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All Journal Pharmacon Al-Kharaj: Jurnal Ekonomi, Keuangan & Bisnis Syariah Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Abdi Geomedisains Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy
Juwita Rahmawati
Fakultas Farmasi, Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Gel Ekstrak Daun Sirsak (Annona muricata L.): Formulasi dan Efektivitas terhadap Microsporum canis Juwita Rahmawati; Amaranggana Lalita Nastiti; Gunawan Setiyadi; Farrel Maulana
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1132

Abstract

Soursop (Annona muricata  L.) leaves contain genistein, steroids, and coumarins, which exhibit potential as natural antifungal agents against Microsporum canis, the causative agent of ringworm. This study aimed to formulate a soursop leaf extract gel using Na-CMC and carbopol 940 as gelling agents, optimized through the Simplex Lattice Design (SLD) with DE version 13, and to evaluate its physical characteristics and antifungal activity. Extraction was carried out by maceration with 96% ethanol. The optimum formula was obtained with 4.3% Na-CMC and 1.7% carbopol 940. The optimized gel exhibited homogeneous texture, characteristic soursop odor, greenish-brown semi-solid appearance, pH of 6.56 ± 0.17, viscosity of 326 ± 16.73 dPas, spreadability of 3.96 ± 0.43 cm², and adhesiveness of 1.58 ± 0.71 seconds. Antifungal testing using the well diffusion method showed an inhibition zone of 15.33 mm, classified as strong activity. ANOVA analysis revealed a significance value of 0.000 (< 0.05), indicating significant differences among the positive control, negative control, optimized gel, and soursop leaf extract. The antifungal activity of the optimum formula was not significantly different from that of the soursop leaf extract (p = 0.795). These results indicate the potential of soursop leaf extract gel as an effective antifungal alternative.
Co-Authors Adinda Dwi Anggraini Amaranggana Lalita Nastiti Anita Sukmawati Annisa Nur Lathifah Amanda Putri Arifah Sri Wahyuni Arini Fadhilah Erindyah Retno Wikantyasning Farrel Maulana Febri Wulandari Fhadilla Aulya Gunawan Setiyadi Gunawan Setyadi Kamila, Rossy Destriana Lilla Prapdhani Agni Hajma Luqman Hakim Maryati Maryati Nibrasa, Lauda Aurynava Peni Indrayudha Rosalia, Vesika Vedantha Sabar Narimo Santhyami Septiana Windarti Teguh Imanto Tri Yulianti Vesika Vedantha Rosalia Vita Fadilah Khairani Wibowo , Farrel Maulana