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All Journal Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) Jurnal Gizi dan Pangan Soedirman (JGPS) Jurnal Teknologi Agro-Industri JMM (Jurnal Masyarakat Mandiri) Journal of Applied Food Technology TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian AgriHealth: Journal of Agri-food, Nutrition and Public Health JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) TEKIBA : Jurnal Teknologi dan Pengabdian Masyarakat Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan IJCOSIN : Indonesian Journal of Community Service and Innovation Journal of Technology and Food Processing (JTFP) Jurnal Abdimas Indonesia Jurnal Sains dan Teknologi Pangan
Ajeng Dyah Kurniawati
Telkom University
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Jurnal Gizi dan Pangan Soedirman (JGPS)

 1 
PENGARUH PEMBERIAN YOGHURT BUAH DELIMA (Punica granatum) TERHADAP GAMBARAN HISTOPATOLOGI KOLON TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI 1,2-dimethilhidrazine (DMH) Kurniawati, Ajeng Dyah; Najah, Sabila; Widyawati, Ana; Latifasari, Nurul; Zunita, Evia
Jurnal Gizi dan Pangan Soedirman Vol 9 No 1 (2025): JURNAL GIZI DAN PANGAN SOEDIRMAN
Publisher : Program Studi Ilmu Gizi, Jurusan Kesmas Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jgipas.2025.9.1.13469

Abstract

This study aimed to discuss the effect of yogurt fortified with pomegranate-fortified yoghurt, containing key antioxidant compounds such as anthocyanins, on male Wistar rats (Rattus norvegicus) induced by 1,2-dimethylhydrazine (DMH), a carcinogenic compound for colon cancer. The first stage of this study was testing antioxidant activity in various methods of making yogurt. A colon cancer rat group was induced with DMH with a dose of 20 mg/kg/body weight for 5 weeks by subcutaneous injection once a week. Induction of 1.2 DMH in experimental animals was carried out for 5 weeks, while the induction of pomegranate yogurt was carried out using oral induction every day for 4 weeks. The highest antioxidant activity was obtained from yogurt made by mixing plain yogurt and fermented pomegranate juice, where the proportion of pomegranate juice was greater, resulting in a percentage inhibition value of 77.96%. Giving pomegranate yogurt for 4 weeks was able to improve the histopathological picture of rats induced by 1.2 DMH. The best improvement in the histopathological in the colon of rats induced by 1.2 DMH was achieved by the P3 treatment group, where the proportion of pomegranate was greater when compared to plain yogurt.
Co-Authors Adanti Wido Paramadini Akmel Lu’lu Alhakim, Rahmat Anis Khairunnisa, Anis Arima Diah Setiowati Ariq Cahya Wardhana Arlian, Fitranaya Budiarly, Dias Feby Chusnul Hidayat Dasril Aldo Diandra Citra Salsabila Dias Feby Budiarly Evia Zunita Dwi Pratiwi Faizah Faizah Faizah Faizah Faizah Faizah Fathan, Faizal Burhani Ulil Fitranaya Arlian Fitranaya Arlian Fitranaya Arlian Cintaya Dewi Gati, Andini Rahyu Lina Fatimah Lishobrina Lu’lu, Akmel Mahazam Afrad Maulana, Ihsan Muhammad Novianto Bayu Saputro Muhammad Tata Awaludin Najah, Sabila Niluh Putu Sonia Agustini Nurjanah, Al Haya Nurul Latifasari Raharditya, Carantia Ratih Windu Arini Rifda Naufalin Salimatul Qolbiyah Silvia Van Marsally Silvia Van Marsally sudianto Sulaeman, Gilang Widyawati, Ana Yasin, Feri Zunita, Evia