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All Journal JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Orthopaedi and Traumatology Surabaya (JOINTS) Narra J Proceedings of International Conference on Multidiciplinary Research Physical Therapy Journal of Indonesia Svāsthya: Trends in General Medicine and Public Health Folia Medica Indonesiana
Safrizal Rahman, Safrizal
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Uji Diagnostik Rasio Neutrofil-Limfosit Pada Apendisitis Akut Di Rumah Sakit Umum Zainoel Abidin Banda Aceh Adyasa Manggala Putra, Idham; Syahputra, Dian Adi; Yusuf, Muhammad; Isa, Muntadhar Muhammad; Rahman, Safrizal; Ismy, Jufriady
Majalah Kedokteran Indonesia Vol 71 No 4 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.4-2021-426

Abstract

Introductions: Acute appendicitis is an inflammation that occurs in the Vermiformis appendix. Inflammatory response to acute appendicitis is characterized by the activation of cellular and molecular effectors, including recruitment and activation of neutrophils. The Neutrophil Lymphocytes Ratio (NLR) is a comparison of neutrophil counts with lymphocytes used as a simple benchmark. Methods: we analysed with observational diagnostic test analytical design of retrospective cross sectional studies. The study subjects were acute appendicitis patients at Zainoel Abidin General Hospital in 2018-2019. Subjects upon arrival performed a blood test, and then calculated NLR, the result of NLR count compared to post-appendectomy anatomical pathology examination. The data is analyzed with descriptive statistical analysis, ROC curve analysis and diagnostic tests.Results: There were 176 samples was came to emergency room with diagnosed appendicitis, the most age was 17-25 years (31.2%), 81 male (46%), 95 female (54%). From patological anatomy result were 129 acute appendicitis and 47 chronic appendicitis. From the AUC ROC 0.96 obtained cut off point NLR greater than 3,209 in acute appendicitis. Diagnostic tests obtained sensitivity 83,72% specificity 82,98%, positive guess value 97,71% and negative guess value 65,00% with 83,52% accuracy.Conclusion: we concluded NLR may predict diagnosis of acute appendicitis with NLR greater than 3,209, sensitivity scores of 83,72% specificity 82,98%.
The Effect of Binahong (Anredera cordifolia (Ten.) Steenis) Leaf Ethanolic Extract on the Reduction of Blood Uric Acid Levels in Hyperuricemic Male White Wistar Rats (Rattus norvegicus) Anugerah, Panji; Rahman, Safrizal
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • Antioxidant flavonoid compounds can be found in binahong leaf extract. • Binahong leaf extract is as effective as allupurinol in reducing uric acid levels. Abstract: Binahong (Anredera cordifolia (Ten.) Steenis) is empirically used to treat burns, rheumatism, gout, typhoid, and stroke. Binahong leaves contain flavonoids that have an antioxidant effect. This study aimed to identify and test binahong leaf flavonoid compounds' antioxidant properties in reducing uric acid levels. This study began by producing binahong leaf extract and then identifying the flavonoid content with a phytochemical test. The results indicated that the binahong leaf extract contained antioxidant flavonoid compounds. The data were followed by testing flavonoid activity in lowering uric acid levels. This study used male white Wistar rats, of which the uric acid was induced by chicken liver juice. The animals used in the test were 25 rats divided into five groups (i.e., negative control group, positive control group, and treatment groups with dose I, dose II, and dose III). In each group, there were five male white rats. This study was a laboratory experiment using a pre-test post-test design with control groups (pre-test post-test control group design), where the grouping was done based on a randomized group design. By using statistical tests, the results obtained showed that there was a significant decrease of uric acid levels in the positive control group and the treatment group. In conclusion, binahong leaf ethanolic extract can reduce blood uric acid levels induced by chicken liver juice in male white Wistar rats.
Co-Authors A. Rivai, Mohammad Adyasa Manggala Putra, Idham Anugerah, Panji Atayoğlu, Ali Timuçin Ayu, Onarisa Azharuddin Azharuddin, Azharuddin AZMI, AZMI Dasrul Dasrul Hanifah Yusuf Hizir Sofyan Husaini, Brury A. Hutagalung, Muhammad Bayu Z Ichsan, T. Isa, Muntadhar Muhammad Ismy, Jufriady Isnanda, Rizki Puji Mubarak, Muhammad Iqbal EL Muhammad Azmi, Muhammad Muhammad Yusuf Murzalina, Cut Naufal, Iflan Oktari, Rina S. Pramana, Setia Rimadeni, Yeni Sugiarto S Syahputra, Dian Adi Yusni Yusni