test, 8 (72.73%) females, and 3 (27,27%) males. Eight (72.73%) persons used ethambutol for ≤2 months and 3 (27.27%) persons for > 2 months. Two (18.18%) persons suffered from partial colour blindness - one male used ethambutol for ≤2 months and one female used ethambutol > 2 months.
Evaluasi Kesesuaian Dosis pada Pasien Pediatri Bronkitis Akut di Rumah Sakit Tentara Kartika Husada Kubu Raya Kharis, Variandini Aldhila; Desnita, Rise; IH, Hariyanto
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Selection and usage of rational drugs determine the success of expected therapeutic effect, especially for pediatrics. Acute bronchitis in pediatrics is one of the highest incidents of Acute Respiratory Infection (ARI) in Army Hospital Kartika Husada Kubu Raya. This study aimed to evaluate rationality of drug doses conformity in outpatient pediatric acute bronchitis in Army Hospital Kartika Husada Kubu Raya on 2015. This research was a descriptive observational research with cross-sectional design. The sample was taken with purposive sampling amounted to 36 prescriptions. Then the evaluation of drug doses conformity was counted according to the literature. The results showed that drugs which were used for acute bronchitis were mucolitics and expectorants, antibiotics, bronchodilators, multivitamins, decongestans, analgesics, and antihistamins. The result of drug dosage conformity evaluation showed that the under-dose drug item (R/) was 51%, over-dose was 15% and appropriate dose was 34%.
Analisis Hubungan Tingkat Pengetahuan terhadap Perilaku Swamedikasi Batuk selama Masa Pandemi Covid-19 Lusi Ariska Triani; Hariyanto IH; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15669

Abstract

The Covid-19 pandemic gave an impact on the limitation of health services in health facilities, causing people to choose self-medication as their treatment method. The purpose of this study is to determine the level of knowledge and self-medication behavior of cough symptoms in Rasau Jaya District and the correlation between those two variables during the Covid-19 pandemic. Cross-sectional design with purposive sampling technique was used as a research method for 75 respondents and questionnaires were used as a measuring tool. Data processing was carried out using SPSS statistical tests. We found that none of the respondents had low knowledge levels with 71 respondents (94,7%) having a good level of knowledge and 4 respondents (5,3%) having sufficient levels. This result are in line with self-medication behavior showed that 73 respondents (97,3%) have a good level of behavior at doing self-medication of cough and 2 respondents (2,7%) have deficient levels. The majority people in Rasau Jaya District have a good level of knowledge and self-medication behavior and we found that there is a correlation between those two variables.
Studi docking untuk skrining senyawa antibakteri dari Jeringau Merah (Acorus calamus L.) menggunakan protein Shigella flexneri sebagai model sistem Riyadh Aqilsya Amaryl Dyas; Bambang Wijianto; Hariyanto IH
Acta Chimica Asiana Vol. 6 No. 2 (2023)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v6i2.161

Abstract

Alpha (a) and beta (β) asarone were identified as the main compounds of red Jeringau (Acorus calamus L.) and had antimicrobial properties. This study aimed to know these two compounds' antibacterial mechanism and toxicity prediction against the PBP 2 protein and 50S Ribosomal Protein of Shigella flexneri. Molecular docking protocol using PyRx device was performed with Exhaustiveness value= 106, grid x=38.738375, y=112.645792, z=46.926417 for PBP2, and grid x=71.721251, y=47.551601, z=9.663173 for 50S Ribosomal Protein. The molecular docking results on the α -Asarone compound obtained an affinity value of -5.7 kcal/mol for PBP2 and an affinity value of -5.6 kcal/mol for 50S Ribosomal Protein. In comparison, β-Asarone had an affinity value of -5.6 kcal/mol to PBP2 and an affinity value of -5.7 kcal/mol for 50S Ribosomal Protein. The α and β-Asarone affinity had better values than the control. Molecular docking of α and β-Asarone compounds results in ionic bonds to the TYR529 amino acid and polar bonds to the ASN552 amino acid of PBP2. However, only β-Asarone produces ionic bonds at the amino acid ILE17 and polar bonds at GLU13 from 50S Ribosomal Protein. Based on this study, the α and β-Asarone compounds were shown to have antibacterial activity by interfering with the permeability of the bacterial cell wall. Both compounds are also predicted to have carcinogenic and mutagen effects.
Co-Authors Albianus Febri Tarung Andres Andres Andres Andres Ardianto, Verdi Bambang WIJIANTO Budiarto, Dwi Carissa, Ingrid Devi Cristin, Bella Delima Fajar Liana Eka K. Untari Esy Nansy Fajar Nugraha Fajar Nugraha Fajriati, Inarah Fajriaty, Inarah Faradilla, Aulia Filomina Dila Putri Fitaloka, Fahira Amanda Hadi Kurniawan Hadi Kurniawan, Hadi Hadi, Kurniawan Hafrizal Riza, Hafrizal Hasni, Ali Almurtadho Ingrid Devi Carissa Irawan, Dandi Isnindar Isnindar Karamigi, Iota Rias Liana, Delima F. Luliana, Sri Lusi Ariska Triani Mahyarudin, Mahyarudin Mardhia Mardhia Mardhia, Mardhia Muhammad Andre Reynaldi Muhammad Asroruddin Muhammad Asroruddin, Muhammad Najini, Robby Nansy, Esy Putri, Lidya Hafidzah Putri, Rizka A. Restika, Risma A. Rifdah, Dzuria Adhana Rise Desnita, Rise Risky Setyaningrum Riyadh Aqilsya Amaryl Dyas Rizka A. Putri Ropiqa, Meri Setyaningrum, Risky Shoma Rizkifani Siti Nani Nurbaeti Syaifitri, Ramidiani Untari, Eka K. Varera, Reski Agus Variandini Aldhila Kharis Variandini Aldhila Kharis, Variandini Aldhila Yuswar, Muhammad Akib